Ownership Submission
FORM 4
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940
OMB APPROVAL
OMB Number: 3235-0287
Expires: January 31, 2005
Estimated average burden hours per response... 0.5

(Print or Type Responses)
1. Name and Address of Reporting Person *
Lichter Jay
  2. Issuer Name and Ticker or Trading Symbol
OTONOMY, INC. [OTIC]
5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
__X__ Director _____ 10% Owner
_____ Officer (give title below) _____ Other (specify below)
(Last)
(First)
(Middle)
C/O AVALON VENTURES, 1134 KLINE STREET
3. Date of Earliest Transaction (Month/Day/Year)
08/31/2017
(Street)

LA JOLLA, CA 92037
4. If Amendment, Date Original Filed(Month/Day/Year)
6. Individual or Joint/Group Filing(Check Applicable Line)
_X_ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3)
2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code
(Instr. 8)
4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)
5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4)
6. Ownership Form: Direct (D) or Indirect (I)
(Instr. 4)
7. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V Amount (A) or (D) Price
Common Stock 08/31/2017   M(1)   141,060 A $ 14.18 2,406,212 I See Footnote (2)
Common Stock 08/31/2017   F(1)   108,851 D $ 18.37 2,297,361 I See Footnote (2)

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB control number. SEC 1474 (9-02)

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 3)
2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year) 3A. Deemed Execution Date, if any (Month/Day/Year) 4. Transaction Code
(Instr. 8)
5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4, and 5)
6. Date Exercisable and Expiration Date
(Month/Day/Year)
7. Title and Amount of Underlying Securities
(Instr. 3 and 4)
8. Price of Derivative Security
(Instr. 5)
9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 4)
10. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 4)
11. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares
Warrant to Purchase Common Stock (Right to Buy) $ 14.18 08/31/2017   M(1)     14,106 08/18/2014 11/04/2018 Common Stock 14,106 $ 0 0 I See Footnote (2)
Warrant to Purchase Common Stock (Right to Buy) $ 14.18 08/31/2017   M(1)     14,106 08/18/2014 12/08/2018 Common Stock 14,106 $ 0 0 I See Footnote (2)
Warrant to Purchase Common Stock (Right to Buy) $ 14.18 08/31/2017   M(1)     14,106 08/18/2014 01/14/2019 Common Stock 14,106 $ 0 0 I See Footnote (2)
Warrant to Purchase Common Stock (Right to Buy) $ 14.18 08/31/2017   M(1)     14,106 08/18/2014 04/13/2019 Common Stock 14,106 $ 0 0 I See Footnote (2)
Warrant to Purchase Common Stock (Right to Buy) $ 14.18 08/31/2017   M(1)     14,106 08/18/2014 07/01/2019 Common Stock 14,106 $ 0 0 I See Footnote (2)
Warrant to Purchase Common Stock (Right to Buy) $ 14.18 08/31/2017   M(1)     14,106 08/18/2014 10/08/2019 Common Stock 14,106 $ 0 0 I See Footnote (2)
Warrant to Purchase Common Stock (Right to Buy) $ 14.18 08/31/2017   M(1)     14,106 08/18/2014 12/15/2019 Common Stock 14,106 $ 0 0 I See Footnote (2)
Warrant to Purchase Common Stock (Right to Buy) $ 14.18 08/31/2017   M(1)     14,106 08/18/2014 01/22/2020 Common Stock 14,106 $ 0 0 I See Footnote (2)
Warrant to Purchase Common Stock (Right to Buy) $ 14.18 08/31/2017   M(1)     14,106 08/18/2014 04/01/2020 Common Stock 14,106 $ 0 0 I See Footnote (2)
Warrant to Purchase Common Stock (Right to Buy) $ 14.18 08/31/2017   M(1)     14,106 08/18/2014 05/28/2020 Common Stock 14,106 $ 0 0 I See Footnote (2)

Reporting Owners

Reporting Owner Name / Address Relationships
 Director  10% Owner  Officer  Other
Lichter Jay
C/O AVALON VENTURES
1134 KLINE STREET
LA JOLLA, CA 92037
  X      

Signatures

 /s/ Jay Lichter, Ph.D.   09/05/2017
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) On August 31, 2017, Avalon Ventures VIII, L.P. ("Avalon VIII LP") exercised certain warrants to purchase an aggregate of 141,060 shares of the Issuer's common stock at an exercise price of $14.18 per share. Avalon VIII LP paid the exercise price of the warrants on a cashless basis, resulting in the Issuer's withholding of 108,851 of the shares of common stock to pay the exercise price and the issuance to Avalon VIII LP of 32,209 shares.
(2) The reported securities are held of record by Avalon VIII LP. The Reporting Person is a managing director of Avalon Ventures VIII GP, LLC, the general partner of Avalon VIII LP, and disclaims beneficial ownership of the securities held by Avalon VIII LP except to the extent of any pecuniary interest therein.

Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.

Potential persons who are to respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB number.