UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                  SCHEDULE 13D

                    Under the Securities Exchange Act of 1934
                               (Amendment No. 4)*

                    INTEGRA LIFESCIENCES HOLDINGS CORPORATION
                    -----------------------------------------
                    (F/K/A INTEGRA LIFESCIENCES CORPORATION)
                    ----------------------------------------
                                (Name of Issuer)

                     Common Stock, Par Value $0.01 Per Share
                     ---------------------------------------
                         (Title of Class of Securities)

                                    457985208
                                    ---------
                                 (CUSIP Number)

                              Stephen M. Vine, Esq.
                    Akin, Gump, Strauss, Hauer & Feld, L.L.P.
                               590 Madison Avenue
                            New York, New York 10022
                                 (212) 872-1000
                  ---------------------------------------------
                  (Name, Address and Telephone Number of Person
                Authorized to Receive Notices and Communications)

                                 August 8, 2001
                      -------------------------------------
                      (Date of Event which Requires Filing
                               of this Statement)

If the filing person has previously  filed a statement on Schedule 13G to report
the  acquisition  that is the subject of this  Schedule  13D, and is filing this
schedule because of ss.ss.240.13d-1(e),  240.13d-1(f) or 240.13d-1(g), check the
following  box.  [_]

Note.  Schedules  filed in paper format shall include a signed original and five
copies of the  schedule,  including  all exhibits.  See  ss.240.13d-7  for other
parties to whom copies are to be sent.

*The  remainder of this cover page shall be filled out for a reporting  person's
initial filing on this form with respect to the subject class of securities, and
for  any  subsequent   amendment   containing   information  which  would  alter
disclosures provided in a prior cover page.

The information required on the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the  Securities  Exchange  Act of
1934 ("Act") or otherwise  subject to the liabilities of that section of the Act
but  shall be  subject  to all other  provisions  of the Act  (however,  see the
Notes).


                         Continued on following page(s)
                               Page 1 of 12 Pages






                                  SCHEDULE 13D
CUSIP No. 457985208                                           Page 2 of 12 Pages


1        Names of Reporting Persons
         I.R.S. Identification Nos. of Above Persons (entities only)

                  QUANTUM INDUSTRIAL PARTNERS LDC

2        Check the Appropriate Box If a Member of a Group (See Instructions)
                                                     a.       [_]
                                                     b.       [X]

3        SEC Use Only

4        Source of Funds (See Instructions)

                  Not Applicable

5        Check Box If Disclosure of Legal  Proceedings  Is Required  Pursuant to
         Items 2(d) or 2(e)

                [_]

6        Citizenship or Place of Organization

                  Cayman Islands

                            7             Sole Voting Power
                                               2,720,625
Number of
  Shares
Beneficially                8             Shared Voting Power
  Owned By                                        0
    Each
Reporting                   9             Sole Dispositive Power
    Person                                     2,720,625
    With
                            10            Shared Dispositive Power
                                                 0

11       Aggregate Amount Beneficially Owned by Each Reporting Person

                  2,720,625

12       Check Box If the Aggregate  Amount in Row (11) Excludes  Certain Shares
         (See Instructions)

                  [X]

13       Percent of Class Represented By Amount in Row (11)

                  10.35%

14       Type of Reporting Person (See Instructions)

                  OO; IV




                                  SCHEDULE 13D
CUSIP No. 457985208                                           Page 3 of 12 Pages


1        Names of Reporting Persons
         I.R.S. Identification Nos. of Above Persons (entities only)

                  QIH MANAGEMENT INVESTOR, L.P.

2        Check the Appropriate Box If a Member of a Group (See Instructions)
                                                     a.       [_]
                                                     b.       [X]

3        SEC Use Only

4        Source of Funds (See Instructions)

                  Not Applicable

5        Check Box If Disclosure of Legal  Proceedings  Is Required  Pursuant to
         Items 2(d) or 2(e)

                  [_]

6        Citizenship or Place of Organization

                  Delaware

                            7             Sole Voting Power
                                               2,720,625
Number of
  Shares
Beneficially                8             Shared Voting Power
  Owned By                                     0
    Each
Reporting                   9             Sole Dispositive Power
    Person                                     2,720,625
    With
                            10            Shared Dispositive Power
                                               0

11       Aggregate Amount Beneficially Owned by Each Reporting Person

                  2,720,625

12       Check Box If the Aggregate  Amount in Row (11) Excludes  Certain Shares
         (See Instructions)

                  [X]

13       Percent of Class Represented By Amount in Row (11)

                  10.35%

14       Type of Reporting Person (See Instructions)

                  PN; IA



                                  SCHEDULE 13D
CUSIP No. 457985208                                           Page 4 of 12 Pages

1        Names of Reporting Persons
         I.R.S. Identification Nos. of Above Persons (entities only)

                  QIH MANAGEMENT, INC.

