Ownership Submission
FORM 4
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940
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(Print or Type Responses)
1. Name and Address of Reporting Person *
TANG KEVIN C
  2. Issuer Name and Ticker or Trading Symbol
Ardea Biosciences, Inc./DE [RDEA]
5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
__X__ Director __X__ 10% Owner
_____ Officer (give title below) _____ Other (specify below)
(Last)
(First)
(Middle)
4747 EXECUTIVE DRIVE,, SUITE 510
3. Date of Earliest Transaction (Month/Day/Year)
06/19/2012
(Street)

SAN DIEGO, CA 92121
4. If Amendment, Date Original Filed(Month/Day/Year)
6. Individual or Joint/Group Filing(Check Applicable Line)
_X_ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3)
2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code
(Instr. 8)
4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)
5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4)
6. Ownership Form: Direct (D) or Indirect (I)
(Instr. 4)
7. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V Amount (A) or (D) Price
Common Stock 06/19/2012   D   15,089 D $ 32 0 D (1)  
Common Stock 06/19/2012   D   67,052 D $ 32 0 I (2) As Trustee (2)
Common Stock 06/19/2012   D   3,733,582 D $ 32 0 I (3) By LP (3)

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
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Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 3)
2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year) 3A. Deemed Execution Date, if any (Month/Day/Year) 4. Transaction Code
(Instr. 8)
5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4, and 5)
6. Date Exercisable and Expiration Date
(Month/Day/Year)
7. Title and Amount of Underlying Securities
(Instr. 3 and 4)
8. Price of Derivative Security
(Instr. 5)
9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 4)
10. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 4)
11. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares
Non-Qualified Stock Option (right to buy) $ 16.49 06/19/2012   D     5,000   (4) 02/01/2014 Common Stock 5,000 $ 15.51 0 D  
Non-Qualified Stock Option (right to buy) $ 13.93 06/19/2012   D     25,000   (4) 06/10/2014 Common Stock 25,000 $ 18.07 0 D  
Non-Qualified Stock Option (right to buy) $ 4.08 06/19/2012   D     10,000   (4) 01/02/2015 Common Stock 10,000 $ 27.92 0 D  
Non-Qualified Stock Option (right to buy) $ 3.5 06/19/2012   D     12,500   (4) 02/12/2016 Common Stock 12,500 $ 28.5 0 D  
Non-Qualified Stock Option (right to buy) $ 4.24 06/19/2012   D     12,500   (4) 01/02/2017 Common Stock 12,500 $ 27.76 0 D  
Non-Qualified Stock Option (right to buy) $ 5.85 06/19/2012   D     1,250   (4) 06/14/2017 Common Stock 1,250 $ 26.15 0 D  
Non-Qualified Stock Option (right to buy) $ 5.85 06/19/2012   D     2,500   (4) 06/14/2017 Common Stock 2,500 $ 26.15 0 D  
Non-Qualified Stock Option (right to buy) $ 15.69 06/19/2012   D     12,500   (4) 01/01/2018 Common Stock 12,500 $ 16.31 0 D  
Non-Qualified Stock Option (right to buy) $ 15.69 06/19/2012   D     7,500   (4) 01/01/2018 Common Stock 7,500 $ 16.31 0 D  
Non-Qualified Stock Option (right to buy) $ 12.16 06/19/2012   D     12,500   (4) 01/01/2019 Common Stock 12,500 $ 19.84 0 D  
Non-Qualified Stock Option (right to buy) $ 12.16 06/19/2012   D     5,000   (4) 01/01/2019 Common Stock 5,000 $ 19.84 0 D  
Non-Qualified Stock Option (right to buy) $ 12.16 06/19/2012   D     2,500   (4) 01/01/2019 Common Stock 2,500 $ 19.84 0 D  
Non-Qualified Stock Option (right to buy) $ 14.29 06/19/2012   D     12,500   (4) 01/03/2020 Common Stock 12,500 $ 17.71 0 D  
Non-Qualified Stock Option (right to buy) $ 25.97 06/19/2012   D     12,500   (4) 01/02/2021 Common Stock 12,500 $ 6.03 0 D  
Non-Qualified Stock Option (right to buy) $ 16.47 06/19/2012   D     12,500   (4) 01/02/2022 Common Stock 12,500 $ 15.53 0 D  
Common Stock Warrant (right to buy) $ 11.14 06/19/2012   D     39,163   (5) 12/18/2013 Common Stock 39,163 $ 20.86 0 I (3) By LP (3)

Reporting Owners

Reporting Owner Name / Address Relationships
 Director  10% Owner  Officer  Other
TANG KEVIN C
4747 EXECUTIVE DRIVE,
SUITE 510
SAN DIEGO, CA 92121
  X   X    

Signatures

 /s/ Kevin C. Tang   06/20/2012
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) The securities are owned by Kevin C. Tang's IRA.
(2) The securities are owned by Kevin C. Tang as custodian for his minor children and as Trustee of the Tang Advisors, LLC Profit Sharing Plan, for which Mr. Tang serves as Trustee and in which he is a participant. Mr. Tang disclaims beneficial ownership of such securities except to the extent of his pecuniary interest therein.
(3) The securities are held by Tang Capital Partners, LP. Kevin C. Tang is the sole manager of Tang Capital Management, LLC, which is the general partner of Tang Capital Partners, LP. Mr. Tang disclaims beneficial ownership of such securities except to the extent of his pecuniary interest therein.
(4) This option was canceled pursuant to the Agreement and Plan of Merger, dated as of April 21, 2012, by and among Ardea Biosciences, Inc. ("Ardea"), Zeneca Inc. and QAM Corp. (the "Merger Agreement"), in exchange for a payment in cash, without interest and less the amount of any required tax withholding, equal to the product of: (i) the excess of $32.00 (the per share merger consideration pursuant to the Merger Agreement) over the exercise price of the option; and (ii) the number of shares of Ardea common stock underlying the option.
(5) This warrant was canceled pursuant to the Merger Agreement in exchange for a payment in cash, without interest and less the amount of any required tax withholding, equal to the product of: (i) the excess of $32.00 (the per share merger consideration pursuant to the Merger Agreement) over the exercise price of the warrant; and (ii) the number of shares of Ardea common stock underlying the warrant.

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