SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                    SCHEDULE 13G

                  Under the Securities Exchange Act of 1934
                                    (Amendment No. 2)*

                           CIPHERGEN BIOSYSTEMS, INC.
         -------------------------------------------------------------
                                    (Name of Issuer)

                          Common Stock, $.001 Par Value
         -------------------------------------------------------------
                           (Title of Class of Securities)

                                   17252Y 10 4
         -------------------------------------------------------------
                                    (CUSIP Number)


Check the following box if a fee is being paid with this statement [ ]. (A fee
is not required only if the filing person: (1) has a previous statement on the
file reporting beneficial ownership of more than five percent of the class of
securities described in Item 1; and (2) has no amendment subsequent thereto
reporting beneficial ownership of five percent or less of such class.) (See Rule
13d-7.)

*The remainder of this cover page shall be filled out for a reporting person's
initial filing of this form with respect to the subject class of securities, and
for any subsequent amendment containing information which would alter the
disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the Securities Exchange Act of
1934 ("Act") or otherwise subject to the liabilities of that section of the Act
but shall be subject to all other provisions of the Act (however, see the
Notes).

This Amendment No. 2 amends and supplements the Statement on Schedule 13G
electronically filed with the Securities and Exchange Commission (the
"Commission") on February 14, 2001, and subsequent Amendment No. 1 filed with
the Commission on February 14, 2002, with respect of the ownership of securities
of Ciphergen Biosystems, Inc. (the "Initial Statement"). Since reporting person
now holds less than 5% with this filing, further reporting under Schedule 13G
is no longer required.

The undersigned hereby amends and supplements Item 5 of the Initial Statement
with the following information (capitalized terms used herein without definition
shall have the same meaning as set forth in the Initial Statement).



(Continued on following page(s))







CUSIP NO. 17252Y 10 4
17252Y 10 4                         13G

1        NAME OF REPORTING PERSON
         S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
         GlaxoSmithKline plc

2        CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*


(a)     [    ]

(b)     [    ]

3        SEC USE ONLY

4 CITIZENSHIP OR PLACE OF ORGANIZATION
England and Wales

                                    5       SOLE VOTING POWER
  NUMBER OF                                 639,442

     SHARES
BENEFICIALLY                        6       SHARED VOTING POWER
  OWNED BY
       EACH
   REPORTING                        7       SOLE DISPOSITIVE POWER
     PERSON                                 639,442
      WITH
8 SHARED DISPOSITIVE POWER

9        AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
         639,442

10       CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES
         [  ]

11       PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

         2.2%

12 TYPE OF REPORTING PERSON*
CO


*SEE INSTRUCTION BEFORE FILLING OUT!
CUSIP NO. 17252Y 10 4                       13G


Item 1.           (a).     Name of Issuer:


                  (b).     Address of Issuer's Principal Executive Offices:



Item 2.           (a).     Names of Person Filing:



                  (b).     Address of Principal Business Office:


                  (c).     Citizenship:


                  (d).     Title of Class of Securities:


                  (e).     CUSIP Number:


Item 3.           Not Applicable.


Item 4.           Ownership.

                  The information in items 1 and 5 through 11 on the cover pages
                  (page 2) on Schedule 13G amendment No. 2 is hereby
                  incorporated by reference.


Item 5.           Ownership of Five Percent or Less of a Class:

                  If this statement is being filed to report the fact that as of
                  the date hereof the reporting person has ceased to be the
                  beneficial owner of more than five percent of the class of
                  securities, check the following [X].

                  In 2003, SRO sold 1,301,720 shares of Common stock.


Item 6.           Ownership of More Than Five Percent on Behalf of Another
                  Person:


Item 7.           Identification and Classification of Subsidiaries Which
                  Acquired the Security Being Reported on by the Parent
                  Holding Company:


Item 8.           Identification and Classification of Members of the Group:


Item 9.           Notice of Dissolution of Group:


Item 10.          Certification:

                  By signing below I certify that, to the best of my knowledge
                  and belief, the securities referred to above were acquired and
                  are not held for the purpose of or with the effect of changing
                  or influencing the control of the issuer of such securities
                  and were not acquired in connection with or as a participant
                  in any transaction having such purpose or effect.

                  Signature:

                  After reasonable inquiry and to the best of my knowledge and
                  belief, I certify that the information set forth in this
                  statement is true, complete and correct.

                                            GLAXOSMITHKLINE PLC


                                            By:      /s/
                                                     S.M. Bicknell
                                                     Company Secretary

Dated:  February 13, 2004.