UNITED STATES
                      SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

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                                  SCHEDULE 13G

                  Under the Securities and Exchange Act of 1934

                                (Amendment No.2)*

                           ORASURE TECHNOLOGIES, INC.

--------------------------------------------------------------------------------
                                (Name of Issuer)

                        Common Stock, $.000001 par value

--------------------------------------------------------------------------------
                         (Title of Class of Securities)

                                   68554V 10 8

--------------------------------------------------------------------------------
                                 (CUSIP Number)

                                December 31, 2002

--------------------------------------------------------------------------------
             (Date of Event Which Requires Filing of this Statement)


     Check the  appropriate  box to  designate  the rule  pursuant to which this
Schedule is filed:

          [_]  Rule 13d-1(b)

          [x]  Rule 13d-1(c)

          [ ]  Rule 13d-1(d)


----------
*    The  remainder  of this  cover  page  shall be filled  out for a  reporting
     person's  initial  filing on this form with respect to the subject class of
     securities,  and for any subsequent amendment containing  information which
     would alter the disclosures provided in a prior cover page.

     The  information  required in the remainder of this cover page shall not be
deemed to be "filed"  for the purpose of Section 18 of the  Securities  Exchange
Act of 1934 or otherwise  subject to the  liabilities of that section of the Act
but  shall be  subject  to all other  provisions  of the Act  (however,  see the
Notes).



CUSIP No. 68554V 10 8                   13G                 Page 2 of 15 Pages


________________________________________________________________________________
1.   NAME OF REPORTING PERSONS
     I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY)


                HealthCare Ventures V, L.P.
________________________________________________________________________________
2.   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                 (a)  [_]
                                                                 (b)  [_]

________________________________________________________________________________
3.   SEC USE ONLY



________________________________________________________________________________
4.   CITIZENSHIP OR PLACE OF ORGANIZATION


                Delaware
________________________________________________________________________________
  NUMBER OF    5.   SOLE VOTING POWER

   SHARES
               _________________________________________________________________
BENEFICIALLY   6.   SHARED VOTING POWER

  OWNED BY          2,933,207
               _________________________________________________________________
    EACH       7.   SOLE DISPOSITIVE POWER

  REPORTING
               _________________________________________________________________
   PERSON      8.   SHARED DISPOSITIVE POWER

    WITH            2,933,207
________________________________________________________________________________
9.   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON


                2,933,207
________________________________________________________________________________
10.  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*

                                                                          [_]

________________________________________________________________________________
11.  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
                7.81%


________________________________________________________________________________
12.  TYPE OF REPORTING PERSON*


                PN
________________________________________________________________________________
                     *SEE INSTRUCTIONS BEFORE FILLING OUT!




CUSIP No. 68554V 10 8                   13G                 Page 3 of 15 Pages

________________________________________________________________________________
1.   NAME OF REPORTING PERSONS
     I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY)


                HealthCare Partners V, L.P.
________________________________________________________________________________
2.   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                 (a)  [_]
                                                                 (b)  [_]

________________________________________________________________________________
3.   SEC USE ONLY



________________________________________________________________________________
4.   CITIZENSHIP OR PLACE OF ORGANIZATION


                Delaware
________________________________________________________________________________
  NUMBER OF    5.   SOLE VOTING POWER

   SHARES
               _________________________________________________________________
BENEFICIALLY   6.   SHARED VOTING POWER

  OWNED BY          2,933,207
               _________________________________________________________________
    EACH       7.   SOLE DISPOSITIVE POWER

  REPORTING
               _________________________________________________________________
   PERSON      8.   SHARED DISPOSITIVE POWER

    WITH            2,933,207
________________________________________________________________________________
9.   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON


                2,933,207
________________________________________________________________________________
10.  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*

                                                                          [_]

________________________________________________________________________________
11.  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
                7.81%


________________________________________________________________________________
12.  TYPE OF REPORTING PERSON*


                PN
________________________________________________________________________________
                     *SEE INSTRUCTIONS BEFORE FILLING OUT!





