sv1za
As filed with the Securities and Exchange Commission on
July 11, 2007
Registration
No. 333-142646
UNITED STATES SECURITIES AND
EXCHANGE COMMISSION
Washington, D.C.
20549
AMENDMENT NO. 3
TO
FORM S-1
REGISTRATION
STATEMENT
UNDER THE SECURITIES ACT OF
1933
ImaRx Therapeutics,
Inc.
(Exact Name of Registrant as
Specified in Its Charter)
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Delaware
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2834
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86-0974730
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(State or Other Jurisdiction
of
Incorporation or Organization)
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(Primary Standard Industrial
Classification Code Number)
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(I.R.S. Employer
Identification Number)
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1635 East 18th Street
Tucson, AZ 85719
(520) 770-1259
(Address, Including Zip Code,
and Telephone Number, Including Area Code, of
Registrants Principal
Executive Offices)
Bradford A. Zakes
1635 East 18th Street
Tucson, AZ 85719
(520) 770-1259
(Name, Address, Including Zip
Code, and Telephone Number,
Including Area Code, of Agent
for Service)
Copies to:
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John M.
Steel, Esq.
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Jody R.
Samuels, Esq.
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Mark F.
Hoffman, Esq.
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Benjamin M.
Alexander, Esq.
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Heidi M. Drivdahl, Esq.
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Richardson & Patel
LLP
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DLA Piper US LLP
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405 Lexington Avenue,
26th Floor
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701 Fifth Avenue,
Suite 7000
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New York, NY 10174
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Seattle, WA
98104-7044
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(212) 907-6686
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(206)
839-4800
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Approximate date of commencement of proposed sale to the
public: As soon as practicable after the
effective date of this Registration Statement.
If any of the securities being registered on this form are to be
offered on a delayed or continuous basis pursuant to
Rule 415 under the Securities Act, check the following
box. o
If this Form is filed to register additional securities for an
offering pursuant to Rule 462(b) under the Securities Act,
check the following box and list the Securities Act registration
statement number of the earlier effective registration statement
for the same
offering. o
If this Form is a post-effective amendment filed pursuant to
Rule 462(c) under the Securities Act, check the following
box and list the Securities Act registration statement number of
the earlier effective registration statement for the same
offering. o
If this Form is a post-effective amendment filed pursuant to
Rule 462(d) under the Securities Act, check the following
box and list the Securities Act registration statement number of
the earlier effective registration statement for the same
offering. o
CALCULATION OF REGISTRATION FEE
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Proposed Maximum
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Title of Each Class of
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Number of Shares
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Offering Price
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Proposed Maximum
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Amount of
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Securities to be Registered
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to be Registered
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per Share
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Aggregate Offering Price(1)
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Registration Fee(3)
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Common Stock, par value
$0.0001 per share
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3,450,000(2)
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$7.50
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$25,875,000
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$794.36
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(1) |
Estimated solely for the purpose of calculating the amount of
the registration fee pursuant to Rule 457(a) under the
Securities Act of 1933.
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(2)
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Represents 3,450,000 shares of the registrants common
stock being offered pursuant to the registrants initial
public offering, including 450,000 shares subject to the
underwriters over-allotment option.
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(3)
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A registration fee of $8,025 has been paid previously by ImaRx
Therapeutics, Inc. on May 19, 2006 in connection with
Registration No.
333-134311.
Pursuant to Rule 457(p), such previous filing fee offsets
the filing fee due herewith.
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The Registrant hereby amends this Registration Statement on
such date or dates as may be necessary to delay its effective
date until the Registrant shall file a further amendment that
specifically states that this Registration Statement shall
thereafter become effective in accordance with Section 8(a)
of the Securities Act of 1933, as amended, or until the
Registration Statement shall become effective on such date as
the Securities and Exchange Commission, acting pursuant to said
Section 8(a), may determine.
EXPLANATORY
NOTE
This Amendment No. 3 to the registrants Registration
Statement on
Form S-1
(File
No. 333-142646)
is being filed solely for the purpose of filing Exhibit 5.1
to Item 16 of Part II of the Registration Statement, and no
changes or additions are being made hereby to the prospectus
which forms a part of the Registration Statement. Accordingly,
the prospectus has been omitted from this filing.
