Ownership Submission
FORM 3
 UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940
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(Print or Type Responses)
1. Name and Address of Reporting Person *
  Hoang Tsvetelina P
 2. Date of Event Requiring Statement (Month/Day/Year)
12/21/2018		 3. Issuer Name and Ticker or Trading Symbol
Marker Therapeutics, Inc. [MRKR]
(Last)
(First)
(Middle)
5 WEST FORSYTH STREET, SUITE 200		 4. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
_____ Director _____ 10% Owner
__X__ Officer (give title below) _____ Other (specify below)
VP, Research and Development
 5. If Amendment, Date Original Filed(Month/Day/Year)
(Street)

JACKSONVILLE, FL 32202		 6. Individual or Joint/Group Filing(Check Applicable Line)
_X_ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Beneficially Owned
1.Title of Security
(Instr. 4)		 2. Amount of Securities Beneficially Owned
(Instr. 4)		 3. Ownership Form: Direct (D) or Indirect (I)
(Instr. 5)		 4. Nature of Indirect Beneficial Ownership
(Instr. 5)
Common Stock 179,711
I
By Husband

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly. SEC 1473 (7-02)
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Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 4)		 2. Date Exercisable and Expiration Date
(Month/Day/Year)		 3. Title and Amount of Securities Underlying Derivative Security
(Instr. 4)		 4. Conversion or Exercise Price of Derivative Security 5. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 5)		 6. Nature of Indirect Beneficial Ownership
(Instr. 5)
Date Exercisable Expiration Date Title Amount or Number of Shares
Employee Stock Option (Right to Buy) (1)   (1) 10/19/2028 Common Stock 200,000 $ 9.18 D  
Employee Stock Option (Right to Buy) (2)   (2) 10/19/2028 Common Stock 1,359,855 $ 9.18 I By Husband

Reporting Owners

Reporting Owner Name / Address Relationships
Director 10% Owner Officer Other
Hoang Tsvetelina P
5 WEST FORSYTH STREET
SUITE 200
JACKSONVILLE, FL 32202		       VP, Research and Development  

Signatures

/s/ Mark A. Catchur as Attorney-In-Fact 12/28/2018
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 5(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) Represents options granted under the Company's 2014 Omnibus Stock Ownership Plan, as amended for service as the Company's Vice President, Research and Development. One quarter of the shares vest on the first anniversary of the grant date, the remainder of the shares vest in monthly installments over a three year period upon the continued employment of the Reporting Person by the Company through the vesting dates. The option exercise price is the closing price on the date of the grant, October 19, 2018.
(2) Represents options granted under the Company's 2014 Omnibus Stock Ownership Plan, as amended to Peter Hoang, Dr. Hoang's husband serves as the Company's Chief Executive Officer and President. The options vested and were exercisable immediately. The option exercise price is the closing price on the date of the grant, October 19, 2018.
 
Remarks:
* Mr. Mark A. Catchur is signing as Attorney-in-Fact pursuant to power of attorney dated December 21, 2018 granted by the Reporting Person, a copy of which is filed as an exhibit and incorporated herein by reference.

Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, See Instruction 6 for procedure.

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