UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                  SCHEDULE 13G

                    Under the Securities Exchange Act of 1934

                                (Amendment No.__________)*

                           Ciphergen Biosystems, Inc.
--------------------------------------------------------------------------------
                                (Name of Issuer)

                                  Common Stock
--------------------------------------------------------------------------------
                         (Title of Class of Securities)

                                    17252Y104
                      ----------------------------------
                                 (CUSIP Number)

                                December 31, 2003
               ---------------------------------------------------
             (Date of Event Which Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule
is filed:

                                [x] Rule 13d-1(b)
                                [_] Rule 13d-1(c)
                                [_] Rule 13d-1(d)

*The remainder of this cover page shall be filled out for a reporting person's
initial filing on this form with respect to the subject class of securities, and
for any subsequent amendment containing information which would alter the
disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the Securities Exchange Act of
1934 ("Act") or otherwise subject to the liabilities of that section of the Act
but shall be subject to all other provisions of the Act (however, see the
Notes).

                               Page 1 of 10 pages



------------------------                                  ----------------------
CUSIP No.  17252Y104                    13G               Page 2 of 10 Pages
------------------------                                  ----------------------

--------------------------------------------------------------------------------
  1  NAME OF REPORTING PERSON
     S.S. or I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

     Columbia Wanger Asset Management, L.P.  36-3820584
--------------------------------------------------------------------------------
  2  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*

     Not Applicable                                                      (a) [_]

                                                                         (b) [_]
--------------------------------------------------------------------------------
  3  SEC USE ONLY

--------------------------------------------------------------------------------
  4  CITIZENSHIP OR PLACE OF ORGANIZATION

     Delaware
--------------------------------------------------------------------------------
     NUMBER OF    5   SOLE VOTING POWER

       SHARES         None
                  --------------------------------------------------------------
    BENEFICIALLY  6   SHARED VOTING POWER

      OWNED BY        1,975,000
                  --------------------------------------------------------------
        EACH      7   SOLE DISPOSITIVE POWER

     REPORTING        None
                  --------------------------------------------------------------
    PERSON WITH   8   SHARED DISPOSITIVE POWER

                      1,975,000
--------------------------------------------------------------------------------
  9  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

     1,975,000
--------------------------------------------------------------------------------
  10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*

     Not Applicable                                                          [_]
--------------------------------------------------------------------------------
  11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

     6.8 %
--------------------------------------------------------------------------------

  12 TYPE OF REPORTING PERSON*

     IA
--------------------------------------------------------------------------------



-------------------------                              -------------------------
CUSIP No.  17252Y104                       13G           Page 3 of 10 Pages
-------------------------                              -------------------------

--------------------------------------------------------------------------------
  1    NAME OF REPORTING PERSON
       S.S. or I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

       WAM Acquisition GP, Inc.
--------------------------------------------------------------------------------
  2    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*

       Not Applicable                                                    (a) [_]

                                                                         (b) [_]
--------------------------------------------------------------------------------
  3    SEC USE ONLY

--------------------------------------------------------------------------------
  4    CITIZENSHIP OR PLACE OF ORGANIZATION

        Delaware
--------------------------------------------------------------------------------
     NUMBER OF      5    SOLE VOTING POWER

       SHARES            None
                    ------------------------------------------------------------
    BENEFICIALLY    6    SHARED VOTING POWER

      OWNED BY           1,975,000
                    ------------------------------------------------------------
        EACH        7    SOLE DISPOSITIVE POWER

     REPORTING           None
                    ------------------------------------------------------------
    PERSON WITH     8    SHARED DISPOSITIVE POWER

                         1,975,000
--------------------------------------------------------------------------------
  9    AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

       1,975,000
--------------------------------------------------------------------------------
  10   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*

       Not Applicable                                                        [_]
--------------------------------------------------------------------------------
  11   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

       6.8 %
--------------------------------------------------------------------------------
  12   TYPE OF REPORTING PERSON*

       CO
--------------------------------------------------------------------------------



-----------------------                                   ----------------------
CUSIP No.  17252Y104                    13G                Page 4 of 10 Pages
-----------------------                                   ----------------------

--------------------------------------------------------------------------------
  1  NAME OF REPORTING PERSON
     S.S. or I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

     Columbia Acorn Trust
--------------------------------------------------------------------------------
  2  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*

     Not Applicable                                                      (a) [_]

                                                                         (b) [_]
--------------------------------------------------------------------------------
  3  SEC USE ONLY

--------------------------------------------------------------------------------
  4  CITIZENSHIP OR PLACE OF ORGANIZATION

     Massachusetts
--------------------------------------------------------------------------------
    NUMBER OF     5   SOLE VOTING POWER

      SHARES          None
                  --------------------------------------------------------------
   BENEFICIALLY   6   SHARED VOTING POWER

     OWNED BY         1,708,000
                  --------------------------------------------------------------
       EACH       7   SOLE DISPOSITIVE POWER

    REPORTING         None
                  --------------------------------------------------------------
   PERSON WITH    8   SHARED DISPOSITIVE POWER

                      1,708,000
--------------------------------------------------------------------------------
  9  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

     1,708,000
--------------------------------------------------------------------------------
  10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*

     Not Applicable                                                          [_]
--------------------------------------------------------------------------------
  11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

     5.9 %
--------------------------------------------------------------------------------

  12 TYPE OF REPORTING PERSON*

     IV
--------------------------------------------------------------------------------



Item 1(a)     Name of Issuer:

                Ciphergen Biosystems, Inc.