PART II
INFORMATION
NOT REQUIRED IN PROSPECTUS
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Item 13.
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Other
Expenses of Issuance and Distribution
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The following table sets forth all expenses, other than the
underwriting discounts and commissions, payable by the
registrant in connection with the sale of the common stock being
registered. All the amounts shown are estimates except the
registration fee, the NASD filing fee and the NASDAQ Capital
Market initial listing fee. We intend to pay all expenses of
registration, issuance and distribution.
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SEC registration fee
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$
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8,025
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NASD filing fee
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8,000
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NASDAQ Capital Market initial
listing fee
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75,000
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Blue sky qualification fees and
expenses
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5,000
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Printing and engraving expenses
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160,000
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Legal fees and expenses
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800,000
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Accounting fees and expenses
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250,000
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Transfer agent and registrar fees
and expenses
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8,000
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Underwriter non-accountable fees
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420,000
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Miscellaneous
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55,975
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Total
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$
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1,790,000
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* |
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To be provided by amendment. |
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Item 14.
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Indemnification
of Officers and Directors
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The registrant is a Delaware corporation. Section 145 of
the Delaware General Corporation Law, or the DGCL, provides that
a corporation may indemnify any person who is or was a director,
officer, employee or agent of a corporation of an enterprise,
against expenses (including attorneys fees), judgments,
fines and amounts paid in settlement actually and reasonably
incurred by such person in connection with any threatened,
pending or completed action, suit or proceeding, whether civil,
criminal, administrative or investigative, by reason of being or
having been in any such capacity, if he acted in good faith in a
manner reasonably believed to be in or not opposed to the best
interest of the corporation, and, with respect to any criminal
action or proceeding, had no reasonable cause to believe his
conduct was unlawful, except that with respect to an action
brought by or in the right of the corporation, such
indemnification is limited to expenses (including
attorneys fees). Under the DGCL, Section 145 is not
exclusive of other rights to which those seeking indemnification
may be entitled under any bylaw, agreement, vote of stockholders
or disinterested directors or otherwise.
In addition, Section 102(b)(7) of the DGCL permits a
corporation to provide in its certificate of incorporation that
a director of the corporation shall not be personally liable to
the corporation or its stockholders for monetary damages for
breach of fiduciary duty as a director, except for liability for
any breach of the directors duty of loyalty to the
corporation or its stockholders, for acts or omissions not in
good faith or which involve intentional misconduct or a knowing
violation of law, for unlawful payments of dividends or unlawful
stock repurchases, redemptions or other distributions, or for
any transaction from which the director derived an improper
personal benefit.
The registrants amended and restated certificate of
incorporation includes a provision that eliminates the personal
liability of its directors for monetary damages for breach of
fiduciary duty as a director to the fullest extent permitted by
the DGCL. The registrants amended and restated certificate
of incorporation requires indemnification of its directors and
officers to the fullest extent permissible under the DGCL and
the registrants amended and restated bylaws provide for
indemnification of officers and directors to the fullest extent
authorized by the DGCL.
II-1
The registrant maintains a liability insurance policy pursuant
to which its directors and officers may be indemnified against
liability incurred for serving in their capacities as directors
and officers.
Prior to the completion of this offering, the registrant intends
to enter into stockholder-approved indemnification agreements
with each of its directors and officers and we intend to enter
into indemnification agreements with any new directors and
officers in the future. The indemnification agreements set forth
certain procedures that will apply in the event of a claim for
indemnification thereunder. At present, no litigation or
proceeding is pending that involves a director or officer of the
registrant regarding which indemnification is sought, nor is the
registrant aware of any threatened litigation that may result in
claims for indemnification.
The form of underwriting agreement filed as an exhibit to this
registration statement provides for indemnification under
certain circumstances by the underwriters of the registrant, its
directors, certain of its officers and its controlling persons
for certain liabilities arising under the Securities Act or
otherwise.
The Second Amended and Restated Investors Rights Agreement
between the registrant and certain investors provides for
cross-indemnification in connection with registration of the
registrants common stock on behalf of such investors.
