UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                            SCHEDULE 14A INFORMATION

                Proxy Statement Pursuant to Section 14(a) of the
                         Securities Exchange Act of 1934
Filed by the Registrant [ X ]
Filed by a Party other than the Registrant [   ]

Check the appropriate box:

[ X  ]   Preliminary Proxy Statement
[    ]   Confidential, For Use of the Commission Only
         (as permitted by Rule 14a-6(e)(2))
[    ]   Definitive Proxy Statement
[    ]   Definitive Additional Materials
[    ]   Soliciting Material pursuant to Rule 14a-11(c) or Rule 14a-12

                           ENZON PHARMACEUTICALS, INC.

                (Name of Registrant as Specified In Its Charter)
                                       N/A
    (Name of Person(s) filing Proxy Statement, if other than the Registrant)

Payment of Filing Fee (Check the appropriate box):

[X ]     No fee required.

[   ]    $500 per each party to the controversy pursuant to Exchange
          Act Rule 14a-6(I)(3).

[   ]    Fee computed on table below per Exchange Act
         Rules 14a-6(I)(4) and 0-11.

               (1)  Title of each  class  of  securities  to  which  transaction
                    applies:

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               (2)  Aggregate number of securities to which transaction applies:

.................................................................................

               (3)  Per  unit  price or other  underlying  value of  transaction
                    computed  pursuant to Exchange Act Rule 0-11:  Set forth the
                    amount on which the filing fee is  calculated  and state how
                    it was determined.

.................................................................................


               (4)  Proposed maximum aggregate value of transaction:

.................................................................................


               (5)  Total fee paid.

.................................................................................

[    ] Check box if any part of the fee is offset as provided  by  Exchange  Act
     rule  0-11(a)(2)  and identify the filing for which the  offsetting fee was
     paid  previously.  Identify the previous filing by  registration  statement
     number, or the Form or Schedule and the date of its filing.

                  1)       Amount Previously Paid:

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                  2)       Form, Schedule or Registration Statement No.:

.................................................................................

                  3)       Filing Party:

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                  4)       Date Filed:

.................................................................................







                          ENZON PHARMACEUTICALS, INC.
                                [GRAPHIC OMITTED]


                                685 Route 202/206
                          Bridgewater, New Jersey 08807
                                 (908) 541-8600

                    NOTICE OF ANNUAL MEETING OF STOCKHOLDERS
                             TO BE HELD MAY 18, 2006

         To our Stockholders:

     The  annual  meeting  of  stockholders  (the  "Annual  Meeting")  of  Enzon
Pharmaceuticals, Inc., a Delaware corporation ("Enzon" or the "Company") will be
held at the Sheraton  Indianapolis  Hotel and Suites,  8787  Keystone  Crossing,
Indianapolis,  Indiana 46240 on Thursday,  May 18, 2006 at 9:00 a.m. local time,
for the following purposes:

1.   To elect one Class I director, to serve for a term of three years until the
     2009 Annual  Meeting and until his successor is elected and  qualified,  in
     accordance with the Company's  Restated  Certificate of  Incorporation  and
     By-Laws (Proposal No. 1);

2.   To approve the amendment of the 2001  Incentive  Stock Plan to increase the
     number of  shares of common  stock  issuable  thereunder  by an  additional
     4,000,000 shares (Proposal No. 2);

3.   To approve the amendment and  restatement  of our Restated  Certificate  of
     Incorporation  to increase the number of authorized  shares of common stock
     from 90,000,000 shares to 170,000,000 shares (Proposal No. 3);

4.   To  ratify  the  selection  of  KPMG  LLP,  independent  registered  public
     accountants,  to audit the consolidated financial statements of the Company
     for the year ending December 31, 2006 (Proposal No. 4); and

5.   To  transact  such other  matters as may  properly  come  before the Annual
     Meeting or any adjournment thereof.

     Only  holders  of  record  of the  Company's  common  stock at the close of
business on April 6, 2006 are entitled to vote at the Annual Meeting.

     We hope that as many  stockholders as possible will  personally  attend the
Annual Meeting. Whether or not you plan to attend the Annual Meeting, your proxy
vote  is  important.  To  assure  your  representation  at the  meeting,  please
complete,  sign and date the  enclosed  proxy card and return it promptly in the
enclosed  envelope.  Sending in your proxy will not  prevent  you from voting in
person at the Annual Meeting.

                            By Order of the Board of Directors,

                            /s/ Paul S. Davit
                            Paul S. Davit
                            Corporate Secretary

         Bridgewater, New Jersey
         April __, 2006


     The Company's  Annual  Report to  Shareholders,  including  its  Transition
Report for the six-month period ended December 31, 2005, accompanies this notice
but is not incorporated as part of the proxy statement and is not to be regarded
as part of the proxy solicitation materials.










                          ENZON PHARMACEUTICALS, INC.
                                [GRAPHIC OMITTED]


                                685 Route 202/206
                              Bridgewater, NJ 08807
                                 (908) 541-8600
                                     _______

                                 PROXY STATEMENT
                                     _______

     This Proxy  Statement and the enclosed  proxy card and voting  instructions
are being  furnished to stockholders  of record of Enzon  Pharmaceuticals,  Inc.
("Enzon"  or the  "Company")  as of  April  6,  2006,  in  connection  with  the
solicitation  of proxies  for use at the annual  meeting  of  stockholders  (the
"Annual  Meeting")  to be  held  on  Thursday,  May  18,  2006  at the  Sheraton
Indianapolis  Hotel and Suites,  8787 Keystone Crossing,  Indianapolis,  Indiana
46240 at 9:00 a.m. local time and at any  postponement  or adjournment  thereof.
The  accompanying  proxy is  solicited by the Board of Directors of Enzon and is
revocable by the stockholder any time before it is voted.  For more  information
concerning  the  procedure  for revoking the proxy,  see  "General."  This Proxy
Statement is being mailed to  stockholders  of the Company on or about April 18,
2006, accompanied by the Company's Annual Report to Stockholders,  including its
Transition  Report  on Form  10-K  for the  six-month  transition  period  ended
December 31, 2005. Enzon's principal  executive offices are located at 685 Route
202/206 Bridgewater, New Jersey 08807, telephone (908) 541-8600.

     Only holders of the Company's  common stock,  par value $.01 per share (the
"Common Stock" or "Common Shares") outstanding at the close of business on April
6, 2006 (the "Record  Date") are entitled to receive  notice of, and to vote at,
the Annual Meeting.  As of the Record Date,  there were _________  Common Shares
outstanding  and entitled to vote at the meeting.  Each Common Share is entitled
to one vote on all  matters.  No other class of  securities  will be entitled to
vote at the Annual Meeting. There are no cumulative voting rights.

     To be elected,  a director  must  receive a  plurality  of the votes of the
Common Shares  present in person or  represented  by proxy at the Annual Meeting
and entitled to vote on the election of directors.  The  affirmative  vote of at
least a majority of the Common Shares  present in person or represented by proxy
at the Annual  Meeting and entitled to vote thereon is necessary for approval of
Proposals No. 2 and No. 4.  Approval of Proposal No. 3 requires the  affirmative
vote of at least a majority of the Common  Shares  outstanding  as of the Record
Date and entitled to vote thereon.  A quorum is  representation  in person or by
proxy  at  the  Annual  Meeting  of at  least  one-third  of the  Common  Shares
outstanding as of the Record Date.

     Pursuant to the Delaware  General  Corporation Law, only votes cast "For" a
matter  constitute  affirmative  votes.  Proxy  cards  that are voted by marking
"Withheld" or "Abstain" on a particular matter are counted as present for quorum
purposes and for purposes of determining the outcome of such matter, but because
they are not cast "For" a particular  matter,  they will have the same effect as
negative  votes or votes  cast  "Against"  a  particular  matter.  If a  validly
executed proxy card is not marked to indicate a vote on a particular  matter and
the proxy granted  thereby is not revoked  before it is voted,  it will be voted
"For" such matter.  Where brokers are prohibited from  exercising  discretionary
authority  for  beneficial  owners  who have not  provided  voting  instructions
(commonly  referred to as "broker  non-votes"),  such broker  non-votes  will be
treated as shares that are present for purposes of determining the presence of a
quorum; however, with respect to proposals which require the affirmative vote of
a percentage of shares present at the Annual  Meeting for approval,  such broker
non-votes will be treated as not present for purposes of determining the outcome
of any such matter.  With respect to proposals that require the affirmative vote
of a percentage  of the  outstanding  shares for  approval,  because such broker
non-votes are not cast "For" a particular matter, they will have the same effect
as negative votes or votes cast "Against" such proposals.

     The cost of proxy solicitation, including the cost of reimbursing banks and
brokers for forwarding  proxies and proxy statements to beneficial owners of the
Common  Stock,  will be paid by the Company.  Proxies may be  solicited  without
extra compensation by some of the officers and other employees of the Company by
telephone or personal interviews. The Company has also retained D.F. King & Co.,
Inc. to assist in the  solicitation  of proxies at an anticipated fee of $______
plus out-of-pocket expenses.



                     PROPOSAL NO. 1 - ELECTION OF DIRECTORS

     Pursuant  to  the  provisions  of the  Company's  Restated  Certificate  of
Incorporation and By-laws,  the Board of Directors is comprised of three classes
of directors, designated Class I, Class II and Class III. One class of directors
is  elected  each  year to  hold  office  until  the  third  annual  meeting  of
stockholders after such election and until successors of such directors are duly
elected and qualified.  The Governance and Nominating  Committee has recommended
to the Board,  and the Board also  recommends  that the  stockholders  elect the
Class I director  nominee at this year's Annual  Meeting to serve until the 2009
Annual Meeting and until his successor is elected and qualified.  Currently, the
Board has set the  number of  directors  at eight.  One of our  current  Class I
directors, Dr. Rosina B. Dixon, is retiring as of April 30, 2006. The Governance
and Nominating Committee is currently evaluating  candidates to fill the vacancy
that  will be  created  by Dr.  Dixon's  retirement,  but has not yet  chosen  a
nominee.  The proxies solicited by this Proxy Statement cannot be voted for more
than one nominee at the Annual  Meeting.  The nominee for election to the office
of director,  and certain  information  with respect to his  background  and the
backgrounds of non-nominee  directors,  are set forth below. It is the intention
of  the  persons  named  in  the  accompanying   proxy  card,  unless  otherwise
instructed,  to vote to elect the nominee  named herein as Class I director.  In
the  event  the  nominee  named  herein  is  unable  to  serve  as  a  director,
discretionary  authority  is  reserved to the Board of  Directors  to vote for a
substitute.  The Board of  Directors  has no reason to believe  that the nominee
named herein will be unable to serve if elected.

     The  name,  age and year in which  the term  expires  of each  member of or
nominee for election to the Board of Directors of the Company is set forth below

                         
                                                                                             Term Expires on the
                                         Director            Position with                   Annual Meeting Held
            Nominee              Age     Since                the Company                      In The Year
---------------------------     ----    ---------       --------------------------              ---------------
Jeffrey H. Buchalter             48       2004          Chief Executive Officer and                   2007
                                                        Chairman of the Board
Goran A. Ando, M.D.              57       2004          Director                                      2007
Victor P. Micati                 66       2004          Director                                      2007
Rolf A. Classon                  60       1997          Director                                      2008
Robert LeBuhn                    73       1994          Director                                      2008
Robert C. Salisbury              62       2005          Director                                      2008
Phillip M. Renfro                60       2005          Director                                      2006
Rosina B. Dixon, M.D.            63       1994          Director                                       *

-----------------------------------------------------------------------------------------------------------------------------------
     * Dr. Dixon is retiring from the Company's Board of Directors effective April 30, 2006.



                                       2


                        BUSINESS EXPERIENCE OF DIRECTORS

Class I Director Nominee for Election at the 2006 Annual Meeting

     Phillip M.  Renfro,  age 60, has served as a director of the Company  since
January  2005.  Mr.  Renfro  has been a partner at the law firm of  Fulbright  &
Jaworski,  L.L.P. since 1984. Prior to joining Fulbright & Jaworski,  Mr. Renfro
was Chief Executive Officer of Resco  International,  an international  oilfield
service   company  and  Vice  President  and  General   Counsel  of  Weatherford
International,  one of the largest  international  oilfield service companies in
the United States from 1977 to 1983.

     The Board of Directors recommends a vote FOR Mr. Renfro as Class I Director
(Proposal No. 1 on the Proxy Card).

Non-Nominee Class II Directors Serving Until the 2007 Annual Meeting

     Jeffrey H.  Buchalter,  age 48, has served as a director of the Company and
as Chairman of the Board of Directors  since  September  2004 and as  President,
Chief Executive Officer since December 2004. Mr. Buchalter  previously served as
the President and Chief  Executive  Officer of Ilex Oncology,  Inc. from January
2002 until December 2004, serving as President of Ilex from September 2001 until
December  2002.  Mr.  Buchalter  was also a director of Ilex from  February 2001
until December 2004.  From 1997 to 2001, Mr.  Buchalter was Group Vice President
for the  Worldwide  Oncology  Franchise at Pharmacia  Corporation.  From 1993 to
1997,  Mr.  Buchalter was a Group  Director with American Home  Products,  Wyeth
Ayerst Laboratories.  Mr. Buchalter was presented the Joseph F. Buckley Memorial
Award from the American  Cancer  Society for  commitment  to cancer  control and
involvement in the pharmaceutical  oncology field.  Additionally,  Mr. Buchalter
was invited by former President George Bush to serve as a collaborating  partner
in the National Dialogue on Cancer.

     Goran A. Ando,  M.D., age 57, has served as a director of the Company since
November 2004.  From April 2003 through July 2004, he served as Chief  Executive
Officer of Celltech Group plc. Prior to joining Celltech in April 2003, Dr. Ando
served in various senior posts at Pharmacia Corporation. In his most recent role
at  Pharmacia,  Dr. Ando was Executive  Vice  President and President of R&D and
also  had  executive   responsibilities   for  IT,  manufacturing  and  business
development. Prior to his most recent role with Pharmacia, Dr. Ando held various
executive positions, including Executive Vice President & Deputy Chief Executive
Officer,  Pharmacia AB, Sweden;  Executive Vice President,  Worldwide  Science &
Technology, Pharmacia & Upjohn, UK; and Chairman, Pharmacia & Upjohn AB, Sweden.
Prior to joining  Pharmacia,  Dr. Ando held various senior  positions with Glaxo
Ltd., Bristol Myers International Group, and Pfizer International.

     Victor P.  Micati,  age 66, has served as a director of the  Company  since
November 2004. Mr. Micati is a retired senior  executive of Pfizer Inc. In 1999,
Mr. Micati  retired from Pfizer where he most recently  served as Executive Vice
President  of the  Pharmaceutical  Group of Pfizer and Vice  President of Pfizer
Inc. Mr. Micati first joined Pfizer in 1965 and over a 34-year  career served in
numerous capacities, including: President of European Operations; Executive Vice
President  of  Pfizer  Europe;  Senior  Vice  President,  Pharmaceuticals;  Vice
President  of  Pharmaceutical  Development,   Pfizer  International;   and  Vice
President of Marketing, Pfizer Laboratories.  Mr. Micati also served as a member
of the Pfizer  International  Board of  Directors.  Mr.  Micati is  currently  a
consultant  to the  pharmaceutical  industry  and is a  member  of the  Board of
Trustees of the Monterey Institute.

Non-Nominee Class III Directors Serving Until the 2008 Annual Meeting

     Rolf A.  Classon,  age 60, has served as a director  of the  Company  since
January  1997.  Since May 2005,  Mr.  Classon  has  served  as  interim  CEO for
Hillenbrand Industries. From 2002 to 2004, Mr. Classon served as Chairman of the
Executive  Committee of Bayer  Healthcare AG and, from 1995 to 2002, Mr. Classon
served as an Executive  Vice  President of Bayer  Corporation  and  President of
Bayer  Diagnostics.  From  1991 to  1995,  Mr.  Classon  was an  Executive  Vice
President in charge of Bayer Diagnostics' Worldwide Marketing, Sales and Service
operations.  From 1990 to 1991,  Mr.  Classon was President and Chief  Operating
Officer of  Pharmacia  Biosystems  A.B.  Prior to 1991,  Mr.  Classon  served as
President of Pharmacia  Development  Company Inc. and Pharmacia  A.B.'s Hospital
Products  Division.   Mr.  Classon  currently  serves  as  a  director  of  ISTA
Pharmaceuticals, Auxilium Pharmaceuticals, Millipore Corporation and Hillenbrand
Industries.

                                       3


     Robert LeBuhn, age 73, has served as a director of the Company since August
1994.  Mr.  LeBuhn is a private  investor.  He is a Trustee and  Chairman of the
Geraldine R. Dodge Foundation,  a Trustee and Treasurer of All Kinds of Minds, a
Trustee of Executive  Service  Corp.,  and a Trustee of the Aspen Music Festival
and School and President of its National Council.

     Robert C. Salisbury,  age 62, has served as a director of the Company since
May 2005. In 1998, Mr. Salisbury retired from Pharmacia & Upjohn,  Inc. where he
most recently  served as Executive Vice President and Chief  Financial  Officer.
Previously, Mr. Salisbury served as Executive Vice President,  Finance and Chief
Financial  Officer at The Upjohn Company.  Mr. Salisbury first joined The Upjohn
Company  in 1974 and over a career of more than 20 years,  he served in  various
management  posts in finance and strategic  planning.  Mr.  Salisbury  currently
serves as a director of Viragen, Inc.

     There are no family  relationships  among any of the Company's directors or
executive officers.

                              DIRECTORS' NOMINATION

     Process  for  Identifying  and  Evaluating  Nominees.  The  Charter  of the
Governance and Nominating Committee specifies the process for nominating persons
for  election to the Board.  The  committee  will  solicit  nominations  for new
directors  and screen the list of  potential  new  directors  submitted to it by
other  directors or any other  sources and decide  whether the  assistance  of a
search  firm is  needed,  and if so,  choose  the firm.  After a review of board
candidates and after considering the advice of the Chairman of the Board and the
Chief Executive Officer, the committee will designate which candidates are to be
interviewed.  Candidates  will be  interviewed by the chairman of the Governance
and  Nominating  Committee,  the  Chairman of the Board and the Chief  Executive
Officer and may be  interviewed  by other  directors of the  Company.  After the
interviews  are  completed,  the  committee  will  recommend  to the Board which
individuals  it  approves  as  nominees  for  membership  on the Board.  Current
directors  standing  for  reelection  are  not  required  to  participate  in an
interview process.

     Criteria for Board Membership. The Charter of the Governance and Nominating
Committee  does  not  set  forth  the  specific  criteria  for  identifying  and
recommending new candidates to serve as directors,  however,  candidates will be
interviewed  by  the  Governance  and  Nominating   Committee  to  evaluate  the
following, among other qualifications it may deem appropriate:

     o  experience  as  a  director  of  another  publicly-traded   corporation,
experience  in  industries  or  with  technologies   relevant  to  the  Company,
accounting  or  financial  reporting  experience,  or  such  other  professional
experience that the Governance and Nominating  Committee determines qualifies an
individual for Board service;

     o candidates' business judgment and temperament, ethical standards, view of
the  relative  responsibilities  of  a  director  and  management,   independent
thinking, articulate communication and intelligence; and

     o any other  factors  as the  Governance  and  Nominating  Committee  deems
appropriate,  including judgment,  skill, diversity,  experience with businesses
and other  organizations  of comparable  size, the interplay of the  candidate's
experience  with the experience of other Board members,  and the extent to which
the candidate  would be a desirable  addition to the Board and any committees of
the Board.

     Stockholder Nominees. The Governance and Nominating Committee will consider
written  proposals  from  stockholders  for  nominees  for  director.  Any  such
nominations  should be submitted to the Governance and Nominating  Committee c/o
the Secretary of the Company and should include the following  information:  (a)
all  information  relating to such  nominee  that is  required  to be  disclosed
pursuant to Regulation 14A under the Securities  Exchange Act of 1934 (including
such person's written consent to being named in the proxy statement as a nominee
and to serving as a director if  elected);  (b) the names and  addresses  of the
stockholders making the nomination and the number of shares of Common Stock that
are owned beneficially and of record by such  stockholders;  and (c) appropriate
biographical information and a statement as to the qualification of the nominee.

                                       4


This  information  should be submitted in the time frame described in the Bylaws
of the Company and under the  caption,  "Stockholder  Proposals  for 2007 Annual
Meeting" below. The manner in which the committee  evaluates potential directors
will  be  the  same  for  candidates  recommended  by  the  stockholders  as for
candidates recommended by others.

     Board Nominees for the 2006 Annual  Meeting.  The Governance and Nominating
Committee recommended that Mr. Renfro, one of our current Class I directors,  be
nominated for  re-election,  Mr. Renfro was elected by the Board in January 2005
to fill a vacancy  on the  Board.  Mr.  Renfro  was  initially  identified  as a
director candidate by Mr. Buchalter.  Mr. Buchalter and Mr. Micati each knew Mr.
Renfro in  connection  with Mr.  Renfro's  role as outside  legal counsel to the
board of directors of Ilex  Oncology,  Inc.,  where he advised the Ilex board on
corporate governance matters.  Prior to his election as a director by the Board,
Mr.  Renfro was  interviewed  by each of the  members of the Board at that time,
including Messrs. Buchalter,  Classon and LeBuhn, and Drs. Ando and Dixon, other
than Mr. Micati.  The Governance and Nominating  Committee  determined  that Mr.
Renfro's  experience  and  expertise,   including  his  extensive  knowledge  of
corporate  governance  matters,  would  be  valuable  to  the  Board  and  would
strengthen   the  Board's   overall   expertise  and   capabilities.   Upon  the
recommendation of the Governance and Nominating Committee, the Board elected Mr.
Renfro to serve as an  independent  director of the Company.  Our other  current
Class I director, Dr. Dixon, is retiring from the Board as of April 30, 2006 and
therefore  is not  standing  for  re-election.  The  Governance  and  Nominating
Committee is currently  evaluating potential candidates to fill the vacancy that
will be created by Dr. Dixon's  retirement.  The proxies solicited by this Proxy
Statement cannot be voted for more than one nominee at the Annual Meeting.

                             DIRECTORS' COMPENSATION

     In September 2004, the Board of Directors  adopted a new compensation  plan
for  non-employee  directors,  which was amended in May 2005 (the "2004  Outside
Director Compensation Plan"). Under the 2004 Outside Director Compensation Plan,
each  non-employee  director will receive an option to purchase 15,000 shares of
Common Stock annually on the first trading day of the calendar year (the "Annual
Option Grant") and a grant of restricted  stock units for shares of Common Stock
with a value of $25,000  on the first  trading  day after  June 30 (the  "Annual
Restricted  Stock Grant").  These grants are made under the 2001 Incentive Stock
Plan. The exercise price of the Annual Option Grant will be equal to the closing
price of the Common  Stock on the date of grant and the number of shares  issued
pursuant to the Annual  Restricted  Stock Grant will be equal to $25,000 divided
by the closing price of the Common Stock on the date of grant. The Annual Option
Grant vests in one tranche on the first  anniversary of the date of grant if the
recipient  director  remains on the Board on that  date.  Once  vested,  options
granted  pursuant to the Annual Option Grant expire on the 10th  anniversary  of
the date of grant. The shares covered by the Annual  Restricted Stock Grant vest
in three equal tranches on each of the first three  anniversaries of the date of
grant if the recipient director remains on the Board on each such date. Upon the
election  of a new  non-employee  director  to the  Board,  such  newly  elected
director  will  receive a grant of options to purchase  20,000  shares of Common
Stock (the  exercise  price of which will be equal to the  closing  price of the
Common  Stock on the date of grant) and a grant of  restricted  stock  units for
shares of Common Stock with a value of $25,000 (the number of shares  covered by
such grant  being equal to $25,000  divided by the  closing  price of the Common
Stock on the date of grant) (the "Welcome  Grant").  The options and  restricted
stock units  included in the Welcome Grant vest in three equal  tranches on each
of the first three anniversaries of the date of grant, if the recipient director
remains on the Board on each such date. Furthermore,  for the Chairperson of the
Board,  if not an  employee  of the  Company,  the  number of option  shares and
restricted  stock units covered by the Annual Option  Grant,  Annual  Restricted
Stock Grant and Welcome Grant are twice the numbers mentioned above.

     In  addition,  under the 2004  Outside  Director  Compensation  Plan,  each
non-employee director receives an annual cash retainer of $20,000.  Non-employee
directors also receive an additional  annual cash retainer of $7,000 for service
as chair of the Finance and Audit  Committee  and $3,500 for service as chair of
any other committee.  Further,  each non-employee director is entitled to a cash
meeting fee of $1,500 for each meeting of the Board  attended and each committee
meeting attended (whether in person or by teleconference).

     Directors who are employees of the Company do not receive  compensation for
their service on our Board of Directors.