Item 1(b)     Address of Issuer's Principal Executive Offices:

                6611 Dumbarton Circle
                Fremont, California 94555

Item 2(a)     Name of Person Filing:

                Columbia Wanger Asset Management, L.P. ("WAM")
                WAM Acquisition GP, Inc., the general partner of WAM ("WAM GP")
                Columbia Acorn Trust ("Acorn")

Item 2(b)     Address of Principal Business Office:

                WAM, WAM GP, and Acorn are all located at:

                227 West Monroe Street, Suite 3000
                Chicago, Illinois 60606

Item 2(c)     Citizenship:

                WAM is a Delaware limited partnership; WAM GP is a Delaware
                corporation; and Acorn is a Massachusetts business trust.

Item 2(d)     Title of Class of Securities:

                Common Stock

Item 2(e)     CUSIP Number:

                17252Y104

Item 3        Type of Person:

                (d) Acorn is an Investment Company under section 8 of the
                    Investment Company Act.

                (e) WAM is an Investment Adviser registered under section 203
                    of the Investment Advisers Act of 1940; WAM GP is the
                    General Partner of the Investment Adviser.

                               Page 5 of 10 pages



Item 4        Ownership (at December 31, 2003):

                (a) Amount owned "beneficially" within the meaning of rule
                    13d-3:

                    1,975,000

                (b) Percent of class:

                    6.8 % (based on 28,861,506 shares outstanding as of
                    October 31, 2003)

                (c) Number of shares as to which such person has:

                        (i)   sole power to vote or to direct the vote: none

                        (ii)  shared power to vote or to direct the vote:
                              1,975,000

                        (iii) sole power to dispose or to direct the disposition
                              of: none

                        (iv)  shared power to dispose or to direct disposition
                              of: 1,975,000

Item 5        Ownership of Five Percent or Less of a Class:

                Not Applicable

Item 6        Ownership of More than Five Percent on Behalf of Another Person:

                The shares reported herein have been acquired on behalf of
                discretionary clients of WAM, including Acorn. Persons other
                than WAM and WAM GP are entitled to receive all dividends from,
                and proceeds from the sale of, those shares. Acorn is the only
                such person known to be entitled to all dividends from, and all
                proceeds from the sale of, shares reported herein to the extent
                of more than 5% of the class.

Item 7        Identification and Classification of the Subsidiary Which Acquired
              the Security Being Reported on by the Parent Holding Company:

                Not Applicable

Item 8        Identification and Classification of Members of the Group:

                Not Applicable

Item 9        Notice of Dissolution of Group:

                Not Applicable

                               Page 6 of 10 Pages



Item 10       Certification:

                 By signing below I certify that, to the best of my knowledge
              and belief, the securities referred to above were acquired and are
              held in the ordinary course of business and were not acquired and
              are not held for the purpose of or with the effect of changing or
              influencing the control of the issuer of the securities and were
              not acquired and are not held in connection with or as a
              participant in any transaction having that purpose or effect.

                               Page 7 of 10 Pages



                                    Signature

     After reasonable inquiry and to the best of my knowledge and belief, I
certify that the information set forth in this statement is true, complete and
correct.

Date: February 13, 2004

               The undersigned corporation, on the date above written, agrees
               and consents to the joint filing on its behalf of this Schedule
               13G in connection with its beneficial ownership of the security
               reported herein.

                                       WAM Acquisition GP, Inc.
                                          for itself and as general partner of
                                          COLUMBIA WANGER ASSET MANAGEMENT, L.P.


                                       By: /s/ Bruce H. Lauer
                                           -------------------------------------
                                           Bruce H. Lauer
                                           Senior Vice President and Secretary

               The undersigned trust, on the date above written, agrees and
               consents to the joint filing on its behalf of this Schedule 13G
               in connection with its beneficial ownership of the security
               reported herein.

                                       COLUMBIA ACORN TRUST


                                       By: /s/ Bruce H. Lauer
                                           -------------------------------------
                                           Bruce H. Lauer
                                           Vice President, Treasurer and
                                           Secretary

                               Page 8 of 10 Pages



                                  Exhibit Index

Exhibit 1      Joint Filing Agreement dated as of February 13, 2004 by and among
               Columbia Wanger Asset Management, L.P., WAM Acquisition GP, Inc.,
               and Columbia Acorn Trust.

                               Page 9 of 10 Pages



                                                                       EXHIBIT 1

                             JOINT FILING AGREEMENT

     The undersigned hereby agree to the joint filing of the Schedule 13G to
which this Agreement is attached.

               Dated: February 13, 2004

                                       WAM Acquisition GP, Inc.
                                        for itself and as general partner of
                                        COLUMBIA WANGER ASSET MANAGEMENT, L.P.


                                       By: /s/ Bruce H. Lauer
                                           -------------------------------------
                                           Bruce H. Lauer
                                           Senior Vice President and Secretary

                                       COLUMBIA ACORN TRUST


                                       By: /s/ Bruce H. Lauer
                                           -------------------------------------
                                           Bruce H. Lauer
                                           Vice President, Treasurer and
                                           Secretary

                               Page 10 of 10 Pages