Securities and Exchange Commission
                              Washington, DC 20549

                                   Form 8-K/A
                                 Amendment No. 1

                                 CURRENT REPORT

                     PURSUANT TO SECTION 13 OR 15(d) OF THE

                         SECURITIES EXCHANGE ACT OF 1934



Date of Report (Date of earliest event reported)  December 31, 2003


                            PATIENT INFOSYSTEMS, INC.
             (Exact Name of Registrant as Specified in its Charter)


             Delaware              0-22319                    16-1476509
(State or Other Jurisdiction (Commission File Number)       (IRS Employer
   of Incorporation)                                      Identification No.)


46 Prince Street, Rochester, New York                                 14607
(Address of Principal Executive Offices)                            (Zip Code)

Registrant's telephone number, including area code  (585) 242-7200



          (Former Name or Former Address, if Changed Since Last Report)



Explanatory Note:

     The Registrant hereby amends Item 7 of its Current Report on Form 8-K filed
on  January  15,  2004  to  include  unaudited  condensed  pro  forma  financial
statements in accordance with paragraph (b) (1) of Item 7 of Form 8-K. Except as
set forth in Item 7 below,  no other  changes are made to the Current  Report on
Form 8-K filed on January 15, 2004.

ITEM 7. FINANCIAL STATEMENTS AND EXHIBITS

(b)  Financial Information

     Patient Infosystems,  Inc. unaudited combined condensed pro forma financial
     statements  at and for  the  nine  months  ended  September  30,  2003  and
     unaudited  condensed pro forma  statements of operations for the year ended
     December 31, 2002, and the notes thereto.

     American Caresourse  Corporation  financial  statements for the years ended
     December 31, 2003 and 2002, and the notes thereto.


(c)  The following exhibits are filed herewith:


EXHIBIT NO.   DESCRIPTION
------------  ---------------------
Exhibit 99.1   Patient Infosystems, Inc. unaudited condensed pro forma financial
               statements  at and for the nine months ended  September  30, 2003
               and unaudited  condensed pro forma  statements of operations  for
               the year ended December 31, 2002, and the notes thereto.

Exhibit 99.2   American  Caresourse  Corporation  financial  statements  for the
               years ended December 31, 2003 and 2002, and the notes thereto.



                                   SIGNATURES

     Pursuant to the  requirements  of the Securities  Exchange Act of 1934, the
registrant  has duly  caused  this  report  to be  signed  on its  behalf by the
undersigned hereunto duly authorized.

                                                PATIENT INFOSYSTEMS, INC.

Date:  March 15, 2004                       By: /s/ Roger L. Chaufourner
       --------------                           --------------------------------
                                                Roger L. Chaufournier
                                                Chief Executive Officer