See also the undertakings set out in response to Item 17.
Reference is made to the following documents filed as exhibits
to this registration statement regarding relevant
indemnification provisions described above and elsewhere herein:
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Exhibit Document
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Number
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Form of Underwriting
Agreement
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1.1
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Registrants Amended and
Restated Certificate of Incorporation, to be effective upon
closing of this offering
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3.4
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Registrants Amended and
Restated Bylaws, to be effective upon closing of this
offering
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3.6
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Form of Indemnification
Agreement
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10.1
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Second Amended and Restated
Investors Rights Agreement, dated April 14, 2006
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10.2
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Previously filed
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Item 15.
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Recent
Sales of Unregistered Securities
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Since January 1, 2004, the registrant has sold the
following securities that were not registered under the
Securities Act:
1. We sold an aggregate of 90,796 shares of our common
stock to certain of our employees, directors and consultants for
cash consideration in the aggregate amount of $365,401 upon the
exercise of stock options granted under our 2000 Stock Plan,
none of which have been repurchased by us.
2. We granted stock options to certain employees, directors
and consultants under our 2000 Stock Plan covering an aggregate
of 791,958 shares of common stock, at exercise prices
ranging from $10.00 to $30.00 per share. Of these, options
covering an aggregate of 309,388 shares were canceled
without being exercised.
3. In March 2004, we issued a warrant to each of Bridge
Ventures, Inc. and Saggi Capital Corp., each of which is an
accredited investor, as partial consideration for annual
consulting services. Each warrant is for the purchase of
50,000 shares of our common stock at an exercise price of
$15.00 per share.
4. In March 2004, we sold 500,000 shares of our common
stock to accredited investors at a purchase price of
$10.00 per share pursuant to a private placement in which
First Montauk Securities Corp. served as our exclusive placement
agent. In connection with this private placement, the
outstanding principal amount and accrued interest under
previously issued convertible promissory notes was automatically
converted into 206,465 shares of our common stock at a
conversion price of $10.00 per share.
II-2
5. In October 2004, we issued a warrant to First Montauk
Securities Corp. and certain executive officers of First Montauk
Securities Corp., each of whom is an accredited investor, to
purchase up to an aggregate of 50,000 shares of common
stock at an exercise price of $10.00 per share.
6. Between October 2004 and February 2005, we sold an
aggregate of 466,663 shares of common stock to accredited
investors at a purchase price of $15.00 per share pursuant
to a private placement in which First Montauk Securities Corp.
served as our exclusive placement agent. In connection with this
offering and as partial consideration for entering into the
placement agency agreement, First Montauk Securities Corp. and
certain executive officers of First Montauk Securities Corp.
also received warrants to purchase up to an aggregate of
46,664 shares of our common stock at an exercise price of
$16.50 per share.
7. In January 2005, as partial consideration for a patent
license, we granted Dr. med. Reinhard Schlief a warrant to
purchase up to an aggregate of 4,000 shares of common stock
at an exercise price of $15.00 per share.
8. In September 2005, we sold 1,000,000 shares of
Series E preferred stock, valued at $4.0 million, to
Abbott Laboratories, an accredited investor, as partial
consideration for our acquisition of certain technologies from
Abbott Laboratories pursuant to an Asset Purchase Agreement
dated September 30, 2005. In connection with this Asset
Purchase Agreement, we also issued Abbott Laboratories a secured
6% of promissory note in the principal amount of $15,000,000. No
underwriters were involved in this sale of securities.
9. In September 2005, we issued secured 6% promissory notes
in the aggregate principal amount of $4,000,000 and warrants for
the purchase of an aggregate of 20,000 shares of our common
stock at an exercise price of $20.00 per share to
accredited investors. No underwriters were involved in this sale
of securities. The secured promissory notes issued in this
offering were repaid in full in October 2005 with proceeds from
the private placement offering described below.
