SECURITIES AND EXCHANGE COMMISSION

                             Washington, D.C. 20549

                                    FORM 8-K

                                 CURRENT REPORT
                       Pursuant to Section 13 or 15(d) of
                       The Securities Exchange Act of 1934

        Date of Report (Date of earliest event reported): July 25, 2006

                          IR BIOSCIENCES HOLDINGS, INC.
             (Exact name of registrant as specified in its charter)


                                    Delaware
                               ------------------
                          (State or other jurisdiction
                                of incorporation)

       033-05384                                          13-3301899
   ------------------                                  ------------------
     (Commission                                        (IRS Employer
     File Number)                                     Identification No.)


 4021 North 75th Street, Suite 201 Scottsdale, Arizona          85251
--------------------------------------------------------------------------
 (Address of principal executive offices)                    (Zip Code)


                                   480-922-3926
             ------------------------------------------------------
               Registrant's telephone number, including area code

                                   Not applicable
             ------------------------------------------------------
        (Former name or former address, if changed since last report.)


Check  the  appropriate  box  below  if the  Form  8-K  filing  is  intended  to
simultaneously  satisfy the filing obligation of the registrant under any of the
following provisions (see General Instruction A.2. below):

|_| Written communications pursuant to Rule 425 under the Securities Act (17 CFR
230.425)

|_| Soliciting  material  pursuant to Rule 14a-12 under the Exchange Act (17 CFR
240.14a-12)

|_| Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange
Act (17 CFR 240.14d-2(b))

|_| Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange
Act (17 CFR 240.13e-4(c))





ITEM 1.01  ENTRY INTO A MATERIAL DEFINITIVE AGREEMENT


Effective July 25, 2006, IR BioSciences  Holdings,  Inc. (the "Company") entered
into an unsecured  Senior  Promissory Note in the amount of $250,000.  Following
the payment of commissions  and expenses,  the Company  received net proceeds of
approximately $210,000.

Effective  August  1,  2006,  the  Company  entered  into two  unsecured  Senior
Promissory Notes in the respective amounts of $50,000 and $20,000 (collectively,
including  the  note  dated  July  25,  2006,  referred  to as the  "Notes"  and
individually  as the "Note").  Following the payment of fees and  expenses,  the
Company received net proceeds of approximately $68,600.

The outstanding  principal amount of each Note, plus interest at the rate of 12%
per annum,  is payable in cash on or before the earlier of (i) one year from the
date of such  Note or (ii) the date  upon  which  the  Company  sells any of its
equity or debt securities in a financing transaction, or a series of financings,
with  gross  proceeds  equal  to  $1,000,000  or  more  ("Subsequent   Financing
Transaction");  provided,  however, that a Subsequent Financing Transaction will
not include (x)  issuances of common stock to employees of the Company,  (y) the
exercise  of any  options  to  purchase  common  stock of the  Company  that are
outstanding  as of the date  hereof,  or (z) the grant,  issuance or exercise of
options  or common  stock of the  Company  under the  Company's  stock,  option,
deferred  stock and  restricted  stock plan for the  purpose of  satisfying  the
Company's payables.

Pursuant to the terms of the Notes,  the Company agreed to use the proceeds from
the Notes for working capital and general corporate  purposes.  The Company also
agreed not to engage in any of the following  actions,  among others, so long as
the Notes  remain  outstanding  or any other amount is owed to the holder of the
Notes:  (i)  increase the base salary of any officer of the Company more than 5%
per year unless required to do so by an outstanding  employment agreement,  (ii)
pay any dividends, (iii) incur indebtedness which is senior or pari passu to the
Notes,  (iv) sell  account  receivables,  (v) expend  more than  $100,000 in any
fiscal year for capital expenditures,  or (vi) advance money to or invest in any
firm, corporation or other person, except in certain enumerated  situations.  In
an event of default, as defined in the Notes, the Notes shall become immediately
due and payable, and during the continuation of an event of default, the Company
must pay  interest  on the  Notes in an amount  equal to 2% per month  until the
event of default is cured or waived.

The  Notes  were  sold to  three  investors,  one of whom is a  Director  of the
Company,  who the Company  had  reasonable  grounds to believe  are  "accredited
investors"  within the meaning of Rule 501 of Regulation D under the  Securities
Act of 1933, as amended (the  "Securities  Act").  The  investors  were provided
access to  business  and  financial  information  about the Company and had such
knowledge and  experience in business and financial  matters that they were able
to evaluate  the risks and merits of an  investment  in the  Company.  The Notes
included a legend to the effect  that the Notes  were not  registered  under the
Securities Act and could not be resold absent  registration or the  availability
of an  applicable  exemption  from  registration.  No  general  solicitation  or
advertising was used in connection with the transaction. The Company paid Joseph
Stevens & Company,  Inc. a  placement  agent fee of $25,000  equal to 10% of the
face amount of the $250,000 note dated July 25, 2006.

The issuance of the Notes was exempt from the  registration  requirements of the
Securities Act by reason of Section 4(2) of the Securities Act and the rules and
regulations, including Regulation D thereunder, as transactions by an issuer not
involving a public offering.

The above description,  which summarizes the material terms of the Notes, is not
complete. Please read the full text of the Notes, which have been filed with the
Securities and Exchange  Commission as Exhibits 10.2, 10.3 and 10.4 to this Form
8-K.

ITEM 2.03  CREATION OF A DIRECT FINANCIAL OBLIGATION OR AN OBLIGATION UNDER
           AN OFF-BALANCE SHEET ARRANGEMENT OF A REGISTRANT.

The  information  set forth  above  under  Item 1.01 is hereby  incorporated  by
reference into this Item 2.03.


ITEM 9.01  FINANCIAL STATEMENTS AND EXHIBITS

(d) Exhibits

10.1     Unsecured 12% Senior  Promissory Note dated July 25, 2006 in the amount
         of $250,000.
10.2     Unsecured 12% Senior Promissory Note dated August 1, 2006 in the amount
         of $50,000.
10.3     Unsecured 12% Senior Promissory Note dated August 1, 2006 in the amount
         of $20,000.








                                   SIGNATURES

Pursuant  to the  requirements  of the  Securities  Exchange  Act of  1934,  the
registrant  has duly  caused  this  report  to be  signed  on its  behalf by the
undersigned hereunto duly authorized.

IR BioSciences Holdings, Inc.

Date: August 4, 2006

By:     /s/ Michael K. Wilhelm
        -----------------------
        Name:  Michael K. Wilhelm
        Title: Chief Executive Officer










                                  EXHIBIT INDEX

10.1     Unsecured 12% Senior  Promissory Note dated July 25, 2006 in the amount
         of $250,000.
10.2     Unsecured 12% Senior Promissory Note dated August 1, 2006 in the amount
         of $50,000.
10.3     Unsecured 12% Senior Promissory Note dated August 1, 2006 in the amount
         of $20,000.