UNITED STATES
                      SECURITIES AND EXCHANGE COMMISSION
                            Washington, D.C. 20549

                                   FORM 13F

                             FORM 13F COVER PAGE

Report for the Calendar Year or Quarter Ended: March 31, 2006

Check here if Amendment [ ]; Amendment Number:
This Amendment (Check only one.): [ ] is a restatement.
                                  [ ] adds new holdings entries.

Institutional Investment Manager Filing this Report:

Name:GENERAL AMERICAN INVESTORS COMPANY, INC.
Address: 450 Lexington Ave, Suite 3300
         New York, NY 10017

13F File Number: 28-461

The institutional investment manager filing this report and the person by whom
it is signed hereby represent that the person signing the report is authorized
to submit it, that all information contained herein is true, correct and
complete, and that it is understood that all required items, statements,
schedules, lists, and tables, are considered integral parts of this form.


Person Signing this Report on Behalf of Reporting Manager:

Name: Eugene S. Stark
Title: Vice-President, Administration
Phone: 212-916-8447
Signature, Place, and Date of Signing:

  Eugene S. Stark   New York, NY   May 05, 2006


Report Type (Check only one.):

[X]    13F HOLDINGS REPORT.

[ ]    13F NOTICE.

[ ]    13F COMBINATION REPORT.


List of Other Managers Reporting for this Manager:

        Form 13F File Number                Name


I AM SIGNING THIS REPORT AS REQUIRED BY THE SECURITIES EXCHANGE ACT OF 1934.


FORM 13F SUMMARY PAGE


Report Summary:

Number of Other Included Managers:       0

Form 13F Information Table Entry Total:  58

Form 13F Information Table Value Total:  $1296364087



List of Other Included Managers:

No.   13F File Number    Name




   COLUMN 1                           COLUMN 2     COLUMN 3  COLUMN 4      COLUMN 5    COLUMN 6  COLUMN 7         COLUMN 8
 --------------                      ---------    ---------  -------- -------------    --------  --------    ------------------
                                                             VALUE    SHARES/ SH/ PUT/ INVSTMT   OTHER    -----VOTING AUTHORITY-----
  NAME OF ISSUER                 -TITLE OF CLASS- --CUSIP-- x$1000    PRN AMT PRN CALL DSCRETN -MANAGERS-     SOLE   SHARED     NONE
                                                                                                      