                                       5



     During  the fiscal  year ended June 30,  2005,  the  Company  recorded  the
following fees earned:



                         
                                                                               Value                  # Shares
                                  Total                   Cash                of Stock          Underlying Restricted
      Board Member            Compensation            Compensation          Compensation             Stock Units
-----------------------    ------------------    ---------------------    ----------------    ------------------------

Goran Ando(1)                   $48,467              $23,467                  $25,000                   1,566
Jeffrey Buchalter(2)            59,845                 9,845                   50,000                   3,234
Rolf Classon                    77,000                52,000                   25,000                   1,989
Rosina Dixon                    79,443                54,443                   25,000                   1,989
David Golde(3)                  28,481                 3,481                   25,000                   1,989
Arthur Higgins(4)               43,154                18,154                   25,000                   1,989
Robert LeBuhn                   85,000                60,000                   25,000                   1,989
Victor Micati(5)                49,717                24,717                   25,000                   1,566
Phillip Renfro(6)               46,140                21,140                   25,000                   1,896
Robert Salisbury(7)             30,722                 5,722                   25,000                   3,597
                           ------------------    ---------------------    ----------------    ------------------------

Totals                        $547,969              $272,969                 $275,000                   21,804
                           ==================    =====================    ================    ========================

(1)  Dr. Ando joined the Board of Directors in November 2004

(2)  Mr. Buchalter  joined the Board of Directors as  non-executive  Chairman in
     September 2004 and became President and Chief Executive Officer in December
     2004

(3)  Dr. Golde passed away in August 2004

(4)  Mr. Higgins resigned from the Board of Directors in December 2004

(5)  Mr. Micati joined the Board of Directors in November 2004

(6)  Mr. Renfro joined the Board of Directors in January 2005

(7)  Mr. Salisbury joined the Board of Directors in May 2005

     During the six-month transition period ended December 31, 2005, the Company
recorded the following fees earned:


                                                                                                        # Shares
                                                                                 Value                 Underlying
                                   Total                   Cash                of Stock             Restricted Stock
      Board Member              Compensation           Compensation          Compensation                 Units
------------------------     -----------------     -------------------    -------------------     --------------------

Goran Ando                        $45,750              $20,750                $25,000                     3,765
Rolf Classon                      56,250                31,250                 25,000                     3,765
Rosina Dixon                      39,500                14,500                 25,000                     3,765
Robert LeBuhn                     59,500                34,500                 25,000                     3,765
Victor Micati                     45,500                20,500                 25,000                     3,765
Phillip Renfro                    51,750                26,750                 25,000                     3,765
Robert Salisbury                  50,000                25,000                 25,000                     3,765
                             -----------------     -------------------    -------------------     --------------------

Totals                          $348,250              $173,250               $175,000                   26,355
                             =================     ===================    ===================     ====================



Directors' Stock Ownership Program

     In October  2000,  the Board of Directors  implemented  a directors'  stock
ownership program that requires each of the directors to beneficially own Common
Stock  with a market  value of at least  $100,000  within  two  years  after the
director first joins the Board of Directors.  The  determination  of whether the
shares  beneficially  owned by a director meet the $100,000 minimum market value
requirement  will be based on the highest  average  trading  price of the Common
Stock over any consecutive  twenty trading days during the two year period after
the director first joins the Board of Directors or the price paid for the Common
Stock by the  director.  Shares of Common Stock  underlying  options held by the
directors will not be counted  towards  satisfaction  of this  requirement.  The
Board of Directors may waive this requirement under certain circumstances.  Each
of the Company's  current  directors  that have served on the Board of Directors
for two years or more meet this requirement.

                                       6


          INFORMATION CONCERNING THE BOARD AND COMMITTEES OF THE BOARD

Independence of Directors

     The  Company's  Board of  Directors  is composed  entirely  of  independent
outside  directors,  with the  exception  of the Chief  Executive  Officer.  The
committees  of the Board  are also  composed  entirely  of  independent  outside
directors,  with the  exception of the Executive  Committee,  of which the Chief
Executive Officer is a member.

     The Board has determined  that the following  directors,  comprising all of
the directors other than the Chief Executive  Officer,  are "independent"  under
current NASDAQ rules: Messrs. Classon,  LeBuhn, Micati, Renfro and Salisbury and
Drs. Ando and Dixon.

Meetings and Attendance

     The Company's  Board of Directors held ten meetings  during the fiscal year
ended June 30, 2005 and held two meetings during the six-month transition period
ended December 31, 2005. Each director attended at least 75% of the total number
of meetings of the Board of Directors,  and committees of the Board of Directors
of which such director was a member, held during each of those periods.

     The independent directors of the Board hold at least two executive sessions
each year at which only the  independent  directors  are present.  In 2005,  the
independent  directors  held two  executive  sessions.  Mr.  Micati  is the Lead
Independent  Director and  presiding  director at these  executive  sessions for
2006.

     Enzon does not have a policy  requiring  the directors to attend the annual
stockholders' meeting.  However, all of the Company's directors in office at the
time of our last annual  stockholders'  meeting  attended  that  meeting.  It is
expected  that all of our  directors  then in office will attend the 2006 Annual
Meeting.

Communications with Directors

     Stockholders   may   communicate   directly   with   the   directors.   All
communications  should  be sent in care of the  Secretary  of Enzon  at  Enzon's
address and should  prominently  indicate on the outside of the envelope that it
is intended for the Board of Directors,  for a specific non-employee director or
a  particular  committee  of  the  Board.  If  no  director  is  specified,  the
communication will be forwarded to the entire Board.

Standing Committees of the Board of Directors

     Enzon's Board of Directors currently has the following standing committees:
Finance and Audit Committee,  Compensation Committee,  Governance and Nominating
Committee, Executive Committee and Scientific and Technology Committee.

     Finance and Audit  Committee.  The Finance  and Audit  Committee  currently
consists  of  Messrs.  Salisbury  (Chairman),  Classon,  LeBuhn and  Renfro.  In
compliance with audit committee requirements for Nasdaq companies, the Board has
determined that all members of the Finance and Audit Committee are  independent,
as  independence  is defined in Rule  4200(a)(15)  of the  National  Association
Securities  Dealers  ("NASD")  listing  standards  and Section  10A(m)(3) of the
Securities  Exchange  Act of  1934.  Each of the  members  is  able to read  and
understand financial  statements.  The Board has determined that the Chairman of

                                       7



the  committee,  Mr.  Salisbury,  and two other  members of the  committee  each
qualifies as an "audit committee  financial expert" as defined in Item 401(h) of
Regulation S-K under the Securities Exchange Act of 1934. The primary purpose of
the  Finance  and Audit  Committee  is to assist the Board of  Directors  in its
oversight   responsibilities  by  monitoring  the  integrity  of  the  Company's
financial  reporting process and financial  statements,  the systems of internal
controls and controls over  financial  reporting,  the compliance by the Company
with legal and regulatory requirements,  and the performance and independence of
the Company's  independent  auditors.  The  committee  meets  periodically  with
management  to consider the adequacy of our internal  control and the  financial
reporting  process.  It  also  discusses  these  matters  with  our  independent
auditors. The committee reviews our financial statements and discusses them with
management and the independent  auditors  before those financial  statements are
filed  with the  Securities  and  Exchange  Commission.  The  Finance  and Audit
Committee  adopted a written  charter during fiscal 2000 and amended its charter
in September 2002 and March 2006. A copy of the charter of the Finance and Audit
Committee  as amended is  attached  to this Proxy  Statement  as Appendix A. The
Charter may also be found on our website at www.enzon.com. The Finance and Audit
Committee held ten meetings during the fiscal year ended June 30, 2005 and eight
meetings during the six-month transition period ended December 31, 2005.

     Compensation  Committee.  The Compensation  Committee currently consists of
Dr. Ando  (Chairman)  and Messrs.  Classon and Micati.  The Board has determined
that all members of the Compensation Committee are independent,  as independence
is  defined in Rule  4200(a)(15)  of the NASD  listing  standards.  The  primary
functions of the  Compensation  Committee are to administer  the Company's  1987
Non-Qualified  Stock Option Plan and 2001  Incentive  Stock Plan,  determine the
compensation  of the  Company's  officers  and  senior  management,  and  review
compensation  policy. The Charter of the Compensation  Committee may be found on
our  website at  www.enzon.com.  There were five  meetings  of the  Compensation
Committee  during the fiscal year ended June 30, 2005 and three meetings  during
the six-month transition period ended December 31, 2005.

     Governance  and  Nominating   Committee.   The  Governance  and  Nominating
Committee currently consists of Messrs. Renfro (Chairman), Micati and Salisbury.
The  Board  has  determined  that  all of the  members  of  the  Governance  and
Nominating  Committee are independent as defined in Rule 4200(a)(15) of the NASD
listing standards.  This committee reviews and sets corporate  governance policy
and is responsible for making recommendations to the Board on Board organization
and procedures,  performance  evaluation of the Board and individual  directors,
and nomination of directors.  The Governance and Nominating  Committee's Charter
may be found on our website at  www.enzon.com.  There were five  meetings of the
Governance and Nominating  Committee  during the fiscal year ended June 30, 2005
and one meeting during the six-month transition period ended December 31, 2005.

     Executive  Committee.  The Executive  Committee  currently  consists of Mr.
Buchalter  (Chairman),  Dr.  Ando,  and Messrs.  Classon and Micati.  In between
meetings  of the Board of  Directors,  the  Executive  Committee  exercises  the
authority  and power of the Board to the full extent  permitted  under  Delaware
Law.

     Scientific  and  Technology   Committee.   The  Scientific  and  Technology
Committee  currently  consists of Dr. Ando  (Chairman),  and Messrs.  Micati and
Renfro.  This committee provides  scientific input to the Board of Directors and
serves as the liaison  between the  Company's  senior  research and  development
management and the Board of Directors.

                                 CODE OF CONDUCT

     The Board of Directors  has adopted a Code of Conduct that is applicable to
all of our directors,  officers and employees.  Any material changes made to the
Code of Conduct or any waivers  granted to any of our  directors  and  executive
officers  will be publicly  disclosed by the filing of a Current  Report on Form
8-K within four business days of such material  change or waiver.  A copy of our
Code of Conduct is available on the Corporate  Governance page of our website at
www.enzon.com  or upon  request,  without  charge,  by  contacting  our Investor
Relations  Department by calling  908-541-8777  or through an e-mail  request to
investor@enzon.com.

           COMPENSATION COMMITTEE INTERLOCKS AND INSIDER PARTICIPATION

     The current members of our  Compensation  Committee are Dr. Ando (Chairman)
and Messrs. Classon and Micati. There are no interlocks among any of the members
of our Compensation Committee and any of our executive officers.


                                       8


                    BUSINESS EXPERIENCE OF EXECUTIVE OFFICERS

     Set forth below is certain information  regarding the executive officers of
the Company who do not serve on the Board of Directors.

     Paul  S.  Davit,  age  51,  has  served  as the  Company's  Executive  Vice
President,  Human Resources since April 2005.   Mr. Davit  previously  served as
Enzon's Senior Vice President,  Human Resources from January 2004 to April 2005,
and Vice President,  Human  Resources from March 2002 to January 2004.  Prior to
joining  Enzon,  Mr.  Davit  ran a  human  resources  consulting  practice  from
September  2001 to March  2002.  From July 1998 to  September  2001,  Mr.  Davit
worked at Caliber Associates and he spent over 11 years with Rhone-Poulenc Rorer
from  October  1986 to May  1998,  where he served  as Vice  President  of Human
Resources for RPR Gencell, Rhone-Poulenc Rorer's start-up biotechnology division
and as Vice President of Human Resources for the North American  Pharmaceuticals
division.  Mr. Davit began his career as a compensation  consultant with the Hay
Group.

     Ralph del  Campo,  age 54,  has  served  as the  Company's  Executive  Vice
President,  Technical  Operations  since April  2005.  Mr. del Campo has over 30
years of diverse industry  experience,  including serving as Enzon's Senior Vice
President,  Technical  Operations  from  October  2002 to April  2005.  Prior to
joining Enzon,  Mr. del Campo was the head of the North  American  operations of
Elan Corporation, plc from May 2000 to September 2002.  Mr. del Campo also spent
over 17 years in various senior operations management positions at Bristol-Myers
Squibb.

     Dr.  Ivan D.  Horak,  age 55, has served as the  Company's  Executive  Vice
President  of  Research  and  Development  and Chief  Scientific  Officer  since
September 2005.  Prior to joining Enzon, Dr. Horak was employed by Immunomedics,
Inc. as Executive Vice President of Research and Development from May 2002 until
July 2003, and as Chief Scientific Officer from July 2003 to August 2005. Before
joining  Immunomedics,  Dr. Horak was employed by Pharmacia as a Vice  President
for Clinical Oncology from November 1999 to May 2002, where he helped direct the
global development of oncology compounds,  including Camptosar(R) for metastatic
colorectal  cancer.  From 1996 to 1999,  Dr.  Horak held a variety  of  clinical
research positions at Janssen Research Foundation, a subsidiary of the Johnson &
Johnson  Company,  including  International  Director for Clinical  Research and
Development,  Oncology.  Prior to joining Janssen, Dr. Horak spent nine years at
the National  Cancer  Institute where he most recently served as a cancer expert
for  the  Metabolism  Branch.  In  addition  to  authoring  over  60  scientific
publications,  Dr. Horak is a member of several  prominent medical societies and
has  served on  various  committees  for the  American  Association  for  Cancer
Research  and the  International  Union  Against  Cancer.  He also serves on the
editorial board of the prestigious journal,  Cancer Research.  He is a fellow of
the American College of Physicians.  Dr. Horak received his M.D. degree from the
University of Komenius, Bratislava, Czechoslovakia.

     Craig A.  Tooman,  age 40,  has  served  as the  Company's  Executive  Vice
President,  Finance and Chief  Financial  Officer  since June 2005.  Mr.  Tooman
served  as the  Company's  Executive  Vice  President,  Strategic  Planning  and
Corporate  Communications  from January  2005 to June 2005,  and he retained the
duties of that position when he was appointed to the position of Executive  Vice
President,  Finance and Chief Financial  Officer.  Prior to joining Enzon,  from
2002 to 2005, Mr. Tooman served as Senior Vice  President of Strategic  Planning
and Corporate  Communications  for Ilex Oncology,  Inc. Before joining Ilex, Mr.
Tooman worked at Pharmacia  Corporation  where he most  recently  served as Vice
President of Investor Relations from 2000 to 2001. Previously, Mr. Tooman served
in various  management  posts at Pharmacia & Upjohn,  including  Assistant  Vice
President  of Investor  Relations  from 1999 to 2000 and  Worldwide  Director of
Investor  Relations  from 1998 to 1999.  Prior to the  merger of  Pharmacia  and
Upjohn,  Mr. Tooman held various  management  positions for the Upjohn  Company,
including assignments in Europe and Japan.


                                       9


                           SUMMARY COMPENSATION TABLE

     The following  table  provides a summary of cash and non-cash  compensation
for each of the last three fiscal  years ended June 30, 2005,  2004 and 2003 and
the  six-month  transition  period  ended  December 31, 2005 with respect to the
Company's  Chief  Executive  Officer and the  Company's  next  four most  highly
compensated  executive  officers for the fiscal year ended June 30, 2005 and the
six-month  transition  period ended December 31, 2005, and two  individuals  for
whom  disclosure  would have been  provided  as one of the next four most highly
compensated  executive  officers  but for the fact that they were not serving as
executive  officers of the Company at the end of the last completed  fiscal year
(the "Named Executive Officers"):


                         
                                                                                                  Long-Term
                                                                                         ----------------------------
                                                                                                 Compensation
                                                          Annual Compensation                        Awards
                                        ---------------------------------------------     ----------------------------
                                                                                           Restricted
                                                                          Other Annual       Stock       Securities
               Name and                                                    Compensation      Awards      Underlying
          Principal Position             Year    Salary($)   Bonus(S)       ($)(1)(3)        ($)(2)      Options(#)
-------------------------------------- -------- ---------- ------------ ---------------- ------------- ---------------
-------------------------------------- -------- ---------- ------------ ---------------- ------------- ---------------

Jeffrey H. Buchalter                   2005*    $296,154   $412,500(4)      $229,966(5)  $836,400(8)        300,000
 Chairman of the Board                 2005      260,192    550,000(4)       229,789(5)  1,065,498(8)     1,515,000
 President, Chief Executive Officer

Craig A. Tooman                        2005*     197,308    150,000(4)       201,704(6)    69,700(9)         50,000
 Executive Vice President, Finance     2005      136,904    300,000(4)       101,631(6)   431,250(9)        225,000
 Chief Financial Officer

Ralph del Campo(15)                    2005*     188,462    100,000(4)         7,890       69,700(10)        50,000
 Executive Vice President              2005      331,327    200,000(4)         5,648      104,250(10)        50,000
 Technical Operation

Paul S. Davit(15)                      2005*     161,538     75,000(4)         3,596       69,700(11)        50,000
 Executive Vice President              2005      283,017    175,000(4)         6,115      104,250(11)        50,000
 Human Resources

Ivan D. Horak, M.D.                    2005*     132,404    165,000(4)         -          409,275(12)       235,000
 Executive Vice President
 Research and Development
 and Chief Scientific Officer

Ulrich Grau Ph.D.(16)                  2005*           -          -            -                -             -
 Chief Scientific Officer              2005      391,227          -          539,602(7)         -                 -
                                       2004      423,942    210,590            4,687      614,875(13)       100,000
                                       2003      400,000    185,000            8,019            -            50,000

Kenneth J. Zuerblis(17)                2005*           -          -            -                -             -
 Executive Vice President,             2005      314,708          -          617,385(7)         -                 -
 Finance, Chief Financial              2004      319,327    258,560            7,000      514,300(14)       125,000
 Officer and Corporate                 2003      303,235    147,000            6,776            -            50,000
 Secretary


___________________________
*   For the six-month period ended December 31, 2005.

(1)  Excludes  perquisites and other personal  benefits that in the aggregate do
     not exceed the  lesser of $50,000 or 10% of the Named  Executive  Officer's
     total annual salary and bonus.

(2)  Calculated by  multiplying  the amount of  restricted  stock by the closing
     market price on the date of the restricted stock grant.

(3) Includes annual Company contributions to a 401(k) plan.

                                       10


(4)  The amounts  represent  performance  bonuses for the fiscal year ended June
     30, 2005 and the six months ended December 31, 2005. Mr.  Buchalter's bonus
     for the fiscal year ended June 30, 2005 includes a guaranteed minimum bonus
     of $412,500  payable under his  employment  agreement.  Mr.  Tooman's bonus
     includes a $125,000  sign-on bonus paid in January 2005.  Dr. Horak's bonus
     includes a $100,000  sign-on bonus paid in September 2005 and a performance
     bonus for the six months ended December 31, 2005.

(5)  The amounts include  reimbursements  related to Mr.  Buchalter's  temporary
     living and  relocation  expenses of $215,539 for the fiscal year ended June
     30, 2005 and $186,649 of temporary  living and relocation  expenses for the
     six months ended December 31, 2005.

(6)  The amounts include reimbursements related to Mr. Tooman's temporary living
     and  relocation  expense of $87,381 for the fiscal year ended June 30, 2005
     and $188,586 for the six months ended December 31, 2005.

(7)  Amounts  include  payments made to Dr. Grau and Mr.  Zuerblis in accordance
     with  their   respective   Separation   Agreements   and   annual   Company
     contributions  to  a  401(K)  plan.  For  additional   information  on  the
     Separation Agreements, see "Employment and Separation Agreements."

(8)  Amount  represents an award of 75,000 shares of restricted stock granted on
     December  22,  2004,  an award of 3,234  shares of  restricted  stock units
     granted on September 28, 2004 and an award of 120,000  shares of restricted
     stock units granted on November 23, 2005. Mr.  Buchalter's 75,000 shares of
     restricted  stock and 120,000  shares of restricted  stock units vest as to
     30% of the shares on the third  anniversary  of the grant date,  30% on the
     fourth  anniversary of the grant date, and 40% on the fifth  anniversary of
     the grant date. Mr.  Buchalter's  3,234  restricted  stock units vest as to
     one-third  of the  shares  on the  first  anniversary  of the  grant  date,
     one-third of the shares on the second  anniversary  of the grant date,  and
     one-third  of the shares on the third  anniversary  of the grant date.  Mr.
     Buchalter's  shares of restricted  stock and restricted  stock units had an
     aggregate  value of $507,000 as of June 30, 2005 and an aggregate  value of
     $1,467,000 as of December 31, 2005.

(9)  Amount  represents  awards of 25,000 shares of restricted  stock granted on
     January 5, 2005, 15,000 shares of restricted stock units granted on May 12,
     2005 and 10,000  shares of  restricted  stock units granted on November 23,
     2005. Mr. Tooman's  restricted  stock and restricted stock units vest as to
     30% of the shares on the third  anniversary  of the grant date,  30% on the
     fourth  anniversary of the grant date, and 40% on the fifth  anniversary of
     the grant date.  As of June 30, 2005,  Mr.  Tooman's  restricted  stock and
     restricted  stock units had an aggregate value of $259,000 and an aggregate
     value of $370,000 as of December 31, 2005.

(10) Amount represents awards of 15,000 shares of restricted stock units granted
     on May 12, 2005 and 10,000 shares of restricted stock units on November 23,
     2005. Mr. del Campo's  restricted  stock units vest as to 30% of the shares
     on the third  anniversary of the grant date, 30% on the fourth  anniversary
     of the grant date,  and 40% on the fifth  anniversary of the grant date. As
     of June 30, 2005, Mr. del Campo's  restricted  stock units had an aggregate
     value of $97,000 and an  aggregate  value of  $185,000  as of December  31,
     2005.

(11) Amount  represents  awards of 15,000  restricted stock units granted on May
     12, 2005 and 10,000 shares of restricted  stock units on November 23, 2005.
     Mr.  Davit's  restricted  stock  units  vest as to 30% of the shares on the
     third  anniversary of the grant date, 30% on the fourth  anniversary of the
     grant date, and 40% on the fifth  anniversary of the grant date. As of June
     30, 2005,  Mr.  Davit's  shares of restricted  stock units had an aggregate
     value of $97,000 and an  aggregate  value of  $185,000  as of December  31,
     2005.

(12) Amount represents awards of 50,000 shares of restricted stock units granted
     on September 2, 2005, pursuant to his employment agreement and 7,500 shares
     of  restricted  stock  units  granted on November  23,  2005.  Dr.  Horak's
     restricted  stock  units  vest  as to  30%  of  the  shares  on  the  third
     anniversary of the grant date,  30% on the fourth  anniversary of the grant
     date,  and 40% on the fifth  anniversary  of the grant date. As of December
     31, 2005,  Dr.  Horak's  restricted  stock units had an aggregate  value of
     $426,000.

(13) Amount  represents  awards of 40,000 shares of restricted  stock granted on
     December 5, 2003 and 12,500  restricted  stock units granted on February 6,
     2004. Dr. Grau's shares of restricted stock and restricted stock units were
     cancelled in March 2005 in accordance with his Separation Agreement.

(14) Amount  represents  awards of 12,500  restricted  stock  units  granted  on
     February 6, 2004 and 27,500 shares of restricted  stock granted on June 14,
     2004. Mr.  Zuerblis'  restricted  stock vested as to 100% of the shares and
     his restricted  stock units were  cancelled  upon his  resignation in April
     2005 in accordance with his Separation Agreement.  As of June 30, 2005, Mr.
     Zuerblis' shares of restricted stock had an aggregate value of $178,000.

                                       11


(15) In April 2005, Messrs. del Campo and Davit were named as executive officers
     of the Company.

(16) In November 2004, the Company entered into a separation  agreement with Dr.
     Grau in connection with his decision to voluntarily resign as the Company's
     Chief Scientific Officer.

(17) In April 2005,  the Company  entered into a separation  agreement  with Mr.
     Zuerblis in  connection  with his decision to  voluntarily  resign from his
     position  as the  Company's  Executive  Vice  President,  Finance and Chief
     Financial Officer.



                    OPTION GRANTS DURING LAST FISCAL YEAR AND
                    SIX-MONTH PERIOD ENDED DECEMBER 31, 2005

     The following  table  contains  information  concerning  the grant of stock
options under the Company's stock option plans to the Named  Executive  Officers
during the fiscal year ended June 30, 2005:


                         
                                           Individual Grants
                        -------------------------------------------------------

                                        % of Total                               Potential Realizable Value at
                          Number of       Options                               Assumed Annual Rates of Stock
                          Securities      Granted to     Exercise                   Price Appreciation for Option
                          Underlying      Employees      or Base                               Term(2)
                           Options          in          Price (1)   Expiration  __________________________________
          Name             Granted     Fiscal Year      ($/Share)      Date        0%($)      5%($)       10%($)
___________________       _________     ___________    _________    __________   ______      _______     ______

Jeffrey H. Buchalter        40,000(3)       1.69%         15.46        9/28/2014     --       388,908      985,570
                           725,000(3)      30.70%         13.54       12/22/2014     --     6,173,544   15,644,973
                           750,000(3)      31.76%          6.95        5/12/2015     --     3,278,113    8,307,382

Paul S. Davit               50,000(4)       2.12%          6.95        5/12/2014     --       218,541      553,826

Ralph del Campo             50,000(5)       2.12%          6.95        5/12/2014     --       218,541      553,826

Craig A. Tooman            125,000(6)       5.29%         13.08         1/5/2015     --     1,028,243    2,605,769
                            50,000(6)       2.12%          6.95        5/12/2015     --       218,541      553,826
                            50,000(6)       2.12%          5.73        6/10/2015     --       179,991      456,025



          (1) All  options  were  granted at an exercise  price that  equaled or
     exceeded  the fair  value of the  Common  Stock  on the date of  grant,  as
     determined  by the last  sale  price as  reported  on the  Nasdaq  National
     Market.

          (2) The amounts set forth in the three columns represent  hypothetical
     gains that might be achieved by the optionees if the respective options are
     exercised at the end of their terms. These gains are based on assumed rates
     of stock price appreciation of 0%, 5% and 10% compounded  annually from the
     dates the respective  options were granted.  The 0% appreciation  column is
     included  because the options  were  granted  with  exercise  prices  which
     equaled or exceeded the market price of the underlying  Common Stock on the
     date of grant, and thus will have no value unless the Company's stock price
     increases above the exercise prices.

          (3) In September 2004, Mr. Buchalter was granted an option to purchase
     40,000 shares of the Company's Common Stock for an exercise price of $15.46
     per share upon his  joining  the Board of  Directors.  The vesting of these
     options  was  accelerated  and they  became  exercisable  in April  2005 in
     connection with the  acceleration of vesting,  in April 2005, of all out of
     the money  options to purchase  shares of the Company's  Common  Stock.  In
     December  2004, Mr.  Buchalter was granted  725,000 shares of the Company's
     Common  Stock at an exercise  price of $13.54,  pursuant to his  employment
     agreement.  The vesting of these  options was  accelerated  and they became
     exercisable in April 2005 in connection  with the  acceleration of vesting,
     in April 2005,  of all out of the money  options to purchase  shares of the
     Company's Common Stock. In May 2005, Mr. Buchalter was granted an option to
     purchase 750,000 shares of the Company's Common Stock for an exercise price
     of $6.95.  The  vesting of these  options was  accelerated  and they became
     exercisable in June 2005 in connection with the acceleration of vesting, in
     June 2005, of all options held by Company officers.

