UNITED STATES

                       SECURITIES AND EXCHANGE COMMISSION

                             WASHINGTON, D.C. 20549


        -----------------------------------------------------------------


                                    FORM 8-K

                                 CURRENT REPORT

                     PURSUANT TO SECTION 13 OR 15(d) OF THE
                         SECURITIES EXCHANGE ACT OF 1934

         Date of report (Date of earliest event reported): June 20, 2006
                                                           -------------
                               CYTOGEN CORPORATION
      --------------------------------------------------------------------
               (Exact Name of Registrant as Specified in Charter)

          Delaware                        000-14879               22-2322400
------------------------------    ------------------------   -------------------
 (State or Other Jurisdiction     (Commission File Number)    (I.R.S. Employer
      of Incorporation)                                      Identification No.)

    650 College Road East, CN 5308, Suite 3100, Princeton, NJ          08540
---------------------------------------------------------------    -------------
          (Address of Principal Executive Offices)                   (Zip Code)

       Registrant's telephone number, including area code: (609) 750-8200
                                                           --------------


--------------------------------------------------------------------------------
          (Former Name or Former Address, if Changed Since Last Report)


     Check the  appropriate  box below if the Form 8-K  filing  is  intended  to
simultaneously  satisfy the filing obligation of the registrant under any of the
following provisions (see General Instruction A.2. below):

     |_|  Written  communications  pursuant to Rule 425 under the Securities Act
(17 CFR 230.425)

     |_|  Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17
CFR 240.14a-12)

     |_|  Pre-commencement  communications  pursuant to Rule 14d-2(b)  under the
Exchange Act (17 CFR 240.14d-2(b))

     |_|  Pre-commencement  communications  pursuant to Rule 13e-4(c)  under the
Exchange Act (17 CFR 240.13e-4(c))





ITEM 5.02   DEPARTURE OF DIRECTORS OR PRINCIPAL OFFICERS; ELECTION OF DIRECTORS;
            APPOINTMENT OF PRINCIPAL OFFICERS.


     On June 20,  2006,  Cytogen  Corporation  (the  "Company")  announced  that
Christopher P. Schnittker,  Senior Vice President and Chief Financial Officer of
the Company,  has resigned  from the Company  effective  June 20, 2006 to pursue
other career opportunities.

     The full text of the June 20, 2006 press release issued in connection  with
the announcement is attached as Exhibit 99.1 to this Current Report on Form 8-K.

     Thu A. Dang, the Company's Vice President, Finance, will serve as principal
financial officer and principal  accounting officer until a replacement has been
found.  Ms.  Dang has served as the  Company's  Vice  President,  Finance  since
January 2003. Ms. Dang joined the Company in September 1988 as Senior  Financial
Reporting Accountant, and was promoted to Director of Finance in May 2000. Prior
to joining the Company, Ms. Dang held numerous positions with Harrisburg Dairies
for six years,  serving  ultimately as their  Controller.  Ms. Dang holds a B.S.
degree in Accounting from Elizabethtown College.


ITEM 9.01   FINANCIAL STATEMENTS AND EXHIBITS.

(d)  Exhibits.

     Exhibit No.                          Description
     -----------                          -----------

         99.1          Press Release of Cytogen Corporation dated June 20, 2006.






                                   SIGNATURES


     Pursuant to the  requirements  of the Securities  Exchange Act of 1934, the
Registrant  has duly  caused  this  report  to be  signed  on its  behalf by the
undersigned hereunto duly authorized.


                                                CYTOGEN CORPORATION



                                                By:  /s/ Michael D. Becker
                                                   -----------------------------
                                                   Michael D. Becker
                                                   President and Chief Executive
                                                   Officer

Dated:   June 20, 2006






                                  EXHIBIT INDEX


     Exhibit No.                          Description
     -----------                          -----------

         99.1          Press Release of Cytogen Corporation dated June 20, 2006.