o
|
Rule 13d-1(b)
|
x
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Rule 13d-1(c)
|
o
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Rule 13d-1(d)
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CUSIP No. 14159L103
|
13G
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Page 2 of 7 Pages
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1.
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Names of Reporting Persons.
I.R.S. Identification Nos. of above persons (entities only).
RA Capital Management, LLC
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2.
|
Check the Appropriate Box if a Member of a Group (See Instructions)
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(a) o
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||||||
(b) o
|
||||||
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||||||
3.
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SEC Use Only
|
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4.
|
Citizenship or Place of Organization Massachusetts
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|
||||||
Number of
Shares
Beneficially
Owned by
Each Reporting
Person With
|
5.
|
Sole Voting Power 0
|
||||
|
||||||
6.
|
Shared Voting Power 0
|
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|
||||||
7.
|
Sole Dispositive Power 0
|
|||||
|
||||||
8.
|
Shared Dispositive Power 0
|
|||||
|
||||||
9.
|
Aggregate Amount Beneficially Owned by Each Reporting Person
0
|
|||||
|
||||||
10.
|
Check if the Aggregate Amount in Row (9) Excludes
Certain Shares (See Instructions) o
|
|||||
|
||||||
11.
|
Percent of Class Represented by Amount in Row (9)
0.00%
|
|||||
|
||||||
12.
|
Type of Reporting Person (See Instructions)
IA
|
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|
CUSIP No. 14159L103
|
13G
|
Page 3 of 7 Pages
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||||||
|
1.
|
Names of Reporting Persons.
I.R.S. Identification Nos. of above persons (entities only).
Peter Kolchinsky
|
||||
|
||||||
2.
|
Check the Appropriate Box if a Member of a Group (See Instructions)
|
|||||
(a) o
|
||||||
(b) o
|
||||||
|
||||||
3.
|
SEC Use Only
|
|||||
|
||||||
4.
|
Citizenship or Place of Organization United States
|
|||||
|
||||||
Number of
Shares
Beneficially
Owned by
Each Reporting
Person With
|
5.
|
Sole Voting Power 0
|
||||
|
||||||
6.
|
Shared Voting Power 0
|
|||||
|
||||||
7.
|
Sole Dispositive Power 0
|
|||||
|
||||||
8.
|
Shared Dispositive Power 0
|
|||||
|
||||||
9.
|
Aggregate Amount Beneficially Owned by Each Reporting Person
0
|
|||||
|
||||||
10.
|
Check if the Aggregate Amount in Row (9) Excludes
Certain Shares (See Instructions) o
|
|||||
|
||||||
11.
|
Percent of Class Represented by Amount in Row (9)
0.00%
|
|||||
|
||||||
12.
|
Type of Reporting Person (See Instructions)
IN
|
|||||
|
CUSIP No. 14159L103
|
13G
|
Page 4 of 7 Pages
|
||||
|
||||||
|
1.
|
Names of Reporting Persons.
I.R.S. Identification Nos. of above persons (entities only).
RA Capital Healthcare Fund, L.P.
|
||||
|
||||||
2.
|
Check the Appropriate Box if a Member of a Group (See Instructions)
|
|||||
(a) o
|
||||||
(b) o
|
||||||
|
||||||
3.
|
SEC Use Only
|
|||||
|
||||||
4.
|
Citizenship or Place of Organization Delaware
|
|||||
|
||||||
Number of
Shares
Beneficially
Owned by
Each Reporting
Person With
|
5.
|
Sole Voting Power 0
|
||||
|
||||||
6.
|
Shared Voting Power 0
|
|||||
|
||||||
7.
|
Sole Dispositive Power 0
|
|||||
|
||||||
8.
|
Shared Dispositive Power 0
|
|||||
|
||||||
9.
|
Aggregate Amount Beneficially Owned by Each Reporting Person
0
|
|||||
|
||||||
10.
|
Check if the Aggregate Amount in Row (9) Excludes
Certain Shares (See Instructions) o
|
|||||
|
||||||
11.
|
Percent of Class Represented by Amount in Row (9)
0.00%
|
|||||
|
||||||
12.
|
Type of Reporting Person (See Instructions)
PN
|
|||||
|
CUSIP No. 14159L103
|
13G
|
Page 5 of 7 Pages
|
Item 3.
|
If this statement is filed pursuant to §§240.13d-1(b) or 240.13d-2(b) or (c), check whether the person filing is a:
|
Item 4.
|
Ownership:
|
(a)
|
Amount Beneficially Owned: 0
|
(b)
|
Percent of Class: 0.00%
|
(c)
|
Number of Shares as to which such person has:
|
(i)
|
sole power to vote or to direct the vote: 0
|
(ii)
|
shared power to vote or to direct the vote: 0
|
CUSIP No. 14159L103
|
13G
|
Page 6 of 7 Pages
|
(iii)
|
sole power to dispose or to direct the disposition of: 0
|
(iv)
|
shared power to dispose or to direct the disposition of: 0
|
Item 5.
|
Ownership of Five Percent or Less of a Class:
|
Item 6.
|
Ownership of More than Five Percent on Behalf of Another Person:
|
Item 7.
|
Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on By the Parent Holding Company or Control Person:
|
Item 8.
|
Identification and Classification of Members of the Group:
|
Item 9.
|
Notice of Dissolution of Group:
|
Item 10.
|
Certification:
|
CUSIP No. 14159L103
|
13G
|
Page 7 of 7 Pages
|
DATE: FEBRUARY 14, 2012
|
|
RA CAPITAL HEALTHCARE FUND, L.P.
|
|
By: RA Capital Management, LLC
|
|
General Partner
|
|
By: /s/ Peter Kolchinsky
|
|
Peter Kolchinsky
|
|
Manager
|
|
RA CAPITAL MANAGEMENT, LLC
|
|
By: /s/ Peter Kolchinsky
|
|
Peter Kolchinsky
|
|
Manager
|
|
PETER KOLCHINSKY
|
|
/s/ Peter Kolchinsky
|
RA CAPITAL HEALTHCARE FUND, L.P.
|
|
By: RA Capital Management, LLC
|
|
General Partner
|
|
By: /s/ Peter Kolchinsky
|
|
Peter Kolchinsky
|
|
Manager
|
|
RA CAPITAL MANAGEMENT, LLC
|
|
By: /s/ Peter Kolchinsky
|
|
Peter Kolchinsky
|
|
Manager
|
|
PETER KOLCHINSKY
|
|
/s/ Peter Kolchinsky
|