CUSIP
No. 023111107
|
13D
|
Page
2 of 9
|
(1)
|
Name
of Reporting Persons
|
Longitude
Capital Partners, LLC
|
|
(2)
|
Check
the Appropriate Box If A Member of a Group
(See Instructions)
|
(a)
o
(b)
o
|
|
(3)
|
SEC
Use Only
|
||
(4)
|
Source
of Funds (See Instructions)
|
OO1
|
|
(5)
|
Check
if Disclosure of Legal Proceedings is Required
Pursuant to Items 2(d) or 2(e)
|
o
|
|
(6)
|
Citizenship
or Place of Organization
|
Delaware
|
|
Number
of Shares Beneficially Owned by Each Reporting Person
with:
|
|||
(7)
|
Sole
Voting Power
|
None
|
|
(8)
|
Shared
Voting Power
|
4,433,0002
|
|
(9)
|
Sole
Dispositive Power
|
None
|
|
(10)
|
Shared
Dispositive Power
|
4,433,0002
|
|
(11)
|
Aggregate
Amount Beneficially Owned by Each
Reporting Person
|
4,433,0002
|
|
(12)
|
Check
if the Aggregate Amount in Row (11) Excludes
Certain Shares (See Instructions)
|
o
|
|
(13)
|
Percent
of Class Represented by Amount in Row
(11)
|
4.41%3
|
|
(14)
|
Type
of reporting person (See Instructions)
|
OO
|
1
|
Investment
funds from limited and general partners of Longitude Venture Partners,
L.P. (“LVP”), and Longitude Capital Associates, L.P. (“LCA”) were used to
acquire those securities over which the Reporting Persons have shared
voting and dispositive power.
|
2
|
Includes
2,630,278 ordinary shares represented by American Depositary Shares
(“ADSs”) owned of record by LVP, 52,722 ordinary shares represented by
ADSs owned of record by LCA, 1,715,613 ordinary shares represented by ADSs
issuable upon exercise of outstanding warrants owned of record by LVP and
34,387 ordinary shares represented by ADSs issuable upon exercise of
outstanding warrants owned of record by
LCA.
|
3
|
Based
on 100,551,982 ordinary shares calculated as follows: 98,801,982 ordinary
shares as of June 25, 2010, as reported by the issuer in its Annual Report
on Form 20-F for the year ended December 31, 2009, and 1,750,000 ordinary
shares represented by ADSs issuable upon exercise of outstanding warrants
owned of record by LVP and LCA,
collectively.
|
CUSIP
No. 023111107
|
13D
|
Page 3
of 9
|
(1)
|
Name
of Reporting Persons
|
Longitude
Venture Partners, L.P.
|
|
(2)
|
Check
the Appropriate Box If A Member of a Group (See
Instructions)
|
(a)
o
(b)
o
|
|
(3)
|
SEC
Use Only
|
||
(4)
|
Source
of Funds (See Instructions)
|
OO1
|
|
(5)
|
Check
if Disclosure of Legal Proceedings is Required Pursuant to Items 2(d) or
2(e)
|
o
|
|
(6)
|
Citizenship
or Place of Organization
|
Delaware
|
|
Number
of Shares Beneficially Owned by Each Reporting Person
with:
|
|||
(7)
|
Sole
Voting Power
|
None
|
|
(8)
|
Shared
Voting Power
|
4,433,0002
|
|
(9)
|
Sole
Dispositive Power
|
None
|
|
(10)
|
Shared
Dispositive Power
|
4,433,0002
|
|
(11)
|
Aggregate
Amount Beneficially Owned by Each Reporting Person
|
4,433,0002
|
|
(12)
|
Check
if the Aggregate Amount in Row (11) Excludes Certain Shares (See
Instructions)
|
o
|
|
(13)
|
Percent
of Class Represented by Amount in Row (11)
|
4.41%3
|
|
(14)
|
Type
of reporting person (See Instructions)
|
PN
|
1
|
Investment
funds from limited and general partners of LVP and LCA were used to
acquire those securities over which the Reporting Persons have shared
voting and dispositive power.
|
2
|
Includes
2,630,278 ordinary shares represented by ADSs owned of record by LVP,
52,722 ordinary shares represented by ADSs owned of record by LCA,
1,715,613 ordinary shares represented by ADSs issuable upon exercise of
outstanding warrants owned of record by LVP and 34,387 ordinary shares
represented by ADSs issuable upon exercise of outstanding warrants owned
of record by LCA.
