Ownership Submission
FORM 5
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
Form 3 Holdings Reported
Form 4 Transactions Reported
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

ANNUAL STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940
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1. Name and Address of Reporting Person *
WILHELM MICHAEL K
 2. Issuer Name and Ticker or Trading Symbol
IR BIOSCIENCES HOLDINGS INC [IRBS] 		5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
__X__ Director __X__ 10% Owner
__X__ Officer (give title below) _____ Other (specify below)
President and CEO
(Last)
(First)
(Middle)

8767 E.VIA DE VENTURA, SUITE 190		 3. Statement for Issuer's Fiscal Year Ended (Month/Day/Year)
12/31/2008
(Street)


SCOTTSDALE, AZ 85258		 4. If Amendment, Date Original Filed(Month/Day/Year)
 6. Individual or Joint/Group Reporting
(check applicable line)

_X_ Form Filed by One Reporting Person
___ Form Filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3)		 2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code
(Instr. 8)		 4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)		 5. Amount of Securities Beneficially Owned at end of Issuer's Fiscal Year
(Instr. 3 and 4)		 6. Ownership Form: Direct (D) or Indirect (I)
(Instr. 4)		 7. Nature of Indirect Beneficial Ownership
(Instr. 4)
Amount (A) or (D) Price
Common Stock 03/06/2004   J4(4) 126,612 A $ 2.4 46,200 (1) I Spouse
Common Stock 03/16/2004   J4(5) 45,800 A $ 0.79 46,200 (1) I Spouse
Common Stock 07/13/2005   J4(7) 500 D $ 0.31 992,527 (1) D  
Common Stock 07/13/2005   J4(7) 25,000 D $ 0.31 992,527 (1) D  
Common Stock 04/13/2006   J4(7) 20,000 D $ 0.18 992,527 (1) D  
Common Stock 04/13/2006   J4(8) 28,000 D $ 0.18 992,527 (1) D  
Common Stock 04/19/2006   J4(8) 250,000 D $ 0.16 992,527 (1) D  
Common Stock 08/24/2007   J4(8) 10,000 D $ 0.16 992,527 (1) D  
Common Stock 08/08/2008   J4(9) 833,334 A $ 0.3 992,527 (1) D  
Common stock 06/21/2005   P4 10,000 A $ 0.005 46,200 (1) I minor child
Common stock 06/21/2005   P4 5,000 A $ 0.005 46,200 (1) I minor child
Common stock 06/21/2005   P4 5,000 A $ 0.005 46,200 (1) I minor child
Common stock 06/21/2005   P4 5,000 A $ 0.005 46,200 (1) I minor child
Common stock 12/15/2006   P4 1,000 A $ 0.17 46,200 (1) I minor child

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly. Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB control number. SEC 2270 (9-02)

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 3)		 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year) 3A. Deemed Execution Date, if any (Month/Day/Year) 4. Transaction Code
(Instr. 8)		 5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4, and 5)		 6. Date Exercisable and Expiration Date
(Month/Day/Year)		 7. Title and Amount of Underlying Securities
(Instr. 3 and 4)		 8. Price of Derivative Security
(Instr. 5)		 9. Number of Derivative Securities Beneficially Owned at End of Issuer's Fiscal Year
(Instr. 4)		 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 4)		 11. Nature of Indirect Beneficial Ownership
(Instr. 4)
(A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares
Warrant to Purchase Common Stock $ 2 12/10/2003   A4 (3) 20,000   12/10/2003 10/10/2006 Common Stock
20,000
$ 0 187,014 (1)
D
 
Warrant to Purchase Common Stock $ 0.01 12/10/2003   A4 (3) 10,000   12/10/2003 12/10/2006 Common Stock
10,000
$ 0 187,014 (1)
D
 
Warrant to Purchase Common Stock $ 0.01 12/10/2003   A4 (2)(4) 20,000   12/10/2003 12/10/2006 Common Stock
20,000
$ 0 187,014 (1)
D
 
Warrant to Purchase Common Stock $ 2 03/06/2004   A4 (2)(4) 500   12/31/2003 12/31/2008 Common Stock
500
$ 0 2,000 (1)
I
Spouse
Warrant to Purchase Common Stock $ 0.25 03/06/2004   A4 (2)(4) 10,000   12/31/2003 12/31/2008 Common Stock
10,000
$ 0 2,000 (1)
I
Spouse
Warrant to Purchase Common Stock $ 0.25 03/06/2004   A4 10,000   12/31/2003 12/31/2008 Common Stock
10,000
$ 0 2,000 (1)
I
Spouse
Warrant to Purchase Common Stock $ 0.125 03/18/2004   A4 224,490   03/18/2004 03/18/2009 Common Stock
224,490
$ 0 187,014
D
 