10. In October 2005 and November 2005, we sold an aggregate
of 750,000 shares of our common stock to accredited
investors at a purchase price of $20.00 per share in a private
placement in which First Montauk Securities Corp. served as our
exclusive placement agent. In connection with its placement
agency agreement, First Montauk Securities Corp. and certain
executive officers of First Montauk Securities Corp. received
warrants to purchase up to 74,996 shares of our common
stock at an exercise price of $21.25 per share.
11. In February 2006 we issued warrants to purchase an
aggregate of up to 15,000 shares of our common stock at an
exercise price of $20.00 per share to consultants.
12. In April 2006 and May 2006, we sold an aggregate of
2,835,000 shares of Series F preferred stock to
accredited investors at a price of $5.00 per share pursuant
to a private placement in which First Albany Capital, First
Montauk Securities Corp. and Maxim Group LLC served as our
placement agents.
13. In April 2006, we issued Abbott Laboratories a secured
6% promissory note in the principal amount of $15,000,000 in
partial consideration for assets we acquired. No underwriters
were involved in this sale of securities.
The sales of the above securities described in items
(1) and (2) above were exempt from registration under
the Securities Act in reliance on Rule 701 promulgated
under the Securities Act as transactions pursuant to
compensatory benefit plans and contracts relating to
compensation as provided under Rule 701. The recipients of
securities in each of these transactions represented their
intention to acquire the securities for investment only and not
with view to or for sale in connection with any distribution
thereof and appropriate legends were affixed to the share
certificates and instruments issued in such transactions. All
recipients had adequate access, through their relationship with
the registrant, to information about the registrant.
The sale of securities described in items (4), (6), (9),
(10) and (12) above were exempt from registration
under the Securities Act in reliance on Rule 506 of
Regulation D promulgated thereunder as transactions by an
issuer not involving a public offering. The recipients of
securities in each of these transactions were
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sophisticated entities, all of whom are accredited
investors, as such term is defined in Rule 501
promulgated under the Securities Act, and all of whom had
adequate access, through their relationship with us, to
information about us.
The sale of securities described in items (3), (5), (7), (8),
(11) and (13) above were exempt from registration
under Section 4(2) of the Securities Act as transactions by
an issuer not involving a public offering. The recipients of
securities in each of these transactions represented their
intention to acquire the securities for investment only and not
with view to or for sale in connection with any distribution
thereof and appropriate legends were affixed to the share
certificates and instruments issued in such transactions. All
recipients had adequate access, through their relationship with
the registrant, to information about the registrant.
No underwriters were involved in the foregoing sales of
securities.
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Item 16.
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Exhibits
and Financial Statement Schedules
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(a) Exhibits.
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Exhibit
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Number
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Description of Document
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1
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.1
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Form of Underwriting Agreement
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3
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.1
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Fourth Amended and Restated
Certificate of Incorporation of the registrant
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3
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.2
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Amendment to Certificate of
Incorporation of the registrant to effect a
six-for-ten
reverse stock split
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3
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.3
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Second Amendment to Certificate of
Incorporation of the registrant to effect a
one-for-three
reverse stock split
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3
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.4
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Form of Amended and Restated
Certificate of Incorporation of the registrant, to be effective
following this offering
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3
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.5
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Bylaws of the registrant, as
amended
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3
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.6
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Form of Amended and Restated
Bylaws of the registrant, to be effective following this offering
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4
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.1
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Specimen certificate evidencing
shares of common stock
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5
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.1
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Opinion of DLA Piper US LLP
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10
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.1
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Form of Indemnification Agreement
entered into between the registrant and each of its directors
and officers
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10
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.2
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Second Amended and Restated
Investors Rights Agreement, dated April 14, 2006, by
and among the registrant and certain stockholders
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10
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.3
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2000 Stock Plan and related
agreements
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10
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.4
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2007 Performance Incentive Plan
and related agreements
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10
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.5
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Bonus Plan
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10
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.6
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License Agreement, dated
January 4, 2005, between the registrant and Dr. med.