CUSIP No. 68554V 10 8                   13G                 Page 4 of 15 Pages

________________________________________________________________________________
1.   NAME OF REPORTING PERSONS
     I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY)


                James H. Cavanaugh, Ph.D.
________________________________________________________________________________
2.   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                 (a)  [_]
                                                                 (b)  [_]

________________________________________________________________________________
3.   SEC USE ONLY



________________________________________________________________________________
4.   CITIZENSHIP OR PLACE OF ORGANIZATION


                United States
________________________________________________________________________________
  NUMBER OF    5.   SOLE VOTING POWER

   SHARES
               _________________________________________________________________
BENEFICIALLY   6.   SHARED VOTING POWER

  OWNED BY          2,933,207
               _________________________________________________________________
    EACH       7.   SOLE DISPOSITIVE POWER

  REPORTING
               _________________________________________________________________
   PERSON      8.   SHARED DISPOSITIVE POWER

    WITH            2,933,207
________________________________________________________________________________
9.   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON


                2,933,207
________________________________________________________________________________
10.  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*

                                                                          [_]

________________________________________________________________________________
11.  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
                7.81%


________________________________________________________________________________
12.  TYPE OF REPORTING PERSON*


                IN
________________________________________________________________________________
                     *SEE INSTRUCTIONS BEFORE FILLING OUT!




CUSIP No. 68554V 10 8                   13G                 Page 5 of 15 Pages

________________________________________________________________________________
1.   NAME OF REPORTING PERSONS
     I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY)


                Harold R. Werner
________________________________________________________________________________
2.   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                 (a)  [_]
                                                                 (b)  [_]

________________________________________________________________________________
3.   SEC USE ONLY



________________________________________________________________________________
4.   CITIZENSHIP OR PLACE OF ORGANIZATION


                United States
________________________________________________________________________________
  NUMBER OF    5.   SOLE VOTING POWER

   SHARES           7,944
               _________________________________________________________________
BENEFICIALLY   6.   SHARED VOTING POWER

  OWNED BY          2,933,207
               _________________________________________________________________
    EACH       7.   SOLE DISPOSITIVE POWER

  REPORTING         7,944
               _________________________________________________________________
   PERSON      8.   SHARED DISPOSITIVE POWER

    WITH            2,933,207
________________________________________________________________________________
9.   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON


                2,941,151
________________________________________________________________________________
10.  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*

                                                                          [_]

________________________________________________________________________________
11.  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
                7.83%


________________________________________________________________________________
12.  TYPE OF REPORTING PERSON*


                IN
________________________________________________________________________________
                     *SEE INSTRUCTIONS BEFORE FILLING OUT!





CUSIP No. 68554V 10 8                   13G                 Page 6 of 15 Pages

________________________________________________________________________________
1.   NAME OF REPORTING PERSONS
     I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY)


                William Crouse
________________________________________________________________________________
2.   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                 (a)  [_]
                                                                 (b)  [_]

________________________________________________________________________________
3.   SEC USE ONLY



________________________________________________________________________________
4.   CITIZENSHIP OR PLACE OF ORGANIZATION


                United States
________________________________________________________________________________
  NUMBER OF    5.   SOLE VOTING POWER

   SHARES           97,111
               _________________________________________________________________
BENEFICIALLY   6.   SHARED VOTING POWER

  OWNED BY          2,933,207
               _________________________________________________________________
    EACH       7.   SOLE DISPOSITIVE POWER

  REPORTING         97,111
               _________________________________________________________________
   PERSON      8.   SHARED DISPOSITIVE POWER

    WITH            2,933,207
________________________________________________________________________________
9.   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON


                3,030,318
________________________________________________________________________________
10.  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*

                                                                          [_]

________________________________________________________________________________
11.  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
                8.07%


________________________________________________________________________________
12.  TYPE OF REPORTING PERSON*


                IN
________________________________________________________________________________
                     *SEE INSTRUCTIONS BEFORE FILLING OUT!