|
3
|
Based
on 100,551,982 ordinary shares calculated as follows: 98,801,982 ordinary
shares as of June 25, 2010, as reported by the issuer in its Annual Report
on Form 20-F for the year ended December 31, 2009, and 1,750,000 ordinary
shares represented by ADSs issuable upon exercise of outstanding warrants
owned of record by LVP and LCA,
collectively.
|
CUSIP
No. 023111107
|
13D
|
Page 4
of 9
|
(1)
|
Name
of Reporting Persons
|
Longitude
Capital Associates, L.P.
|
|
(2)
|
Check
the Appropriate Box If A Member of a Group (See
Instructions)
|
(a)
o
(b)
o
|
|
(3)
|
SEC
Use Only
|
||
(4)
|
Source
of Funds (See Instructions)
|
OO1
|
|
(5)
|
Check
if Disclosure of Legal Proceedings is Required Pursuant to Items 2(d) or
2(e)
|
o
|
|
(6)
|
Citizenship
or Place of Organization
|
Delaware
|
|
Number
of Shares Beneficially Owned by Each Reporting Person
with:
|
|||
(7)
|
Sole
Voting Power
|
None
|
|
(8)
|
Shared
Voting Power
|
4,433,0002
|
|
(9)
|
Sole
Dispositive Power
|
None
|
|
(10)
|
Shared
Dispositive Power
|
4,433,0002
|
|
(11)
|
Aggregate
Amount Beneficially Owned by Each Reporting Person
|
4,433,0002
|
|
(12)
|
Check
if the Aggregate Amount in Row (11) Excludes Certain Shares (See
Instructions)
|
o
|
|
(13)
|
Percent
of Class Represented by Amount in Row
(11)
|
4.41%3
|
|
(14)
|
Type
of reporting person (See Instructions)
|
PN
|
1
|
Investment
funds from limited and general partners of LVP and LCA were used to
acquire those securities over which the Reporting Persons have shared
voting and dispositive power.
|
2
|
Includes
2,630,278 ordinary shares represented by ADSs owned of record by LVP,
52,722 ordinary shares represented by ADSs owned of record by LCA,
1,715,613 ordinary shares represented by ADSs issuable upon exercise of
outstanding warrants owned of record by LVP and 34,387 ordinary shares
represented by ADSs issuable upon exercise of outstanding warrants owned
of record by LCA.
|
3
|
Based
on 100,551,982 ordinary shares calculated as follows: 98,801,982 ordinary
shares as of June 25, 2010, as reported by the issuer in its Annual Report
on Form 20-F for the year ended December 31, 2009, and 1,750,000 ordinary
shares represented by ADSs issuable upon exercise of outstanding warrants
owned of record by LVP and LCA,
collectively.
|
CUSIP
No. 023111107
|
13D
|
Page 5
of 9
|
(1)
|
Name
of Reporting Persons
|
Patrick
G. Enright
|
|
(2)
|
Check
the Appropriate Box If A Member of a Group (See
Instructions)
|
(a)
o
(b)
o
|
|
(3)
|
SEC
Use Only
|
||
(4)
|
Source
of Funds (See Instructions)
|
OO1
|
|
(5)
|
Check
if Disclosure of Legal Proceedings is Required Pursuant to Items 2(d) or
2(e)
|
o
|
|
(6)
|
Citizenship
or Place of Organization
|
United
States
|
|
Number
of Shares Beneficially Owned by Each Reporting Person
with:
|
|||
(7)
|
Sole
Voting Power
|
None
|
|
(8)
|
Shared
Voting Power
|
4,433,0002
|
|
(9)
|
Sole
Dispositive Power
|
None
|
|
(10)
|
Shared
Dispositive Power
|
4,433,0002
|
|
(11)
|
Aggregate
Amount Beneficially Owned by Each Reporting Person
|
4,433,0002
|
|
(12)
|
Check
if the Aggregate Amount in Row (11) Excludes
Certain Shares (See Instructions)
|
o
|
|
(13)
|
Percent
of Class Represented by Amount in Row
(11)
|
4.41%3
|
|
(14)
|
Type
of reporting person (See Instructions)
|
IN
|
1
|
Investment
funds from limited and general partners of LVP and LCA were used to
acquire those securities over which the Reporting Persons have shared
voting and dispositive power.