Reinhard Schlief
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10
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.7
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Exclusive Sublicense Agreement,
dated October 10, 2003, between the registrant and UNEMED
Corporation
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10
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.8
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Assignment, Assumption and License
Agreement, dated October 7, 1999, between the registrant
and Bristol-Myers Squibb Medical Imaging, Inc. (as successor to
DuPont Contrast Imaging, Inc.) dated October 7, 1999, and
amendments thereto
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10
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.9
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License Agreement, dated
February 10, 2006, between the registrant and the
University of Arkansas for Medical Sciences
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10
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.10
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Asset Purchase Agreement, dated
April 10, 2006, between the registrant and Abbott
Laboratories, and amendments thereto
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10
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.11
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Escrow Agreement, dated
April 14, 2006, between the registrant and Abbott
Laboratories
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10
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.12
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Inventory Trademark License
Agreement, dated April 14, 2006, between the registrant and
Abbott Laboratories
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10
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.13
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Security Agreement, dated
April 14, 2006, between the registrant and Abbott
Laboratories
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II-4
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Exhibit
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Number
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Description of Document
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10
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.14
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Secured Promissory Note, dated
April 14, 2006, between the registrant and Abbott
Laboratories
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10
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.15
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Second Amended Executive
Employment Agreement, dated May 15, 2006, between the
registrant and Evan C. Unger
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10
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.16
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Consulting Agreement, dated
October 20, 2006, between the registrant and Evan
C. Unger
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10
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.17
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Confidential Separation Agreement
and Mutual General Release of All Claims, dated
November 28, 2006, between the registrant and Evan C. Unger
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10
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.18
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Consulting Agreement, dated
April 11, 2005, between the registrant and Greg Cobb
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10
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.19
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Amended Executive Employment
Agreement, dated February 1, 2007, between the registrant
and Greg Cobb
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10
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.20
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Amended Executive Employment
Agreement, dated February 1, 2007, between the registrant
and Bradford A. Zakes
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10
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.21
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Agreement, dated March 31,
2006, by and among the registrant, John A. Moore and Edson Moore
Healthcare Ventures
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10
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.22
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Subscription Agreement and
Investor Questionnaire, dated March 2004, between the registrant
and each of the signatory investors, offering price
$2.00 per share
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10
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.23
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Subscription Agreement and
Investor Questionnaire, dated December 2004, between the
registrant and each of the signatory investors, offering price
$3.00 per share
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10
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.24
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Subscription Agreement and
Investor Questionnaire, dated September and October 2004,
between the registrant and each of the signatory investors,
offering price $4.00 per share
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10
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.25
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Commercial Lease
Triple Net, dated November 1, 2002, between the registrant
and ImaRx Investments L.L.C.
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10
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.26
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Standard Commercial
Industrial Lease, dated December 30, 1997, between the
registrant and Tucson Tech Park and addenda thereto
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21
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.1
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Subsidiaries of the registrant
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23
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.1
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Consent of Ernst & Young
LLP
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23
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.2
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Consent of DLA Piper US LLP
(included in Exhibit 5.1)
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24
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.1
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Power of Attorney
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All schedules are omitted because they are not required, are not
applicable or the information is included in the financial
statements or notes thereto.
The undersigned registrant hereby undertakes to provide to the
underwriters at the closing specified in the underwriting
agreement certificates in such denominations and registered in
such names as required by the underwriters to permit prompt
delivery to each purchaser.
Insofar as indemnification for liabilities arising under the
Securities Act may be permitted to directors, officers, and
controlling persons of the registrant pursuant to the foregoing
provisions or otherwise, the registrant has been advised that in
the opinion of the Securities and Exchange Commission such
indemnification is against public policy as expressed in the
Securities Act and is, therefore, unenforceable. In the event
that a claim for indemnification against such liabilities (other
than the payment by the registrant of expenses incurred or paid
by a director, officer, or controlling person of the registrant
in the successful defense of any action, suit, or proceeding) is
asserted by such director, officer, or controlling person in
connection with the securities being registered, the registrant
will, unless in the opinion of its counsel the matter has been
settled by controlling precedent, submit to a court of
appropriate jurisdiction the question whether such
indemnification by it is against public policy as expressed in
the Act and will be governed by the final adjudication of such
issue.
