UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                   FORM 12b-25

                         Commission File Number 0-24696

                           NOTIFICATION OF LATE FILING

(Check One):   |X| Form 10-K    |_| Form 11-K    |_| Form 20-F
| | Form 10-Q  |_| Form N-SAR

         For Period Ended: December 31, 2007

     |_| Transition Report on Form 10-K

     |_| Transition Report on Form 20-F

     |_| Transition Report on Form 11-K

     |_| Transition Report on Form 10-Q

     |_| Transition Report on Form N-SAR

         For the Transition Period Ended:

      Read attached  instruction  sheet before  preparing form.  Please print or
type.  Nothing in this form shall be construed to imply that the  Commission has
verified any information contained herein.

      If the  notification  relates to a portion of the  filing  checked  above,
identify the item(s) to which the notification relates:

                                     PART I
                             REGISTRANT INFORMATION


                      Nanobac Pharmaceuticals, Incorporated
                      -------------------------------------
                             Full Name of Registrant

                            Former Name if Applicable

                          3000 Bayport Drive, Suite 910
                          -----------------------------
            Address of Principal Executive Office (Street and Number)
                              Tampa, Florida 33607
                              --------------------
                            City, State and Zip Code




                                     PART II
                             RULE 12b-25(b) AND (c)

      If the subject  report could not be filed without  unreasonable  effort or
expense  and  the  registrant  seeks  relief  pursuant  to Rule  12b-25(b),  the
following should be completed. (Check box if appropriate.)

      (a) The reasons  described in  reasonable  detail in Part III of this form
could not be eliminated without unreasonable effort or expense;

      (b) The subject annual report,  semi-annual  report,  transition report on
Form 10-K,  Form 20-F,  Form 11-K or Form N-SAR,  or portion [X] thereof will be
filed on or before the 15th calendar day following the  prescribed  due date; or
the  subject  quarterly  report or  transition  report on Form 10-Q,  or portion
thereof  will be filed  on or  before  the  fifth  calendar  day  following  the
prescribed  due  date;  and (c) The  accountant's  statement  or  other  exhibit
required by Rule 12b-25(c) has been attached if applicable.


                                    PART III
                                    NARRATIVE

      State below in reasonable detail why the Form 10-K, 11-K, 20-F 10-Q, N-SAR
or the  transition  report  portion  thereof  could  not  be  filed  within  the
prescribed time period. (Attach extra sheets if needed.)

            The review of the Form 10-K for the period ending  December 31, 2007
could not be completed within the prescribed time period by the Company's public
accountants.


                                     PART IV
                                OTHER INFORMATION

(1)  Name  and  telephone  number  of  person  to  contact  in  regard  to  this
notification

              John Stanton                     (813)264-2241
              ------------                     -------------
                 (Name)                 (Area Code) (Telephone Number)


(2) Have all other  periodic  reports  required under Section 13 or 15(d) of the
Securities  Exchange Act of 1934 or Section 30 of the Investment  Company Act of
1940  during  the  preceding  12  months  or for such  shorter  period  that the
registrant was required to file such report(s) been filed?  If the answer is no,
identify report(s). |X| Yes |_| No

(3) Is it anticipated that any significant  change in results of operations from
the  corresponding  period for the last  fiscal  year will be  reflected  by the
earnings statements to be included in the subject report or portion thereof? |_|
Yes |X| No

      If so: attach an explanation of the anticipated  change,  both narratively
and  quantitatively,  and, if  appropriate,  state the reasons why a  reasonable
estimate of the results cannot be made.


                      Nanobac Pharmaceuticals, Incorporated
                  --------------------------------------------
                  (Name of Registrant as Specified in Charter)

Has caused this notification to be signed on its behalf by the undersigned
thereunto duly authorized.


Date     March 31, 2008                   By /s/John Stanton
         --------------                      ------------------
                                             John Stanton
                                             Chief Executive Officer