|
2
|
Includes
2,630,278 ordinary shares represented by ADSs owned of record by LVP,
52,722 ordinary shares represented by ADSs owned of record by LCA,
1,715,613 ordinary shares represented by ADSs issuable upon exercise of
outstanding warrants owned of record by LVP and 34,387 ordinary shares
represented by ADSs issuable upon exercise of outstanding warrants owned
of record by LCA.
|
3
|
Based
on 100,551,982 ordinary shares calculated as follows: 98,801,982 ordinary
shares as of June 25, 2010, as reported by the issuer in its Annual Report
on Form 20-F for the year ended December 31, 2009, and 1,750,000 ordinary
shares represented by ADSs issuable upon exercise of outstanding warrants
owned of record by LVP and LCA,
collectively.
|
CUSIP
No. 023111107
|
13D
|
Page 6
of 9
|
(1)
|
Name
of Reporting Persons
|
Juliet
Tammenoms Bakker
|
|
(2)
|
Check
the Appropriate Box If A Member of a Group (See
Instructions)
|
(a)
o
(b)
o
|
|
(3)
|
SEC
Use Only
|
||
(4)
|
Source
of Funds (See Instructions)
|
OO1
|
|
(5)
|
Check
if Disclosure of Legal Proceedings is Required Pursuant to Items 2(d) or
2(e)
|
o
|
|
(6)
|
Citizenship
or Place of Organization
|
United
States
|
|
Number
of Shares Beneficially Owned by Each Reporting Person
with:
|
|||
(7)
|
Sole
Voting Power
|
None
|
|
(8)
|
Shared
Voting Power
|
4,433,0002
|
|
(9)
|
Sole
Dispositive Power
|
None
|
|
(10)
|
Shared
Dispositive Power
|
4,433,0002
|
|
(11)
|
Aggregate
Amount Beneficially Owned by Each Reporting Person
|
4,433,0002
|
|
(12)
|
Check
if the Aggregate Amount in Row (11) Excludes Certain Shares (See
Instructions)
|
o
|
|
(13)
|
Percent
of Class Represented by Amount in Row
(11)
|
4.41%3
|
|
(14)
|
Type
of reporting person (See Instructions)
|
IN
|
1
|
Investment
funds from limited and general partners of LVP and LCA were used to
acquire those securities over which the Reporting Persons have shared
voting and dispositive power.
|
2
|
Includes
2,630,278 ordinary shares represented by ADSs owned of record by LVP,
52,722 ordinary shares represented by ADSs owned of record by LCA,
1,715,613 ordinary shares represented by ADSs issuable upon exercise of
outstanding warrants owned of record by LVP and 34,387 ordinary shares
represented by ADSs issuable upon exercise of outstanding warrants owned
of record by LCA.
|
3
|
Based
on 100,551,982 ordinary shares calculated as follows: 98,801,982 ordinary
shares as of June 25, 2010, as reported by the issuer in its Annual Report
on Form 20-F for the year ended December 31, 2009, and 1,750,000 ordinary
shares represented by ADSs issuable upon exercise of outstanding warrants
owned of record by LVP and LCA,
collectively.
|
CUSIP
No. 023111107
|
13D
|
Page 7
of 9
|
Explanatory
Note:
|
Item
2.
|
Identity and
Background.
|
Item
5.
|
Interest in Securities
of the Issuer.
|
CUSIP
No. 023111107
|
13D
|
Page
8 of 9
|
CUSIP
No. 023111107
|
13D
|
Page 9
of 9
|
LONGITUDE
VENTURE PARTNERS, L.P.
|
||||
By:
LONGITUDE CAPITAL PARTNERS, LLC
|
||||
Its: General
Partner
|
||||
/s/ Patrick G. Enright
|
By:
|
/s/ Patrick G. Enright
|
||
Patrick G. Enright
|
Patrick
G. Enright, Managing Member
|
|||
|
||||
LONGITUDE
CAPITAL ASSOCIATES, L.P.
|
||||
By:
LONGITUDE CAPITAL PARTNERS, LLC
|
||||
Its: General
Partner
|
||||
/s/ Juliet Tammenoms Bakker
|
By:
|
/s/ Patrick G. Enright
|
||
Juliet Tammenoms Bakker
|
|
Patrick
G. Enright, Managing Member
|
||
|
||||
LONGITUDE
CAPITAL PARTNERS, LLC
|
||||
By:
|
/s/ Patrick G. Enright
|
|||
|
Patrick
G. Enright, Managing Member
|
|||
|