Ownership Submission
FORM 4
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940
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(Print or Type Responses)
1. Name and Address of Reporting Person *
Blum Robert I
   2. Issuer Name and Ticker or Trading Symbol
CYTOKINETICS INC [CYTK] 		5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
_____ Director _____ 10% Owner
__X__ Officer (give title below) _____ Other (specify below)
EVP, Corp. Development & CBO
(Last)
(First)
(Middle)
280 EAST GRAND AVENUE		 3. Date of Earliest Transaction (Month/Day/Year)
11/07/2005
(Street)

SOUTH SAN FRANCISCO, CA 94080		 4. If Amendment, Date Original Filed(Month/Day/Year)
 6. Individual or Joint/Group Filing(Check Applicable Line)
_X_ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3)		 2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code
(Instr. 8)		 4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)		 5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4)		 6. Ownership Form: Direct (D) or Indirect (I)
(Instr. 4)		 7. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V Amount (A) or (D) Price
Common Stock 11/07/2005   M   2,500 A $ 1.2 67,500 D  
Common Stock 11/07/2005   S   2,500 D $ 8.65 65,000 D  
Common Stock 11/07/2005   M   2,400 A $ 1.2 67,400 D  
Common Stock 11/07/2005   S   2,400 D $ 8.76 65,000 D  
Common Stock 11/07/2005   M   100 A $ 1.2 65,100 D  
Common Stock 11/07/2005   S   100 D $ 8.75 65,000 D  
Common Stock 11/08/2005   M   5,000 A $ 1.2 70,000 D  
Common Stock 11/08/2005   S   5,000 D $ 8.47 65,000 D  
Common Stock               12,500 I by Trust 1 (1)
Common Stock               12,500 I by Trust 2 (2)

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Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 3)		 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year) 3A. Deemed Execution Date, if any (Month/Day/Year) 4. Transaction Code
(Instr. 8)		 5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4, and 5)		 6. Date Exercisable and Expiration Date
(Month/Day/Year)		 7. Title and Amount of Underlying Securities
(Instr. 3 and 4)		 8. Price of Derivative Security
(Instr. 5)		 9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 4)		 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 4)		 11. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares
Non-Qualified Stock Option (right to buy) $ 1.2 11/07/2005   M     2,500 07/10/2002(3) 07/10/2012 Common Stock 2,500 $ 8.65 64,167 D  
Non-Qualified Stock Option (right to buy) $ 1.2 11/07/2005   M     2,400 07/10/2002(3) 07/10/2012 Common Stock 2,400 $ 8.76 61,767 D  
Non-Qualified Stock Option (right to buy) $ 1.2 11/07/2005   M     100 07/10/2002(3) 07/10/2012 Common Stock 100 $ 8.75 61,667 D  
Non-Qualified Stock Option (right to buy) $ 1.2 11/08/2005   M     5,000 07/10/2002(3) 07/10/2012 Common Stock 5,000 $ 8.47 56,667 D  
Incentive Stock Option (right to buy) $ 0.58             01/14/2000(4) 11/14/2010 Common Stock 112,500   112,500 D  
Incentive Stock Option (right to buy) $ 1.2             07/10/2002(3) 07/10/2012 Common Stock 83,333   83,333 D  
Incentive Stock Option (right to buy) $ 1.2             05/21/2003(5) 05/21/2013 Common Stock 37,500   37,500 D  
Incentive Stock Option (right to buy) $ 2             12/18/2003(6) 12/18/2013 Common Stock 27,500   27,500 D  
Incentive Stock Option (right to buy) $ 6.59             04/11/2005(7) 04/11/2015 Common Stock 45,000   45,000 D  
Non-Qualified Stock Option (right to buy) $ 2             12/18/2003(6) 12/18/2013 Common Stock 114,425   114,425 D  

Reporting Owners

Reporting Owner Name / Address Relationships
 Director  10% Owner  Officer  Other
Blum Robert I
280 EAST GRAND AVENUE
SOUTH SAN FRANCISCO, CA 94080		       EVP, Corp. Development & CBO  

Signatures

 Robert I. Blum   11/09/2005
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) Shares held by The Bridget Blum 2003 Irrevocable Trust.
(2) Shares held by The Brittany Blum 2003 Irrevocable Trust.
(3) When the ISO and NQ dated 07/10/02 are combined for a total grant of 150,000 shares, the option is immediately exercisable upon grant and shall vest as to 2,500 shares on 04/15/02 and the balance of 147,500 divided into equal monthly installments thereafter such that the option shall be 100% vested on 03/15/07.
(4) This option is immediately exercisable upon grant and shall vest as to 25,000 shares on 11/14/00 and the balance of 87,500 divided into equal monthly installments thereafter such that the option shall be 100% vested on 11/14/05.
(5) This option is immediately exercisable upon grant and shall vest as to 781 shares on 04/01/03 and the balance of 36,719 divided into equal monthly installments thereafter such that the option shall be 100% vested on 03/01/07.
(6) When the ISO and NQ dated 12/18/03 are combined for a total grant of 141,925 shares, the option is immediately exercisable upon grant and shall vest as to 2,365 shares on 01/18/04 and the balance of 139,560 divided into equal monthly installments thereafter such that the option shall be 100% vested on 12/18/08.
(7) This option shall vest and become exercisable as to 45,000 shares divided into equal monthly installments such that the option shall be 100% vested on 03/01/2009.

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