ABB Ltd. ADR                     COMMON           000375204    14433  1150000 SH       SOLE                1150000        0        0
Arch Capital Group Ltd.          COMMON           G0450A105    20209   350000 SH       SOLE                 350000        0        0
Adams Express Company            COMMON           006212104     1397   105075 SH       SOLE                 105075        0        0
American International Group,Inc COMMON           026874107    23132   350000 SH       SOLE                 350000        0        0
Alkermes, Inc.                   COMMON           01642T108     5292   240000 SH       SOLE                 240000        0        0
The Allstate Corporation         COMMON           020002101    14330   275000 SH       SOLE                 275000        0        0
American Tower Corporation       COMMON           029912201    20466   675000 SH       SOLE                 675000        0        0
Apache Corporation               COMMON           037411105    43564   665000 SH       SOLE                 665000        0        0
AXIS Capital Holdings Limited    COMMON           G0692U109     5980   200000 SH       SOLE                 200000        0        0
Bank of America Corporation      COMMON           060505104    12751   280000 SH       SOLE                 280000        0        0
Bed Bath & Beyond Inc.           COMMON           075896100     7680   200000 SH       SOLE                 200000        0        0
Bancroft Convertible Fund        COMMON           059695106      405    21578 SH       SOLE                  21578        0        0
Biogen Idec Inc.                 COMMON           09062X103     8007   170000 SH       SOLE                 170000        0        0
Berkshire Hathaway Inc. Class A  COMMON           084670108    27105      300 SH       SOLE                    300        0        0
Brooks Automation, Inc.          COMMON           114340102     4600   323000 SH       SOLE                 323000        0        0
Cephalon, Inc.                   COMMON           156708109     9038   150000 SH       SOLE                 150000        0        0
Central Securities Corporation   COMMON           155123102      641    26055 SH       SOLE                  26055        0        0
Costco Wholesale Corporation     COMMON           22160K105    37912   700000 SH       SOLE                 700000        0        0
Cisco Systems, Inc.              COMMON           17275R102    19503   900000 SH       SOLE                 900000        0        0
CEMEX, S.A. de C.V. ADR          COMMON           151290889    74618  1143041 SH       SOLE                1143041        0        0
Cytokinetics, Incorporated       COMMON           23282W100     4410   604900 SH       SOLE                 604900        0        0
Diageo plc                       COMMON           25243Q205    22201   350000 SH       SOLE                 350000        0        0
Dollar General Corporation       COMMON           256669102    13253   750000 SH       SOLE                 750000        0        0
Genentech, Inc.                  COMMON           368710406    25776   305000 SH       SOLE                 305000        0        0
EMC Corporation                  COMMON           268648102     4089   300000 SH       SOLE                 300000        0        0
EMCORE Corporation               COMMON           290846104     1020   100000 SH       SOLE                 100000        0        0
EOG Resources, Inc.              COMMON           26875P101    14400   200000 SH       SOLE                 200000        0        0
Golden West Financial            COMMON           381317106    39722   585000 SH       SOLE                 585000        0        0
Halliburton Company              COMMON           406216101    32129   440000 SH       SOLE                 440000        0        0
The Home Depot, Inc.             COMMON           437076102    66411  1570000 SH       SOLE                1570000        0        0
Lamar Advertising Company        COMMON           512815101    18414   350000 SH       SOLE                 350000        0        0
Medtronic, Inc.                  COMMON           585055106    22838   450000 SH       SOLE                 450000        0        0
MedImmune, Inc.                  COMMON           584699102    14632   400000 SH       SOLE                 400000        0        0
MetLife, Inc.                    COMMON           59156R108    13785   285000 SH       SOLE                 285000        0        0
MFA Mortgage Investments, Inc.   COMMON           55272X102     8255  1300000 SH       SOLE                1300000        0        0
Molex Incorporated Class A       COMMON           608554200    16346   550000 SH       SOLE                 550000        0        0
Microsoft Corporation            COMMON           594918104    38094  1400000 SH       SOLE                1400000        0        0
M&T Bank Corporation             COMMON           55261F104    35383   310000 SH       SOLE                 310000        0        0
North Fork Bancorporation, Inc.  COMMON           659424105    13694   475000 SH       SOLE                 475000        0        0
Annaly Mortgage Management, Inc. COMMON           035710409     6070   500000 SH       SOLE                 500000        0        0
PepsiCo, Inc.                    COMMON           713448108    10113   175000 SH       SOLE                 175000        0        0
Pfizer Inc                       COMMON           717081103    48519  1947000 SH       SOLE                1947000        0        0
PartnerRe Ltd.                   COMMON           G6852T105    22663   365000 SH       SOLE                 365000        0        0
Patterson-UTI Energy, Inc.       COMMON           703481101    31960  1000000 SH       SOLE                1000000        0        0
Everest Re Group, Ltd.           COMMON           G3223R108    51354   550000 SH       SOLE                 550000        0        0
Republic Services, Inc.          COMMON           760759100    49949  1175000 SH       SOLE                1175000        0        0
Rio Tinto plc ADR                COMMON           767204100    13455    65000 SH       SOLE                  65000        0        0
Royce Value Trust                COMMON           780910105     2399   114908 SH       SOLE                 114908        0        0
SunTrust Banks, Inc.             COMMON           867914103    14552   200000 SH       SOLE                 200000        0        0
Constellation Brands, Inc.       COMMON           21036P108     2505   100000 SH       SOLE                 100000        0        0
The TJX Companies, Inc.          COMMON           872540109    62050  2500000 SH       SOLE                2500000        0        0
Talisman Energy Inc.             COMMON           87425E103    53180  1000000 SH       SOLE                1000000        0        0
Total S.A. ADR                   COMMON           89151E109    43471   330000 SH       SOLE                 330000        0        0
Transatlantic Holdings, Inc.     COMMON           893521104    13151   225000 SH       SOLE                 225000        0        0
VeriSign, Inc.                   COMMON           92343E102     3203   133500 SH       SOLE                 133500        0        0
Weatherford International Ltd.   COMMON           G95089101    55815  1220000 SH       SOLE                1220000        0        0
Wal-Mart Stores, Inc.            COMMON           931142103    27163   575000 SH       SOLE                 575000        0        0
Xerox Corporation                COMMON           984121103    28880  1900000 SH       SOLE                1900000        0        0