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                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                         -------------------------------

                                    FORM 8-K
                         -------------------------------

                                 CURRENT REPORT
                     PURSUANT TO SECTION 13 OR 15(D) OF THE
                         SECURITIES EXCHANGE ACT OF 1934

      DATE OF REPORT (DATE OF EARLIEST EVENT REPORTED): SEPTEMBER 27, 2005

                                    ---------
                                 CRYOLIFE, INC.
             (Exact name of registrant as specified in its charter)
                            -------------------------



                                                                            
               FLORIDA                              1-13165                           59-2417093
-------------------------------------- ----------------------------------- ----------------------------------
    (State or Other Jurisdiction            (Commission File Number)                 (IRS Employer
          of Incorporation)                                                       Identification No.)


              1655 ROBERTS BOULEVARD, N.W., KENNESAW, GEORGIA 30144
               (Address of principal executive office) (zip code)

       REGISTRANT'S TELEPHONE NUMBER, INCLUDING AREA CODE: (770) 419-3355

          -------------------------------------------------------------
          (Former name or former address, if changed since last report)
                            -------------------------

     Check the  appropriate  box below if the Form 8-K  filing  is  intended  to
simultaneously  satisfy the filing obligation of the registrant under any of the
following provisions (see General Instruction A.2. below):

|_|  Written  communications  pursuant to Rule 425 under the  Securities Act (17
     CFR 230.425)

|_|  Soliciting  material pursuant to Rule 14a-12 under the Exchange Act (17 CFR
     240.14a-12)

|_|  Pre-commencement   communications  pursuant  to  Rule  14d-2(b)  under  the
     Exchange Act (17 CFR 240.14d-2(b))

|_|  Pre-commencement   communications  pursuant  to  Rule  13e-4(c)  under  the
     Exchange Act (17 CFR 240.13e-4(c))

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SECTION 1 - REGISTRANT'S BUSINESS AND OPERATIONS
ITEM 1.01 ENTRY INTO A MATERIAL DEFINITIVE AGREEMENT.

     On February  8, 2005,  Cryolife,  Inc.  ("Cryolife")  and its  subsidiaries
entered into a credit  agreement with Wells Fargo  Foothill,  Inc. The agreement
created a revolving  credit facility in an aggregate  amount equal to the lesser
of
     o    $15.0  million that includes a letter of credit  subfacility  up to an
          aggregate $2.0 million; or
     o    a borrowing base determined in accordance with the terms of the credit
          agreement.
For further information on the credit agreement, please refer to Section 2.03 of
CryoLife's Form 8-K dated February 8, 2005, and filed on February 10, 2005 which
is incorporated herein by reference.

     On September 27, 2005, Cryolife,  its subsidiaries,  and the lender amended
the  credit  agreement.  The  main  purpose  of the  amendment  was  to  provide
specifically  that the settlement of the shareholder  class action suit does not
constitute an event of default under the credit agreement. CryoLife reported the
settlement of the shareholder  class action suit on its Form 8-K dated and filed
on July 28, 2005.

     The amendment to the credit  agreement is attached hereto as Exhibit 10.2.1
and incorporated herein by reference.


SECTION 2 - FINANCIAL INFORMATION

SECTION 2.03 CREATION OF A DIRECT FINANCIAL OBLIGATION OR AN OBLIGATION UNDER AN
OFF-BALANCE SHEET ARRANGEMENT OF A REGISTRANT.

     On September 27, 2005,  Cryolife,  Inc., its subsidiaries,  and Wells Fargo
Foothill,  Inc.  amended their February 8, 2005 credit  agreement.  Item 1.01 of
this report describes the amendment. It is incorporated herein by reference.





SECTION 9 - FINANCIAL STATEMENTS AND EXHIBITS
ITEM 9.01 FINANCIAL STATEMENTS AND EXHIBITS

(a) Financial statements of business acquired.  (Not applicable.)

(b) Pro forma financial information.  (Not applicable.)

(c) Shell company transactions. (Not applicable.)

(d) Exhibits.

Exhibit 
Number         Description
-------        -----------

10.2.1         "First  Amendment to the Credit  Agreement,"  signed on September
               27, 2005,  amends the February 8, 2005 Credit  Agreement  between
               Wells Fargo Foothill, Inc., Cryolife, Inc., and its subsidiaries





                                   SIGNATURES

     Pursuant  to the  requirements  of the  Securities  Exchange  Act of  1934,
CryoLife,  Inc.  has duly  caused  this report to be signed on its behalf by the
undersigned, hereunto duly authorized.

                                        CRYOLIFE, INC.



Date:  September 28, 2005               By: /s/ D.Ashley Lee
                                            --------------------------------
                                            Name:   D. Ashley Lee
                                            Title:  Executive Vice President, 
                                            Chief Operating Officer and Chief
                                            Financial Officer





                                  EXHIBIT INDEX


Exhibit 
Number         Description
-------        -----------

10.2.1         "First  Amendment to the Credit  Agreement,"  signed on September
               27, 2005,  amends the February 8, 2005 Credit  Agreement  between
               Wells Fargo Foothill, Inc., Cryolife, Inc., and its subsidiaries