CUSIP No. 68554V 10 8                   13G                 Page 7 of 15 Pages

________________________________________________________________________________
1.   NAME OF REPORTING PERSONS
     I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY)


                John W. Littlechild
________________________________________________________________________________
2.   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                 (a)  [_]
                                                                 (b)  [_]

________________________________________________________________________________
3.   SEC USE ONLY



________________________________________________________________________________
4.   CITIZENSHIP OR PLACE OF ORGANIZATION


                United States
________________________________________________________________________________
  NUMBER OF    5.   SOLE VOTING POWER

   SHARES
               _________________________________________________________________
BENEFICIALLY   6.   SHARED VOTING POWER

  OWNED BY          2,933,207
               _________________________________________________________________
    EACH       7.   SOLE DISPOSITIVE POWER

  REPORTING
               _________________________________________________________________
   PERSON      8.   SHARED DISPOSITIVE POWER

    WITH            2,933,207
________________________________________________________________________________
9.   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON


                2,933,207
________________________________________________________________________________
10.  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*

                                                                          [_]

________________________________________________________________________________
11.  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
                7.81%


________________________________________________________________________________
12.  TYPE OF REPORTING PERSON*


                IN
________________________________________________________________________________
                     *SEE INSTRUCTIONS BEFORE FILLING OUT!





CUSIP No. 68554V 10 8                   13G                 Page 8 of 15 Pages

________________________________________________________________________________
1.   NAME OF REPORTING PERSONS
     I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY)


                Christopher Mirabelli, Ph.D.
________________________________________________________________________________
2.   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                 (a)  [_]
                                                                 (b)  [_]

________________________________________________________________________________
3.   SEC USE ONLY



________________________________________________________________________________
4.   CITIZENSHIP OR PLACE OF ORGANIZATION


                United States
________________________________________________________________________________
  NUMBER OF    5.   SOLE VOTING POWER

   SHARES
               _________________________________________________________________
BENEFICIALLY   6.   SHARED VOTING POWER

  OWNED BY          2,933,207
               _________________________________________________________________
    EACH       7.   SOLE DISPOSITIVE POWER

  REPORTING
               _________________________________________________________________
   PERSON      8.   SHARED DISPOSITIVE POWER

    WITH            2,933,207
________________________________________________________________________________
9.   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON


                2,933,207
________________________________________________________________________________
10.  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*

                                                                          [_]

________________________________________________________________________________
11.  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
                7.81%


________________________________________________________________________________
12.  TYPE OF REPORTING PERSON*


                IN
________________________________________________________________________________
                     *SEE INSTRUCTIONS BEFORE FILLING OUT!





CUSIP No. 68554V 10 8                   13G                 Page 9 of 15 Pages

________________________________________________________________________________
1.   NAME OF REPORTING PERSONS
     I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY)


                Augustine Lawlor
________________________________________________________________________________
2.   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                 (a)  [_]
                                                                 (b)  [_]

________________________________________________________________________________
3.   SEC USE ONLY



________________________________________________________________________________
4.   CITIZENSHIP OR PLACE OF ORGANIZATION


                United States
________________________________________________________________________________
  NUMBER OF    5.   SOLE VOTING POWER

   SHARES
               _________________________________________________________________
BENEFICIALLY   6.   SHARED VOTING POWER

  OWNED BY          2,933,207
               _________________________________________________________________
    EACH       7.   SOLE DISPOSITIVE POWER

  REPORTING
               _________________________________________________________________
   PERSON      8.   SHARED DISPOSITIVE POWER

    WITH            2,933,207
________________________________________________________________________________
9.   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON


                2,933,207
________________________________________________________________________________
10.  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*

                                                                          [_]

________________________________________________________________________________
11.  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
                7.81%


________________________________________________________________________________
12.  TYPE OF REPORTING PERSON*


                IN
________________________________________________________________________________
                     *SEE INSTRUCTIONS BEFORE FILLING OUT!