                                       12


          (4) In May 2005,  Mr.  Davit was granted an option to purchase  50,000
     shares of the Company's  Common Stock for an exercise  price of $6.95.  The
     vesting of these options was  accelerated  and they became  exercisable  in
     June 2005 in connection with the acceleration of vesting,  in June 2005, of
     all options held by Company officers.

          (5) In May  2005,  Mr.  del Campo was  granted  an option to  purchase
     50,000 shares of the Company's Common Stock for an exercise price of $6.95.
     The vesting of these options was accelerated and they became exercisable in
     June 2005 in connection with the acceleration of vesting,  in June 2005, of
     all options held by Company officers.

          (6) In January  2005,  Mr.  Tooman was  granted an option to  purchase
     125,000  shares of the  Company's  Common  Stock for an  exercise  price of
     $13.08 pursuant to his employment  agreement.  The vesting of these options
     was  accelerated  and they became  exercisable  in April 2005 in connection
     with the  acceleration  of vesting,  in April 2005, of all out of the money
     options to purchase shares of the Company's  Common Stock. In May 2005, Mr.
     Tooman was granted an option to  purchase  50,000  shares of the  Company's
     Common stock at an exercise  price of $6.95.  The vesting of these  options
     was accelerated and they became exercisable in June 2005 in connection with
     the  acceleration of vesting,  in June 2005, of all options held by Company
     officers. In June 2005, Mr. Tooman was granted an option to purchase 50,000
     shares of the Company's Common Stock at an exercise price of $5.73 pursuant
     to his appointment as Executive Vice President, Finance and Chief Financial
     Officer.  The  vesting of these  options  was  accelerated  and they became
     exercisable in June 2005 in connection with the acceleration of vesting, in
     June 2005, of all options held by Company officers.

          The following table contains information concerning the grant of stock
     options  under the  Company's  stock  option  plans to the Named  Executive
     Officers during the six-month transition period ended December 31, 2005:


                         
                                           Individual Grants
                        -------------------------------------------------------

                                        % of Total                               Potential Realizable Value at
                          Number of       Options                               Assumed Annual Rates of Stock
                          Securities      Granted to     Exercise                   Price Appreciation for Option
                          Underlying      Employees      or Base                              Term(2)
                           Options          in          Price (1)   Expiration  __________________________________
          Name             Granted    Six Month Period  ($/Share)      Date        0%($)      5%($)       10%($)
___________________       _________     ___________    _________    __________   ______      _______     ______

Jeffrey H. Buchalter       300,000(3)     31.30%          6.97      11/23/2015     -       1,315,019   3,332,515

Paul S. Davit               50,000(4)      5.22%          6.97      11/23/2015     -         219,170     555,419

Ralph del Campo             50,000(4)      5.22%          6.97      11/23/2015     -         219,170     555,419

Ivan D. Horak, M.D.        200,000(5)     20.87%          7.14       9/2/2015      -         898,062   2,275,864
                            35,000(4)      3.65%          6.97      11/23/2015     -         153,419     388,794

Craig A. Tooman             50,000(4)      5.22%          6.97      11/23/2015     -         219,170     555,419



(1)  All options were granted at an exercise  price that equaled or exceeded the
     fair value of the Common Stock on the date of grant,  as  determined by the
     last sale price as reported on the Nasdaq National Market.

(2)  The amounts set forth in the three  columns  represent  hypothetical  gains
     that might be  achieved  by the  optionees  if the  respective  options are
     exercised at the end of their terms. These gains are based on assumed rates
     of stock price appreciation of 0%, 5% and 10% compounded  annually from the
     dates the respective  options were granted.  The 0% appreciation  column is
     included  because the options  were  granted  with  exercise  prices  which
     equaled or exceeded the market price of the underlying  Common Stock on the
     date of grant, and thus will have no value unless the Company's stock price
     increases above the exercise prices.

                                       13


(3)  Of the 300,000  shares  granted,  96,000  vested on November 23, 2005,  and
     51,000 will vest on each of November 23, 2006,  November 23, 2007, November
     23, 2008 and November 23, 2009 so long as Mr. Buchalter remains an employee
     of the Company on those dates.

(4)  The option  vests in four equal annual  installments  beginning on November
     23, 2006.

(5)  The option vests in four equal annual  installments  beginning on September
     2, 2006.


                  OPTION EXERCISES DURING LAST FISCAL YEAR AND
            SIX-MONTHS ENDED DECEMBER 31, 2005 AND PERIOD-END VALUES

     The following  table sets forth the  information  with respect to the Named
Executive  Officers  concerning  the exercise of options  during the fiscal year
ended June 30, 2005 and unexercised options held as of June 30, 2005.


                         
                                                          Number of Securities          Value of Unexercised
                                                         Underlying Unexercised         In-the-Money Options
                                                         Options at FY-End (#)              at FY-End ($)(1)
                        Shares Acquired    Value        ---------------------          -------------------------
          Name          On Exercise (#) Realized($)   Exercisable   Unexercisable   Exercisable   Unexercisable
------------------      --------------- ------------  ------------  ------------    ------------  -------------
Jeffrey H. Buchalter            -                      1,515,000        -               -             -
                                          -

Paul S. Davit                   -         -             190,000         -               -             -

Ralph del Campo                  -        -             210,000         -                -            -

Craig A. Tooman                  -        -             225,000         -              $37,500        -


(1)  Based  upon a market  value of our  common  stock of $6.48  per  share,  as
     determined by the last sale price as reported on the Nasdaq National Market
     on June 30, 2005.  If the  exercise  price is equal to or greater than such
     last sale price, the option is deemed to have no value.

     The following  table sets forth the  information  with respect to the Named
Executive  Officers  concerning  the  exercise of options  during the  six-month
transition  period ended  December 31, 2005 and  unexercised  options held as of
December 31, 2005.


                         
                                                          Number of Securities          Value of Unexercised
                                                         Underlying Unexercised         In-the-Money Options
                                                    Options at Six Month Period End (#) at Six Month Period End ($)(1)
                        Shares Acquired    Value        ---------------------          -------------------------
          Name          On Exercise (#) Realized($)   Exercisable   Unexercisable   Exercisable   Unexercisable
------------------      --------------- ------------  ------------  ------------    ------------  -------------
Jeffrey H. Buchalter          -              -        1,611,000       204,000        $378,780       $87,720

Paul S. Davit                 -              -          190,000        50,000          22,500        21,500

Ralph del Campo               -              -          210,000        50,000          22,500        21,500

Ivan D. Horak, M.D.           -              -                -       235,000               -        67,050

Craig A. Tooman               -              -          225,000        50,000         106,000        21,500


(1)  Based  upon a market  value of our  common  stock of $7.40  per  share,  as
     determined by the last sale price as reported on the Nasdaq National Market
     on December  30, 2005.  If the  exercise  price is equal to or greater than
     such last sale price, the option is deemed to have no value.

                                       14



                      EMPLOYMENT AND SEPARATION AGREEMENTS

Jeffrey H. Buchalter

     In December  2004, we entered into an employment  agreement with Jeffrey H.
Buchalter,  the  Chairman  of our  Board of  Directors,  pursuant  to which  Mr.
Buchalter  will serve as our Chief  Executive  Officer.  The initial term of the
employment  agreement will expire no earlier than December 31, 2009 and no later
than twelve  months after either party gives notice to the other that such party
does not wish for the agreement to continue beyond such  twelve-month  period (a
"notice of non-renewal").

     The  agreement  provides  for a  base  salary  of  $550,000  per  year  and
participation  in Enzon's bonus plan for  management.  Under the bonus plan, Mr.
Buchalter will be eligible to receive an annual  performance-based cash bonus in
an amount  between  zero and 200% of base  salary,  based on  individual  and/or
corporate  factors to be  established  and  determined by the Board of Directors
each year.  The annual  target  bonus is equal to 100% of Mr.  Buchalter's  base
salary.  For the fiscal year ended June 30, 2005, Mr. Buchalter's bonus included
a guaranteed minimum bonus in the amount of $412,500.

     Under the  agreement,  Mr.  Buchalter  was granted an option under our 2001
Incentive  Stock Plan to purchase  725,000  shares of our Common  Stock at a per
share exercise price of $13.54 (the last reported sale price of our common stock
on  December  22,  2004,  the date of  grant).  This  option  vested  and became
exercisable in April 2005 in connection  with the  acceleration  of vesting,  in
April 2005, of all out of the money options to purchase  shares of the Company's
Common Stock.  Mr.  Buchalter also received  75,000 shares of restricted  Common
Stock,  22,500  of  which  shares  will  vest on each of the  third  and  fourth
anniversaries of the date of grant and the remaining 30,000 of which shares will
vest on the fifth  anniversary  of the date of  grant,  provided  Mr.  Buchalter
remains employed as our Chief Executive Officer on each such date.

     In the event Mr.  Buchalter's  employment is terminated by us without cause
(as defined in the employment agreement) or terminated by Mr. Buchalter for good
reason (as defined in the employment agreement),  Mr. Buchalter will be entitled
to (i) a cash  payment  equal to any  unpaid  base  salary  through  the date of
termination  plus any earned bonus  relating to the  preceding  fiscal year that
remains  unpaid on the date of  termination  plus  (ii) a lump sum cash  payment
equal to four times his annual base salary plus a pro rata portion of his target
bonus for the period  worked  during the  fiscal  year in which the  termination
occurs. In addition,  we will reimburse Mr. Buchalter for any medical and dental
coverage  available  to him and  his  family  for a  period  of up to 18  months
commencing on the date of termination,  and all options and shares of restricted
stock described above that have not vested at the time of termination  will vest
immediately upon termination.

     If we  experience  a change  of  control  (as  defined  in Mr.  Buchalter's
employment agreement) and we terminate Mr. Buchalter's  employment without cause
or he terminates his employment for good reason within the period  commencing 90
days  before  such  change of control  and ending two years  after the change of
control,  Mr.  Buchalter  will be  entitled to (i) a cash  payment  equal to any
unpaid  base  salary  through  the date of  termination  plus any  earned  bonus
relating  to the  preceding  fiscal  year  that  remains  unpaid  on the date of
termination plus (ii) a lump sum cash payment equal to six times his annual base
salary plus a pro rata portion of his target bonus for the period  worked during
the fiscal year in which the termination occurs. In addition,  we will reimburse
Mr.  Buchalter  for any medical  and dental  coverage  available  to him and his
family for a period of up to 18 months  commencing  on the date of  termination.
Further,  upon a change of control  any of Mr.  Buchalter's  options to purchase
Common Stock and shares of restricted stock described above that have not vested
immediately  prior to the effective  date of the change of control shall vest at
such time.

     If any payments or  compensation  received by Mr.  Buchalter in  connection
with a change of control are subject to an excise tax under  Section 4999 of the
Internal  Revenue Code, we will be obligated to make additional  payments to Mr.
Buchalter equal to any such tax liability he may incur.

     Mr.  Buchalter's   employment   agreement  requires  him  to  maintain  the
confidentiality of our proprietary  information during the term of his agreement
and  thereafter.  Mr.  Buchalter is precluded  from competing with us during the

                                       15



term of his  employment  agreement  and for two years  after his  employment  is
terminated  (one  year  if  the  termination  occurs  pursuant  to a  notice  of
nonrenewal from us).

Craig A. Tooman

     In January  2005,  we entered into an  employment  agreement  with Craig A.
Tooman,  pursuant to which Mr. Tooman was appointed our Executive Vice President
Strategic  Planning and Corporate  Communications.  In June 2005,  Mr.  Tooman's
employment  agreement  was amended in  connection  with his  appointment  to the
position of Executive Vice President, Finance and Chief Financial Officer, while
retaining his duties and responsibilities as Executive Vice President, Strategic
Planning and Corporate  Communications.  The employment  agreement,  as amended,
will be  effective  until June 10,  2008,  subject to  automatic  renewal for an
additional twenty-four months.

     The amended  agreement  provides for a base salary of $365,000 per year and
participation  in Enzon's bonus plan for  management.  Under the bonus plan, Mr.
Tooman will be eligible to receive an annual  performance-based cash bonus in an
amount  between  zero and  82.5% of base  salary,  based  on  individual  and/or
corporate  factors to be  established  and  determined by the Board of Directors
each year. The annual target bonus is equal to 50% of Mr.  Tooman's base salary.
Within five days of the commencement of Mr. Tooman's  employment,  he received a
sign-on cash bonus in the amount of $125,000.

     Pursuant to the agreement,  Mr. Tooman was granted an option under our 2001
Incentive  Stock Plan to purchase  125,000  shares of our Common  Stock at a per
share exercise price of $13.08 (the last reported sale price of our common stock
on  January  5,  2005,  the date of  grant).  These  options  vested  and became
exercisable in April 2005 in connection  with the  acceleration  of vesting,  in
April 2005, of all out of the money options to purchase  shares of the Company's
Common Stock. Mr. Tooman also received 25,000 shares of restricted Common Stock,
7,500 of which shares will vest on each of the third and fourth anniversaries of
the date of  grant  and the  remaining  10,000  shares  will  vest on the  fifth
anniversary of the date of grant,  provided Mr. Tooman  remains  employed by the
Company on each such date. In connection  with Mr.  Tooman's  appointment to the
position of Executive Vice President Finance and Chief Financial Officer, he was
granted  an  option to  purchase  50,000  shares of Common  Stock at a per share
exercise  price of $5.73 per share (the last  reported  sale price of our common
stock on June 10,  2005,  the date of  grant).  The  option  vested  and  became
exercisable in June 2005 in connection with the acceleration of vesting, in June
2005, of all options held by Company officers.

     In the event Mr. Tooman's  employment is terminated by us without cause (as
defined in the employment agreement) or terminated by Mr. Tooman for good reason
(as defined in the employment  agreement),  Mr. Tooman will be entitled to (i) a
cash  payment  equal to any unpaid base salary  through the date of  termination
plus any earned bonus relating to the preceding  fiscal year that remains unpaid
on the date of  termination;  (ii) a cash payment  equal to one year of his base
salary  plus a cash  payment  equal to the target  bonus  which  would have been
payable for the fiscal year which  commences  immediately  following the date of
his  termination  and (iii) a cash  payment  equal to a pro rata  portion of his
target  bonus for the  fiscal  year  during  which the  termination  occurs.  In
addition,  we will  reimburse  Mr.  Tooman for any medical  and dental  coverage
available  to him and his family for a period of up to 18 months  commencing  on
the  date of  termination,  and all  options  and  shares  of  restricted  stock
described  above  that  have not  vested  at the time of  termination  will vest
immediately upon termination.

     If we experience a change of control (as defined in Mr. Tooman's employment
agreement)  and  we  terminate  Mr.  Tooman's  employment  without  cause  or he
terminates his  employment for good reason within the period  commencing 90 days
before  such  change in control and ending one year after the change of control,
Mr.  Tooman  will be  entitled  to (i) a cash  payment  equal to any unpaid base
salary  through the date of  termination  plus any earned bonus  relating to the
preceding  fiscal year that remains  unpaid on the date of  termination;  (ii) a
cash payment  equal to two times the sum of his base salary and target bonus for
the fiscal year in which the  termination  occurs and (iii) a cash payment equal
to a pro rata  portion of his target  bonus for the fiscal year during which the
termination  occurs.  In addition,  we will reimburse Mr. Tooman for any medical
and  dental  coverage  available  to him and his family for a period of up to 18
months commencing on the date of termination.  Further, upon a change of control
any of Mr.  Tooman's  options to purchase  Common Stock and shares of restricted
Common  Stock that have been  granted to him,  but not yet vested,  prior to the
effective date of the change of control shall vest at such time.

                                       16


     Mr.   Tooman's   employment   agreement   requires   him  to  maintain  the
confidentiality of our proprietary  information during the term of his agreement
and  thereafter.  Mr. Tooman is precluded from competing with us during the term
of his employment agreement and for one year after his employment is terminated.

Paul S. Davit

     In May 2004,  we entered into an amended and restated  severance  agreement
with Mr. Davit, then the Company's Senior Vice-President,  Human Resources,  the
initial term of which  expired on December 31, 2004,  with an automatic  renewal
for an  additional  twelve  months in January of each year,  unless the  Company
provides   notice  of  non-renewal  by  September  30  of  the  preceding  year.
Notwithstanding  such  notice by the  Company  not to extend,  in the event that
there  occurs,  during the term, a change in control (as defined in Mr.  Davit's
agreement),  the agreement  shall then continue in effect for a period of twelve
months beyond the date of such change of control.

     In the event Mr.  Davit's  employment is terminated by us without cause (as
defined in Mr. Davit's  agreement),  or by Mr. Davit for good reason (as defined
in Mr.  Davit's  agreement)  Mr.  Davit will be entitled  to: (i) a cash payment
equal to his annual base salary through the date of termination, and (ii) a cash
payment  equal to the target  bonus  which  would be payable for the fiscal year
during which such termination  occurs.  If we experience a change of control and
we  terminate  Mr.  Davit's  employment  without  cause  or  he  terminates  his
employment  for good  reason  within the period  commencing  90 days before such
change of control  and ending one year after the change of  control,  Mr.  Davit
will be  entitled  to (i) a cash  payment  equal to one and one half  times  his
annual  base  salary,  (ii) a cash  payment  equal to one and one half times the
target  bonus  which  would  be  payable  for  the  fiscal  year in  which  such
termination  occurs,  (iii)  reimbursement  for any medical and dental  coverage
available  to Mr.  Davit and any family  member  for a period of up to  eighteen
months commencing on the date of termination, (iv) all options to acquire shares
of the  Company  shall fully vest prior to the  effective  date of the change in
control, and any options not exercised prior to the effective date of the change
in control  shall  terminate  as of the  effective  date,  and (v) all shares of
restricted stock and/or restricted stock units will fully vest.

     Upon entering into this agreement,  Mr. Davit's change of control agreement
that had previously been in effect was terminated.

Ralph del Campo

     In May 2004,  we entered into an amended and restated  severance  agreement
with Mr. del Campo, then the Company's Senior  Vice-President,  Operations,  the
initial term of which  expired on December 31, 2004,  with an automatic  renewal
for an  additional  twelve  months in January of each year,  unless the  Company
provides   notice  of  non-renewal  by  September  30  of  the  preceding  year.
Notwithstanding  such  notice by the  Company  not to extend,  in the event that
there  occurs,  during  the term,  a change in  control  (as  defined in Mr. del
Campo's agreement),  the agreement shall then continue in effect for a period of
twelve months beyond the date of such change of control.

     In the event Mr. del Campo's  employment  is terminated by us without cause
(as defined in Mr. del Campo's  agreement),  or by Mr. del Campo for good reason
(as defined in Mr. del Campo's agreement) Mr. del Campo will be entitled to: (i)
a cash payment equal to his annual base salary through the date of  termination,
and (ii) a cash payment equal to the target bonus which would be payable for the
fiscal year during which such termination  occurs.  If we experience a change of
control  and we  terminate  Mr.  del  Campo's  employment  without  cause  or he
terminates his  employment for good reason within the period  commencing 90 days
before  such  change of control and ending one year after the change of control,
Mr. del Campo will be entitled to (i) a cash  payment  equal to one and one half
times his annual  base  salary,  (ii) a cash  payment  equal to one and one half
times the target  bonus which would be payable for the fiscal year in which such
termination  occurs  (iii)  reimbursement  for any medical  and dental  coverage
available to Mr. del Campo and any family  member for a period of up to eighteen
months commencing on the date of termination, (iv) all options to acquire shares
of the  Company  shall fully vest prior to the  effective  date of the change in
control, and any options not exercised prior to the effective date of the change
in control  shall  terminate  as of the  effective  date,  and (v) all shares of
restricted stock and/or restricted stock units will fully vest.

     Upon  entering  into this  agreement,  Mr.  del  Campo's  change of control
agreement that had previously been in effect was terminated.

                                       17


Ivan D. Horak, M.D.

     In September  2005,  we entered into an employment  agreement  with Ivan D.
Horak,  pursuant to which Dr. Horak was appointed our Executive  Vice  President
for  Research and  Development  and Chief  Scientific  Officer.  The  employment
agreement  will be  effective  until  September  2, 2009,  subject to  automatic
renewal for an additional twenty-four months.

     The  agreement  provides  for a  base  salary  of  $425,000  per  year  and
participation  in Enzon's bonus plan for  management.  Under the bonus plan, Dr.
Horak will be eligible to receive an annual  performance-based  cash bonus in an
amount  between  zero and  82.5% of base  salary,  based  on  individual  and/or
corporate  factors to be  established  and  determined by the Board of Directors
each year.  The annual target bonus is equal to 50% of Dr.  Horak's base salary.
Within five days of the  commencement of Dr. Horak's  employment,  he received a
sign-on cash bonus in the amount of $100,000.

     Pursuant to the  agreement,  Dr. Horak was granted an option under our 2001
Incentive  Stock Plan to purchase  200,000  shares of our Common  Stock at a per
share  exercise price of $7.14 (the last reported sale price of our common stock
on September 2, 2005,  the date of grant).  One-quarter of the options will vest
on each of the first four  anniversaries  of the grant.  Dr. Horak also received
50,000  shares of restricted  Common Stock,  15,000 of which shares will vest on
each  of the  third  and  fourth  anniversaries  of the  date of  grant  and the
remaining 20,000 shares will vest on the fifth anniversary of the date of grant,
provided Dr. Horak remains  employed as our Executive  Vice  President and Chief
Scientific Officer on each such date.

     In the event Dr.  Horak's  employment is terminated by us without cause (as
defined in the employment  agreement) or terminated by Dr. Horak for good reason
(as defined in the  employment  agreement),  Dr. Horak will be entitled to (i) a
cash  payment  equal to any unpaid base salary  through the date of  termination
plus any earned bonus relating to the preceding  fiscal year that remains unpaid
on the date of  termination;  (ii) a cash payment  equal to one year of his base
salary  plus a cash  payment  equal to the target  bonus  which  would have been
payable for the fiscal year which  commences  immediately  following the date of
his  termination  and (iii) a cash  payment  equal to a pro rata  portion of his
target  bonus for the  fiscal  year  during  which the  termination  occurs.  In
addition,  we will  reimburse  Dr.  Horak for any  medical  and dental  coverage
available  to him and his family for a period of up to 18 months  commencing  on
the  date of  termination,  and all  options  and  shares  of  restricted  stock
described  above  that  have not  vested  at the time of  termination  will vest
immediately upon termination.

     If we  experience  a  change  of  control  (as  defined  in the  employment
agreement)  and  we  terminate  Dr.  Horak's  employment  without  cause  or  he
terminates  his  employment  for  good  reason  (as  defined  in the  employment
agreement)  within the period  commencing  90 days before such change in control
and ending one year after the change of control,  Dr.  Horak will be entitled to
(i) a cash  payment  equal  to any  unpaid  base  salary  through  the  date  of
termination  plus any earned bonus  relating to the  preceding  fiscal year that
remains  unpaid on the date of  termination;  (ii) a cash  payment  equal to two
times the sum of his base  salary and target  bonus for the fiscal year in which
the  termination  occurs and (iii) a cash payment equal to a pro rata portion of
his target bonus for the fiscal year during  which the  termination  occurs.  In
addition,  we will  reimburse  Dr.  Horak for any  medical  and dental  coverage
available  to him and his family for a period of up to 18 months  commencing  on
the date of  termination.  Further,  upon a change of control any of Dr. Horak's
options to purchase Common Stock and shares of restricted Common Stock that have
been  granted to him,  but not yet vested,  prior to the  effective  date of the
change of control shall vest at such time.

     Dr.   Horak's   employment   agreement   requires   him  to  maintain   the
confidentiality of our proprietary  information during the term of his agreement
and thereafter. Dr. Horak is precluded from competing with us during the term of
his employment agreement and for one year after his employment is terminated.

Kenneth J. Zuerblis

     In  April  2005,  we  entered  into a  separation  agreement  with  Kenneth
Zuerblis.  Under the separation agreement,  Mr. Zuerblis voluntarily resigned as
Executive Vice  President,  Chief  Financial  Officer  effective April 21, 2005.
Pursuant to the Separation Agreement, Mr. Zuerblis received a cash payment equal
to his annual  base salary of  $320,000,  a cash  payment  equal to the pro rata
amount of his annual target bonus for the fiscal year 2005 (which was 50% of his
base salary) or $133,000,  and a cash payment  equal to his annual  target bonus

                                       18



for fiscal year 2006 or $160,000.  All options to acquire  shares in the Company
held  by  Mr.  Zuerblis  as of the  separation  date  vested  and  shall  remain
exercisable  after such date in accordance  with the terms of the relevant plans
and  granting  instruments  (to the  extent  any  provision  of  this  agreement
conflicts  with any provision of any stock option plan or agreement  between the
Company and Mr. Zuerblis,  the provisions of the Separation Agreement shall take
precedence).  In addition,  the period of time he has to exercise certain of his
options  was  extended  to 18 months;  the  vesting of some of his  options  and
restricted  stock were  accelerated;  and he will be reimbursed  for his medical
insurance premiums for up to 36 months.

Dr. Ulrich Grau

     In November 2004, we entered into a Separation Agreement with Dr. Grau. Dr.
Grau  voluntarily  resigned as Executive  Vice  President  and Chief  Scientific
Officer  effective  March 31, 2005.  Pursuant to the Separation  Agreement,  Dr.
Grau's  received  a cash  payment  equal to nine  months  of his base  salary or
$334,000  as well as a cash  payment of 90% his annual  target  bonus for fiscal
year 2005 (50% of base salary) payable in August 2005 of $200,250.

