FORM 4 Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940

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(Print or Type Responses)

1. Name and Address of Reporting Person * SCANGOS GEORGE A   2. Issuer Name and Ticker or Trading Symbol EXELIXIS INC [EXEL] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable) __X__ Director _____ 10% Owner __X__ Officer (give title below) _____ Other (specify below) President & CEO (Last) (First) (Middle) C/O EXELIXIS INC., 170 HARBOR WAY, PO BOX 0511 3. Date of Earliest Transaction (Month/Day/Year) 11/03/2006 (Street) SOUTH SAN FRANCISCO, CA 94083-0511 4. If Amendment, Date Original Filed(Month/Day/Year) 6. Individual or Joint/Group Filing(Check Applicable Line) _X_ Form filed by One Reporting Person ___ Form filed by More than One Reporting Person (City) (State) (Zip) Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned

1.Title of Security (Instr. 3) 2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4) Code V Amount (A) or (D) Price Common Stock 11/03/2006   S(1)   100 D $ 8.05 1,391,031 D   Common Stock 11/03/2006   S(1)   300 D $ 8.27 1,390,731 D   Common Stock 11/03/2006   S(1)   100 D $ 8.31 1,390,631 D   Common Stock 11/03/2006   S(1)   200 D $ 8.22 1,390,431 D   Common Stock 11/03/2006   S(1)   300 D $ 8.2 1,390,131 D   Common Stock 11/03/2006   S(1)   100 D $ 8.24 1,390,031 D   Common Stock 11/03/2006   S(1)   100 D $ 8.18 1,389,931 D   Common Stock 11/03/2006   S(1)   100 D $ 8.19 1,389,831 D   Common Stock 11/03/2006   S(1)   100 D $ 8.17 1,389,731 D   Common Stock 11/03/2006   S(1)   100 D $ 8.23 1,389,631 D   Common Stock 11/03/2006   S(1)   200 D $ 8.29 1,389,431 D   Common Stock 11/03/2006   S(1)   100 D $ 8.32 1,389,331 D   Common Stock 11/03/2006   S(1)   100 D $ 8.33 1,389,231 D   Common Stock 11/03/2006   S(1)   100 D $ 8.38 1,389,131 D   Common Stock 11/03/2006   S(1)   100 D $ 8.41 1,389,031 D   Common Stock 11/03/2006   S(1)   100 D $ 8.42 1,388,931 D   Common Stock 11/03/2006   S(1)   100 D $ 8.44 1,388,831 D   Common Stock 11/03/2006   S(1)   100 D $ 8.5 1,388,731 D   Common Stock 11/03/2006   S(1)   100 D $ 8.53 1,388,631 D   Common Stock               6,855 I By Trust (2) Common Stock               6,855 I By Trust (3) Common Stock               3,324 I By 401(k) Plan (4)

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
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Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)

1. Title of Derivative Security (Instr. 3)

2. Conversion or Exercise Price of Derivative Security

3. Transaction Date (Month/Day/Year)

3A. Deemed Execution Date, if any (Month/Day/Year)

4. Transaction Code (Instr. 8)

5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4, and 5)

6. Date Exercisable and Expiration Date (Month/Day/Year)

7. Title and Amount of Underlying Securities (Instr. 3 and 4)

8. Price of Derivative Security (Instr. 5)

9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)

10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4)

11. Nature of Indirect Beneficial Ownership (Instr. 4)

Code

V

(A)

(D)

Date Exercisable

Expiration Date

Title

Amount or Number of Shares

Reporting Owners

Reporting Owner Name / Address	Relationships
	Director	10% Owner	Officer	Other
SCANGOS GEORGE A C/O EXELIXIS INC. 170 HARBOR WAY, PO BOX 0511 SOUTH SAN FRANCISCO, CA 94083-0511	X		President & CEO

Signatures

/s/ George A. Scangos		11/06/2006
**Signature of Reporting Person		Date

Explanation of Responses:

*	If the form is filed by more than one reporting person, see Instruction 4(b)(v).
**	Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1)	The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on August 15, 2006.
(2)	Shares held by George A. Scangos and Leslie S. Wilson, as Trustees of the Katherine Scangos Trust.
(3)	Shares held by George A. Scangos and Leslie S. Wilson, as Trustees of the Jennifer Scangos Trust.
(4)	Represents units in the Exelixis stock fund based on a plan statement dated November 3, 2006.

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