Warrant to Purchase Common Stock $ 0.25 04/13/2004   A4 250,000   04/13/2004 04/13/2009 Common Stock
250,000
$ 0 187,014 (1)
D
 
Warrant to Purchase Common Stock $ 0.25 04/13/2004   A4 250,000   04/13/2004 04/13/2009 Common Stock
250,000
$ 0 187,014 (1)
D
 
Warrant to Purchase Common Stock $ 0.25 05/17/2004   A4 75,000   05/17/2004 05/17/2009 Common Stock
75,000
$ 0 187,014 (1)
D
 
Warrant to Purchase Common Stock $ 2 07/22/2004   A4 5,000   07/22/2004 07/22/2009 Common Stock
5,000
$ 0 187,014 (1)
D
 
Warrant to Purchase Common Stock $ 0.05 07/22/2004   A4 80,000   07/22/2004 07/22/2009 Common Stock
80,000
$ 0 187,014 (1)
D
 
Warrant to Purchase Common Stock $ 0.25 07/30/2004   A4 20,000   07/30/2004 07/30/2009 Common Stock
20,000
$ 0 2,000 (1)
I
Spouse
Warrant to Purchase Common Stock $ 2 08/18/2004   A4 1,550   08/18/2004 08/18/2009 Common Stock
1,550
$ 0 187,014 (1)
D
 
Warrant to Purchase Common Stock $ 0.09 08/18/2008   A4 20,800   08/18/2008 08/18/2009 Common Stock
20,800
$ 0 187,014 (1)
D
 
Warrant to Purchase Common Stock $ 0.12 10/15/2004   A4 (2) 5,000,000   10/15/2004 09/30/2006 Common Stock
5,000,000
$ 0 2,000 (1)
I
See Footnote 6 (6)
Warrant to Purchase Common Stock $ 0.3 05/20/2005   A4 80,811   05/20/2005 05/20/2010 Common Stock
80,811
$ 0 187,014 (1)
D
 
Warrant to Purchase Common Stock $ 0.25 07/14/2006   A4 300,000   07/14/2006 07/14/2011 Common Stock
300,000
$ 0 187,014 (1)
D
 
Options to Purchase Common Stock $ 0.44 05/20/2005   A4 150,000   06/19/2005 05/20/2010 Common Stock
150,000
$ 0 815,000 (1)
D
 
Options to Purchase Common Stock $ 0.33 08/10/2005   A4 103,030   09/09/2005 08/10/2010 Common Stock
103,030
$ 0 815,000 (1)
D
 
Options to Purchase Common Stock $ 0.231 07/14/2006   A4 1,896,970   08/13/2006 07/14/2011 Common Stock
1,896,970
$ 0 815,000 (1)
D
 
Options to Purchase Common Stock $ 0.22 09/13/2006   A4 454,545   10/13/2006 09/12/2011 Common Stock
454,545
$ 0 815,000 (1)
D
 
Options to Purchase Common Stock $ 0.22 09/13/2006   A4 3,045,455   10/13/2006 09/12/2011 Common Stock
3,045,455
$ 0 815,000 (1)
D
 
Options to Purchase Common Stock $ 0.166 08/01/2007   A4 2,000,000   08/31/2007 07/31/2017 Common Stock
2,000,000
$ 0 815,000 (1)
D
 
Options to Purchase Common Stock $ 0.195 08/01/2007   A4 500,000   08/31/2007 07/31/2017 Common Stock
500,000
$ 0 815,000 (1)
D
 

Reporting Owners

Reporting Owner Name / Address Relationships
Director 10% Owner Officer Other
WILHELM MICHAEL K
8767 E.VIA DE VENTURA
SUITE 190
SCOTTSDALE, AZ 85258		   X   X   President and CEO  

Signatures

Michael Wilhelm 02/18/2009
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) Adjusted for 1 for 10 stock split in August 2008.
(2) Reported for initial Form 4 reporting purposes only. Warrants have expired
(3) Reported for initial Form 4 reporting purposes only. Warrants have been exercised.
(4) Reflects indirect ownership as a result of marriage on March 6, 2004.
(5) Conversion of fees due for services.
(6) Warrants held by Foresight Capital Corp. which Mr. Wilhelm is deemed to beneficially own as principal owner of Foresight Capital Corp.
(7) Private transfer
(8) Given per terms of loan agreement
(9) Per employment agreement dated August 10, 2005, as amended November 7, 2005

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