2        Check the Appropriate Box If a Member of a Group (See Instructions)
                                                     a.       [_]
                                                     b.       [X]

3        SEC Use Only

4        Source of Funds (See Instructions)

                  Not Applicable

5        Check Box If Disclosure of Legal  Proceedings  Is Required  Pursuant to
         Items 2(d) or 2(e)

                  [_]

6        Citizenship or Place of Organization

                  Delaware

                            7             Sole Voting Power
                                               2,720,625
Number of
  Shares
Beneficially                8             Shared Voting Power
  Owned By                                     0
    Each
Reporting                   9             Sole Dispositive Power
    Person                                     2,720,625
    With
                            10            Shared Dispositive Power
                                               0

11       Aggregate Amount Beneficially Owned by Each Reporting Person

                  2,720,625

12       Check Box If the Aggregate  Amount in Row (11) Excludes  Certain Shares
         (See Instructions)

                  [X]

13       Percent of Class Represented By Amount in Row (11)

                  10.35%

14       Type of Reporting Person (See Instructions)

                  CO


                                  SCHEDULE 13D
CUSIP No. 457985208                                           Page 5 of 12 Pages


1        Names of Reporting Persons
         I.R.S. Identification Nos. of Above Persons (entities only)

                  SOROS FUND MANAGEMENT LLC

2        Check the Appropriate Box If a Member of a Group (See Instructions)
                                                        a.       [_]
                                                        b.       [X]

3        SEC Use Only

4        Source of Funds (See Instructions)

                  Not Applicable

5        Check Box If Disclosure of Legal  Proceedings  Is Required  Pursuant to
         Items 2(d) or 2(e)

                  [_]

6        Citizenship or Place of Organization

                  Delaware

                            7             Sole Voting Power
                                                 2,720,625
Number of
  Shares
Beneficially                8             Shared Voting Power
  Owned By                                       0
    Each
Reporting                   9             Sole Dispositive Power
    Person                                       2,720,625
    With
                            10            Shared Dispositive Power
                                                 0

11       Aggregate Amount Beneficially Owned by Each Reporting Person

                  2,720,625

12       Check Box If the Aggregate  Amount in Row (11) Excludes  Certain Shares
         (See Instructions)

                  [X]

13       Percent of Class Represented By Amount in Row (11)

                  10.35%

14       Type of Reporting Person (See Instructions)

                  OO; IA




                                  SCHEDULE 13D
CUSIP No. 457985208                                           Page 6 of 12 Pages

1        Names of Reporting Persons
         I.R.S. Identification Nos. of Above Persons (entities only)

                  GEORGE SOROS (in the capacity described herein)

2        Check the Appropriate Box If a Member of a Group (See Instructions)
                                                        a.       [_]
                                                        b.       [X]

3        SEC Use Only

4        Source of Funds (See Instructions)

                  Not Applicable

5        Check Box If Disclosure of Legal  Proceedings  Is Required  Pursuant to
         Items 2(d) or 2(e)

                  [_]

6        Citizenship or Place of Organization

                  United States

                            7             Sole Voting Power
                                                 3,445,300
Number of
  Shares
Beneficially                8             Shared Voting Power
  Owned By                                       0
    Each
Reporting                   9             Sole Dispositive Power
    Person                                       3,445,300
    With
                            10            Shared Dispositive Power
                                                 0

11       Aggregate Amount Beneficially Owned by Each Reporting Person

                  3,445,300

12       Check Box If the Aggregate  Amount in Row (11) Excludes  Certain Shares
         (See Instructions)

                  [_]