CUSIP No. 68554V 10 8                   13G                 Page 10 of 15 Pages

Item 1(a).  Name of Issuer:


                        Orasure Technologies, Inc.
            ____________________________________________________________________

Item 1(b).  Address of Issuer's Principal Executive Offices:

                        150 Webster Street
                        Bethlehem, PA  18015

            ____________________________________________________________________

Item 2(a).  Name of Person Filing:

                  HealthCare Ventures V, L.P. ("HCV V"), HealthCare Partners V,
                  L.P. ("HCP V"), Drs. Cavanaugh and Mirabelli and Messrs.
                  Werner, Littlechild, Crouse and Lawlor. See attached Exhibit
                  A, which is a copy of their agreement in writing to file this
                  statement on behalf of each of them.(1)

            ____________________________________________________________________

Item 2(b).  Address of Principal Business Office, or if None, Residence:

                  The business address for HCV V, HCP V, Dr. Cavanaugh and
                  Messrs. Werner and Crouse is 44 Nassau Street, Princeton, New
                  Jersey 08542. The business address for Dr. Mirabelli and
                  Messrs. Littlechild and Lawlor is One Kendall Square, Building
                  300, Cambridge, Massachusetts 02339.

            ____________________________________________________________________

Item 2(c).  Citizenship:

                  HCV V, and HCP V are limited partnerships organized under the
                  laws of the State of Delaware. Drs. Cavanaugh and Mirabelli
                  and Messrs. Werner, Littlechild, Crouse and Lawlor are each
                  United States citizens.

            ____________________________________________________________________

Item 2(d).  Title of Class of Securities:


                  Common Stock par value $.000001 (the "Shares")
                  ______________________________________________________________


(1)      Drs. Cavanaugh and Mirabelli and Messrs. Werner, Littlechild, Crouse
         and Lawlor are general partners of HCP V, the general partner of HCV V,
         the record holder of the Issuer's Common Stock reported hereto.



CUSIP No. 68554V 10 8                   13G                 Page 11 of 15 Pages

Item 2(e).  CUSIP Number:

                68554V 10 8

            ____________________________________________________________________

Item 3.     If This Statement  is Filed  Pursuant to  Rule 13d-1(b), or 13d-2(b)
            or (c), Check Whether the Person Filing is a:  Not Applicable

     (a)  [_]  Broker or dealer registered under Section 15 of the Exchange Act.

     (b)  [_]  Bank as defined in Section 3(a)(6) of the Exchange Act.

     (c)  [_]  Insurance  company as defined in Section 3(a)(19) of the Exchange
               Act.

     (d)  [_]  Investment  company  registered under Section 8 of the Investment
               Company Act.

     (e)  [_]  An investment adviser in accordance with Rule 13d-1(b)(1)(ii)(E);

     (f)  [_]  An employee  benefit plan or endowment  fund in  accordance  with
               Rule 13d-1(b)(1)(ii)(F);

     (g)  [_]  A parent  holding  company or control  person in accordance  with
               Rule 13d-1(b)(1)(ii)(G);

     (h)  [_]  A savings  association  as defined in Section 3(b) of the Federal
               Deposit Insurance Act;

     (i)  [_]  A  church  plan  that  is  excluded  from  the  definition  of an
               investment  company  under  Section  3(c)(14)  of the  Investment
               Company Act;

     (j)  [_]  Group, in accordance with Rule 13d-1(b)(1)(ii)(J).







CUSIP No. 68554V 10 8                   13G                 Page 12 of 15 Pages

Item 4.  Ownership.

     Provide  the  following  information  regarding  the  aggregate  number and
percentage of the class of securities of the issuer identified in Item 1.

     (a)  Amount beneficially owned:

                  As of December 31, 2002: HCV V and HCP V beneficially owned
                  2,933,207 Shares of the Issuer's Common Stock; Drs. Cavanaugh
                  and Mirabelli and Messrs. Littlechild and Lawlor each
                  beneficially owned 2,933,207 Shares; Mr. Crouse beneficially
                  owned 3,030,318 Shares consisting of 2,933,207 Shares of the
                  Issuer's Common Stock and options to purchase 97,111 Shares of
                  the Issuer's Common Stock(2); Mr. Werner beneficially owned
                  2,941,151 Shares consisting of 2,933,207 of the Issuer's
                  Common Stock and options to purchase 7,944 Shares of the
                  Issuer's Common Stock.
                  ______________________________________________________________

