Ownership Submission
FORM 4
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940
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(Print or Type Responses)
1. Name and Address of Reporting Person *
POLAN MARY LAKE PH D
  2. Issuer Name and Ticker or Trading Symbol
QUIDEL CORP /DE/ [QDEL]
5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
__X__ Director _____ 10% Owner
_____ Officer (give title below) _____ Other (specify below)
(Last)
(First)
(Middle)
10165 MCKELLAR COURT
3. Date of Earliest Transaction (Month/Day/Year)
03/04/2010
(Street)

SAN DIEGO, CA 92121
4. If Amendment, Date Original Filed(Month/Day/Year)
6. Individual or Joint/Group Filing(Check Applicable Line)
_X_ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3)
2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code
(Instr. 8)
4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)
5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4)
6. Ownership Form: Direct (D) or Indirect (I)
(Instr. 4)
7. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V Amount (A) or (D) Price
Common Stock 03/04/2010   M   20,000 A $ 5.5 34,930 D  
Common Stock 03/04/2010   M   20,000 A $ 4.26 54,930 D  
Common Stock 03/04/2010   M   10,000 A $ 5.45 64,930 D  
Common Stock 03/04/2010   S(1)   13,400 D $ 13.6366 (2) 51,530 D  
Common Stock 03/05/2010   S(1)   5,000 D $ 13.7135 (3) 46,530 D  

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Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 3)
2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year) 3A. Deemed Execution Date, if any (Month/Day/Year) 4. Transaction Code
(Instr. 8)
5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4, and 5)
6. Date Exercisable and Expiration Date
(Month/Day/Year)
7. Title and Amount of Underlying Securities
(Instr. 3 and 4)
8. Price of Derivative Security
(Instr. 5)
9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 4)
10. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 4)
11. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares
Non-Qualified Stock Option $ 5.5 03/04/2010   M     20,000   (4) 11/01/2010 Common Stock 20,000 $ 0 0 D  
Non-Qualified Stock Option $ 4.26 03/04/2010   M     20,000   (4) 05/23/2011 Common Stock 20,000 $ 0 0 D  
Non-Qualified Stock Option $ 5.45 03/04/2010   M     10,000   (4) 05/21/2013 Common Stock 10,000 $ 0 0 D  

Reporting Owners

Reporting Owner Name / Address Relationships
 Director  10% Owner  Officer  Other
POLAN MARY LAKE PH D
10165 MCKELLAR COURT
SAN DIEGO, CA 92121
  X      

Signatures

 Robert J. Bujarski, attorney-in-fact for Mary Lake Polan   03/08/2010
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) Reporting Person sold these securities in payment of the exercise price of the options listed on Table II.
(2) The weighted average purchase price for these transactions was $13.6366 per share, with a range of $13.56 to $13.82 per share. Upon request, the Reporting Person hereby undertakes to provide to staff of the U.S. Securities and Exchange Commission, the Issuer, or a security holder, the full information regarding the number of shares purchased at each separate price.
(3) The weighted average purchase price for these transactions was $13.7135 per share, with a range of $13.65 to $13.87 per share. Upon request, the Reporting Person hereby undertakes to provide to staff of the U.S. Securities and Exchange Commission, the Issuer, or a security holder, the full information regarding the number of shares purchased at each separate price.
(4) Twenty-five percent (25%) of the shares vested on the first anniversary date of the grant date and the remaining shares vested quarterly at a rate of 6.25% per quarter.

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