     At the time of Dr.  Grau's  resignation,  none of the shares of  restricted
stock or restricted  stock units granted had vested.  At that time, all unvested
shares of restricted  Common Stock and all unvested  options to purchase  Common
Stock were  canceled.  All options to purchase  Common Stock  granted  under the
Company's  Non-Qualified  Stock  Plan that had  vested by his  resignation  date
remained outstanding and exercisable until October 2005. All options to purchase
Common  Stock under the  Company's  Incentive  Stock Plan that had vested by his
resignation date shall remain outstanding and exercisable until March 2006.

     Dr. Grau's separation  agreement  requires him to comply with a non-compete
covenant of up to two years with respect to certain technologies and compounds.

Share Ownership Guidelines for Senior Management

     In July 2005, the Board of Directors  approved share  ownership  guidelines
for  our  senior  management.  These  guidelines  are  applicable  to the  Chief
Executive Officer,  Executive Officers and other Vice President level employees.
Under  the  share  ownership  guidelines,   members  of  senior  management  are
encouraged to acquire and maintain share holdings in the Company's  Common Stock
in amounts expressed as a multiple of base salary.  The guidelines provide for a
four-year window within which the share ownership level is to be achieved. These
ownership   guidelines  are  designed  to  further  align  executive  ownership,
long-term  strategic thinking and compensation  programs to Company  performance
and the interests of its stockholders.

         The following multiples of base salary apply:

          o three times base salary for the Chief Executive Officer;

          o two times base salary for Executive Officers; and

          o two times base salary for other Vice President level employees.


         The following will be counted in determining share ownership:

          o shares purchased on the open market;

          o shares owned jointly with or separately by spouse and/or children;

          o shares held by the individual in the Company's 401(k) plan;

          o shares obtained through stock option exercise;

          o restricted stock or restricted stock units; and

          o vested and "in the money" unexercised  options,  provided that these
          shares may not exceed 50% of the requirement total.

                                       19


Executive Deferred Compensation Plan

     The Executive  Deferred  Compensation  Plan (the "Plan")  provides a select
group of  management  or highly  compensated  employees  of the Company with the
opportunity to defer the receipt of certain cash compensation. Effective January
1,  2005,  the Plan  was  amended  and  restated  to  comply  with the  deferred
compensation  provisions  in the American  Jobs  Creation  Act of 2004,  and the
restated  Plan  applies to all  deferrals  which  relate  entirely  to  services
performed  on or before  December 31, 2004 (i.e.,  with respect to  compensation
that was earned and vested as of December 31, 2004) and  deferrals  which relate
all or in part to services performed on or after January 1, 2005.

     The  obligations of the Company under the Plan (the "Deferred  Compensation
Obligations")  shall be that of an unfunded and unsecured promise of the Company
to  pay  money  in  the  future  to   participating   eligible   employees  (the
"Participants") in accordance with the terms of the Plan from the general assets
of the Company, and will rank pari passu with other unsecured and unsubordinated
indebtedness of the Company from time to time outstanding.

     Each  Participant may elect to defer under the Plan all or a portion of his
or her base salary and/or annual  incentive  compensation  that may otherwise be
payable in a calendar year. In addition,  the committee  administering  the Plan
may, in its sole  discretion,  award  non-elective  deferred  compensation  to a
Participant.  Any  credit of  non-elective  deferred  compensation  will vest in
accordance  with  the  schedule   determined  by  the  committee  and  shall  be
distributed in a manner consistent with the election last made by the particular
Participant.

     A Participant's  compensation  deferrals are credited to the  Participant's
bookkeeping account  ("Account")  maintained under the Plan. A Participant shall
allocate his or her Account among the deemed investment  options available under
the Plan from time to time. Amounts credited to Participants'  Accounts for each
year are adjusted for earnings or losses based on the investment options elected
by the Participant. The Company is not obligated to actually invest any deferred
amounts in those investment options. Each Participant's Account is credited on a
daily basis with a deemed rate of interest and/or  earnings or losses  depending
upon the investment performance of the deemed investment option.

     The  Participant  may generally elect the time and manner of payment of the
Deferred Compensation Obligations.  At the election of the Participant,  payment
of the  Deferred  Compensation  Obligations  may  be  made  in a lump  sum or in
substantially equal annual installments (subject to a maximum of ten (10) annual
installments).  The time for payment elected by the Participant  shall be a date
certain at the time of election or the date of the Participant's separation from
service,  provided that such  specified date shall actually occur on or prior to
the  Participant's  separation from service,  disability or death or a change in
control of the  Company.  In the event of a change in control of the  Company in
accordance  with the terms of the Plan,  payments  will be made in the form of a
lump sum.

     Neither  a  Participant,  nor any  other  person,  shall  have any right to
commute,  sell,  assign,  transfer,  pledge,  anticipate,  mortgage or otherwise
encumber, transfer,  hypothecate or convey any amounts payable under the Plan in
advance of the actual receipt of such amounts.

     The Deferred  Compensation  Obligations  are not subject to redemption,  in
whole  or in  part,  prior  to the  individual  payment  dates  selected  by the
Participants,  except that  Participants  may  withdraw  all or a portion of the
value of their Plan accounts under certain  specified  circumstances and certain
mandatory lump sum  distributions may be made. The Company reserves the right to
amend or  terminate  the Plan at any time,  provided  that,  except as otherwise
provided in the Plan, no amendment  shall decrease the benefits to a Participant
on compensation  deferred prior to the date of the amendment without the consent
of the Participant.

             SECTION 16(a) BENEFICIAL OWNERSHIP REPORTING COMPLIANCE

     Ownership of and  transactions  in the Company's  Common Stock by executive
officers and directors of the Company and owners of 10% or more of the Company's
outstanding  Common  Stock are  required to be reported  to the  Securities  and
Exchange  Commission pursuant to Section 16(a) of the Securities Exchange Act of
1934,  as amended.  Based  solely on the  Company's  review of such  reports and
written  representations  from certain reporting  persons,  during the six-month
transition  period ended  December  31,  2005,  all such reports were filed in a

                                       20



timely manner except as follows:  Messrs. Ando, Classon, LeBuhn, Micati, Renfro,
Salisbury and Dr. Dixon were late in filing Form 4s relating to restricted stock
units  granted  to each of them on July 1, 2005.  The Form 4s were  subsequently
filed on September 8, 2005.

         REPORT OF THE COMPENSATION COMMITTEE OF THE BOARD OF DIRECTORS

     During the fiscal  year ended June 30,  2005 and the  six-month  transition
period  ended  December  31, 2005,  the  Compensation  Committee of the Board of
Directors  consisted of at least three  non-employee  directors  all of whom are
independent  under  Rule  4200(a)(15)  of  the  NASD  Listing   Standards.   The
Compensation  Committee  determines  all  compensation  paid or  awarded  to the
Company's  executive  officers,  including the Named  Executive  Officers in the
Summary Compensation Table.

Compensation Philosophy

     The  philosophy  of our  compensation  programs is to enhance the Company's
performance  and  stockholder  value by aligning the financial  interests of the
Company's  senior  managers  with those of its  stockholders,  while keeping the
overall compensation package competitive.  The compensation package for officers
includes a number of  components.  The package is  designed to align  individual
compensation with the short-term and long-term performance of the Company and is
based on the following principles:

     o    Pay for the  achievement  of business  and  strategic  objectives,  as
          measured by the Company's financial and operating performance, as well
          as individual strategic, management and development goals.

     o    Pay  competitively,  with compensation set at levels that will attract
          and retain key employees.  The Company regularly reviews  compensation
          surveys  of  companies  in the  biopharmaceutical  industry  and  sets
          compensation levels based on the results of these reviews.

     o    Align compensation with the interests of stockholders through equity.

     The compensation  package for each of the Named Executive  Officers as well
as other officers who are members of the Company's  executive  staff consists of
four elements:  (1) base salary,  (2) annual  performance-based  incentive,  (3)
stock  incentive  programs,  and  (4)  various  other  benefits.  More  specific
information on each of these elements follows.

Base Salary

     The  Compensation  Committee  aims to set base  salaries at levels that are
competitive with those paid to senior executives with comparable qualifications,
experience and  responsibilities  at other companies in the  pharmaceutical  and
biotechnology  industries,  including a selected subset of companies included in
the Nasdaq  Biotechnology Index line of the stock performance graph that appears
in this  proxy  statement.  The  Compensation  Committee  believes  that this is
necessary  to attract  and  retain the  executive  talent  required  to lead the
Company,  since the Company  competes  with a large  number of  companies in the
biopharmaceutical  industry,   including  large  pharmaceutical  companies,  for
executive  talent.  Salaries  are  reviewed  annually  and  in  connection  with
promotions.  Industry,  peer group and national survey results are considered in
making salary  determinations  to align the  Company's pay practices  with other
companies in the  pharmaceutical  and biotechnology  industries.  In addition to
survey  results,  individual  job  performance  is also  considered  in  setting
salaries. The Chief Executive Officer conducts performance reviews of members of
executive management and makes recommendations to the Compensation  Committee on
salary,  including salary  increases,  based on his judgment of the individual's
performance.   The   Compensation   Committee   reviews  these   recommendations
independently and approves, with any modifications it considers appropriate, the
annual salary and salary increases.

     In connection with the Company's  change in fiscal year end from June 30 to
December 31, the Compensation  Committee  reviewed base salaries  following both
the fiscal year ended June 30, 2005 and the  six-month  transition  period ended
December 31, 2005, and effected salary increases at each time.

                                       21


Annual Performance Based Incentive Compensation

     The Company maintains an incentive program that provides an opportunity for
officers and employees to earn an incentive  based upon the  performance of both
the  Company and the  individual  (the  "Performance  Incentive  Program").  The
incentive  potential is stated as a percentage of the  officer's and  employee's
base salary and varies by position.  Financial and individual  performance goals
are set at the  start of the  fiscal  year and are  based on  business  criteria
specified in this program.  Actual  incentives  are calculated at the end of the
fiscal year based on goal  performance.  All executive  management  had the same
Company goals for the periods covered by this report. Other goals and weightings
for each participant varied,  depending on the participant's  position and areas
of responsibility and the participant's effect on the Company's performance.

     In connection with the Company's  change in fiscal year end from June 30 to
December  31,  the  Compensation  Committee  calculated  performance  incentives
following both the fiscal year ended June 30, 2005 and the six-month  transition
period  ended  December  31,  2005,  and  the  Company  paid  those  performance
incentives at each time.

Stock Incentive Programs

     The Compensation  Committee  believes that stock incentive programs such as
stock options  directly  link the amounts  earned by officers with the amount of
appreciation   realized  by  the  Company's   stockholders.   Restricted  stock,
restricted  stock  units and stock  options  also serve as a critical  retention
incentive.  Stock incentive programs have always been viewed as a major means to
attract and retain highly qualified executives and key personnel and have always
been a major component of the  compensation  package,  consistent with practices
throughout the pharmaceutical and biotechnology industries.  The Company's stock
incentive  programs are structured to encourage key employees to continue in the
employ of the  Company and  motivate  performance  that will meet the  long-term
expectations  of  stockholders.  In  determining  the  size  of  any  option  or
restricted stock or restricted stock unit award ("Incentive Stock Grants"),  the
Compensation Committee considers the individual's past performance and potential
and the position held by the individual.

     The Compensation  Committee  generally  considers and makes incentive stock
grants to officers and all other  employees once a year.  Incentive Stock Grants
may also be granted at other times during the year in connection with promotions
or for new hires or as special performance  awards.  Option grants to members of
executive  management  are made under the Stock  Option  Plans with the exercise
price equal to the last reported sale price of the Company's Common Stock on the
date of grant and expire up to ten years after the date of the grant. Vesting on
most  incentive  stock grants  occurs over a four to five year period,  which is
designed to encourage retention.

Other Benefits

     Executive  staff members  participate  in various  medical,  dental,  life,
disability  and  benefit  programs  that are  generally  made  available  to all
salaried employees.

CEO Compensation

     The  compensation  of Mr.  Buchalter,  the  Company's  President  and Chief
Executive Officer,  was initially  established by the full Board of Directors in
connection  with his  appointment  as President and Chief  Executive  Officer in
December  2004.  In  establishing   his   compensation,   the  Board  took  into
consideration  Mr.  Buchalter's  extensive prior experience and credentials as a
chief executive officer and senior executive in the pharmaceutical  industry, as
well as Mr. Buchalter's qualifications to address the challenges facing Enzon at
that  time and the  limited  market of  candidates  possessing  those  necessary
qualifications.  The Board  reviewed and considered  the  compensation  of chief
executive  officers at comparable  companies and also received  guidance from an
executive  search firm engaged by the Company in connection with the recruitment
of a chief executive  officer based on such firm's  knowledge of the competitive
marketplace for chief executive officers and the relative  compensation of chief
executive  officers  at  comparable  companies.  The Board  determined  that Mr.
Buchalter's  compensation,   as  so  established,   was  commensurate  with  his
experience  and   credentials   and  reasonable   relative  to  the  competitive
marketplace for chief executive officers.


                                       22


     For the fiscal year ended June 30, 2005 and the six-month transition period
ended  December 31,  2005,  Mr.  Buchalter  was awarded  performance  bonuses in
accordance with his employment  agreement  (including a guaranteed minimum bonus
for the  fiscal  year  ended  June  30,  2005)  and  based  on the  Compensation
Committee's   evaluation  of  his  individual   performance  and  the  Company's
performance during each of those periods.

                                           THE COMPENSATION COMMITTEE
                                           Goran A. Ando, Chairman
                                           Rolf A. Classon
                                           Victor P. Micati


                                       23



                 CERTAIN RELATIONSHIPS AND RELATED TRANSACTIONS

     In addition to the  agreements  described  in the section  "Employment  and
Separation   Agreements"   above,   the  Company   entered  into  the  following
relationships:

     Craig A. Tooman  received  benefits in connection  with his  appointment as
Executive Vice President,  Strategic Planning and Corporate  Communications.  We
are party to a relocation  services  agreement with an  independent  third party
(the "Provider") pursuant to which, in accordance with our relocation policy, in
March 2005 the Provider  purchased Mr.  Tooman's  residence at a purchase  price
calculated using the average of two independent  appraisals of the property (the
"Purchase  Price").  Mr.  Tooman  was  paid  $324,388  in  connection  with  the
transaction which amount represented Mr. Tooman's equity in the property.  Under
the  relocation  services  agreement,  we reimbursed the Provider for the equity
component  of  the  Purchase  Price  and  the  related  closing  costs.  We  are
responsible  for a $2,500  service fee to the  Provider as well as carrying  and
sales costs that the Provider incurs in connection with selling the property. On
October 26, 2005,  the property was sold for less than the Purchase  Price,  and
the Company  reimbursed the Provider for $162,689,  which includes the amount of
the deficiency, closing and carrying costs.

     Jeffrey H. Buchalter  received  relocation  benefits in connection with his
appointment  as Chief  Executive  Officer.  The Company is  administering  these
benefits through a relocation services agreement with an independent third party
(the  "Provider")  pursuant to which,  in  accordance  with  Enzon's  relocation
policy, in September 2005 the Provider purchased Mr. Buchalter's  residence at a
purchase price calculated using the average of two independent appraisals of the
property (the "Purchase  Price").  Mr. Buchalter was paid $412,384 in connection
with the  transaction  which amount  represented Mr.  Buchalter's  equity in the
property.  Under the relocation services  agreement,  the Company reimbursed the
Provider for the equity  component of the Purchase Price and the related closing
costs.  The Company is  responsible  for a $2,500 service fee to the Provider as
well as carrying and sales costs that the  Provider  incurs in  connection  with
selling the property.  The Company will receive the net proceeds from the resale
of the property,  and, if the property is sold for less than the Purchase Price,
it is responsible for reimbursing the Provider for the amount of the deficiency.

                                       24



                  REPORT OF THE FINANCE AND AUDIT COMMITTEE OF
                             THE BOARD OF DIRECTORS

     The  Company's  Finance and Audit  Committee  consists of four  independent
members of the Board of Directors as defined in Rule 4200(a)(15) of the National
Association of Securities  Dealers'  listing  standards.  The Board of Directors
adopted a written  charter for the Finance and Audit  Committee  on June 7, 2000
and the  Finance  and Audit  Committee  reviewed  and  revised  such  charter on
September  11, 2002 and on March 15, 2006.  The charter of the Finance and Audit
Committee as amended is attached to this Proxy Statement as Appendix A.

     The primary  purpose of the Finance  and Audit  Committee  is to assist the
Board of Directors in its oversight responsibilities by monitoring the integrity
of the  Company's  financial  reporting  process and financial  statements,  the
systems  of  internal  controls  and  controls  over  financial  reporting,  the
compliance  by the  Company  with  legal and  regulatory  requirements,  and the
performance and independence of the Company's independent  auditors.  Management
of the Company is responsible for the preparation, presentation and integrity of
the  Company's  financial  statements  and for the  maintenance  of policies and
internal controls  necessary to assure compliance with accounting  standards and
applicable laws and  regulations.  The independent  auditors are responsible for
planning  and  conducting  an  audit  of the  Company's  consolidated  financial
statements,   reviews  of  the  Company's  quarterly  financial  statements  and
performing such other procedures  required by applicable  Statements of Auditing
Standards or requested by the  Committee.  The  independent  auditors  audit the
annual  financial  statements  prepared by management,  express an opinion as to
whether those financial statements present fairly, in all material respects, the
financial  position,  results of  operations  and cash  flows of the  company in
conformity with accounting  principles  generally  accepted in the United States
and discuss with us their  independence  and any other matters they are required
to discuss  with us or that they  believe  should be raised  with us. We oversee
these processes,  although we must rely on the information provided to us and on
the representations made by management and the independent auditors.

     The Finance and Audit  Committee  has  reviewed and  discussed  the audited
financial  statements  for the fiscal year ended June 30, 2005 and the six-month
transition  period ended  December 31, 2005 with  management.  Furthermore,  the
Finance  and  Audit  Committee  has  discussed  with the  Company's  independent
auditors,  KPMG LLP,  the  matters  required to be  discussed  by  Statement  of
Auditing  Standards No. 61. Also,  the Finance and Audit  Committee has received
the written disclosures and letter from KPMG required by Independence  Standards
Board  Standard  No.  1  and  has  discussed  with  KPMG  such  auditing  firm's
independence.  Based on these  reviews  and  discussions  the  Finance and Audit
Committee  recommended that the audited financial  statements be included in the
Company's Annual Report on Form 10-K for the fiscal year ended June 30, 2005 and
the Company's Transition Report on Form 10-K for the six-month transition period
ended  December 31, 2005,  the last fiscal  periods for filing such reports with
the U.S. Securities and Exchange Commission.


                                   THE FINANCE AND AUDIT COMMITTEE
                                   Robert C. Salisbury, Chairman
                                   Rolf A. Classon
                                   Robert LeBuhn
                                   Phillip M. Renfro

                                       25



                      STOCKHOLDER RETURN PERFORMANCE GRAPH

     The graph below summarizes the total cumulative  return  experienced by the
Company's stockholders from June 29, 2001 through December 31, 2005, compared to
the Nasdaq  National  Market-US  Index and the Company's  Peer Group index,  the
Nasdaq  Biotechnology  Index. The changes for the periods shown in the graph and
table  below are based on the  assumption  that  $100 had been  invested  in the
Company's  Common Stock,  including the  reinvestment of dividends,  and in each
index below on June 29, 2001.

  Comparison of 54 Month Cumulative Total Return Among Enzon Pharmaceuticals,
             Inc., The Nasdaq National Market Index and Peer Groups




                         
                [GRAPHIC OMITTED]                    Cumulative Total Return
                                  -------- --------- --------- --------- --------- ---------
                                   6/01      6/02      6/03      6/04      6/05     12/05

    ENZON PHARMACEUTICALS, INC.    100.00     40.19     20.08     20.42     10.37     11.84
    NASDAQ STOCK MARKET (U.S.)     100.00     70.23     78.15     98.60     99.30    107.39
    NASDAQ BIOTECHNOLOGY           100.00     49.74     49.07     57.05     62.21     76.71


                                       26


                          SECURITY OWNERSHIP OF CERTAIN
                        BENEFICIAL OWNERS AND MANAGEMENT

     The  following  table sets forth certain  information  as of April 14, 2006
concerning  stock  ownership  of  all  persons  known  by  the  Company  to  own
beneficially 5% or more of the outstanding shares of the Company's voting stock,
each director,  each current executive officer named in the Summary Compensation
Table and all  directors  and  current  executive  officers  of the Company as a
group:


                         
                                                                        Amount and Nature
                                                                          of Beneficial        Percentage of Voting
    Name and Address of Beneficial Owner or Identity of Group(1)           Ownership(2)        Stock Outstanding(3)
--------------------------------------------------------------          ----------------        --------------------

Jeffrey H. Buchalter                                                      1,632,078(4)                 3.6%
Dr. Goran A. Ando                                                            35,522(5)                  *
Rolf A. Classon                                                              95,598(6)                  *
Dr. Rosina B. Dixon                                                         179,607(7)                  *
Robert LeBuhn                                                               126,134(8)                  *
Victor P. Micati                                                             35,522(9)                  *
Phillip M. Renfro                                                            20,632(10)                 *
Robert C. Salisbury                                                           8,667(11)                 *
Paul S. Davit                                                               196,800(12)                 *
Ralph del Campo                                                             210,101(13)                 *
Dr. Ivan D. Horak                                                             8,500                     *
Craig A. Tooman                                                             226,000(14)                 *

Pequot Capital Management,  Inc., 500 Nyala Farm Road,  Westport,  CT     5,068,000(15)                11.6
06880

Group  comprised of Barclay Global  Investors,  N.A.,  Barclay Global     3,743,463(16)                8.6
Fund Advisors,  Barclays Global  Investors,  Ltd, and Barclays Global
Investors  Japan  Trust  and  Banking  Company  Limited,  45  Fremont
Street, San Francisco, CA  94105

Group  comprised of OrbiMed  Advisors  LLC,  OrbiMed  Capital LLC and     2,740,500(17)                6.3
Samual D. Isaly,  767 Third Avenue, New York, NY 10017

All Executive Officers and Directors as a group (12 persons)              2,775,161(18)                6.0


      * Less than one percent

(1)  The address of all current executive officers and directors listed above is
     in the care of the Company.

(2)  All shares  listed are Common  Stock.  Except as discussed  below,  none of
     these  shares are  subject to rights to acquire  beneficial  ownership,  as
     specified in Rule 13d-3(d)(1) under the Securities Exchange Act of 1934, as
     amended,  and the beneficial  owner has sole voting and  investment  power,
     subject to community property laws where applicable.

(3)  Based  on  43,746,855   shares  of  Common  Stock  which  were  issued  and
     outstanding as of April 14, 2006. Each share of Common Stock is entitled to
     one vote. The percentage of voting stock  outstanding for each  stockholder
     is  calculated  by dividing (i) the number of shares of Common Stock deemed
     to be  beneficially  held by such  stockholder as of April 14, 2006 by (ii)
     the sum of (A) the number of shares of Common Stock outstanding as of April
     14,  2006 plus (B) the  number of shares  of  Common  Stock  issuable  upon
     exercise of options held by such  stockholder  which were exercisable as of
     April 14, 2006 or which will become  exercisable within 60 days after April
     14, 2006.

                                       27


(4)  Includes (i) 1,611,000  shares subject to options which were exercisable as
     of April 14,  2006 or which will  become  exercisable  within 60 days after
     April 14, 2006 and (ii) 1,078 shares of restricted stock which vested.

(5)  Includes (i) 35,000 shares subject to options which were  exercisable as of
     April 14, 2006 or which will become  exercisable within 60 days after April
     14, 2006 and (ii) 522 shares of restricted stock which vested.

(6)  Includes (i) 85,000 shares subject to options which were  exercisable as of
     April 14,  2006 or will become  exercisable  within 60 days after April 14,
     2006 and (ii) 663 shares of restricted stock which vested.

(7)  Includes (i) 125,000 shares subject to options which were exercisable as of
     April 14, 2006 or which will become  exercisable within 60 days after April
     14,  2006,  (ii) 663 shares of  restricted  stock that  vested and (ii) 500
     shares  held  by  Dr.  Dixon's  husband.  Dr.  Dixon  disclaims  beneficial
     ownership as to shares held by her husband.

(8)  Includes (i) 85,000 shares subject to options which were  exercisable as of
     April 14, 2006 or which will become  exercisable within 60 days after April
     14, 2006 and (ii) 663 shares of restricted stock that vested.

(9)  Includes (i) 35,000 shares subject to options which were  exercisable as of
     April 14, 2006 or which will become  exercisable within 60 days after April
     14, 2006 and (ii) 522 shares of restricted stock which vested.

(10) Includes (i) 20,000 shares subject to options which were  exercisable as of
     April 14, 2006 or which will become  exercisable within 60 days after April
     14, 2006 and (ii) 632 shares of restricted stock which vested.

(11) Includes 6,667 shares subject to options which were exercisable as of April
     14, 2006.

(12) Includes (i) 190,000 shares subject to options which were exercisable as of
     April 14, 2006 or which will become  exercisable within 60 days after April
     14, 2006. (ii) 300 shares held through Mr. Davit's 401(k) account.

(13) Includes  210,000  shares  subject to options which were  exercisable as of
     April 14, 2006 or which will become  exercisable within 60 days after April
     14, 2006. (ii) 101 shares held through Mr. del Campo's 401(k) account.

(14)Includes  225,000  shares  subject to options which were  exercisable  as of
     April 14, 2006 or which will become  exercisable within 60 days after April
     14, 2006.

(15) Information concerning stock ownership was obtained from Schedule 13G filed
     with the Securities and Exchange Commission on February 14, 2006.

