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                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549
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                                  SCHEDULE 13G

                                 (RULE 13D-102)

               INFORMATION TO BE INCLUDED IN STATEMENTS FILED
                 PURSUANT TO RULES 13D-1(B), (C) AND (D) AND
             AMENDMENTS THERETO FILED PURSUANT TO RULE 13D-2(B)
                                 -----------
                               (AMENDMENT NO. _)*


                           ALTUS PHARMACEUTICALS, INC.
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                                (NAME OF ISSUER)


  COMMON STOCK, PAR VALUE $0.01 PER
                SHARE                                 02216N105
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   (TITLE OF CLASS OF SECURITIES)                  (CUSIP NUMBER)


                                DECEMBER 31, 2006
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           (DATE OF EVENT WHICH REQUIRES FILING OF THIS STATEMENT)


CHECK THE APPROPRIATE BOX TO DESIGNATE THE RULE PURSUANT TO WHICH THIS SCHEDULE
IS FILED:

[_]  RULE 13D-1(B)
[_]  RULE 13D-1(C)
[X]  RULE 13D-1(D)

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*The remainder of this cover page shall be filled out for a reporting person's
initial filing on this form with respect to the subject class of securities, and
for any subsequent amendment containing information which would alter the
disclosures provided in a prior cover page. The information required in the
remainder of this cover page shall not be deemed to be "filed" for the purpose
of Section 18 of the Securities Exchange Act of 1934 or otherwise subject to the
liabilities of that section of the Act but shall be subject to all other
provisions of the Act (however, see the Notes).

                          Continued on Following Pages
                                     Page 1

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      1        NAME OF REPORTING         NOMURA INTERNATIONAL PLC ON BEHALF
               PERSONS:                  OF NOMURA PHASE4 VENTURES LP, NOMURA
                                         PHASE4 GP LIMITED AND NOMURA PHASE4
                                         VENTURES LIMITED

               I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY):
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      2        CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP:
                                                                         (A) [_]
                                                                         (B) [X]
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      3        SEC USE ONLY

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      4        CITIZENSHIP OR PLACE OF   ENGLAND AND WALES
               ORGANIZATION:

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    NUMBER OF      5  SOLE VOTING POWER:         SHARES OF COMMON STOCK:
      SHARES                                     1,516,449
                                                 WARRANT TO PURCHASE COMMON
                                                 STOCK: 210,499
                   ------------------------------------------------------------
   BENEFICIALLY    6  SHARED VOTING POWER:       -0-
     OWNED BY
                   ------------------------------------------------------------
       EACH        7  SOLE DISPOSITIVE POWER:    SHARES OF COMMON STOCK:
     REPORTING                                   1,516,449
                                                 WARRANT TO PURCHASE COMMON
                                                 STOCK: 210,499
                   ------------------------------------------------------------
   PERSON WITH     8  SHARED DISPOSITIVE         -0-
                      POWER:
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      9        AGGREGATE AMOUNT BENEFICIALLY     SHARES OF COMMON STOCK:
               OWNED BY EACH REPORTING PERSON:   1,516,449
                                                 WARRANT TO PURCHASE COMMON
                                                 STOCK: 210,499
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      10       CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9)
               EXCLUDES CERTAIN SHARES:                               [  ]

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      11       PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9): 7.5%

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      12       TYPE OF REPORTING PERSON: CO, OO
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ITEM 1.    NAME OF ISSUER AND ADDRESS OF ISSUER'S PRINCIPAL EXECUTIVE OFFICES

           (a) and (b) This Statement on Schedule 13G (the "Schedule 13G")
relates to the Common Stock, par value $0.01 per share (the "Common Stock"), of
Altus Pharmaceuticals, Inc., a Delaware corporation (the "Issuer"). The address
of the principal executive offices of the Issuer is 125 Sidney Street,
Cambridge, Massachusetts, 02139.

ITEM 2.    NAME OF PERSON FILING

           (a)        Name of Persons Filing:

                      See Item 1 on the cover page. See also Schedule I.

           (b)        Address of Principal Business Office or, if None,
                      Residence:

           The principal business office of each of the Reporting Persons listed
in Item 2(a) is as follows:

           Nomura House
           1 St Martins -le- Grand
           London, EC1A  4NP
           United Kingdom

           (c), (d) and (e) For information with respect to citizenship of each
of the Reporting Persons, title of class of securities and CUSIP number for the
shares held by such persons, see the appropriate cover page above.