II-5
The undersigned registrant undertakes that:
(1) for purposes of determining any liability under the
Securities Act, the information omitted from the form of
prospectus filed as part of this registration statement in
reliance upon Rule 430A and contained in the form of
prospectus filed by the registrant pursuant to
Rule 424(b)(1) or (4) or 497(h) under the Securities
Act shall be deemed to be part of this registration statement as
of the time it was declared effective,
(2) for the purpose of determining any liability under the
Securities Act, each post-effective amendment that contains a
form of prospectus shall be deemed to be a new registration
statement relating to the securities offered therein, and the
offering of such securities at that time shall be deemed to be
the initial bona fide offering thereof,
(3) for purposes of determining any liability under the
Securities Act, if the registrant is subject to Rule 430C,
each prospectus filed pursuant to Rule 424(b) as part of a
registration statement relating to an offering, other than
registration statements relying on Rule 430B or other than
prospectuses filed in reliance on Rule 430A, shall be
deemed to be part of and included in the registration statement
as of the date it is first used after effectiveness. Provided,
however, that no statement made in a registration statement or
prospectus that is part of the registration statement or made in
a document incorporated or deemed incorporated by reference into
the registration statement or prospectus that is part of the
registration statement will, as to a purchaser with a time of
contract of sale prior to such first use, supersede or modify
any statement that was made in the registration statement or
prospectus that was part of the registration statement or made
in any such document immediately prior to such date of first
use, and
(4) for purposes of determining any liability under the
Securities Act, in a primary offering of securities of the
undersigned registrant pursuant to this registration statement,
regardless of the underwriting method used to sell the
securities to the purchaser, if the securities are offered or
sold to such purchaser by means of any of the following
communications, the undersigned registrant will be a seller to
the purchaser and will be considered to offer or sell such
securities to such purchaser:
(i) Any preliminary prospectus or prospectus of the
undersigned registrant relating to the offering required to be
filed pursuant to Rule 424;
(ii) Any free writing prospectus relating to the offering
prepared by or on behalf of the undersigned registrant or used
or referred to by the undersigned registrant;
(iii) The portion of any other free writing prospectus
relating to the offering containing material information about
the undersigned registrant or its securities provided by or on
behalf of the undersigned registrant; and
(iv) Any other communication that is an offer in the
offering made by the undersigned registrant to the purchaser.
II-6
SIGNATURES
Pursuant to the requirements of the Securities Act of 1933, as
amended, the registrant has duly caused this Amendment
No. 3 to Registration Statement to be signed on its behalf
by the undersigned, thereunto duly authorized, in the city of
Tucson, in the County of Pima, State of Arizona, on the 11th day
of July, 2007.
IMARX THERAPEUTICS, INC.
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By:
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/s/ Bradford
A. Zakes
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Bradford A. Zakes
President and Chief Executive Officer
Pursuant to the requirements of the Securities Act of 1933, as
amended, this Amendment No. 3 to Registration Statement has
been signed below by the following persons in the capacities and
on the dates indicated.
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Signature
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Title
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Date
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/s/ Bradford
A. Zakes
Bradford
A. Zakes
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President, Chief Executive
Officer
and Director
(principal executive officer)
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July 11, 2007
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/s/ Greg
Cobb
Greg
Cobb
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Chief Financial Officer
(principal financial and
accounting officer)
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July 11, 2007
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/s/ Richard
Love*
Richard
Love
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Director
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July 11, 2007
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/s/ Richard
Otto*
Richard
Otto
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Director
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July 11, 2007
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/s/ Thomas
W.
Pew*
Thomas
W. Pew
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Director
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July 11, 2007
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/s/ Philip
Ranker*
Philip
Ranker
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Director
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July 11, 2007
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/s/ James
M.