(16) Information concerning stock ownership was obtained from Schedule 13G filed
     with the Securities and Exchange Commission on January 26, 2006.

(17) Information concerning stock ownership was obtained from Schedule 13G filed
     with the Securities and Exchange Commission on February 2, 2006.

(18) Includes all shares  owned  beneficially  by the  directors  and  executive
     officers named in the Summary Compensation Table.

                                       28



     PROPOSAL NO. 2 - APPROVAL OF AMENDMENT TO THE 2001 INCENTIVE STOCK PLAN

General

     The  Board  believes  that  in  order  to  attract  and  retain   qualified
executives,  employees  and board  members it is essential to offer  significant
potential rewards based upon the Company's success through the issuance of stock
options,  restricted  stock  grants  and  other  stock-based  awards.  The  2001
Incentive  Stock Plan,  which was approved by our  stockholders in December 2001
and amended with stockholder  approval in December 2003,  provides for the grant
of  stock  options  and  other  stock-based   awards  to  employees,   officers,
consultants,  independent  contractors and directors providing services to Enzon
and its  subsidiaries  as determined by the Board of Directors or by a committee
of  directors  designated  by the  Board of  Directors  to  administer  the 2001
Incentive  Stock Plan. The amendment to the Plan increasing the shares of Common
Stock  authorized for issuance  presented  herein to the  stockholders for their
approval is designed to assist the Company in  accomplishing  this goal.  Of the
6,000,000  shares  currently  authorized  for  issuance  under  the  2001  Stock
Incentive Plan and the 7,900,000 shares currently  authorized for issuance under
the Company's Non-Qualified Stock Option Plan, at April 6, 2006,  ______________
shares in the aggregate remained available for future grants.

     Since October 2003, the number of persons eligible to participate under the
2001 Incentive Stock Plan has remained relatively constant, creating a continued
need for our stock  options and  restricted  stock  grants.  The current  shares
available  under the 2001 Incentive  Stock Plan have declined to a point whereby
we will  soon not be able to offer  future  awards  without  additional  shares.
Therefore,  an  amendment  to the 2001  Incentive  Stock  Plan  proposed  herein
provides  for the  increase  in the number of shares of common  stock  available
thereunder by 4,000,000 to an aggregate of 10,000,000 shares.

     In  order  to  facilitate  approval  of  Proposal  No.  2 and  assuage  any
stockholder concerns regarding the number of options, restricted stock awards or
restricted  stock units awards the Company intends to grant in a given year, the
Board of Directors of the Company commits to the Company's stockholders that for
the next  three  fiscal  years it will not  grant in a fiscal  year a number  of
shares  subject to options,  restricted  stock awards or restricted  stock units
awards to employees (whether under the 1987 Non-Qualified Stock Option Plan, the
2001 Incentive Stock Plan or other plans not approved by  stockholders)  greater
than  5.57% of the  number of  shares of the  Company's  Common  Stock  that the
Company  believes will be  outstanding  at the end of the same fiscal year.  For
purposes of calculating the number of shares granted in a year, restricted stock
awards or  restricted  stock units  awards will count as  equivalent  to (i) 1.5
option shares if the Company's  annual stock price  volatility is 53% or higher,
(ii) two option shares if the Company's annual stock price volatility is between
25% and 52%, and (iii) four option  shares if the  Company's  annual stock price
volatility is less than 25%.

     The following  summary of the 2001 Incentive  Stock Plan, as it is proposed
to be amended, is qualified in its entirety by reference to the full text of the
2001 Incentive Stock Plan, as it is proposed to be amended, which is attached to
this Proxy Statement as Appendix B.

     On December  17,  2002 and  December  20,  2004,  Enzon filed  registration
statements  on Form S-8  covering  the  securities  to be issued  under the 2001
Incentive  Stock Plan. If this  Proposal No. 2 is approved by the  stockholders,
Enzon intends to file a Form S-8 covering the additional securities to be issued
under the 2001 Incentive Stock Plan.

Summary of the 2001 Incentive Stock Plan

     Purpose.  The  purpose of the 2001  Incentive  Stock Plan is to promote the
interests  of Enzon and its  stockholders  by  aiding  Enzon in  attracting  and
retaining  employees,   officers,   consultants,   independent  contractors  and
non-employee  directors  capable of contributing to the future success of Enzon,
to offer such persons incentives to put forth maximum efforts for the success of
Enzon's  business  and to  afford  such  persons  an  opportunity  to  acquire a
proprietary  interest in Enzon. The Compensation  Committee  believes that stock
based compensation directly links the amount earned by employees with the amount
of appreciation realized by the Company's stockholders.

     Administration. The Compensation Committee has been designated by the Board
of Directors to  administer  the 2001  Incentive  Stock Plan.  The  Compensation
Committee  will have full  power and  authority  to  determine  when and to whom

                                       29



awards will be granted and the type, amount, form of payment and other terms and
conditions of each award,  consistent  with the provisions of the 2001 Incentive
Stock Plan.  Subject to the  provisions of the 2001  Incentive  Stock Plan,  the
Compensation  Committee  may  amend or waive  the  terms  and  conditions  of an
outstanding  award.  The  Compensation  Committee  will have full  authority  to
interpret the 2001 Incentive  Stock Plan and establish rules and regulations for
the administration of the 2001 Incentive Stock Plan. The Compensation  Committee
may delegate to one or more  directors or officers,  or a committee of directors
or  officers,  or  the  Board  of  Directors  may  exercise,   the  Compensation
Committee's powers and duties under the 2001 Incentive Stock Plan.

     Eligibility. Any employee, officer,  consultant,  independent contractor or
director providing services to Enzon and its subsidiaries will be eligible to be
selected  by the  Compensation  Committee  to  receive  awards  under  the  2001
Incentive  Stock  Plan.  As of April 6, 2006,  there were  approximately  ______
persons  who  were  eligible  as a  class  to be  selected  by the  Compensation
Committee to receive awards under the 2001 Incentive Stock Plan.

     Number of Shares. As it is proposed to be amended, the 2001 Incentive Stock
Plan would provide for the issuance of up to 10,000,000  shares of Common Stock,
subject to  adjustment in the event of a stock  dividend or other  distribution,
recapitalization,  stock split,  reverse  stock split,  reorganization,  merger,
consolidation,  split-up, spin-off,  combination,  issuance of warrants or other
rights to purchase  shares of Common Stock or other  securities  of Enzon to all
holders of Common  Stock pro rata  whether as a dividend or  otherwise  or other
similar  changes in the corporate  structure or stock of Enzon.  Currently,  the
maximum number of shares  available for issuance under the 2001 Incentive  Stock
Plan is  6,000,000.  Shares of Common  Stock  subject  to awards  under the 2001
Incentive  Stock Plan which are not used or are forfeited  because the terms and
conditions  of the awards are not met, or because the award  terminates  without
delivery of any shares, may again be used for awards (other than Incentive Stock
Options) under the 2001 Incentive  Stock Plan.  Shares of Common Stock used by a
participant  as full or partial  payment to Enzon of the purchase price relating
to an award, or in connection with the satisfaction of tax obligations  relating
to an award,  will also be available for awards under the 2001  Incentive  Stock
Plan. The shares of Common Stock issued under the 2001 Incentive  Stock Plan may
be  authorized  but  unissued  shares or shares  acquired  on the open market or
otherwise.  The last reported sale price of Enzon's  Common Stock as reported by
the Nasdaq  National  Market on April 6, 2006, was $____.  No participant may be
granted stock options and any other award, the value of which is based solely on
an increase in the price of the Common Stock,  of more than 1,000,000  shares in
the aggregate in any calendar year.

     Types of Awards and Certain Terms and Conditions.  The types of awards that
may be granted  under the 2001  Incentive  Stock Plan are stock  options,  stock
appreciation  rights,  restricted  stock,  restricted  stock units,  performance
awards,  dividend equivalents,  other stock grants, other stock-based awards and
any combination  thereof. The 2001 Incentive Stock Plan provides that all awards
are to be evidenced by written agreements containing the terms and conditions of
the  awards.  The  Compensation  Committee  may not  amend  or  discontinue  any
outstanding  award without the consent of the holder of the award if such action
would adversely affect the rights of the holder.  Except as provided by the 2001
Incentive Stock Plan,  awards (other than Other Stock Grants,  as defined in the
2001  Incentive  Stock Plan) will not be  transferable  other than (1) to family
members (as determined by the Compensation Committee), (2) by will or (3) by the
laws of descent and distribution. During the lifetime of a participant, an award
may be  exercised  only by the  participant  to whom such  award is granted or a
permitted  assignee.  Awards may be granted for no cash consideration or for any
cash or other  consideration as may be determined by the Compensation  Committee
or required by law. Generally, the consideration to be received by Enzon for the
grant of awards under the 2001  Incentive  Stock Plan will be the  participant's
past, present or expected future contributions to Enzon.

     Stock Options.  Incentive stock options meeting the requirements of Section
422 of the Internal Revenue Code ("Incentive  Stock Options") and  non-qualified
options may be granted under the 2001  Incentive  Stock Plan.  The  Compensation
Committee will determine the exercise price of any option granted under the 2001
Incentive Stock Plan,  provided  however that the exercise price of options will
not be less than the fair market value of the Common Stock on the date of grant.
The term of the option will be determined  by the  Compensation  Committee,  but
shall in no event  exceed  10 years  from  the  date on which  such  option  was
granted.  Stock options will be  exercisable  at such times as the  Compensation
Committee  determines.  Stock  options may be  exercised  in whole or in part by
payment  in  full  of  the  exercise  price  in  cash  or  such  other  form  of

                                       30



consideration as the Compensation  Committee may specify,  including delivery of
shares of Common Stock having a fair market value on the date of exercise  equal
to the exercise price. The Compensation  Committee may grant reload options when
a participant  pays the exercise  price or tax  withholding  upon exercise of an
option by using  shares of Common  Stock.  The reload  option  would be for that
number of shares surrendered or withheld.

     Stock  Appreciation  Rights.  The  Compensation  Committee  may grant stock
appreciation  rights exercisable at such times and subject to such conditions or
restrictions  as the  Compensation  Committee may determine.  Upon exercise of a
stock  appreciation  right by a holder,  the holder is  entitled  to receive the
excess of the fair  market  value of one  share of  Common  Stock on the date of
exercise  over the fair market value of one share of Common Stock on the date of
grant.  The payment may be made in cash or shares of Common Stock, or other form
of payment, as determined by the Compensation Committee.

     Restricted Stock and Restricted Stock Units. The Compensation Committee may
grant shares of  restricted  stock and  restricted  stock units  subject to such
restrictions and terms and conditions as the Compensation  Committee may impose.
Shares of restricted  stock granted under the 2001 Incentive  Stock Plan will be
evidenced  by  stock  certificates,  which  will  be  held  by  Enzon,  and  the
Compensation Committee may, in its discretion,  grant voting and dividend rights
with  respect to such  shares.  No shares of stock will be issued at the time of
award of restricted stock units. A restricted stock unit will have a value equal
to the fair market  value of one share of Common  Stock and may  include,  if so
determined by the  Compensation  Committee,  the value of any dividends or other
rights  or  property  received  by  stockholders  after the date of grant of the
restricted  stock unit.  The  Compensation  Committee has the right to waive any
vesting  requirements  or to  accelerate  the  vesting  of  restricted  stock or
restricted  stock units.  The maximum  number of shares of restricted  stock and
restricted  stock units that the  Compensation  Committee  is permitted to grant
under  the 2001  Incentive  Stock  Plan is 50% of the  total  number  of  shares
available  for issuance  pursuant to all awards under the 2001  Incentive  Stock
Plan.

     Dividend  Equivalents.   The  Compensation  Committee  may  grant  dividend
equivalents under which a holder shall be entitled to receive payments, in cash,
Common Stock,  other  securities or other property,  equivalent to the amount of
cash  dividend paid by Enzon to holders of Common Stock with respect to a number
of  shares  of  Common  Stock  determined  by the  Compensation  Committee.  The
Compensation  Committee will determine the terms and conditions of such dividend
equivalents.

     Performance  Awards. A performance award will entitle the holder to receive
payments upon the achievement of specified  performance  goals. The Compensation
Committee  will  determine  the terms and  conditions  of a  performance  award,
including the performance  goals to be achieved  during the performance  period,
the length of the  performance  period and the amount and form of payment of the
performance  award.  A performance  award may be denominated or payable in cash,
shares of stock or other securities, or other awards or property.

     Other Stock Grants.  The Compensation  Committee may otherwise grant shares
of Common Stock as are deemed by the  Compensation  Committee  to be  consistent
with the purpose of the 2001 Incentive  Stock Plan. The  Compensation  Committee
will determine the terms and conditions of such other stock grant.

     Other Stock-Based Awards. The Compensation Committee may grant other awards
denominated  or payable in,  valued by reference  to, or  otherwise  based on or
related to shares of Common Stock as are deemed by the Compensation Committee to
be  consistent   with  the  purpose  of  the  2001  Incentive  Stock  Plan.  The
Compensation  Committee  will  determine the terms and  conditions of such other
stock-based  award,  including the consideration to be paid for shares of Common
Stock or other securities  delivered  pursuant to a purchase right granted under
such award.  The value of such  consideration  shall be the fair market value of
such shares or other securities as of the date such purchase right is granted.

     Duration,   Termination  and  Amendment.  Unless  earlier  discontinued  or
terminated  by the Board of  Directors,  no awards may be granted under the 2001
Incentive  Stock Plan ten years after the effective  date of the 2001  Incentive
Stock Plan.  The 2001  Incentive  Stock Plan  permits the Board of  Directors to
amend, alter, suspend, discontinue or terminate the 2001 Incentive Stock Plan at
any time,  except  that prior  stockholder  approval  will be  required  for any
amendment to the 2001 Incentive  Stock Plan that requires  stockholder  approval
under the rules or  regulations  of the Nasdaq  Stock  Market or any  securities
exchange that are applicable to Enzon.

                                       31


Federal Tax Consequences

     The following is a summary of the principal federal income tax consequences
generally applicable to awards under the 2001 Incentive Stock Plan.

     Stock  Options  and Stock  Appreciation  Rights.  The grant of an option or
stock appreciation right is not expected to result in any taxable income for the
recipient.  The  holder of an  Incentive  Stock  Option  generally  will have no
taxable  income upon  exercising  the  Incentive  Stock  Option  (except  that a
liability may arise pursuant to the alternative minimum tax), and Enzon will not
be entitled to a tax deduction when an Incentive Stock Option is exercised. Upon
exercising a non-qualified  stock option,  the optionee must recognize  ordinary
income  equal to the  excess of the fair  market  value of the  shares of Common
Stock acquired on the date of exercise over the exercise  price,  and Enzon will
be entitled at that time to a tax deduction for the same amount. Upon exercising
a stock appreciation  right, the amount of any cash received and the fair market
value on the exercise date of any shares of Common Stock received are taxable to
the recipient as ordinary income and deductible by Enzon. The tax consequence to
an optionee upon a  disposition  of shares  acquired  through the exercise of an
option will depend on how long the shares have been held and whether such shares
were  acquired by  exercising  an  Incentive  Stock  Option or by  exercising  a
non-qualified stock option or stock appreciation right. Generally, there will be
no tax  consequence to Enzon in connection  with  disposition of shares acquired
under an option,  except that Enzon may be entitled  to a tax  deduction  in the
case of a disposition of shares  acquired under an Incentive Stock Option before
the applicable  Incentive Stock Option holding periods set forth in the Internal
Revenue Code have been satisfied.

     Other Awards. With respect to other awards granted under the 2001 Incentive
Stock Plan that are  payable  either in cash or shares of Common  Stock that are
either transferable or not subject to substantial risk of forfeiture, the holder
of such an award will recognize  ordinary  income at the time of receipt of such
award, in an amount equal to the excess of (a) the cash or the fair market value
of the  shares  of  Common  Stock  received  (determined  as of the date of such
receipt)  over (b) the amount (if any) paid for such  shares of Common  Stock by
the holder of the award,  and Enzon will be entitled at that time to a deduction
for the same  amount.  With  respect  to an award  that is  payable in shares of
Common  Stock  that  are  restricted  as  to  transferability   and  subject  to
substantial  risk of forfeiture,  unless a special  election is made pursuant to
the  Internal  Revenue  Code,  the holder of the award must  recognize  ordinary
income at the time the  restrictions  lapse  equal to the excess of (i) the fair
market value of the shares of Common Stock received  (determined as of the first
time the  shares  become  transferable  or not  subject to  substantial  risk of
forfeiture,  whichever  occurs  earlier)  over (ii) the amount (if any) paid for
such shares of Common  Stock by the  holder,  and Enzon will be entitled at that
time to a tax deduction for the same amount.

     Satisfaction of Tax  Obligations.  Under the 2001 Incentive Stock Plan, the
Compensation  Committee may permit participants  receiving or exercising awards,
subject to the discretion of the Compensation  Committee and upon such terms and
conditions as it may impose,  to surrender shares of Common Stock (either shares
received upon the receipt or exercise of the award or shares previously owned by
the  participant)  to Enzon to satisfy  federal  and state tax  obligations.  In
addition,  pursuant to its general authority outside of the 2001 Incentive Stock
Plan, the Compensation  Committee may grant,  subject to its discretion,  a cash
bonus to a  participant  in order to  provide  funds to pay all or a portion  of
federal and state taxes due as a result of the  exercise or receipt of (or lapse
of  restrictions  relating  to) an award.  The  amount of any such bonus will be
taxable  to  the  participant  as  ordinary  income,   and  Enzon  will  have  a
corresponding  deduction  equal  to such  amount  (subject  to the  usual  rules
concerning reasonable compensation).

     Section  162(m)  Requirements.  The  2001  Incentive  Stock  Plan  has been
designed to meet the requirements of Section 162(m) of the Internal Revenue Code
regarding the deductibility of executive compensation and the Company strives to
maximize the deductibility of tax consequences where reasonable.  However, there
are occasions when it is not feasible to take all steps which are necessary, and
in this instance non-deductibility could occur in certain instances.


                                       32


     The following table sets forth information  regarding  outstanding  options
and shares reserved for future issuance under our equity  compensation  plans as
of December 31, 2005 (in thousands, except per share data):


                         
                                                                                                    Remaining
Plan Category                                                  To be issued     Exercise price      available
----------------------------------------------                 --------------  -----------------  ---------------
                                                                   (a)              (b)               (c)

Equity compensation plans approved by security holders            6,114            $14.17            2,318
Equity compensation plans not approved by security holders            -              -                   -
                                                               -------------  -----------------  ---------------

Total                                                             6,114            $14.17            2,318
                                                               =============  =================  ===============


(a)  Number of securities to be issued upon exercise of outstanding options.

(b)  Weighted-average exercise price of outstanding options.

(c)  Number of securities  remaining  available for future issuance under equity
     compensation plans of which 817,000 were reserved for issuance upon vesting
     of outstanding restricted stock unit awards.




     As of April 14, 2006,  ___________  shares had been issued upon exercise of
options  granted  under the Plan,  options to  purchase  __________  shares were
outstanding  and  __________  shares  remained  available for future grant.  The
following  table sets forth  information  with respect to the stock  options and
restricted stock granted to the Named Executive Officers,  all current executive
officers as a group, all current and former  non-employee  directors as a group,
and all employees and  consultants  (including all current  officers who are not
executive officers):


                         
                                                                               Number of Shares of
                                                                              Restricted Stock and
                                                                               Shares Underlying            Weighted
                                                                             Options Granted Under         Average
                                                                               the 2001 Incentive       Exercise Price
                                   Name                                            Stock Plan             per Share
-------------------------------------------------------------------------    ---------------------     ---------------

Jeffrey H. Buchalter                                                                    1,263,234              $11.42
Paul S. Davit                                                                             167,500               10.69
Ralph del Campo                                                                           267,500               13.57
Dr. Ivan D. Horak                                                                          92,500                7.06
Craig A. Tooman                                                                           225,000               11.04
Executive Officers as a Group (5 persons)                                               2,015,734               11.40
Non-Employee Directors as a Group (12 persons)                                          1,212,462               19.27
All Employees Other than Executive Officers as a Group (347 persons)                    3,421,000               14.16
                                                                             ---------------------     ---------------
Total                                                                                   6,649,196              $14.26



     The Board of  Directors  recommends  a vote FOR the  amendment  to the 2001
Incentive  Stock  Plan as  proposed  (Proposal  No. 2 on the  proxy  card).  The
affirmative  vote of a majority of the shares  represented in person or by proxy
at the  meeting  and  entitled  to vote on the  proposal  will be  required  for
approval.


                                       33


      PROPOSAL NO. 3 - AMENDMENT AND RESTATEMENT OF THE COMPANY'S RESTATED
  CERTIFICATE OF INCORPORATION TO INCREASE THE NUMBER OF AUTHORIZED SHARES OF
                                  COMMON STOCK

     Our current Restated  Certificate of Incorporation  authorizes the issuance
of 90,000,000  shares of common stock and 3,000,000  shares of preferred  stock.
The Board has proposed an amendment and restatement of the Restated  Certificate
of  Incorporation  in the form  attached as Appendix C to increase the number of
authorized  shares of common stock from 90,000,000 to 170,000,000.  The Restated
Certificate of  Incorporation  will remain the same in all other  respects.  The
stockholders  are being asked to approve the proposed  amendment  in  accordance
with Delaware law.

     As of March 31, 2006, there were approximately  43,786,786 shares of common
stock  issued and  outstanding.  This number does not include  8,432,000  shares
reserved for issuance as of March 31, 2006  pursuant to  outstanding  options to
purchase shares of Common Stock and outstanding  restricted stock units, as well
as 5,551,085  shares  reserved for issuance as of March 31, 2006 upon conversion
of our 4 1/2% Convertible Subordinated Notes due 2008.

     The  following  is the text of Article  THIRD  Section 4(A) of the Restated
Certificate of Incorporation, as proposed to be amended:

     "(A) The total  number of shares of  capital  stock  which the  Corporation
shall have authority to issue is 173,000,000 shares, of which 170,000,000 shares
shall be Common Stock,  par value $0.01 per share, and 3,000,000 shares shall be
Preferred Stock, par value $0.01 per share."

     The purpose of the  proposed  amendment is to allow us to have a sufficient
number of shares of authorized and unissued  common stock which can be issued in
connection  with such corporate  purposes as may be considered  advisable by the
Board.  Having such  shares  available  for  issuance in the future will give us
greater flexibility and will allow such shares to be issued as determined by the
Board  without the expense and delay of a special  stockholders'  meeting.  Such
stock could be used, for example,  for  acquisitions,  for stock splits or stock
dividends,  for  our  employee  benefit  plans,  or in  connection  with  equity
financings.

     The increase in authorized  common stock will not have any immediate effect
on the  rights  of  existing  stockholders.  However,  the  Board  will have the
authority to issue authorized common stock without requiring future  stockholder
approval of such  issuances,  except as may be required  by the  Certificate  of
Incorporation  and  applicable  law and  regulations.  To the  extent  that  the
additional  authorized  shares are issued in the future,  they will decrease the
existing stockholders' percentage equity ownership and, depending upon the price
at which they are issued as compared to the price paid by existing  stockholders
for their shares, could be dilutive to our existing stockholders. The holders of
common  stock  have no  preemptive  rights  to  subscribe  for or  purchase  any
additional shares of common stock that may be issued in the future.

     The  increase in the  authorized  number of shares of common  stock and the
subsequent  issuance  of such  shares  could  have the  effect  of  delaying  or
preventing  a change in control of the  Company  without  further  action by the
stockholders.  Shares of authorized and unissued  common stock could (within the
limits imposed by applicable  law) be issued in one or more  transactions  which
would make a change in control of the Company more difficult, and therefore less
likely.  Any such issuance of additional stock could have the effect of diluting
the earnings per share and book value per share of outstanding  shares of common
stock, and such additional shares could be used to dilute the stock ownership or
voting rights of a person seeking to obtain control of the Company. The Board is
not aware of any attempt to take  control of the  Company and has not  presented
this proposal with the intention that the increase in the  authorized  shares of
common stock be used as a type of antitakeover device.

     The Board of Directors  recommends a vote FOR the amendment and restatement
of the Restated  Certificate of Incorporation as proposed (Proposal No. 3 on the
proxy card).  The affirmative  vote of a majority of the  outstanding  shares of
common stock of the Company entitled to vote at the meeting will be required for
approval of Proposal No. 3.


                                       34


                    PROPOSAL NO. 4 - RATIFICATION OF AUDITORS

     The  Finance and Audit  Committee  of the Board of  Directors,  pursuant to
authority granted by the Board of Directors,  has approved the retention of KPMG
LLP  ("KPMG"),  independent  registered  public  accounting  firm,  to audit the
consolidated  financial  statements  of the  Company  for the fiscal year ending
December  31,  2006.  KPMG  served  as  auditor  of the  consolidated  financial
statements  of the Company for the fiscal years ended June 30, 2005,  2004,  and
2003  and  the   six-month   transition   period   ended   December   31,  2005.
Representatives  of KPMG are  expected  to be present at the Annual  Meeting and
will have the opportunity to make a statement  should they desire to do so. Such
representatives are also expected to be available to respond to questions.

Pre-Approval Policies and Procedures.

     The Audit  Committee  is required to  pre-approve  the audit and  non-audit
services  performed by the  independent  accountants in order to assure that the
provision of such services does not impair the  accountants'  independence.  The
Audit Committee  specifically  pre-approves  all audit fees, audit related fees,
tax service fees and all other fees. The Audit Committee has delegated authority
to the  Chair  of  the  Committee  to  approve  any  services  not  specifically
pre-approved by the Committee provided that disclosure of such services and fees
is made to the Audit  Committee at the next  scheduled  meeting  following  such
approval.

