FORM 4 Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940

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(Print or Type Responses)

1. Name and Address of Reporting Person * WEISER MICHAEL   2. Issuer Name and Ticker or Trading Symbol ZIOPHARM ONCOLOGY INC [ZIOP] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable) __X__ Director _____ 10% Owner _____ Officer (give title below) _____ Other (specify below) (Last) (First) (Middle) 50 WEST 57TH STREET, 15TH FLOOR 3. Date of Earliest Transaction (Month/Day/Year) 12/12/2007 (Street) NEW YORK, NY 10019 4. If Amendment, Date Original Filed(Month/Day/Year) 6. Individual or Joint/Group Filing(Check Applicable Line) _X_ Form filed by One Reporting Person ___ Form filed by More than One Reporting Person (City) (State) (Zip) Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned

1.Title of Security (Instr. 3) 2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4) Code V Amount (A) or (D) Price Common Stock, $.001 par value               83,445 D

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Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)

1. Title of Derivative Security (Instr. 3)

2. Conversion or Exercise Price of Derivative Security

3. Transaction Date (Month/Day/Year)

3A. Deemed Execution Date, if any (Month/Day/Year)

4. Transaction Code (Instr. 8)

5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4, and 5)

6. Date Exercisable and Expiration Date (Month/Day/Year)

7. Title and Amount of Underlying Securities (Instr. 3 and 4)

8. Price of Derivative Security (Instr. 5)

9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)

10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4)

11. Nature of Indirect Beneficial Ownership (Instr. 4)

Code

V

(A)

(D)

Date Exercisable

Expiration Date

Title

Amount or Number of Shares

Warrants to Purchase Common Stock

$ 4.75

09/13/2005

05/31/2012

Common Stock, $.001 par value

35,566

35,566

D

Director Stock Option (right to buy)

$ 4.31

(1)

12/22/2014

Common Stock, $.001 par value

15,029

15,029

D

Director Stock Option (right to buy)

$ 5.01

04/26/2006

04/26/2016

Common Stock, $.001 par value

15,000

15,000

D

Warrants to purchase Common Stock

$ 5.09

05/03/2006

05/03/2013

Common Stock, $.001 par value

18,319

18,319

D

Director Stock Option (right to buy)

$ 6.49

(2)

12/13/2016

Common Stock, $.001 par value

15,000

15,000

D

Stock Option (right to buy)

$ 4.85

(3)

06/18/2017

Common Stock

15,000

15,000

D

Stock Option (right to buy)

$ 2.73

12/12/2007

A

20,000

(4)

12/12/2017

Common Stock

20,000

$ 0

20,000

D

Reporting Owners

Reporting Owner Name / Address	Relationships
	Director	10% Owner	Officer	Other
WEISER MICHAEL 50 WEST 57TH STREET, 15TH FLOOR NEW YORK, NY 10019	X

Signatures

/s/ Richard Bagley as attorney-in-fact for Michael Weiser		12/17/2007
**Signature of Reporting Person		Date

Explanation of Responses:

*	If the form is filed by more than one reporting person, see Instruction 4(b)(v).
**	Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1)	7,515 shares vest on 7/20/06 and 7,514 shares vest on 7/20/07.
(2)	5,000 shares vest on each of 12/13/07, 12/13/08 and 12/13/09.
(3)	5,000 shares vest on each of 6/18/08, 6/18/09 and 6/18/10.
(4)	6,667 shares vest on each of 12/12/08 and 12/12/09; 6,666 shares vest on 12/12/10.

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