13       Percent of Class Represented By Amount in Row (11)

                  13.06%

14       Type of Reporting Person (See Instructions)

                  IA



                                                              Page 7 of 12 Pages

          This  Amendment  No. 4 to  Schedule  13D  relates  to shares of Common
Stock,  $0.01 par  value  per share  (the  "Shares"),  of  Integra  LifeSciences
Holdings  Corporation (the "Issuer") (f/k/a Integra  LifeSciences  Corporation).
This  Amendment No. 4  supplementally  amends the initial  statement on Schedule
13D, dated April 8, 1999 and all amendments thereto (collectively,  the "Initial
Statement"),  filed by the Reporting Persons (as defined herein). This Amendment
No. 4 is being  filed by the  Reporting  Persons  to report  that the  number of
Shares of which the Reporting  Persons may be deemed to be the beneficial owners
has decreased by more than one percent of the outstanding  shares of the Issuer.
Capitalized  terms used but not defined herein shall have the meanings  ascribed
to them in the  Initial  Statement.  The  Initial  Statement  is  supplementally
amended as follows.

Item 2.   Identity and Background.


          This  Statement  is being  filed on  behalf  of each of the  following
persons (collectively, the "Reporting Persons"):


     i)   Quantum Industrial Partners LDC ("QIP");

     ii)  QIH Management Investor, L.P. ("QIHMI");

     iii) QIH Management, Inc. ("QIH Management");

     iv)  Soros Fund Management LLC ("SFM LLC"); and

     v)   Mr. George Soros ("Mr. Soros").


          This Statement  relates to the Shares held for the accounts of QIP and
SFM Domestic Investments LLC ("SFM Domestic Investments").


          Set forth in Annex A hereto, and incorporated by reference, is updated
information concerning the identity and background of the officers and directors
of QIP and QIH Management.


Item 5.   Interest in Securities of the Issuer.

          (a)  (i) Each of QIP, QIHMI,  QIH Management and SFM LLC may be deemed
the  beneficial  owner of 2,720,625  Shares  (approximately  10.35% of the total
number of Shares which would be outstanding assuming the exercise and conversion
of all of the securities  held for the account of QIP). This number includes (A)
1,908,975  Shares held for the account of QIP; (B) 541,100 Shares  issuable upon
conversion of 48,699 Series C Preferred  Shares held for the account of QIP; and
(C) 270,550  Shares  issuable  upon  exercise of 270,550  warrants  held for the
account of QIP.


                                                              Page 8 of 12 Pages

               (ii) Mr.  Soros may be deemed the  beneficial  owner of 3,445,300
Shares  (approximately  13.06% of the total  number  of  Shares  which  would be
outstanding  assuming the exercise and conversion of all of the securities  held
for the accounts of QIP and SFM Domestic Investments).  This number includes (A)
1,908,975  Shares held for the account of QIP; (B) 541,100 Shares  issuable upon
conversion of 48,699 Series C Preferred  Shares held for the account of QIP; (C)
270,550 Shares  issuable upon exercise of 270,550  warrants held for the account
of QIP; (D) 636,325 Shares held for the account of SFM Domestic Investments; (E)
58,900 Shares issuable upon  conversion of 5,301 Series C Preferred  Shares held
for the account of SFM Domestic Investments; and (F) 29,450 Shares issuable upon
exercise of 29,450 warrants held for the account of SFM Domestic Investments.

          (b)  (i) Each of QIP, QIHMI,  QIH Management and SFM LLC (by virtue of
the QIP  contract)  and Mr. Soros (as a result of his position with SFM LLC) may
be deemed to have the sole power to direct the  voting  and  disposition  of the
2,720,625  Shares held for the account of QIP  (assuming  the  conversion of all
Series C Preferred  Shares and the exercise of all warrants held for the account
of QIP).

               (ii) Mr.  Soros  in his  capacity  as a  managing  member  of SFM
Domestic  Investments  may be deemed to have the sole power to direct the voting
and  disposition  of the 724,675  Shares  held for the  account of SFM  Domestic
Investments  (assuming the  conversion of all Series C Preferred  Shares and the
exercise of all warrants held for the account of SFM Domestic Investments).

          (c)       Except for the transactions listed in Annex B hereto,  there
have been no transactions effected with respect to the Shares since July 5, 2001
(the date of the most  recent  filing on Schedule  13D) by any of the  Reporting
Persons.