Audit Fees

     The following  table sets forth the aggregate fees billed to the Company by
KPMG for  professional  services  rendered for the six-month  transition  period
ended December 31, 2005 and for the fiscal years ending June 30, 2005 and 2004:


                                                                                                    
                                                                                        Year Ended June 30,
                                                     Six-Month               ----------------------------------------
                                              Transition Period Ended             2005                  2004
                                                 December 31, 2005
                                           ------------------------------    -----------------    ------------------
         Audit fees (1)                                         $926,000         $1,018,000              $210,000
         Audit related fees (2)                                        -             53,000                10,000
         Tax fees (3)                                                  -                                   93,000
                                           ------------------------------    -----------------    ------------------
            Total fees                                          $926,000         $1,071,000              $313,000
                                           ==============================    =================    ==================


     (1)  Includes  services  relating  to the audit of the annual  consolidated
          financial  statements,   review  of  quarterly  financial  statements,
          issuance  of  consents,  review  of  documents  filed  with  the  SEC,
          accounting consultations, and the audit of management effectiveness of
          internal controls over financial reporting.

     (2)  Includes services relating to the audit of employee benefit plans.

     (3)  Includes services for tax compliance and tax advisory services.

     The Finance and Audit Committee has considered whether the provision of all
other services by KPMG is compatible with  maintaining  KPMG's  independence and
concluded that KPMG is "independent".

     The Board of Directors  recommends a vote FOR ratification of the selection
of KPMG,  independent  registered public accountants,  to audit the consolidated
financial statements of the Company for the fiscal year ending December 31, 2006
(Proposal No. 4 on the Proxy Card).

                          ANNUAL REPORT TO STOCKHOLDERS

     The Company's  Annual  Report to  Stockholders,  including  its  Transition
Report on Form 10-K for the six-month transition period ended December 31, 2005,
accompanies this Proxy Statement.

                                       35


                             STOCKHOLDERS' PROPOSALS

     In  order  for a  stockholder  to have a  proposal  included  in the  proxy
statement for the 2007 annual  stockholders'  meeting,  the proposal must comply
with both the procedures  identified by Rule 14a-8 under the Securities Exchange
Act of 1934,  as amended (the  Exchange  Act") and be received in writing by the
Company's Secretary on or before 5:00 P.M. Eastern Standard Time on December 19,
2006.  Such a  proposal  will be  considered  at the 2007  annual  stockholders'
meeting.

     Article II Section 2.15 of the Company's  By-laws  requires a stockholder's
proposal  to be  delivered  to or mailed and  received by the  Secretary  of the
Company not later than 120 days prior to the 2007 annual  stockholders'  meeting
in order for a  stockholder's  proposal to be  considered  at such  meeting.  We
expect that the 2007 annual  stockholders  meeting will be held on May 17, 2007,
so any such proposal must be received by January 17, 2007. The Company's  Bylaws
further  require the  stockholder  to provide to the  Secretary  of the Company,
among other things,  the name and address of the stockholder who intends to make
the  nominations or propose the business,  the name and address of the person or
persons to be  nominated,  a  description  of the  business to be proposed and a
representation  that the  stockholder  is a  holder  of  record  of stock of the
Company entitled to vote at such meeting. The chairman of the meeting may refuse
to acknowledge  the nomination of any person or the proposal of any business not
made in compliance with the foregoing  procedure.  Rule 14a-8 under the Exchange
Act requires the stockholder to comply with the provisions of that rule in order
for the stockholder's  proposal to be included in the Company's proxy statement.
In order for a  stockholder's  proposal to be included  in the  Company's  proxy
statement for the 2007 annual meeting, Rule 14a-8 requires that such proposal be
received at the Company's principal executive offices not less than 120 calendar
days before the date of this proxy statement (or December 19, 2006).

     Any proposal  received  after January 17, 2007 will be considered  untimely
within Rule  14a-4(c)  under the Exchange Act and the persons named in the proxy
for such meeting may exercise their  discretionary  voting power with respect to
such proposal,  including  voting  against such proposal,  even though it is not
discussed in the proxy statement for such meeting.

                                     GENERAL

     The cost of soliciting proxies will be borne by the Company. In addition to
mailing,  proxies may be solicited by personal  interview  and  telephone and by
directors,  officers  and regular  employees  of the  Company,  without  special
compensation therefor. The Company expects to reimburse banks, brokers and other
persons for their reasonable  out-of-pocket expenses in handling proxy materials
for beneficial owners of the Company's Common Stock.

     Unless contrary instructions are indicated on the proxy card, all shares of
Common Stock represented by valid proxies received pursuant to this solicitation
(and not revoked  before  they are voted) will be voted FOR the  election of the
nominees for directors named herein and FOR Proposals No. 2, No. 3 and No. 4.

     Any proxy given pursuant to this  solicitation may be revoked by the person
giving it at any time before it is voted.  Proxies may be revoked by filing with
the Secretary of the Company  written notice of revocation  bearing a later date
than the proxy, by duly executing a subsequent proxy relating to the same shares
of Common  Stock or by  attending  the  Annual  Meeting  and  voting in  person.
Attendance at the Annual Meeting will not in and of itself constitute revocation
of a proxy  unless the  stockholder  votes his or her shares of Common  Stock in
person at the Annual Meeting.  Any notice revoking a proxy should be sent to the
Secretary of the Company,  Paul S. Davit,  at Enzon  Pharmaceuticals,  Inc., 685
Route 202/206, Bridgewater, New Jersey 08807.

     The Board of Directors knows of no business other than that set forth above
to be  transacted at the meeting,  but if other matters  requiring a vote of the
stockholders  arise,  the persons  designated as proxies will vote the shares of
Common Stock  represented  by the proxies in accordance  with their  judgment on
such matters. If a stockholder specifies a different choice on the proxy, his or
her shares of Common Stock will be voted in accordance with the specification so
made.

     Please complete,  sign and date the enclosed proxy card, which is revocable
as described herein, and mail it promptly in the enclosed postage-paid envelope.

                                       36


     IT IS IMPORTANT THAT PROXIES BE RETURNED PROMPTLY.  WE URGE YOU TO FILL IN,
SIGN AND RETURN THE  ACCOMPANYING  PROXY CARD, NO MATTER HOW LARGE OR SMALL YOUR
HOLDINGS MAY BE.

                                    By order of the Board of Directors,



                                    /s/ Paul S. Davit
                                    Paul S. Davit
                                    Corporate Secretary

Bridgewater, New Jersey
April __, 2006

                                       37


                                   APPENDIX A

                           ENZON PHARMACEUTICALS, INC.
                       FINANCE AND AUDIT COMMITTEE CHARTER

Purpose

The Finance and Audit Committee (the "Committee") of the Board of Directors (the
"Board") of Enzon Pharmaceuticals,  Inc. (the "Company"), is appointed to assist
the Board in its oversight responsibilities by monitoring:

     1.   the  integrity  of  the  Company's  financial  reporting  process  and
          financial statements;

     2.   the  systems  of  internal   controls  and  controls  over   financial
          reporting,

     3.   the compliance by the Company with legal and regulatory  requirements,
          and;

     4.   the  performance  and   independence  of  the  Company's   independent
          auditors.

Membership

The  Committee  shall be comprised of not less than three  members of the Board,
shall be  appointed by the Board for such terms as the Board may  determine  and
shall meet the  requirements  of applicable  Securities and Exchange  Commission
(the "SEC") and NASD  regulations and rules. The Board will designate a Chair of
the Committee. Members of the Committee shall be directors who:

     1.   Meet  the  applicable  SEC  and  NASD   independence   and  experience
          requirements,

     2.   Shall have the  ability to read and  understand  the  Company's  basic
          financial  statements  or shall at the time of  appointment  undertake
          training for that purpose. and;

     3.   At least  one  member  shall  be  designated  by the  Board as being a
          "financial expert" through having  demonstrated  accounting or related
          financial management expertise.

Charter

The Committee  shall  maintain a written  charter that is approved by the Board.
The charter will be reviewed and updated at least  annually.  The Committee will
report its  activities to the full Board on a regular basis  including an annual
assessment of Committee performance.

Meetings

The  Committee  will meet at least four times per year,  or more  frequently  as
circumstances  dictate.  The  Committee  shall  meet  regularly  with the  Chief
Financial  Officer,  the independent  auditors and the head of internal auditing
(if applicable) in private executive sessions.

Responsibilities

The function of the Committee is oversight.

Management of the Company is responsible for the  preparation,  presentation and
integrity of the  Company's  financial  statements  and for the  maintenance  of
policies and internal  controls  necessary to assure  compliance with accounting
standards and applicable laws and regulations.

The independent auditors are responsible for planning and conducting an audit of
the  Company's  consolidated  financial  statements,  reviews  of the  Company's
quarterly financial  statements and performing such other procedures required by
applicable Statements of Auditing Standards or requested by the Committee.

The Committee shall have the following duties and responsibilities:




Oversight of the Independent Auditors:

     1.   The   Committee   is  directly   responsible   for  the   appointment,
          compensation  and oversight of the work of the  independent  auditors,
          who shall report directly to the Committee.

     2.   Pre-approve, or adopt appropriate procedures to pre-approve, all audit
          and non-audit services to be provided by the independent auditors.

     3.   Review the audit scope and audit plan,

     4.   Obtain and review,  at least  annually,  a report which  describes the
          independent  auditors'  internal  compliance  procedures,  any  issues
          related to peer review or other quality  reviews of the auditors' firm
          and the independence of the auditors.

     5.   Obtain and review, at least annually,  a formal written statement from
          the independent  auditor  regarding all  relationships  that may exist
          between the  independent  auditor and the Company  consistent with the
          Independence Standards Board, Statement No. 1, regarding relationships
          and services, which may impact the objectivity and independence of the
          independent auditor.

     6.   The independent auditors shall inform the Committee of reasons for and
          the disposition of consultations  with their national office regarding
          the Company.

     7.   Set  hiring  policies  for  employees  or  former   employees  of  the
          independent auditors.

     8.   Resolve disagreements between management and the independent auditors.

Oversight of the Company's Internal Controls:

     9.   Discuss  the  adequacy  of  the  company's   internal   controls  with
          management and the independent  auditors  including  reports regarding
          significant  deficiencies  and  material  weaknesses  in the design or
          operation of internal  controls.  Review steps taken by  management to
          remediate significant deficiencies or material weaknesses.

     10.  Review and  discuss  with  management  and the  independent  auditors,
          management's  annual report on the Company's  internal  control system
          and  the  independent  auditors  attestation  regarding   management's
          report.

     11.  Review the Chief  Executive  Officer's and Chief  Financial  Officer's
          certifications filed in SEC forms 10K and 10Q.

     12.  Review and approve related party  transactions  disclosed in SEC forms
          10K and 10Q.

Oversight of the Financial Statements

     13.  Review  with  management  and the  independent  auditors  prior to the
          filing of Forms  10-K and 10-Q,  the annual  and  quarterly  financial
          statements  of the Company,  including:  (i) any  material  changes in
          accounting  principles  or practices  used in preparing  the financial
          statements  (ii)  disclosures   relating  to  internal  controls  over
          financial  reporting;  (iii) items  required by  Statement of Auditing
          Standards  61 as in  effect  at that  time in the  case of the  annual
          statements  and  Statement of Auditing  Standards  100 as in effect at
          that time in the case of the  quarterly  statements;  and (iv) meet to
          review  the  Company's   specific   disclosures  under   "Management's
          Discussion  and  Analysis  of  Financial  Conditions  and  Results  of
          Operations" included in the Forms 10-K or 10-Q.

     14.  Recommend to the Board,  approval of the  financial  statements  to be
          included in the annual report on Form 10-K.

     15.  Review  earnings  press  releases,  as well as Company  policies  with
          respect to earnings press releases, financial information and earnings
          guidance provided to analysts and rating agencies.

     16.  Review the role and operation of the Disclosure  Committee and meeting
          minutes.

Oversight of Compliance with Legal and Regulatory Requirements

     17.  Discuss  and  review  with  management,   company  counsel,   and  the
          independent   auditors  any  significant   issues  raised  by  counsel
          concerning  litigation,  contingencies  or  claims,  and any  material
          reports  or  inquiries   received  from   regulators  or  governmental
          agencies.  The  Committee  should  understand  how  such  matters  are
          reflected in the Company's financial statements.

     18.  Obtain,  review and evaluate  reports from  management with respect to
          the  Company's  policies  and  procedures  regarding  compliance  with
          applicable legal and regulatory  requirements,  and the Company's Code
          of Conduct and Corporate Values.



                                       2




Other Authority

     19.  Review  procedures  to  promote  and  protect  employee  reporting  of
          suspected  fraud or wrongdoing  relating to  accounting,  auditing and
          financial reporting including procedures for: (i) receiving, retaining
          and  addressing  complaints  received  relating to such matters;  (ii)
          enabling  employees to submit to the Committee,  on a confidential and
          anonymous  basis,  any concerns  regarding  such matters,  and;  (iii)
          protecting reporting employees from retaliation.

     20.  Provide  the report of the  Committee  as  required  by the SEC in the
          Company's annual proxy statement.

     21.  Inquire of management as to significant  financial  risks or exposures
          and evaluate steps taken to assess, minimize and manage such risks.

     22.  Provide input to the CEO on performance of the Chief Financial Officer
          and finance department and to the Compensation  Committee of the Board
          on performance of the Chief Financial Officer.

     23.  Conduct  or  authorize  investigations  into any  matters  within  the
          Committee's  scope of  responsibilities.  The Committee may retain (at
          the Company's expense) independent counsel,  accountants, or others to
          assist in the conduct of any investigation.

Internal Audit

     If an Internal  Audit  function is formed,  the  Committee  will review the
scope and staffing of the functions.  The head of the Internal Audit  department
will report  directly to the  Committee  and will review  plans and  findings of
internal audits and will meet in executive session with the Committee.




                                       3




                                   APPENDIX B

                           Enzon Pharmaceuticals, Inc.

                      2001 INCENTIVE STOCK PLAN AS AMENDED*

                           * As proposed to be amended

Section 1.          Purpose

     The purpose of the Plan is to promote the  interests of the Company and its
shareholders  by aiding  the  Company in  attracting  and  retaining  employees,
officers,  consultants,   independent  contractors  and  Non-Employee  Directors
capable of  contributing  to the future  success of the  Company,  to offer such
persons incentives to put forth maximum efforts for the success of the Company's
business  and to afford such  persons an  opportunity  to acquire a  proprietary
interest in the Company.

Section 2.          Definitions

     As used in the Plan, the following  terms shall have the meanings set forth
below:

1    "Affiliate" shall mean (i) any entity that,  directly or indirectly through
     one or more  intermediaries,  is  controlled  by the  Company  and (ii) any
     entity in which the Company has a significant equity interest, in each case
     as determined by the Committee.

2    "Award" shall mean any Option, Stock Appreciation Right,  Restricted Stock,
     Restricted Stock Unit, Performance Award, Dividend Equivalent,  Other Stock
     Grant or Other Stock-Based Award granted under the Plan.

3    "Award  Agreement"  shall mean any  written  agreement,  contract  or other
     instrument or document  evidencing  any Award granted under the Plan.  Each
     Award Agreement shall be subject to the applicable  terms and conditions of
     the Plan and any other  terms and  conditions  (not  inconsistent  with the
     Plan) determined by the Committee.

4    "Board" shall mean the Board of Directors of the Company.

5    "Code" shall mean the Internal  Revenue Code of 1986,  as amended from time
     to time, and any regulations promulgated thereunder.

6    "Committee" shall mean a committee of Directors  designated by the Board to
     administer the Plan. The Committee shall be comprised of not less than such
     number of Directors as shall be required to permit Awards granted under the
     Plan by the Committee to qualify  under Rule 16b-3,  and each member of the
     Committee  shall be a  "Non-Employee  Director"  within the meaning of Rule
     16b-3 and an "outside director" within the meaning of Section 162(m) of the
     Code. The Company expects to have the Plan  administered in accordance with
     the   requirements   for  the   award   of   "qualified   performance-based
     compensation" within the meaning of Section 162(m) of the Code.

7    "Company" shall mean Enzon  Pharmaceuticals,  Inc., a Delaware corporation,
     and any successor corporation.

8    "Director"  shall  mean a  member  of  the  Board,  including  Non-Employee
     Directors.

9    "Dividend  Equivalent"  shall mean any right  granted under Section 6(E) of
     the Plan.




10   "Eligible Person" shall mean any employee, officer, consultant, independent
     contractor or Director  (including  any  Non-Employee  Director)  providing
     services to the Company or any Affiliate  whom the Committee  determines to
     be an Eligible Person.

11   "Exchange Act" shall mean the Securities Exchange Act of 1934, as amended.

12   "Fair Market  Value" shall mean,  with respect to any property  (including,
     without limitation, any Shares or other securities),  the fair market value
     of such  property  determined  by such  methods or  procedures  as shall be
     established  from  time  to  time  by the  Committee.  Notwithstanding  the
     foregoing,  unless otherwise  determined by the Committee,  the Fair Market
     Value of a Share as of a given date shall be, if the Shares are then traded
     on the Nasdaq National Market, the last reported sale price of one Share as
     reported  on the  Nasdaq  National  Market on such  date or, if the  Nasdaq
     National  Market is not open for  trading on such date,  on the most recent
     preceding date when it is open for trading.

13   "Family  Members"  shall be  those  persons  related  to a  Participant  as
     determined by the Committee.

14   "Incentive  Stock Option" shall mean an option  granted under Section 6A of
     the Plan that is  intended to meet the  requirements  of Section 422 of the
     Code or any successor provision.

15   "Non-Employee  Director"  shall  have the  meaning  ascribed  in Rule 16b-3
     promulgated under the Exchange Act or any successor provision.

16   "Non-Qualified  Stock Option" shall mean an option granted under Section 6A
     of the Plan that is not intended to be an Incentive Stock Option.

17   "Option"  shall mean an  Incentive  Stock Option or a  Non-Qualified  Stock
     Option.

18   "Other Stock Grant" shall mean any right  granted  under  Section 6F of the
     Plan.

19   "Other  Stock-Based Award" shall mean any right granted under Section 6G of
     the Plan.

20   "Participant"  shall mean an Eligible  Person  designated  to be granted an
     Award under the Plan.

21   "Performance  Award" shall mean any right  granted  under Section 6D of the
     Plan.

22   "Person" shall mean any individual, corporation,  partnership,  association
     or trust.

23   "Plan" shall mean the Enzon  Pharmaceuticals,  Inc.  2001  Incentive  Stock
     Plan, as amended from time to time,  the  provisions of which are set forth
     herein.

24   "Plan Year" shall mean a consecutive  12-month period ending on December 31
     of each year.

25   "Reload  Option"  shall mean any Option  granted under Section 6A(5) of the
     Plan.

26   "Restricted  Stock" shall mean any Shares  granted  under Section 6C of the
     Plan.

27   "Restricted Stock Unit" shall mean any unit granted under Section 6C of the
     Plan  evidencing  the right to receive a Share (or a cash payment  equal to
     the Fair Market Value of a Share) at some future date.

28   "Rule  16b-3"  shall  mean Rule 16b-3  promulgated  by the  Securities  and
     Exchange  Commission  under the  Exchange  Act,  or any  successor  rule or
     regulation.

                                       2


29   "Share" or "Shares" shall mean shares of common stock,  $0.01 par value per
     share,  of the Company or such other  securities  or property as may become
     subject to Awards  pursuant to an  adjustment  made under Section 4C of the
     Plan.

30   "Stock Appreciation Right" shall mean any right granted under Section 6B of
     the Plan.

Section 3.          Administration

     A. Power and Authority of the Committee.  The Plan shall be administered by
the Committee.  Subject to the express  provisions of the Plan and to applicable
law,  the  Committee  shall have full  power and  authority  to:  (i)  designate
Participants;  (ii)  determine the type or types of Awards to be granted to each
Participant  under the Plan;  (iii) determine the number of Shares to be covered
by (or the method by which  payments,  or other rights are to be  calculated  in
connection  with) each Award;  (iv)  determine  the terms and  conditions of any
Award or Award  Agreement;  (v) amend the terms and  conditions  of any Award or
Award Agreement and accelerate the  exercisability  of any Award or the lapse of
restrictions  relating to any Award; (vi) determine whether,  to what extent and
under what  circumstances  Awards may be exercised in cash,  Shares,  promissory
notes, other securities,  other Awards or other property, or canceled, forfeited
or  suspended;   (vii)  determine  whether,   to  what  extent  and  under  what
circumstances  cash, Shares,  promissory notes, other securities,  other Awards,
other property and other amounts payable with respect to an Award under the Plan
shall be deferred either  automatically or at the election of the holder thereof
or the Committee; (viii) interpret and administer the Plan and any instrument or
agreement,  including an Award Agreement,  relating to the Plan; (ix) establish,
amend, suspend or waive such rules and regulations and appoint such agents as it
shall deem appropriate for the proper  administration  of the Plan; and (x) make
any other  determination  and take any other  action  that the  Committee  deems
necessary or desirable  for the  administration  of the Plan.  Unless  otherwise
expressly   provided   in   the   Plan,   all   designations,    determinations,
interpretations  and other  decisions  under or with  respect to the Plan or any
Award shall be within the sole  discretion of the Committee,  may be made at any
time and shall be final, conclusive and binding upon any Participant, any holder
or beneficiary of any Award and any employee of the Company or any Affiliate.

     B.  Delegation.  The Committee may delegate its powers and duties under the
Plan to one or more  Directors or officers of the Company,  or to a committee of
Directors or officers,  subject to such terms, conditions and limitations as the
Committee  may establish in its sole  discretion,  provided,  however,  that the
Committee  shall not  delegate  its powers  and  duties  under the Plan (i) with
regard to officers or directors of the Company or any  Affiliate who are subject
to Section 16 of the  Exchange  Act or (ii) in such a manner as would  cause the
Plan not to comply with the requirements of Section 162(m) of the Code.

     C.  Power and  Authority  of the  Board.  Notwithstanding  anything  to the
contrary  contained  herein,  the Board may,  at any time and from time to time,
without any further action of the  Committee,  exercise the powers and duties of
the Committee under the Plan.

Section 4.          Shares Available for Awards

     A. Shares Available. Subject to adjustment as provided in Section 4C of the
Plan,  the aggregate  number of Shares that may be issued under all Awards under
the Plan shall be  10,000,000;  provided  that, any Shares with respect to which
Awards may be issued, but are not issued,  under the Plan in any Plan Year shall
be carried  forward and shall be available to be covered by Awards issued in any
subsequent Plan Year in which Awards may be issued under the Plan.  Shares to be
issued under the Plan may be either  authorized  but  unissued  Shares or Shares
acquired  in the  open  market  or  otherwise.  Any  Shares  that  are used by a
Participant  as full or partial  payment to the  Company of the  purchase  price
relating to an Award, or in connection with the  satisfaction of tax obligations
relating to an Award,  shall again be available for granting  Awards (other than
Incentive  Stock Options) under the Plan. In addition,  if any Shares covered by
an Award or to which an Award relates are not purchased or are forfeited,  or if
an Award otherwise terminates without delivery of any Shares, then the number of


                                       3


Shares counted against the aggregate  number of Shares  available under the Plan
with respect to such Award, to the extent of any such forfeiture or termination,
shall again be available for granting Awards under the Plan. Notwithstanding the
foregoing,  the number of Shares available for granting  Incentive Stock Options
under the Plan shall not exceed  10,000,000  shares  subject  to  adjustment  as
provided in the Plan and subject to the  provisions of Section 422 or 424 of the
Code or any successor provision.

     B.  Accounting  for Awards.  For  purposes  of this  Section 4, if an Award
entitles the holder thereof to receive or purchase Shares,  the number of Shares
covered by such Award or to which  such  Award  relates  shall be counted on the
date of grant of such Award against the aggregate number of Shares available for
granting Awards under the Plan.

     C.  Adjustments.  In the event that the Committee  shall determine that any
dividend  or other  distribution  (whether  in the form of cash,  Shares,  other
securities  or other  property),  recapitalization,  stock split,  reverse stock
split, reorganization,  merger, consolidation,  split-up, spin-off, combination,
issuance of warrants or other rights to purchase  Shares or other  securities of
the  Company to all  holders of common  stock pro rata  whether as a dividend or
otherwise or other  similar  corporate  transaction  or event affects the Shares
such that an adjustment is  determined  by the  Committee to be  appropriate  in
order to prevent  dilution or enlargement of the benefits or potential  benefits
intended to be made available under the Plan, then the Committee  shall, in such
manner as it may deem equitable, adjust any or all of (i) the number and type of
Shares (or other  securities or other  property) that thereafter may be made the
subject of Awards,  (ii) the number and type of Shares (or other  securities  or
other property) subject to outstanding Awards and (iii) the purchase or exercise
price with respect to any Award;  provided,  however,  that the number of Shares
covered  by any Award or to which  such Award  relates  shall  always be a whole
number.

     D. Award  Limitations Under the Plan. No Eligible Person may be granted any
Award or  Awards  under the  Plan,  the value of which  Award or Awards is based
solely on an increase in the value of the Shares after the date of grant of such
Award or Awards,  for more than  1,000,000  Shares  (subject  to  adjustment  as
provided  for in Section  4(c) of the Plan),  in the  aggregate  in any calendar
year. The foregoing  annual  limitation  specifically  includes the grant of any
Award or Awards representing "qualified  performance-based  compensation" within
the meaning of Section 162(m) of the Code.

Section 5.          Eligibility.

     Any Eligible  Person shall be eligible to be designated a  Participant.  In
determining  which Eligible  Persons shall receive an Award and the terms of any
Award,  the Committee may take into account the nature of the services  rendered
by the respective Eligible Persons, their present and potential contributions to
the  success  of the  Company or such other  factors  as the  Committee,  in its
discretion,  shall deem relevant.  Notwithstanding  the foregoing,  an Incentive
Stock Option may only be granted to full or part-time  employees  (which term as
used herein includes,  without  limitation,  officers and Directors who are also
employees), and an Incentive Stock Option shall not be granted to an employee of
an Affiliate  unless such  Affiliate is also a "subsidiary  corporation"  of the
Company  within  the  meaning  of  Section  424(f) of the Code or any  successor
provision.

