FORM 4 Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940

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(Print or Type Responses)

1. Name and Address of Reporting Person * SICIGNANO HENRY III   2. Issuer Name and Ticker or Trading Symbol 22nd Century Group, Inc. [XXII] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable) __X__ Director _____ 10% Owner __X__ Officer (give title below) _____ Other (specify below) President and CEO (Last) (First) (Middle) 9530 MAIN STREET 3. Date of Earliest Transaction (Month/Day/Year) 01/25/2016 (Street) CLARENCE, NY 14031 4. If Amendment, Date Original Filed(Month/Day/Year) 6. Individual or Joint/Group Filing(Check Applicable Line) _X_ Form filed by One Reporting Person ___ Form filed by More than One Reporting Person (City) (State) (Zip) Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned

1.Title of Security (Instr. 3) 2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4) Code V Amount (A) or (D) Price Common Stock 01/25/2016   X   9,025 A $ 1.2018 24,025 I Custodian for Minor Children Common Stock 01/25/2016   F   8,575 D $ 1.265 15,450 I Custodian for Minor Children Common Stock               2,292,603 D   Common Stock               20,000 I IRA Common Stock               2,542,347 I Manager (1)

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Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)

1. Title of Derivative Security (Instr. 3)

2. Conversion or Exercise Price of Derivative Security

3. Transaction Date (Month/Day/Year)

3A. Deemed Execution Date, if any (Month/Day/Year)

4. Transaction Code (Instr. 8)

5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4, and 5)

6. Date Exercisable and Expiration Date (Month/Day/Year)

7. Title and Amount of Underlying Securities (Instr. 3 and 4)

8. Price of Derivative Security (Instr. 5)

9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)

10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4)

11. Nature of Indirect Beneficial Ownership (Instr. 4)

Code

V

(A)

(D)

Date Exercisable

Expiration Date

Title

Amount or Number of Shares

Warrant to Purchase

$ 1.2018

01/25/2016

X

9,025

01/25/2011

01/25/2016

Common Stock

9,025

$ 0

0

I

Custoian for Minor Children

Warrant to Purchase

$ 0.6

05/15/2012

05/15/2017

Common Stock

20,000

20,000

D

Warrant to Purchase (1)

$ 0.6

11/09/2012

11/09/2017

Common Stock

300,000

300,000

D

Stock Option (right to buy)

$ 0.69

05/18/2012

05/18/2022

Common Stock

100,000

100,000

D

Stock Option (right to buy)

$ 0.96

02/16/2016

02/16/2025

Common Stock

350,000

350,000

D

Reporting Owners

Reporting Owner Name / Address	Relationships
	Director	10% Owner	Officer	Other
SICIGNANO HENRY III 9530 MAIN STREET CLARENCE, NY 14031	X		President and CEO

Signatures

/s/ John J. Wolfel, Attorney-in-Fact for Henry Sicignano, III		01/27/2016
**Signature of Reporting Person		Date

Explanation of Responses:

*	If the form is filed by more than one reporting person, see Instruction 4(b)(v).
**	Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1)	Shares are owned by Henry Sicignano III Group, LLC.

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