ITEM 3.    IF THIS STATEMENT IS FILED PURSUANT TO RULE 13D-1(B), OR 13D-2(B)
           OR (C), CHECK WHETHER THE PERSON FILING IS:

           (a) [ ] Broker or dealer registered under Section 15 of the Exchange
Act;

           (b) [ ] Bank as defined in Section 3(a)(6) of the Exchange Act;

           (c) [ ] Insurance company as defined in Section 3(a)(19) of the
Exchange Act;

           (d) [ ] Investment company registered under Section 8 of the
Investment Company Act;

           (e) [ ] An investment adviser in accordance with Rule
13d-1(b)(1)(ii)(E);

           (f) [ ] An Employee benefit plan or endowment fund in accordance with
Rule 13d-1(b)(1)(ii)(F);

           (g) [ ] A parent holding company or control person in accordance with
Rule 13d-1(b)(1)(ii)(G);

           (h) [ ] A Savings association as defined in Section 3(b) of the
Federal Deposit Insurance Act;

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           (i) [ ] A church plan that is excluded from the definition of an
investment company under Section 3(c)(14) of the Investment Company Act;

           (j) [ ] Group, in accordance with Rule 13d-1(b)(1)(ii)(J).

           Not applicable.

ITEM 4.    OWNERSHIP

(a) - (c) These responses are as of December 31, 2006. The response of the
Reporting Persons to Items 5 through 11 on the Cover Sheets which relate to the
beneficial ownership of the Common Stock of the Issuer is incorporated herein by
reference. The percentage ownership of each of the Reporting Persons is based on
23,129,859 shares of Common Stock outstanding as of January 10, 2007, as
reported by the Issuer in Amendment 1 to its Form 10-Q/A for the period ending
September 30, 2006 filed with the Securities and Exchange Commission on January
16, 2007, and includes, where appropriate, securities not outstanding which are
subject to options that are exercisable within 60 days. See also Schedule I.

ITEM 5.    OWNERSHIP OF FIVE PERCENT OR LESS OF A CLASS

           If this statement is being filed to report the fact that as of the
date hereof the reporting person has ceased to be the beneficial owner of more
than five percent of the class of Securities, check the following |__|.

           Not applicable.

ITEM 6.    OWNERSHIP OF MORE THAN FIVE PERCENT ON BEHALF OF ANOTHER PERSON

           Not applicable.

ITEM 7.    IDENTIFICATION AND CLASSIFICATION OF THE SUBSIDIARY WHICH
           ACQUIRED THE SECURITY BEING REPORTED ON BY THE PARENT HOLDING
           COMPANY

           See Schedule I.

ITEM 8.    IDENTIFICATION AND CLASSIFICATION OF MEMBERS OF THE GROUP.

           Not applicable.

ITEM 9.    NOTICE OF DISSOLUTION OF GROUP

           Not applicable.

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ITEM 10.   CERTIFICATION

           (a) Not applicable.

           (b) By signing below, the undersigned certifies that, to the best of
his or its knowledge and belief, the securities referred to above were not
acquired and are not held for the purpose of or with the effect of changing or
influencing the control of the issuer of the securities and were not acquired
and are not held in connection with or as a participant in any transaction
having that purpose or effect.


             [The remainder of this page intentionally left blank.]




















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                                    SIGNATURE

           After reasonable inquiry and to the best of our knowledge and belief,
the undersigned certify that the information set forth in this statement is
true, complete and correct.


Date: February 13, 2007
                                     NOMURA INTERNATIONAL PLC


                                     By:  /s/  Denise Pollard-Knight
                                          ---------------------------------
                                          Name:  Denise Pollard-Knight
                                          Title: Head of Nomura Phase 4 Ventures




















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                                   SCHEDULE I


This statement is being filed by Nomura International plc ("NI"), a public
limited company incorporated under the laws of England and Wales, and on behalf
of itself and Nomura Phase4 Ventures LP ("NLP", Nomura Phase4 Ventures GP
Limited ("NGP") and Nomura Phase4 Ventures Limited ("NVL") (collectively, the
"Reporting Entities"). Each of the Reporting Entities has the address of Nomura
House, 1 St Martins-le-Grand, London, EC1A 4NP, United Kingdom. NI owns directly
all of the stock of NVL. NVL owns directly all of the stock of NGP. NGP is the
general partner of NLP.

At the time of the closing of the Issuer's initial public offering on January
31, 2006 (the "IPO"), NI acquired 1,194,236 shares of Common Stock and a warrant
to purchase 100,044 shares of Common Stock and NLP acquired 552,227 shares of
Common Stock and a warrant to purchase 110,455 shares of Common Stock, both
pursuant to a conversion of securities acquired prior to the IPO.

NI and NGP (as general partner of NLP) have each delegated their investment and
voting powers in relation to the securities of the Issuer to NVL.

NI, NGP and NLP each disclaim beneficial ownership of the securities.






















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