Investors are overlooking this one thing, major bank says as it sets 4,000 target on S&P 500 By: MarketWatch December 02, 2020 at 06:33 AM EST Barclays says the S&P 500 will reach 4,000 by the end of 2021, along with a 10-year Treasury yield of 1.25%. Read More >> Related Stocks: Biontech Se ADR Emrg Mkts Ishares MSCI ETF Facebook Pfizer Salesforce Slack Technologies Inc Twitter, Inc.