          (d)  (i)  The  shareholders  of  QIP,   including  Quantum  Industrial
Holdings,  Ltd., a British Virgin Islands  international  business company, have
the right to participate in the receipt of dividends  from, or proceeds from the
sale of, the  securities  held for the account of QIP in  accordance  with their
ownership interests in QIP.


               (ii) Certain members of SFM Domestic  Investments  have the right
to participate  in the receipt of dividends  from, or proceeds from the sale of,
the securities held for the account of SFM Domestic Investments.


          (e)  Not applicable.





                                                              Page 9 of 12 Pages

                                   SIGNATURES


          After  reasonable  inquiry and to the best of my knowledge and belief,
the  undersigned  certifies that the  information set forth in this Statement is
true, complete and correct.

Date: August 14, 2001            QUANTUM INDUSTRIAL PARTNERS LDC


                                 By:      _________________________________
                                          Richard D. Holahan, Jr.
                                          Attorney-in-Fact


                                 QIH MANAGEMENT INVESTOR, L.P.

                                 By:      QIH Management, Inc.,
                                          its General Partner

                                 By: ______________________________________
                                     Richard D. Holahan, Jr.
                                     Vice President


                                 QIH MANAGEMENT, INC.


                                 By: ______________________________________
                                     Richard D. Holahan, Jr.
                                     Vice President


                                 SOROS FUND MANAGEMENT LLC


                                 By: ______________________________________
                                     Richard D. Holahan, Jr.
                                     Assistant General Counsel


                                 GEORGE SOROS


                                 By: __________________________________
                                     Richard D. Holahan, Jr.
                                     Attorney-in-Fact





                                                                                           Page 10 of 12 Pages

                                                    ANNEX A

                           Directors and Officers of Quantum Industrial Partners LDC

Name/Title/Citizenship                            Principal Occupation                       Business Address
----------------------                            --------------------                       ----------------
                                                                                       

    Curacao Corporation                           Managing Director of                       Kaya Flamboyan 9
    Company N.V.                                  Netherlands Antilles                       Willemstad
      Managing Director                           corporations                               Curacao,
      (Netherlands Antilles)                                                                 Netherlands Antilles

    Inter Caribbean Services Limited              Administrative services                    Citco Building
      Secretary                                                                              Wickhams Cay
      (British Virgin Islands)                                                               Road Town
                                                                                             Tortola
                                                                                             British Virgin Islands

                                Directors and Officers of QIH Management, Inc.

Name/Title/Citizenship                            Principal Occupation                       Business Address
----------------------                            --------------------                       ----------------

    Frank V. Sica                                 Managing Partner of Soros Private Equity   888 Seventh Avenue
    Director and President                        Partners LLC                               28th Floor
    (United States)                                                                          New York, NY  10106

    Armando Belly                                 General Counsel of SFM LLC                 888 Seventh Avenue
    Director and Secretary                                                                   33rd Floor
    (United States)                                                                          New York, NY  10106

    Dan Eule                                      Tax Director of SFM LLC                    888 Seventh Avenue
    Director                                                                                 33rd Floor
    (United States)                                                                          New York, NY  10106

    Eve Mongiardo                                 Chief Financial Officer of                 888 Seventh Avenue
    Director and Treasurer                        Soros Private Funds Management LLC         28th Floor
    (United States)                                                                          New York, NY  10106

    Richard D. Holahan, Jr.                       Assistant General Counsel of               888 Seventh Avenue
    Vice President                                SFM LLC                                    33rd Floor
    (United States)                                                                          New York, NY  10106


                                                             Page 11 of 12 Pages

          To the best of the Reporting Persons' knowledge:

               (a) None of the above persons hold any Shares.

               (b) None of the above  persons has any  contracts,  arrangements,
understandings or relationships with respect to the Shares.





                                                                                           Page 12 of 12 Pages

                                                    ANNEX B

                                   RECENT TRANSACTIONS IN THE SECURITIES OF
                                   INTEGRA LIFESCIENCES HOLDINGS CORPORATION

                               Date of                Nature of         Number of
For the Account of           Transaction             Transaction       Securities                Price
------------------           -----------             -----------       ----------                -----
                                                                                     

QIP                          8/8/01                  Sale              234,375                   $25.50 per Share

SFM Domestic Investments     8/8/01                  Sale              78,125                    $25.50 per Share