                                       4


Section 6.
  Awards

A.   Options.  The  Committee is hereby  authorized to grant Options to Eligible
     Persons with the following  terms and conditions  and with such  additional
     terms and  conditions not  inconsistent  with the provisions of the Plan as
     the Committee shall determine:

     1.   Exercise  Price.  The purchase  price per Share  purchasable  under an
          Option shall be determined by the Committee;  provided,  however, that
          such  purchase  price  shall not be less than 100% of the Fair  Market
          Value of a Share on the date of grant of such Option.

     2.   Option Term.  The term of each Option shall be fixed by the Committee,
          but,  shall in no event  exceed 10 years  from the date on which  such
          Option is granted.

     3.   Time and Method of Exercise. The Committee shall determine the time or
          times at which an Option may be  exercised in whole or in part and the
          method or methods by which, and the form or forms (including,  without
          limitation,  cash, Shares,  promissory notes, other securities,  other
          Awards or other property,  or any combination  thereof,  having a Fair
          Market Value on the  exercise  date equal to the  applicable  exercise
          price) in which,  payment of the exercise  price with respect  thereto
          may be made or deemed to have been made.

     4.   Incentive Stock Options.  Notwithstanding  anything in the Plan to the
          contrary, the following additional provisions shall apply to the grant
          of stock  options  which are  intended to qualify as  Incentive  Stock
          Options:

          (a)  The aggregate  Fair Market Value  (determined  as of the time the
               option is granted) of the Shares with respect to which  Incentive
               Stock  Options  are   exercisable  for  the  first  time  by  any
               Participant  during any  calendar  year  (under this Plan and all
               other plans of the Company and its  Affiliates)  shall not exceed
               $100,000.

          (b)  All Incentive Stock Options must be granted within ten years from
               the  earlier  of the date on which  this Plan was  adopted by the
               Board or the date this Plan was approved by the  shareholders  of
               the Company.

          (c)  Unless sooner exercised, all Incentive Stock Options shall expire
               and no longer be  exercisable  no later  than 10 years  after the
               date of grant; provided,  however, that in the case of a grant of
               an Incentive Stock Option to a Participant  who, at the time such
               Option is granted, owns (within the meaning of Section 422 of the
               Code) stock possessing more than 10% of the total combined voting
               power of all classes of stock of the Company or of its Affiliate,
               such  Incentive  Stock  Option  shall  expire  and no  longer  be
               exercisable no later than 5 years from the date of grant.

          (d)  The purchase price per Share for an Incentive  Stock Option shall
               be not less than 100% of the Fair Market  Value of a Share on the
               date of grant of the Incentive Stock Option;  provided,  however,
               that, in the case of the grant of an Incentive  Stock Option to a
               Participant who, at the time such Option is granted, owns (within
               the  meaning of Section 422 of the Code)  stock  possessing  more
               than 10% of the total  combined  voting  power of all  classes of
               stock of the Company or of its Affiliate,  the purchase price per
               Share  purchasable  under an Incentive  Stock Option shall be not
               less than 110% of the Fair Market Value of a Share on the date of
               grant of the Inventive Stock Option.

          (e)  Any  Incentive  Stock  Option  authorized  under  the Plan  shall
               contain  such  other  provisions  as  the  Committee  shall  deem
               advisable, but shall in all events be consistent with and contain
               all  provisions  required  in order to  qualify  the Option as an
               Incentive Stock Option.

                                       5


          5. Reload Options. The Committee may grant Reload Options,  separately
     or together with another  Option,  pursuant to which,  subject to the terms
     and  conditions  established  by the Committee,  the  Participant  would be
     granted a new Option when the payment of the exercise price of a previously
     granted  option is made by the delivery of Shares owned by the  Participant
     pursuant to Section 6A(3) hereof or the relevant provisions of another plan
     of the  Company,  and/or when Shares are tendered or withheld as payment of
     the amount to be withheld  under  applicable  income tax laws in connection
     with the  exercise  of an Option,  which new  Option  would be an Option to
     purchase  the number of Shares not  exceeding  the sum of (A) the number of
     Shares so provided as  consideration  upon the  exercise of the  previously
     granted  option to which such Reload  Option  relates and (B) the number of
     Shares,  if any,  tendered  or  withheld  as  payment  of the  amount to be
     withheld under  applicable tax laws in connection  with the exercise of the
     option  to which  such  Reload  Option  relates  pursuant  to the  relevant
     provisions of the plan or agreement relating to such option. Reload Options
     may be granted with respect to Options previously granted under the Plan or
     any other stock option plan of the Company or may be granted in  connection
     with any Option  granted  under the Plan or any other stock  option plan of
     the Company at the time of such grant. Such Reload Options shall have a per
     share  exercise price equal to the Fair Market Value of one Share as of the
     date of grant of the new  Option.  Any  Reload  Option  shall be subject to
     availability  of  sufficient  Shares  for  grant  under  the  Plan.  Shares
     surrendered  as part or all of the exercise price of the Option to which it
     relates that have been owned by the optionee  less than six months will not
     be counted  for  purposes of  determining  the number of Shares that may be
     purchased pursuant to a Reload Option.

     B. Stock  Appreciation  Rights. The Committee is hereby authorized to grant
Stock  Appreciation  Rights to Eligible Persons subject to the terms of the Plan
and any applicable Award Agreement. A Stock Appreciation Right granted under the
Plan shall confer on the holder thereof a right to receive upon exercise thereof
the  excess of (i) the Fair  Market  Value of one Share on the date of  exercise
(or, if the Committee shall so determine,  at any time during a specified period
before or after  the date of  exercise)  over (ii) the grant  price of the Stock
Appreciation Right as specified by the Committee,  which price shall not be less
than  100% of the Fair  Market  Value  of one  Share on the date of grant of the
Stock  Appreciation  Right.  Subject to the terms of the Plan and any applicable
Award Agreement,  the grant price, term, methods of exercise, dates of exercise,
methods  of  settlement  and  any  other  terms  and  conditions  of  any  Stock
Appreciation  Right shall be as determined by the  Committee.  The Committee may
impose such conditions or restrictions on the exercise of any Stock Appreciation
Right as it may deem appropriate.

                                       6


     C.  Restricted  Stock and Restricted  Stock Units.  The Committee is hereby
authorized  to grant  Restricted  Stock and  Restricted  Stock Units to Eligible
Persons with the following terms and conditions and with such  additional  terms
and conditions not inconsistent with the provisions of the Plan as the Committee
shall determine:

     1.   Restrictions.  Shares of Restricted  Stock and Restricted  Stock Units
          shall be  subject to such  restrictions  as the  Committee  may impose
          (including,  without  limitation,  a waiver by the  Participant of the
          right to vote or to receive  any  dividend  or other right or property
          with respect thereto),  which  restrictions may lapse separately or in
          combination at such time or times,  in such  installments or otherwise
          as the Committee may deem appropriate.

     2.   Stock Certificates.  Any Restricted Stock granted under the Plan shall
          be  registered  in the  name  of the  Participant  and  shall  bear an
          appropriate legend referring to the terms, conditions and restrictions
          applicable to such Restricted Stock.

     3.   Forfeiture.  Except as otherwise  determined by the Committee,  upon a
          Participant's  termination of employment (as determined under criteria
          established  by  the  Committee)  during  the  applicable  restriction
          period, all Shares of Restricted Stock and Restricted Stock Units held
          by the  Participant  at such time shall be forfeited and reacquired by
          the Company; provided,  however, that the Committee may, when it finds
          that a waiver would be in the best  interest of the Company,  waive in
          whole or in part any or all  remaining  restrictions  with  respect to
          Shares of Restricted Stock or Restricted Stock Units.

     4.   Aggregate  Limit. The maximum number of shares of Restricted Stock and
          Restricted  Stock  Units that the  Committee  may grant under the Plan
          shall not exceed 50% of the total number of shares  issuable  pursuant
          to all Awards under the Plan.

     D.  Performance  Awards.  The  Committee  is  hereby  authorized  to  grant
Performance  Awards to Eligible Persons subject to the terms of the Plan and any
applicable Award Agreement.  A Performance  Award granted under the Plan (i) may
be  denominated  or  payable in cash,  Shares  (including,  without  limitation,
Restricted Stock and Restricted Stock Units), other securities,  other Awards or
other  property and (ii) shall confer on the holder thereof the right to receive
payments,  in whole or in part, upon the achievement of such  performance  goals
during such performance periods as the Committee shall establish. Subject to the
terms of the Plan and any applicable Award Agreement,  the performance  goals to
be achieved during any performance period, the length of any performance period,
the  amount of any  Performance  Award  granted,  the  amount of any  payment or
transfer to be made  pursuant to any  Performance  Award and any other terms and
conditions of any Performance Award shall be determined by the Committee.

     E.  Dividend  Equivalents.  The  Committee  is hereby  authorized  to grant
Dividend  Equivalents to Eligible  Persons under which the Participant  shall be
entitled to receive payments (in cash, Shares, other securities, other Awards or
other property as determined in the  discretion of the Committee)  equivalent to
the amount of cash  dividends  paid by the  Company  to  holders of Shares  with
respect to a number of Shares determined by the Committee.  Subject to the terms
of the Plan and any applicable  Award Agreement,  such Dividend  Equivalents may
have such terms and conditions as the Committee shall determine.

     F. Other Stock Grants. The Committee is hereby  authorized,  subject to the
terms of the Plan and any  applicable  Award  Agreements,  to grant to  Eligible
Persons Shares without restrictions thereon as are deemed by the Committee to be
consistent with the purpose of the Plan.

     G. Other Stock-Based Awards. The Committee is hereby authorized to grant to
Eligible  Persons,  subject  to the terms of the Plan and any  applicable  Award
Agreements,  such other  Awards that are  denominated  or payable in,  valued in
whole or in part by reference  to, or otherwise  based on or related to,  Shares
(including,  without  limitation,  securities  convertible into Shares),  as are
deemed by the Committee to be consistent with the purpose of the Plan. Shares or
other  securities  delivered  pursuant to a purchase  right  granted  under this
Section 6(G) shall be  purchased  for such  consideration,  which may be paid by
such method or methods and in such form or forms (including, without limitation,
cash, Shares, promissory notes, other securities, other Awards or other property
or any  combination  thereof),  as the Committee shall  determine,  the value of
which  consideration,  as established  by the Committee,  shall not be less than
100% of the Fair Market Value of such Shares or other  securities as of the date
such purchase right is granted.

                                       7


H.       General

     1.   Consideration  for  Awards.  Awards  shall  be  granted  for  no  cash
          consideration  or  for  any  cash  or  other  consideration  as may be
          determined by the Committee or required by applicable law.

     2.   Awards May Be Granted  Separately  or  Together.  Awards  may,  in the
          discretion of the  Committee,  be granted  either alone or in addition
          to,  in tandem  with or in  substitution,  for any other  Award or any
          award  granted  under any plan of the Company or any  Affiliate  other
          than the Plan.  Awards  granted in addition to or in tandem with other
          Awards or in addition to or in tandem  with awards  granted  under any
          such other plan of the Company or any Affiliate may be granted  either
          at the same  time as or at a  different  time  from the  grant of such
          other Awards or awards.

     3.   Forms of Payment under Awards. Subject to the terms of the Plan and of
          any applicable  Award  Agreement,  payments or transfers to be made by
          the Company or an Affiliate upon the grant,  exercise or payment of an
          Award  may be made  in  such  form or  forms  as the  Committee  shall
          determine  (including,  without limitation,  cash, Shares,  promissory
          notes,  other  securities,  other  Awards  or  other  property  or any
          combination thereof), and may be made in a single payment or transfer,
          in  installments  or on a deferred  basis,  in each case in accordance
          with rules and procedures established by the Committee. Such rules and
          procedures may include, without limitation, provisions for the payment
          or  crediting  of  reasonable  interest  on  installment  or  deferred
          payments  or the  grant or  crediting  of  Dividend  Equivalents  with
          respect to installment or deferred payments.

                                       8


     4.   Limits on Transfer of Awards. No Award (other than Other Stock Grants)
          and  no  right  under  any  such  Award  shall  be  transferable  by a
          Participant  otherwise  than  by will or by the  laws of  descent  and
          distribution  and the Company  shall not be required to recognize  any
          attempted  assignment  of such  rights by any  Participant;  provided,
          however,  that, if so determined by the Committee,  a Participant may,
          in  the  manner   established  by  the  Committee,   (a)  designate  a
          beneficiary or beneficiaries to exercise the rights of the Participant
          and receive any property  distributable with respect to any Award upon
          the death of the  Participant and (b) transfer  Awards,  except in the
          case of an Incentive Stock Option, to Family Members pursuant to terms
          determined by the Committee. Except as otherwise provided in this Plan
          or in any applicable Award Agreement or amendment  thereto (other than
          an Award Agreement relating to an Incentive Stock Option), pursuant to
          terms determined by the Committee, each Award or right under any Award
          shall be  exercisable  during the  Participant's  lifetime only by the
          Participant   or,  if  permissible   under   applicable  law,  by  the
          Participant's  guardian or legal  representative.  Except as otherwise
          provided  in  this  Plan  or in  any  applicable  Award  Agreement  or
          amendment  thereto  (other  than an  Award  Agreement  relating  to an
          Incentive Stock Option), no Award or right under any such Award may be
          pledged,   alienated,   attached  or  otherwise  encumbered,  and  any
          purported pledge, alienation,  attachment or encumbrance thereof shall
          be void and unenforceable against the Company or any Affiliate.

     5.   Term of Awards. The term of each Award shall be for such period as may
          be determined by the Committee; provided, however, that in the case of
          an Incentive  Stock Option such Option shall not be exercisable  after
          the expiration of 10 years from the date such Option is granted.

     6.   Restrictions;   Securities  Exchange  Listing.  All  Shares  or  other
          securities  delivered  under  the Plan  pursuant  to any  Award or the
          exercise  thereof  shall  be  subject  to  such  restrictions  as  the
          Committee may deem  advisable  under the Plan,  applicable  federal or
          state securities laws and regulatory  requirements,  and the Committee
          may cause  appropriate  entries  to be made or legends to be placed on
          the  certificates  for such Shares or other securities to reflect such
          restrictions.  If the Shares or other  securities  of the  Company are
          traded on a securities exchange,  the Company shall not be required to
          deliver any Shares or other securities  covered by an Award unless and
          until such Shares or other  securities  have been admitted for trading
          on such securities exchange.

Section 7.          Amendment and Termination; Adjustments

     A. Amendments to the Plan. The Board may amend, alter, suspend, discontinue
or terminate the Plan at any time; provided,  however, that, notwithstanding any
other provision of the Plan or any Award Agreement,  without the approval of the
shareholders  of  the  Company,  no  such  amendment,  alteration,   suspension,
discontinuation  or termination  shall be made that,  absent such approval would
violate  the rules or  regulations  of the Nasdaq  National  Market or any other
securities exchange that is applicable to the Company.

                                       9


     B.  Amendments  to Awards.  The  Committee  may waive any  conditions of or
rights  of  the  Company  under  any   outstanding   Award,   prospectively   or
retroactively. Except as otherwise provided herein or in an Award Agreement, the
Committee  may  not  amend,  alter,   suspend,   discontinue  or  terminate  any
outstanding  Award,  prospectively  or  retroactively,   if  such  action  would
adversely affect the rights of the holder of such Award,  without the consent of
the Participant or holder or beneficiary thereof. Notwithstanding the foregoing,
without the prior  approval of Enzon's  stockholders,  options issued under this
Plan will not be repriced,  replaced, or regranted through  cancellation,  or by
lowering the option exercise price of a previously granted Award.

     C. Correction of Defects, Omissions and Inconsistencies.  The Committee may
correct any defect,  supply any omission or reconcile any  inconsistency  in the
Plan or any Award in the manner and to the  extent it shall  deem  desirable  to
carry the Plan into effect.

Section 8.          Income Tax Withholding

     In order to comply with all applicable  national,  federal,  state or local
income tax laws or  regulations,  the  Company  may take such action as it deems
appropriate  to ensure that all  applicable  national,  federal,  state or local
payroll,  withholding,  income or other  taxes,  which are the sole and absolute
responsibility   of  a   Participant,   are  withheld  or  collected  from  such
Participant.  In order to assist a Participant in paying all or a portion of the
national,  federal,  state and local  taxes to be  withheld  or  collected  upon
exercise or receipt of (or the lapse of restrictions  relating to) an Award, the
Committee, in its discretion and subject to such additional terms and conditions
as it may adopt,  may permit the  Participant  to satisfy such tax obligation by
(i) electing to have the Company  withhold a portion of the Shares  otherwise to
be delivered upon exercise or receipt of (or the lapse of restrictions  relating
to) such Award  with a Fair  Market  Value  equal to the amount of such taxes or
(ii)  delivering to the Company Shares other than Shares  issuable upon exercise
or receipt of (or the lapse of restrictions  relating to) such Award with a Fair
Market Value equal to the amount of such taxes.  The  election,  if any, must be
made on or before the date that the amount of tax to be withheld is determined.

Section 9.          General Provisions

     A. No Rights to Awards.  No Eligible  Person,  Participant  or other Person
shall have any claim to be  granted  any Award  under the Plan,  and there is no
obligation  for  uniformity of treatment of Eligible  Persons,  Participants  or
holders or  beneficiaries  of Awards under the Plan. The terms and conditions of
Awards need not be the same with respect to any  Participant  or with respect to
different Participants.

     B. Plan  Provisions  Control.  In the event that any  provision of an Award
Agreement conflicts with or is inconsistent in any respect with the terms of the
Plan as set forth herein or  subsequently  amended,  the terms of the Plan shall
control.

     C. No Rights of  Shareholders.  Except with respect to Shares of Restricted
Stock as to which the Participant has been granted the right to vote,  neither a
Participant nor the Participant's legal  representative shall be, or have any of
the rights and  privileges  of, a stockholder of the Company with respect to any
Shares issuable to such  Participant  upon the exercise or payment of any Award,
in whole or in part,  unless and until such  Shares have been issued in the name
of  such  Participant  or  such  Participant's  legal   representative   without
restrictions thereto.

                                       10


     D. No Limit on Other  Compensation  Arrangements.  Nothing contained in the
Plan shall prevent the Company or any  Affiliate  from adopting or continuing in
effect other or additional compensation arrangements,  and such arrangements may
be either generally applicable or applicable only in specific cases.

     E. No Right to Employment.  The grant of an Award shall not be construed as
giving a  Participant  the right to be  retained in the employ of the Company or
any  Affiliate,  nor will it affect in any way the  right of the  Company  or an
Affiliate to terminate such  employment at any time,  with or without cause.  In
addition, the Company or an Affiliate may at any time dismiss a Participant from
employment  free from any  liability  or any claim  under the Plan or any Award,
unless  otherwise  expressly  provided  in the Plan or in any  Award  Agreement.
Nothing in this Plan shall  confer on any  person any legal or  equitable  right
against the Company or any Affiliate,  directly or  indirectly,  or give rise to
any cause of action at law or in equity against the Company or an Affiliate. The
Awards granted  hereunder  shall not form any part of the wages or salary of any
Eligible  Person for  purposes  of  severance  pay or  termination  indemnities,
irrespective of the reason for termination of employment. Under no circumstances
shall any person  ceasing to be an employee of the Company or any  Affiliate  be
entitled to any compensation for any loss of any right or benefit under the Plan
which  such  employee  might  otherwise  have  enjoyed  but for  termination  of
employment,  whether such compensation is claimed by way of damages for wrongful
or unfair  dismissal,  breach of contract or otherwise.  By participating in the
Plan,  each  Participant  shall be deemed to have accepted all the conditions of
the Plan and the terms and  conditions of any rules and  regulations  adopted by
the Committee and shall be fully bound thereby.

     F. Governing Law. The validity,  construction and effect of the Plan or any
Award, and any rules and regulations relating to the Plan or any Award, shall be
determined in accordance  with the internal  laws, and not the law of conflicts,
of the State of Delaware.

     G. Severability. If any provision of the Plan or any Award is or becomes or
is deemed to be invalid,  illegal or  unenforceable in any jurisdiction or would
disqualify  the  Plan or any  Award  under  any  law  deemed  applicable  by the
Committee,  such  provision  shall be construed or deemed  amended to conform to
applicable laws, or if it cannot be so construed or deemed amended  without,  in
the determination of the Committee, materially altering the purpose or intent of
the Plan or the Award,  such provision shall be stricken as to such jurisdiction
or Award,  and the  remainder of the Plan or any such Award shall remain in full
force and effect.

     H. No Trust or Fund Created. Neither the Plan nor any Award shall create or
be  construed  to  create a trust or  separate  fund of any kind or a  fiduciary
relationship between the Company or any Affiliate and a Participant or any other
Person.  To the extent that any Person acquires a right to receive payments from
the  Company or any  Affiliate  pursuant  to an Award,  such  right  shall be no
greater than the right of any unsecured  general  creditor of the Company or any
Affiliate.

     I. Other Benefits. No compensation or benefit awarded to or realized by any
Participant  under the Plan shall be included for the purpose of computing  such
Participant's compensation under any compensation-based retirement,  disability,
or similar plan of the Company unless  required by law or otherwise  provided by
such other plan.

                                       11


     J. No Fractional  Shares. No fractional Shares shall be issued or delivered
pursuant to the Plan or any Award,  and the Committee  shall  determine  whether
cash shall be paid in lieu of any fractional  Shares or whether such  fractional
Shares  or any  rights  thereto  shall  be  canceled,  terminated  or  otherwise
eliminated.

     K. Headings. Headings are given to the Sections and subsections of the Plan
solely as a convenience  to  facilitate  reference.  Such headings  shall not be
deemed in any way material or relevant to the construction or  interpretation of
the Plan or any provision thereof.

Section 10.         Effective Date of the Plan.

     The Plan shall be  effective on December 4, 2001 subject to approval by the
shareholders of the Company on such date.

Section 11.         Term of the Plan.

     No Award shall be granted under the Plan ten years after the effective date
or any earlier date of  discontinuation or termination  established  pursuant to
Section 7A of the Plan. However, unless otherwise expressly provided in the Plan
or in an applicable Award Agreement,  any Award  theretofore  granted may extend
beyond such date, and the authority of the Committee provided for hereunder with
respect to the Plan and any Awards,  and the authority of the Board to amend the
Plan, shall extend beyond the termination of the Plan.




                                       12








                                   APPENDIX C

                              AMENDED AND RESTATED
                          CERTIFICATE OF INCORPORATION
                                       OF
                           ENZON PHARMACEUTICALS, INC.

     The  undersigned,  Jeffrey  H.  Buchalter,  being the  President  and Chief
Executive Officer of Enzon  Pharmaceuticals,  Inc., a corporation  organized and
existing  under the laws of the State of Delaware  (the  "Corporation"),  hereby
certifies as follows:

     FIRST:  The  present  name  of  the  corporation  (hereinafter  called  the
"Corporation") is Enzon Pharmaceuticals, Inc.

     SECOND: The name under which the corporation was originally incorporated is
Enzon, Inc. and the date of filing the original  certificate of incorporation of
the Corporation  with the Secretary of State of the State of Delaware is May 11,
1983.

     THIRD: This Amended and Restated Certificate of Incorporation has been duly
adopted by the Corporation's Board of Directors and stockholders pursuant to the
provisions of Sections 242 and 245 of the General  Corporation  Law of the State
of Delaware in the form set forth as follows:

     1. Name. The name of the corporation is Enzon Pharmaceuticals, Inc.

     2. Address;  Registered Agent. The  Corporation's  registered office in the
State of Delaware is located at  Corporation  Trust Center,  1209 Orange Street,
City of Wilmington, County of New Castle and the name of its registered agent at
such address is The Corporation Trust Company.

     3.  Purpose.  The nature of the  business  and  purposes to be conducted or
promoted by the  Corporation  are to engage in,  carry on and conduct any lawful
act or  activity  for which  corporations  may be  organized  under the  General
Corporation Law of Delaware.

     4. Number of Shares.  (A) The total number of shares of capital stock which
the Corporation  shall have authority to issue is 173,000,000  shares,  of which
170,000,000  shares  shall be  Common  Stock,  par  value  $.01 per  share,  and
3,000,000 shares shall be Preferred Stock, par value $.01 per share.

     (B) The  Preferred  Stock  may be  issued  from time to time in one or more
series. The Board of Directors of the Corporation is hereby expressly authorized
to provide,  by resolution or resolutions  duly adopted by it prior to issuance,
for the creation of each such series and to fix the  designation and the powers,
preferences,  rights,  qualifications,  limitations and restrictions relating to
the shares of each such series.  The  authority  of the Board of Directors  with
respect to each series of Preferred Stock shall include,  but not be limited to,
determining the following:

     a. the designation of such series,  the number of shares to constitute such
series and the stated value thereof if different from the par value thereof;

     b. whether the shares of such series shall have voting rights,  in addition
to any voting  rights  provided  by law,  and,  if so, the terms of such  voting
rights, which may be general or limited;

     c.  the  dividends,  if any,  payable  on such  series,  whether  any  such
dividends shall be cumulative,  and, if so, from what dates,  the conditions and
dates upon which such dividends shall be payable, and the preference or relation
which such dividends shall bear to the dividends  payable on any shares of stock
of any other class or any other series of Preferred Stock;

     d. whether the shares of such series shall be subject to  redemption by the
Corporation,  and,  if so,  the  times,  prices  and  other  conditions  of such
redemption;




     e. the amount or amounts  payable upon shares of such series upon,  and the
rights  of  the  holders  of  such  series  in,  the  voluntary  or  involuntary
liquidation,  dissolution or winding up, or upon any distribution of the assets,
of the Corporation;

     f. whether the shares of such series shall be subject to the operation of a
retirement  or  sinking  fund and,  if so, the extent to and manner in which any
such  retirement  or sinking fund shall be applied to the purchase or redemption
of the shares of such series for  retirement or other  corporation  purposes and
the terms and provisions relating to the operation thereof;

     g.  whether  the  shares  of such  series  shall be  convertible  into,  or
exchangeable  for,  shares  of stock of any other  class or any other  series of
Preferred  Stock or any other  securities and, if so, the price or prices or the
rate or rates of conversion or exchange and the method, if any, of adjusting the
same, and any other terms and conditions of conversion or exchange;

     h.  the  conditions  or   restrictions,   if  any,  upon  the  creation  of
indebtedness  of the  Corporation  or upon the  issue of any  additional  stock,
including  additional  shares of such series or of any other series of Preferred
Stock or of any other class; and

     i. any other powers, preferences and relative, participating,  optional and
other special rights,  and any  qualifications,  limitations  and  restrictions,
thereof.