     (b)  Percent of class:

                  As of December 31, 2002: the 2,933,207 Shares beneficially
                  owned by HCV V and HCP V constitutes 7.81% of the Shares
                  outstanding; the 2,933,207 Shares beneficially owned by Drs.
                  Cavanaugh and Mirabelli and Messrs. Littlechild and Lawlor
                  constitutes 7.81% of the Shares outstanding; the 3,030,318
                  Shares beneficially owned by Mr. Crouse constitute 8.07% of
                  the Shares outstanding; and the 2,941,151 Shares beneficially
                  owned by Mr. Werner constitutes 7.83% of the Shares
                  outstanding.
                  ______________________________________________________________

(2)      Does not include options to purchase an additional 30,833 Shares of the
         Issuer's Common Stock which were granted to Mr. Crouse as a director of
         the Issuer and which are not currently exercisable within 60 days of
         12/31/02. 3,333 of these options become exercisable as to 1,666.66
         Shares per month for 2 months beginning on March 17, 2003, and 27,500
         of these options become exercisable as to 2,500 shares per month for 11
         months beginning on March 30, 2003. (Mr. Crouse is not deemed to
         beneficially own these Shares at the date of this report.)





CUSIP No. 68554V 10 8                   13G                 Page 13 of 15 Pages

(c)  Number of shares as to which such person has:

         (i)      Sole power to vote or to direct the vote:

         Mr. Crouse has the sole power to vote or direct the vote as to the
         97,111 Shares of the Issuer's Common Stock beneficially owned by him.

         Mr. Werner has the sole power to vote or direct the vote as to the
         7,944 Shares of the Issuer's Common Stock beneficially owned by him.


         (ii)     Shared power to vote or to direct the vote:

         HCV V, HCP V, Drs. Cavanaugh and Mirabelli and Messrs. Werner,
         Littlechild, Crouse and Lawlor share the power to vote or direct the
         vote of those Shares owned by HCV V.

         (iii)    Sole power to dispose or to direct the disposition of:

         Mr. Crouse has the sole power to dispose of or to direct the
         disposition of the 97,111 Shares of the Issuer's Common Stock
         beneficially owned by him.

         Mr. Werner has the sole power to dispose of or to direct the
         disposition of the 7,944 Shares of the Issuer's Common Stock
         beneficially owned by him.


         (iv)     Shared power to dispose or to direct the disposition of:

         HCV V, HCP V, Drs. Cavanaugh and Mirabelli and Messrs. Werner,
         Littlechild, Crouse and Lawlor share the power to dispose of or direct
         the disposition of those Shares owned by HCV V.




CUSIP No. 68554V 10 8                   13G                 Page 14 of 15 Pages

Item 5.  Ownership of Five Percent or Less of a Class.

     If this statement is being filed to report the fact that as of the date
hereof the reporting person has ceased to be the beneficial owner of more than
five percent of the class of securities check the following [ ].

                                 Not Applicable
         _______________________________________________________________________

Item 6.  Ownership of More Than Five Percent on Behalf of Another Person.


                                 Not Applicable.
         _______________________________________________________________________

Item 7.  Identification and  Classification of the Subsidiary Which Acquired the
         Security  Being  Reported on by the Parent  Holding  Company or Control
         Person.


                                 Not Applicable.
         _______________________________________________________________________

Item 8.  Identification  and  Classification  of Members of the Group.


                                 Not Applicable.
         _______________________________________________________________________

Item 9.  Notice of Dissolution of Group.


                                 Not Applicable.
          ______________________________________________________________________

Item 10.  Certifications.

     By signing below, I certify that, to the best of my knowledge and belief,
the securities referred to above were not acquired and are not held for the
purpose of or with the effect of changing or influencing the control of the
Issuer of the securities and were not acquired and are not held in connection
with or as a participant in any transaction having that purpose or effect.




