Ownership Submission
FORM 3
 UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940
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(Print or Type Responses)
1. Name and Address of Reporting Person *
  Duarte Ira
 2. Date of Event Requiring Statement (Month/Day/Year)
04/01/2010		 3. Issuer Name and Ticker or Trading Symbol
CORNERSTONE THERAPEUTICS INC [CRTX]
(Last)
(First)
(Middle)
C/O CORNERSTONE THERAPEUTICS, 1255 CRESCENT GREEN DRIVE, SUITE 250		 4. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
_____ Director _____ 10% Owner
__X__ Officer (give title below) _____ Other (specify below)
Principal Accounting Officer
 5. If Amendment, Date Original Filed(Month/Day/Year)
(Street)

CARY, NC 27518		 6. Individual or Joint/Group Filing(Check Applicable Line)
_X_ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Beneficially Owned
1.Title of Security
(Instr. 4)		 2. Amount of Securities Beneficially Owned
(Instr. 4)		 3. Ownership Form: Direct (D) or Indirect (I)
(Instr. 5)		 4. Nature of Indirect Beneficial Ownership
(Instr. 5)

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly. SEC 1473 (7-02)
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Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 4)		 2. Date Exercisable and Expiration Date
(Month/Day/Year)		 3. Title and Amount of Securities Underlying Derivative Security
(Instr. 4)		 4. Conversion or Exercise Price of Derivative Security 5. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 5)		 6. Nature of Indirect Beneficial Ownership
(Instr. 5)
Date Exercisable Expiration Date Title Amount or Number of Shares
Option to Purchase Common Stock (Right to Buy)   (1) 05/31/2019 Common Stock 20,000 $ 7.28 D  
Option to Purchase Common Stock (Right to Buy)   (2) 03/02/2020 Common Stock 8,000 $ 5.26 D  

Reporting Owners

Reporting Owner Name / Address Relationships
Director 10% Owner Officer Other
Duarte Ira
C/O CORNERSTONE THERAPEUTICS
1255 CRESCENT GREEN DRIVE, SUITE 250
CARY, NC 27518		       Principal Accounting Officer  

Signatures

/s/ Ira Duarte 04/08/2010
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 5(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) This option vests as to 25% of the original number of shares on June 1, 2010 and as to another 2.09% of the original number of shares at the end of each sucessive one-month period following June 1, 2010 until June 1, 2013.
(2) This option vests as to 25% of the original number of shares on March 3, 2011 and as to another 2.09% of the original number of shares at the end of each sucessive one-month period following March 3, 2011 until March 3, 2014.

Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, See Instruction 6 for procedure.

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