     The powers,  preferences  and relative,  participating,  optional and other
special  rights  of each  series of  Preferred  Stock,  and the  qualifications,
limitations or  restrictions  thereof,  if any, may differ from those of any and
all  other  series at any time  outstanding.  All  shares  of any one  series of
Preferred Stock shall be identical in all respects with all other shares of such
series,  except  that  shares of any one series  issued at  different  times may
differ as to the dates from which dividends thereof shall be cumulative.

     Pursuant to the authority  conferred by this Article  Fourth upon the Board
of Directors  of the  Corporation,  the Board of  Directors  created a series of
Preferred  Stock  designated as Series B Preferred Stock by filing a Certificate
of Designations  of the Corporation  with the Secretary of State of the State of
Delaware  (the  "Secretary  of State") on May 22, 2002,  and the voting  powers,
designations, preferences and relative, participating, optional or other special
rights,  and the  qualifications,  limitations or restrictions  thereof,  of the
Corporation's  Series B  Preferred  Stock are set forth in Appendix A hereto and
are incorporated herein by reference.

     5. Name and Address of  Incorporator.  The name and mailing  address of the
incorporator is Dan Brecher, 260 Madison Avenue, New York, New York, 10016.

     6. Election of Directors.  Members of the Board of Directors may be elected
either by written ballot or by voice vote.

     7. Adoption, Amendment and/or Repeal of By-Laws. The Board of Directors may
from time to time (after adoption by the undersigned of the original  by-laws of
the Corporation) make, alter or repeal the by-laws of the Corporation; provided,
that any by-laws  made,  amended or repealed  by the Board of  Directors  may be
amended or repealed,  and any by-laws may be made,  by the  stockholders  of the
Corporation.

     8.  Compromises and  Arrangements.  Whenever a compromise or arrangement is
proposed  between the  Corporation and its creditors or any class of them and/or
between this Corporation and its stockholders or any class of them, any court of
equitable jurisdiction within the State of Delaware may, on the application in a
summary way of this Corporation or of any creditor or stockholder  thereof or on
the  application  of any receiver or receivers  appointed  for this  Corporation
under the  provisions  of section 291 of Title 8 of the Delaware  Code or on the
application of trustees in dissolution or of any receiver or receivers appointed
for this  Corporation  under the  provisions  of  section  279 of Title 8 of the
Delaware Code, order a meeting of the creditors or class of creditors, and/or of
the stockholders or class of stockholders of this  Corporation,  as the case may
be, to be summoned in such  manner as the said court  directs.  If a majority in
number  representing  three-fourths  in  value  of the  creditors  or  class  of


                                       2



creditors,  and/or  of  the  stockholders  or  class  of  stockholders  of  this
Corporation,  as the case may be, agree to any compromise or arrangement  and to
any  reorganization  of this  Corporation as  consequence of such  compromise or
arrangement,  the said  compromise or  arrangement  and the said  reorganization
shall,  if sanctioned by the court to which the said  application has been made,
be  binding  on all the  creditors  or class  of  creditors,  and/or  on all the
stockholders or class of stockholders,  of this Corporation, as the case may be,
and also on this Corporation.

     9. Number of  Directors.  (A) The Board of Directors  shall  consist of not
less than three nor more than fifteen  directors,  the exact number of directors
to be determined from time to time by resolution  adopted by affirmative vote of
a majority of the whole Board of Directors,  and such exact number shall be four
until  otherwise  determined  by  resolution  adopted by  affirmative  vote of a
majority of the whole Board of  Directors.  As used in this  Article 9, the term
"whole Board" means the total number of directors,  which the Corporation  would
have if there  were no  vacancies.  The  Board of  Directors  shall  divide  the
directors into three classes and, when the number of directors is changed, shall
determine  the class or classes to which the  increased or  decreased  number of
directors  shall be  apportioned;  provided,  that no  decrease in the number of
directors shall affect the term of any director then in office.  Notwithstanding
the foregoing,  and except as otherwise required by law, whenever the holders of
any one or  more  series  of  Preferred  Stock  shall  have  the  right,  voting
separately as a class,  to elect one or more directors of the  Corporation,  the
terms of the director or directors  elected by such holders  shall expire at the
next succeeding annual meeting of stockholders.  The term of office of directors
elected at the 1986  Annual  Meeting of  Stockholders  held on January  20, 1987
shall be as follows:  the term of office of  directors  of the first class shall
expire at the first annual meeting of  stockholders  after their  election;  the
term of office of  directors  of the  second  class  shall  expire at the second
annual meeting of stockholders  after their election;  and the term of office of
directors  of the  third  class  shall  expire at the third  annual  meeting  of
stockholders after their election; and as to directors of each class, when their
respective  successors  are elected  and  qualified.  At each annual  meeting of
stockholders  subsequent to the 1986 Annual Meeting of  Stockholders,  directors
elected to succeed those whose terms are expiring shall be elected for a term of
office to expire at the third succeeding annual meeting of stockholders and when
their respective successors are elected and qualified.

     (B) Vacancies in the Board of Directors,  however caused, and newly created
directorships shall be filled solely by a majority vote of the directors then in
office,  whether or not a quorum,  and any  director so chosen shall hold office
for a term expiring at the annual meeting of  stockholders  at which the term of
the class to which the director has been chosen  expires and when the director's
successor is elected and qualified.

     (C) The affirmative  vote of the holders of not less than two-thirds of the
outstanding  voting shares of capital stock of the Corporation  entitled to vote
generally in the election of directors shall be required to amend, alter, change
or repeal,  or adopt any provisions  inconsistent with this Article 9, provided,
however,  that this paragraph shall not apply to, and such two-thirds vote shall
not be required for, any amendment,  alteration,  change,  repeal or adoption of
any inconsistent  provision  declared advisable by the Board of Directors by the
affirmative  vote of two-thirds of the Board and submitted to  stockholders  for
their  consideration,  but only if a  majority  of the  members  of the Board of
Directors  acting  upon such  matter  shall be  Continuing  Directors.  The term
"Continuing  Director" shall mean a director who was a member of the Board as of
October 1, 1986.

     10. Limitation of Directors' Liability;  Indemnification. A director of the
Corporation   shall  not  be  personally   liable  to  the  Corporation  or  its
stockholders  for monetary  damages for breach of fiduciary  duty as a director,
except for liability (i) for any breach of the director's duty of loyalty to the
Corporation or its stockholders, (ii) for acts or omissions not in good faith or
which involve intentional  misconduct or a knowing violation of law, (iii) under
Section  174 of the  Delaware  General  Corporation  Law,  as the same exists or
hereafter may be amended,  or (iv) for any  transaction  from which the director
derived an improper  personal benefit.  If the Delaware General  Corporation Law
hereafter is amended to authorize the further  elimination  or limitation of the
liability of directors, then the liability of a director of the Corporation,  in
addition to the  limitation  on personal  liability  provided  herein,  shall be
limited  to the  fullest  extent  permitted  by  the  amended  Delaware  General
Corporation   Law.  Any  repeal  or   modification  of  this  paragraph  by  the
stockholders  of the  Corporation  shall be  prospective  only,  and  shall  not
adversely  affect any limitation on the personal  liability of a director of the
corporation existing at the time of such repeal or modification.

                          (SIGNATURE ON FOLLOWING PAGE)

                                       3



     I,  Jeffrey H.  Buchalter,  President  and Chief  Executive  Officer of the
Corporation,  for the  purpose  of  amending  and  restating  the  Corporation's
Certificate of Incorporation  pursuant to the Delaware General  Corporation Law,
do make this certificate,  hereby declaring and certifying that the facts stated
herein  are true and this is my act and deed on behalf of the  Corporation  this
___ day of May, 2006.


                                By:      Jeffrey H. Buchalter
                                Title:   President and Chief Executive Officer



                                       4





              CERTIFICATE OF DESIGNATION, PREFERENCES AND RIGHTS OF


                            SERIES B PREFERRED STOCK

                                       OF

                                   ENZON, INC.

                         Pursuant to Section 151 of the
                General Corporation Law of the State of Delaware

     Enzon, Inc. (the "Corporation"), a corporation organized and existing under
the laws of the State of Delaware,  does hereby  certify  that,  pursuant to the
authority  conferred  on  the  Board  of  Directors  of the  Corporation  by the
Certificate of Incorporation,  as amended,  of the Corporation and in accordance
with Section 151 of the General  Corporation  Law of the State of Delaware,  the
Board of Directors of the Corporation adopted the following  resolution creating
the preferences  and rights of its series of 600,000 shares of Preferred  Stock,
no shares of which have been issued, designated as " Series B Preferred Stock."

     RESOLVED,  that pursuant to the authority  vested in the Board of Directors
of this  Corporation  in accordance  with the  provisions of its  Certificate of
Incorporation,  as amended,  a series of preferred  stock of the  Corporation is
hereby  created  and the  designation  and amount of such  series and the voting
powers,  preferences  and  relative,  participating,  optional and other special
rights of the shares of such  series,  and the  qualifications,  limitations  or
restrictions thereof are as follows:

     a. Designation and Amount. The shares of such series shall be designated as
"Series B Preferred  Stock" (the " Series B Preferred  Stock") and the number of
shares  constituting  the Series B Preferred Stock shall be six hundred thousand
(600,000).  Such number of shares may be increased or decreased by resolution of
the Board of Directors;  provided,  that no decrease  shall reduce the number of
shares of Series B  Preferred  Stock to a number  less than the number of shares
then  outstanding  plus the  number of shares  reserved  for  issuance  upon the
exercise of  outstanding  options,  rights or warrants or upon the conversion of
any outstanding  securities issued by the Corporation  convertible into Series B
Preferred Stock.

     b. Dividends and Distributions.

     (i)  Subject  to the  rights of the  holders of any shares of any series of
preferred  stock (or any similar stock) ranking prior and superior to the Series
B Preferred  Stock with respect to dividends,  the holders of shares of Series B
Preferred  Stock,  in preference to the holders of Common Stock,  par value $.01
(the "Common Stock"),  of the Corporation,  and of any other junior stock, shall
be entitled to receive,  when,  as and if declared by the Board of Directors out
of funds legally available for the purpose,  quarterly dividends payable in cash
on the first day of March, June,  September and December in each year (each such
date  being  referred  to  herein  as  a  "Quarterly  Dividend  Payment  Date"),
commencing on the first Quarterly Dividend Payment Date after the first issuance
of a share or fraction of a share of Series B Preferred  Stock, in an amount per
share  (rounded  to the  nearest  cent) equal to the greater of (a) $1.00 or (b)
subject to the provision for adjustment  hereinafter set forth,  1,000 times the
aggregate per share amount of all cash dividends,  and 1,000 times the aggregate
per  share  amount  (payable  in  kind)  of  all  non-cash  dividends  or  other
distributions,  other  than a dividend  payable  in shares of Common  Stock or a
subdivision of the outstanding  shares of Common Stock (by  reclassification  or
otherwise),  declared  on the  Common  Stock  since  the  immediately  preceding
Quarterly Dividend Payment Date or, with respect to the first Quarterly Dividend
Payment  Date,  since the first  issuance of any share or fraction of a share of
Series B Preferred  Stock. In the event the Corporation  shall at any time after
June 3, 2002,  declare or pay any dividend on the Common Stock payable in shares
of Common Stock, or effect a subdivision or combination or  consolidation of the


                                       1


outstanding  shares of Common Stock (by  reclassification  or otherwise)  into a
greater or lesser number of shares of Common  Stock,  then in each such case the
amount to which  holders of shares of Series B  Preferred  Stock  were  entitled
immediately prior to such event under clause (b) of the preceding sentence shall
be adjusted by multiplying such amount by a fraction,  the numerator of which is
the number of shares of Common Stock  outstanding  immediately  after such event
and the  denominator  of which is the number of shares of Common Stock that were
outstanding immediately prior to such event.

     (ii) The Corporation shall declare a dividend or distribution on the Series
B Preferred Stock as provided in paragraph (A) of this Section immediately after
it  declares a  dividend  or  distribution  on the Common  Stock  (other  than a
dividend  payable in shares of Common Stock or a subdivision of the  outstanding
Common  Stock);  provided that, in the event no dividend or  distribution  shall
have been  declared on the Common Stock during the period  between any Quarterly
Dividend Payment Date and the next subsequent Quarterly Dividend Payment Date, a
dividend of $1.00 per share on the Series B Preferred  Stock shall  nevertheless
be payable,  out of funds legally available for such purpose, on such subsequent
Quarterly Dividend Payment Date.

     (iii)  Dividends  shall begin to accrue and be  cumulative  on  outstanding
shares of Series B Preferred Stock from the Quarterly Dividend Payment Date next
preceding  the date of issue of such  shares,  unless  the date of issue of such
shares is prior to the  record  date for the first  Quarterly  Dividend  Payment
Date, in which case dividends on such shares shall begin to accrue from the date
of issue of such  shares,  or unless the date of issue is a  Quarterly  Dividend
Payment Date or is a date after the record date for the determination of holders
of shares of Series B Preferred  Stock entitled to receive a quarterly  dividend
and before such Quarterly  Dividend Payment Date, in either of which events such
dividends shall begin to accrue and be cumulative  from such Quarterly  Dividend
Payment Date.  Accrued but unpaid  dividends shall not bear interest.  Dividends
paid on the shares of Series B Preferred  Stock in an amount less than the total
amount of such dividends at the time accrued and payable on such shares shall be
allocated pro rata on a  share-by-share  basis among all such shares at the time
outstanding.  The Board of Directors may fix a record date for the determination
of holders of shares of Series B Preferred  Stock entitled to receive payment of
a dividend or distribution declared thereon, which record date shall be not more
than 60 days prior to the date fixed for the payment thereof.

     c. Voting Rights.  The holders of shares of Series B Preferred  Stock shall
have the following voting rights:

     (i) Subject to the provision for  adjustment  hereinafter  set forth,  each
share of Series B  Preferred  Stock shall  entitle  the holder  thereof to 1,000
votes on all matters submitted to a vote of the stockholders of the Corporation.
In the event the  Corporation  shall at any time after June 3, 2002,  declare or
pay any  dividend  on the Common  Stock  payable in shares of Common  Stock,  or
effect a subdivision or combination or consolidation  of the outstanding  shares
of Common  Stock (by  reclassification  or  otherwise)  into a greater or lesser
number of shares of Common Stock, then in each such case the number of votes per
share to which  holders  of shares of Series B  Preferred  Stock  were  entitled
immediately  prior to such event shall be adjusted by multiplying such number by
a  fraction,  the  numerator  of which is the  number of shares of Common  Stock
outstanding  immediately  after such event and the  denominator  of which is the
number of shares of Common Stock that were outstanding immediately prior to such
event.

     (ii) Except as  otherwise  provided  herein,  in any other  Certificate  of
Designation  creating a series of preferred  stock or any similar  stock,  or by
law, the holders of shares of Series B Preferred Stock and the holders of shares
of Common Stock and any other capital stock of the  Corporation  having  general
voting  rights  shall vote  together as one class on all matters  submitted to a
vote of stockholders of the Corporation.

                                       2


     (iii) Except as set forth herein, or as otherwise  provided by law, holders
of Series B  Preferred  Stock  shall  have no  special  voting  rights and their
consent  shall not be required  (except to the extent they are  entitled to vote
with  holders of Common  Stock as set forth  herein)  for  taking any  corporate
action.

4.       Certain Restrictions.

     (i)  Whenever  quarterly  dividends  or other  dividends  or  distributions
payable on the Series B Preferred Stock as provided in Section 2 are in arrears,
thereafter and until all accrued and unpaid dividends and distributions, whether
or not declared,  on shares of Series B Preferred Stock  outstanding  shall have
been paid in full, the Corporation shall not:

     (1)  declare  or pay  dividends,  or make any other  distributions,  on any
shares of stock  ranking  junior  (either as to dividends  or upon  liquidation,
dissolution or winding up) to the Series B Preferred Stock;

     (2)  declare  or pay  dividends,  or make any other  distributions,  on any
shares of stock ranking on a parity (either as to dividends or upon liquidation,
dissolution or winding up) with the Series B Preferred  Stock,  except dividends
paid ratably on the Series B Preferred  Stock and all such parity stock on which
dividends  are payable or in arrears in proportion to the total amounts to which
the holders of all such shares are then entitled;

     (3) redeem or purchase or otherwise acquire for consideration shares of any
stock ranking junior (either as to dividends or upon liquidation, dissolution or
winding up) to the Series B Preferred  Stock,  provided that the Corporation may
at any time  redeem,  purchase or  otherwise  acquire  shares of any such junior
stock in  exchange  for shares of any stock of the  Corporation  ranking  junior
(either as to dividends or upon  dissolution,  liquidation or winding up) to the
Series B Preferred Stock; or

     (4) redeem or purchase or otherwise acquire for consideration any shares of
Series B Preferred  Stock,  or any shares of stock  ranking on a parity with the
Series B Preferred  Stock,  except in accordance  with a purchase  offer made in
writing or by  publication  (as  determined  by the Board of  Directors)  to all
holders  of such  shares  upon  such  terms  as the  Board of  Directors,  after
consideration of the respective  annual dividend rates and other relative rights
and  preferences of the respective  series and classes,  shall determine in good
faith will result in fair and equitable treatment among the respective series or
classes.

     (ii) The Corporation  shall not permit any subsidiary of the Corporation to
purchase  or  otherwise  acquire  for  consideration  any shares of stock of the
Corporation unless the Corporation could, under paragraph (A) of this Section 4,
purchase or otherwise acquire such shares at such time and in such manner.

     e. Reacquired  Shares.  Any shares of Series B Preferred Stock purchased or
otherwise  acquired by the Corporation in any manner whatsoever shall be retired
and cancelled promptly after the acquisition thereof. All such shares shall upon
their cancellation  become authorized but unissued shares of preferred stock and
may be  reissued  as part of a new  series of  preferred  stock  subject  to the
conditions and restrictions on issuance set forth herein,  in the Certificate of
Incorporation, as amended, or in any other certificate of designation creating a
series of preferred stock or any similar stock or as otherwise required by law.



                                       3


     f.   Liquidation,   Dissolution  or  Winding  Up.  Upon  any   liquidation,
dissolution or winding up of the Corporation,  no distribution shall be made (1)
to the holders of shares of stock ranking junior (either as to dividends or upon
liquidation,  dissolution or winding up) to the Series B Preferred Stock unless,
prior  thereto,  the  holders of shares of Series B  Preferred  Stock shall have
received  the greater of (i) $1,000 per share,  plus an amount  equal to accrued
and unpaid dividends and distributions thereon,  whether or not declared, to the
date of such  payment,  or (ii) an  aggregate  amount per share,  subject to the
provision  for  adjustment  hereinafter  set  forth,  equal to 1,000  times  the
aggregate  amount to be  distributed  per share to  holders  of shares of Common
Stock,  or (2) to the holders of shares of stock ranking on a parity  (either as
to dividends or upon  liquidation,  dissolution or winding up) with the Series B
Preferred  Stock,  except  distributions  made ratably on the Series B Preferred
Stock and all such parity stock in  proportion to the total amounts to which the
holders of all such shares are entitled upon such  liquidation,  dissolution  or
winding up. In the event the  Corporation  shall at any time after June 3, 2002,
declare  or pay any  dividend  on the Common  Stock  payable in shares of Common
Stock,  or  effect  a  subdivision  or  combination  or   consolidation  of  the
outstanding  shares of Common Stock (by  reclassification  or otherwise)  into a
greater or lesser number of shares of Common  Stock,  then in each such case the
aggregate  amount to which  holders of shares of Series B  Preferred  Stock were
entitled  immediately  prior to such event under clause (1)(ii) of the preceding
sentence  shall be  adjusted  by  multiplying  such  amount  by a  fraction  the
numerator  of  which  is the  number  of  shares  of  Common  Stock  outstanding
immediately  after  such  event and the  denominator  of which is the  number of
shares of Common Stock that were outstanding immediately prior to such event.

     g. Consolidation, Merger, Etc. In case the Corporation shall enter into any
consolidation,  merger,  combination or other transaction in which the shares of
Common Stock are exchanged for or changed into other stock or  securities,  cash
and/or  any  other  property,  then in any such  case  each  share  of  Series B
Preferred Stock shall at the same time be similarly exchanged or changed into an
amount per share, subject to the provision for adjustment hereinafter set forth,
equal to 1,000 times the aggregate amount of stock, securities,  cash and/or any
other  property  (payable in kind),  as the case may be, into which or for which
each share of Common Stock is changed or exchanged. In the event the Corporation
shall at any time after June 3, 2002,  declare or pay any dividend on the Common
Stock payable in shares of Common Stock,  or effect a subdivision or combination
or consolidation of the outstanding shares of Common Stock (by  reclassification
or otherwise) into a greater or lesser number of shares of Common Stock, then in
each such case the amount set forth in the  preceding  sentence  with respect to
the  exchange or change of shares of Series B Preferred  Stock shall be adjusted
by multiplying  such amount by a fraction,  the numerator of which is the number
of shares of Common  Stock  outstanding  immediately  after  such  event and the
denominator  of  which is the  number  of  shares  of  Common  Stock  that  were
outstanding immediately prior to such event.

     h. No  Redemption.  The  shares of Series B  Preferred  Stock  shall not be
redeemable.

     i. Rank.  The Series B  Preferred  Stock shall  rank,  with  respect to the
payment of dividends and the distribution of assets, junior to all series of any
other class of the Corporation's preferred stock.

     j. Fractional Shares.  Series B Preferred Stock may be issued in fractions
of a share  which  shall  entitle the holder,  in  proportion  to such  holder's
fractional  shares,  to receive  dividends,  participate in distributions and to
have the benefit of all other rights of holders of Series B Preferred Stock.

     k.  Amendment.  The  Certificate  of  Incorporation,  as  amended  of  the
Corporation  shall not be amended in any manner which would  materially alter or
change the powers,  preferences or rights of the Series B Preferred  Stock so as
to affect them adversely without the affirmative vote of the holders of at least
two-thirds  of the  outstanding  shares  of  Series B  Preferred  Stock,  voting
together as a single class.

                                       4



Proxy Card


                           ENZON PHARMACEUTICALS, INC.

                   Annual Meeting of Stockholders May 18, 2006
           This Proxy Is Solicited on Behalf of the Board of Directors

     Jeffrey H. Buchalter and Craig A. Tooman and each of them, as proxies, with
full power of substitution  in each of them, are hereby  authorized to represent
and to vote, as  designated  below and on the reverse side, on all proposals and
in the  discretion  of the proxies on such other  matters as may  properly  come
before the annual meeting of  stockholders of Enzon  Pharmaceuticals,  Inc. (the
"Company") to be held on May 18, 2006 or any adjournment(s), postponement(s), or
other  delay(s)  thereof  (the  "Annual  Meeting"),  all  shares of stock of the
Company to which the undersigned is entitled to vote at the Annual Meeting.

     UNLESS OTHERWISE DIRECTED, THIS PROXY WILL BE VOTED "FOR" PROPOSALS 1, 2, 3
AND 4 AND WILL BE VOTED IN THE  DISCRETION  OF THE PROXIES ON SUCH OTHER MATTERS
AS MAY  PROPERLY  COME BEFORE THE ANNUAL  MEETING.  THE BOARD OF  DIRECTORS  HAS
PROPOSED AND RECOMMENDS THAT STOCKHOLDERS VOTE "FOR" PROPOSALS 1, 2, 3 AND 4.

                         
(1)  Election of the  following  nominee as Class I Director  to serve in such  capacity  until his  successor is
     duly elected and qualified:

              Phillip M. Renfro

                (Authority to vote for the nominee may be withheld by lining through the name of such nominee.)


                           /  / FOR the nominee                   /  / WITHHOLD authority for the nominee

(2) Approval  of the  amendment  of the 2001  Incentive  Stock  Plan to  increase  the number of shares of common
     stock  issuable thereunder by an additional 4,000,000 shares.

                      /  / FOR         /  / AGAINST          /  / ABSTAIN

(3) To approve the amendment and  restatement of our Restated  Certificate of  Incorporation  to increase the
    number of authorized shares of common stock from 90,000,000 shares to 170,000,000 shares.

                      /  / FOR         /  / AGAINST          /  / ABSTAIN

(4) Ratification of the selection of KPMG LLP to audit the  consolidated  financial  statements of the Company
    for the fiscal year ending December 31, 2006.

                      /  / FOR         /  / AGAINST          /  / ABSTAIN

/  /Please check this box if you expect to attend the Annual Meeting in person.

                                  (Please sign exactly as name  appears to the left,  date and return.  If shares are held by
                                  joint  tenants,  both should  sign.  When  signing as  attorney,  executor,  administrator,
                                  trustee or  guardian,  please give full title as such.  If a  corporation,  please sign in
                                  full  corporate name by president or other  authorized  officer.  If a partnership,  please
                                  sign in partnership name by authorized person.)



                                            Date:


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                        ________________________________________
                           Signature (if held jointly)

                        ________________________________________

              Capacity (Title or Authority, i.e. Executor, Trustee)
                    PLEASE SIGN, DATE AND MAIL YOUR PROXY TODAY