Strickland*
James
M. Strickland
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Director
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July 11, 2007
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*By:
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/s/ Greg
Cobb
Greg
Cobb
Attorney-in-Fact
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II-7
EXHIBIT
INDEX
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Exhibit
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Number
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Description of Document
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1
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.1
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Form of Underwriting Agreement
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3
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.1
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Fourth Amended and Restated
Certificate of Incorporation of the registrant
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3
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.2
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Amendment to Certificate of
Incorporation of the registrant to effect a
six-for-ten
reverse stock split
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3
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.3
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Second Amendment to Certificate of
Incorporation of the registrant to effect a
one-for-three
reverse stock split
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3
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.4
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Form of Amended and Restated
Certificate of Incorporation of the registrant, to be effective
following this offering
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3
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.5
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Bylaws of the registrant, as
amended
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3
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.6
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Form of Amended and Restated
Bylaws of the registrant, to be effective following this offering
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4
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.1
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Specimen certificate evidencing
shares of common stock
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5
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.1
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Opinion of DLA Piper US LLP
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10
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.1
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Form of Indemnification Agreement
entered into between the registrant and each of its directors
and officers
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10
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.2
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Second Amended and Restated
Investors Rights Agreement, dated April 14, 2006, by
and among the registrant and certain stockholders
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10
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.3
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2000 Stock Plan and related
agreements
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10
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.4
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2007 Performance Incentive Plan
and related agreements
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10
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.5
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Bonus Plan
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10
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.6
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License Agreement, dated
January 4, 2005, between the registrant and Dr. med.
Reinhard Schlief
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10
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.7
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Exclusive Sublicense Agreement,
dated October 10, 2003, between the registrant and UNEMED
Corporation
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10
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.8
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Assignment, Assumption and License
Agreement, dated October 7, 1999, between the registrant
and Bristol-Myers Squibb Medical Imaging, Inc. (as successor to
DuPont Contrast Imaging, Inc.) dated October 7, 1999, and
amendments thereto
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10
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.9
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License Agreement, dated
February 10, 2006, between the registrant and the
University of Arkansas for Medical Sciences
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10
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.10
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Asset Purchase Agreement, dated
April 10, 2006, between the registrant and Abbott
Laboratories, and amendments thereto
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10
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.11
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Escrow Agreement, dated
April 14, 2006, between the registrant and Abbott
Laboratories
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10
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.12
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Inventory Trademark License
Agreement, dated April 14, 2006, between the registrant and
Abbott Laboratories
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10
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.13
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Security Agreement, dated
April 14, 2006, between the registrant and Abbott
Laboratories
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10
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.14
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Secured Promissory Note, dated
April 14, 2006, between the registrant and Abbott
Laboratories
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10
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.15
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Second Amended Executive
Employment Agreement, dated May 15, 2006, between the
registrant and Evan C. Unger
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10
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.16
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Consulting Agreement, dated
October 20, 2006, between the registrant and Evan
C. Unger
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10
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.17
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Confidential Separation Agreement
and Mutual General Release of All Claims, dated
November 28, 2006, between the registrant and Evan C. Unger
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10
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.18
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Consulting Agreement, dated
April 11, 2005, between the registrant and Greg Cobb
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10
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.19
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Amended Executive Employment
Agreement, dated February 1, 2007, between the registrant
and Greg Cobb
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10
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.20
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Amended Executive Employment
Agreement, dated February 1, 2007, between the registrant
and Bradford A. Zakes
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10
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.21
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Agreement, dated March 31,
2006, by and among the registrant, John A. Moore and Edson Moore
Healthcare Ventures
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II-8
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Exhibit
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Number
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Description of Document
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10
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.22
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Subscription Agreement and
Investor Questionnaire, dated March 2004, between the registrant
and each of the signatory investors, offering price
$2.00 per share
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10
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.23
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Subscription Agreement and
Investor Questionnaire, dated December 2004, between the
registrant and each of the signatory investors, offering price
$3.00 per share
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10
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.24
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Subscription Agreement and
Investor Questionnaire, dated September and October 2004,
between the registrant and each of the signatory investors,
offering price $4.00 per share
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10
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.25
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Commercial Lease
Triple Net, dated November 1, 2002, between the registrant
and ImaRx Investments L.L.C.
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10
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.26
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Standard Commercial
Industrial Lease, dated December 30, 1997, between the
registrant and Tucson Tech Park and addenda thereto
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21
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.1
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Subsidiaries of the registrant
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23
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.1
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Consent of Ernst & Young
LLP
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23
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.2
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Consent of DLA Piper US LLP
(included in Exhibit 5.1)
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24
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.1
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Power of Attorney
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II-9