CUSIP No. 68554V 10 8                   13G                 Page 15 of 15 Pages

                                    SIGNATURE

     After  reasonable  inquiry and to the best of my  knowledge  and belief,  I
certify that the information  set forth in this statement is true,  complete and
correct.



                             
February 3, 2003                HealthCare Ventures V, L.P.
Princeton, New Jersey           By:  its General Partner, HealthCare Partners V, L.P.



                                By: /s/ Jeffrey Steinberg
                                    --------------------------------------------
                                    Jeffrey Steinberg, Administrative Partner


February 3, 2003                HealthCare Partners V, L.P.
Princeton, New Jersey


                                By: /s/ Jeffrey Steinberg
                                    --------------------------------------------
                                    Jeffrey Steinberg, Administrative Partner



February  3, 2003                   /s/ Jeffrey Steinberg, Attorney-in-Fact
Princeton, New Jersey               --------------------------------------------
                                    James H. Cavanaugh, Ph.D



February  3, 2003                   /s/ Jeffrey Steinberg, Attorney-in-Fact
Princeton, New Jersey               --------------------------------------------
                                    Harold Werner



February  3, 2003                   /s/ Jeffrey Steinberg, Attorney-in-Fact
Princeton, New Jersey               --------------------------------------------
                                    William Crouse



February 3, 2003                    /s/ Jeffrey Steinberg, Attorney-in-Fact
Cambridge, Massachusetts            --------------------------------------------
                                    John W. Littlechild



February 3, 2003                    /s/ Jeffrey Steinberg, Attorney-in-Fact
Cambridge, Massachusetts            --------------------------------------------
                                    Christopher Mirabelli, Ph.D.



February 3, 2003                    /s/ Jeffrey Steinberg, Attorney-in-Fact
Cambridge, Massachusetts            --------------------------------------------
                                    Augustine Lawlor





                                   EXHIBIT A

                                   AGREEMENT

                          JOINT FILING OF SCHEDULE 13G


     The undersigned hereby agree to jointly prepare and file with regulatory
authorities a Schedule 13G and any future amendments thereto reporting each of
the undersigned's ownership of securities of Orasure Technologies, Inc.
Corporation and hereby affirm that such Schedule 13G is being filed on behalf of
each of the undersigned.





                             
February 3, 2003                HealthCare Ventures V, L.P.
Princeton, New Jersey           By:  its General Partner, HealthCare Partners V, L.P.



                                By: /s/ Jeffrey Steinberg
                                    --------------------------------------------
                                    Jeffrey Steinberg, Administrative Partner


February 3, 2003                HealthCare Partners V, L.P.
Princeton, New Jersey


                                By: /s/ Jeffrey Steinberg
                                    --------------------------------------------
                                    Jeffrey Steinberg, Administrative Partner



February 3, 2003                    /s/ Jeffrey Steinberg, Attorney-in-Fact
Princeton, New Jersey               --------------------------------------------
                                    James H. Cavanaugh, Ph.D



February 3, 2003                    /s/ Jeffrey Steinberg, Attorney-in-Fact
Princeton, New Jersey               --------------------------------------------
                                    Harold Werner



February 3, 2003                    /s/ Jeffrey Steinberg, Attorney-in-Fact
Princeton, New Jersey               --------------------------------------------
                                    William Crouse



February 3, 2003                    /s/ Jeffrey Steinberg, Attorney-in-Fact
Cambridge, Massachusetts            --------------------------------------------
                                    John W. Littlechild



February 3, 2003                    /s/ Jeffrey Steinberg, Attorney-in-Fact
Cambridge, Massachusetts            --------------------------------------------
                                    Christopher Mirabelli, Ph.D.



February 3, 2003                    /s/ Jeffrey Steinberg, Attorney-in-Fact
Cambridge, Massachusetts            --------------------------------------------
                                    Augustine Lawlor




Note.  Schedules  filed in paper format shall include a signed original and five
copies of the schedule, including all exhibits. See Rule 13d-7 for other parties
for whom copies are to be sent.

Attention.  Intentional  misstatements  or omissions of fact constitute  federal
criminal violations (see 18 U.S.C. 1001).