UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                                   FORM 12B-25

                           NOTIFICATION OF LATE FILING

(Check One) [X] Form 10-K [ ] Form 20-F [ ] Form 11-K [ ] Form 10-Q
[ ] Form N-SAR  [ ] Form N-CSR

For Period Ended:  December 31, 2005
                   -----------------

[ ] Transition Report on Form 10-K
[ ] Transition Report on Form 20-F
[ ] Transition Report on Form 11-K
[ ] Transition Report on Form 10-Q
[ ] Transition Report on Form N-SAR

For the Transition Period Ended:

Read Instruction (on back page) Before Preparing Form. Please Print or Type.

NOTHING IN THIS FORM SHALL BE CONSTRUED TO IMPLY THAT THE COMMISSION HAS
VERIFIED ANY INFORMATION CONTAINED HEREIN.

If the notification relates to a portion of the filing checked above, identify
the Item(s) to which the notification
relates:______________________________________________________________

                         PART I - REGISTRANT INFORMATION

Cord Blood America, Inc.
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Full Name of Registrant

9000 W. Sunset Boulevard, Suite 400
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Address of Principal Executive Office (Street and Number)

West Hollywood, California  90069
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City, State and Zip Code



                        PART II - RULES 12B-25(B) AND (C)

         If the subject report could not be filed without unreasonable effort or
expense and the registrant seeks relief pursuant to Rule 12b-25(b), the
following should be completed. (Check box, if appropriate) [X]

         (a) The reasons described in reasonable detail in Part III of this form
could not be eliminated without unreasonable effort or expense;

 [X] (b) The subject annual report, semi-annual report, transition report on
Form 10-K, Form 20-F, 11-K, Form N-SAR or Form N-CSR, or portion thereof will be
filed on or before the fifteenth calendar day following the prescribed due date;
or the subject quarterly report or transition report on Form 10-Q, or portion
thereof will be filed on or before the fifth calendar day following the
prescribed due date; and

         (c) The accountant's statement or other exhibit required by Rule
12b-25(c) has been attached if applicable.

                              PART III - NARRATIVE

           State below in reasonable detail the reasons why the Form 1O-K, 20-F,
11-K, 10-Q, N-SAR, N-CSR or the transition report or portion thereof could not
be filed within the prescribed time period.

         As of March 31, 2006, Cord Blood America, Inc. requires additional time
to complete its quarterly report on Form 10-KSB for the following reason. The
registrant appointed a new independent registered public accounting firm and
certain aspects of the registrant's review process have not been completed prior
to the filing date.

                           PART IV - OTHER INFORMATION

(1) Name and telephone number of person to contact in regard to this
notification:

Sandra D. Smith, Chief Financial Officer
----------------------------------------
(Name)

(310) 432-4090
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(Area Code) (Telephone Number)

(2) Have all other periodic reports required under Section 13 or 15(d) of the
Securities Exchange Act of 1934 or Section 30 of the Investment Company Act of
1940 during the preceding 12 months or for such shorter period that the
registrant was required to file such report(s) been filed? If the answer is no,
identify report(s). [X] Yes [ ] No

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(3) Is it anticipated that any significant change in results of operations from
the corresponding period for the last fiscal year will be reflected by the
earnings statements to be included in the subject report or portion thereof? [ ]
Yes [X] No If so: attach an explanation of the anticipated change, both
narratively and quantitatively, and, if appropriate, state the reasons why a
reasonable estimate of the results cannot be made.

Cord Blood America, Inc. has caused this notification to be signed on its behalf
by the undersigned thereunto duly authorized.

                                                     Cord Blood America, Inc.


Date:  March 31, 2005                                By /s/ Sandra Smith
                                                     -------------------
                                                     Sandra Smith
                                                     Chief Financial Officer

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