1. Title of Derivative Security (Instr. 4) |
2. Date Exercisable and Expiration Date (Month/Day/Year) |
3. Title and Amount of Securities Underlying Derivative Security (Instr. 4) |
4. Conversion or Exercise Price of Derivative Security |
5. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 5) |
6. Nature of Indirect Beneficial Ownership (Instr. 5) |
Date Exercisable |
Expiration Date |
Title |
Amount or Number of Shares |
Mandatorily Convertible Preferred Stock
|
Â
(1)
|
Â
(1)
|
Common Stock
|
170
|
$
(1)
|
I
|
See footnotes
(4)
|
Mandatorily Convertible Preferred Stock
|
Â
(1)
|
Â
(1)
|
Common Stock
|
707
|
$
(1)
|
I
|
See footnotes
(5)
|
Mandatorily Convertible Preferred Stock
|
Â
(1)
|
Â
(1)
|
Common Stock
|
191
|
$
(1)
|
I
|
See footnotes
(6)
|
Mandatorily Convertible Preferred Stock
|
Â
(1)
|
Â
(1)
|
Common Stock
|
1,165
|
$
(1)
|
I
|
See footnotes
(7)
|
Mandatorily Convertible Preferred Stock
|
Â
(1)
|
Â
(1)
|
Common Stock
|
4,749
|
$
(1)
|
I
|
See footnotes
(8)
|
Mandatorily Convertible Preferred Stock
|
Â
(1)
|
Â
(1)
|
Common Stock
|
23
|
$
(1)
|
I
|
See footnotes
(9)
|
Mandatorily Convertible Preferred Stock
|
Â
(1)
|
Â
(1)
|
Common Stock
|
50
|
$
(1)
|
I
|
See footnotes
(10)
|
Mandatorily Convertible Preferred Stock
|
Â
(1)
|
Â
(1)
|
Common Stock
|
92
|
$
(1)
|
I
|
See footnotes
(11)
|
Mandatorily Convertible Preferred Stock
|
Â
(1)
|
Â
(1)
|
Common Stock
|
109
|
$
(1)
|
I
|
See footnotes
(12)
|
Warrants to Purchase Series D-1 Convertible Preferred Stock
|
Â
(2)
|
Â
(3)
|
Common Stock
|
27,844
|
$
3.5
|
I
|
See footnotes
(4)
|
Warrants to Purchase Series D-1 Convertible Preferred Stock
|
Â
(2)
|
Â
(3)
|
Common Stock
|
116,019
|
$
3.5
|
I
|
See footnotes
(5)
|
Warrants to Purchase Series D-1 Convertible Preferred Stock
|
Â
(2)
|
Â
(3)
|
Common Stock
|
31,293
|
$
3.5
|
I
|
See footnotes
(6)
|
Warrants to Purchase Series D-1 Convertible Preferred Stock
|
Â
(2)
|
Â
(3)
|
Common Stock
|
191,369
|
$
3.5
|
I
|
See footnotes
(7)
|
* |
If the form is filed by more than one reporting person, see Instruction 5(b)(v). |
** |
Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a). |
(1) |
Mandatorily Convertible Preferred Stock has no expiration date and is convertible at any time at the option of the holder and will automatically convert upon the closing of the Issuer's initial public offering, at a conversion ratio of one share of Mandatorily Convertible Preferred Stock for every 66.88 shares of Common Stock, for no additional consideration. |
(2) |
Warrants became exercisable on March 8, 2007. |
(3) |
Warrants to purchase Series D-1 Convertible Preferred will be automatically net exercised immediately prior to the closing of the Issuer's initial public offering. Series D-1 Preferred Stock has no expiration date and is convertible at any time at the option of the holder and will automatically convert upon the closing of the Issuer's initial public offering, at a conversion ratio of one share of Common Stock for every two shares of Series D-1 Preferred Stock, for no additional consideration. |
(4) |
By Sanderling V Beteilingungs GmbH & Co KG. Fred Middleton, a member of the Issuer's board of directors is a managing director of Middleton, McNeil & Mills Associates V, LLC the sole general partner of Sanderling V Beteilingungs GmbH & Co KG and has voting and investment power over the shares held by Sanderling V Beteilingungs GmbH & Co KG. Mr. Middleton disclaims beneficial ownership of these shares except to the extent of his pecuniary interest therein. |
(5) |
By Sanderling V Biomedical Co-Investment Fund L.P. Fred Middleton, a member of the Issuer's board of directors is a managing director of Middleton, McNeil & Mills Associates V, LLC the sole general partner of Sanderling V Biomedical Co-Investment Fund L.P and has voting and investment power over the shares held by Sanderling V Biomedical Co-Investment Fund L.P. Mr. Middleton disclaims beneficial ownership of these shares except to the extent of his pecuniary interest therein. |
(6) |
By Sanderling V Limited Partnership. Fred Middleton, a member of the Issuer's board of directors is a managing director of Middleton, McNeil & Mills Associates V, LLC the sole general partner of Sanderling V Limited Partnership and has voting and investment power over the shares held by Sanderling V Limited Partnership. Mr. Middleton disclaims beneficial ownership of these shares except to the extent of his pecuniary interest therein. |
(7) |
By Sanderling Venture Partners V Co-Investment Fund, L.P. Fred Middleton, a member of the Issuer's board of directors is a managing director of Middleton, McNeil & Mills Associates V, LLC the sole general partner of Sanderling Venture Partners V Co-Investment Fund, L.P and has voting and investment power over the shares held by Sanderling Venture Partners V Co-Investment Fund, L.P. Mr. Middleton disclaims beneficial ownership of these shares except to the extent of his pecuniary interest therein. |
(8) |
By Sanderling Venture Partners VI Co-Investment Fund, L.P. Fred Middleton, a member of the Issuer's board of directors is a managing director of Middleton, McNeil, Mills & Associates VI, LLC the sole general partner of Sanderling Venture Partners VI Co-Investment Fund, L.P and has voting and investment power over the shares held by Sanderling Venture Partners VI Co-Investment Fund, L.P. Mr. Middleton disclaims beneficial ownership of these shares except to the extent of his pecuniary interest therein. |
(9) |
By Sanderling Ventures Management V. Fred Middleton, a member of the Issuer's board of directors is an owner of Sanderling Ventures Management V and has voting and investment power over the shares held by Sanderling Ventures Management V. Mr. Middleton disclaims beneficial ownership of these shares except to the extent of his pecuniary interest therein. |
(10) |
By Sanderling Ventures Management VI. Fred Middleton, a member of the Issuer's board of directors is an owner of Sanderling Ventures Management VI and has voting and investment power over the shares held by Sanderling Ventures Management VI. Mr. Middleton disclaims beneficial ownership of these shares except to the extent of his pecuniary interest therein. |
(11) |
By Sanderling VI Beteilingungs GmbH & Co KG. Fred Middleton, a member of the Issuer's board of directors is a managing director of Middleton, McNeil, Mills & Associates VI, LLC the sole general partner of Sanderling VI Beteilingungs GmbH & Co KG and has voting and investment power over the shares held by Sanderling VI Beteilingungs GmbH & Co KG. Mr. Middleton disclaims beneficial ownership of these shares except to the extent of his pecuniary interest therein. |
(12) |
By Sanderling VI Limited Partnership. Fred Middleton, a member of the Issuer's board of directors is a general partner of Middleton, McNeil, Mills & Associates VI, LLC the sole general partner of Sanderling VI Limited Partnership and has voting and investment power over the shares held by Sanderling VI Limited Partnership. Mr. Middleton disclaims beneficial ownership of these shares except to the extent of his pecuniary interest therein. |