Ownership Submission
FORM 4
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940
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(Print or Type Responses)
1. Name and Address of Reporting Person *
Cooper Jeffrey H
   2. Issuer Name and Ticker or Trading Symbol
BIOMARIN PHARMACEUTICAL INC [BMRN] 		5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
_____ Director _____ 10% Owner
__X__ Officer (give title below) _____ Other (specify below)
SVP, Chief Financial Officer
(Last)
(First)
(Middle)
C/O BIOMARIN PHARMACEUTICAL INC., 105 DIGITAL DRIVE		 3. Date of Earliest Transaction (Month/Day/Year)
02/29/2008
(Street)

NOVATO, CA 94949		 4. If Amendment, Date Original Filed(Month/Day/Year)
 6. Individual or Joint/Group Filing(Check Applicable Line)
_X_ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3)		 2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code
(Instr. 8)		 4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)		 5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4)		 6. Ownership Form: Direct (D) or Indirect (I)
(Instr. 4)		 7. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V Amount (A) or (D) Price
Common Stock 02/29/2008   M   2,084 A $ 8.1 3,089 D  
Common Stock 02/29/2008   M   1,042 A $ 7.76 4,131 D  
Common Stock 02/29/2008   M   1,250 A $ 5.15 5,381 D  
Common Stock 02/29/2008   M   19,999 A $ 6.13 25,380 D  
Common Stock 02/29/2008   M   31,250 A $ 11.74 56,630 D  
Common Stock 02/29/2008   S   1,100 D $ 37.53 55,530 D  
Common Stock 02/29/2008   S   400 D $ 37.55 55,130 D  
Common Stock 02/29/2008   S   7,400 D $ 37.56 47,730 D  
Common Stock 02/29/2008   S   8,900 D $ 37.57 38,830 D  
Common Stock 02/29/2008   S   3,350 D $ 37.58 35,480 D  
Common Stock 02/29/2008   S   525 D $ 37.59 34,955 D  
Common Stock 02/29/2008   S   10,800 D $ 37.6 24,155 D  
Common Stock 02/29/2008   S   1,666 D $ 37.61 22,489 D  
Common Stock 02/29/2008   S   1,208 D $ 37.62 21,281 D  
Common Stock 02/29/2008   S   200 D $ 37.63 21,081 D  
Common Stock 02/29/2008   S   33 D $ 37.64 21,048 D  
Common Stock 02/29/2008   S   2,381 D $ 37.65 18,667 D  
Common Stock 02/29/2008   S   700 D $ 37.66 17,967 D  
Common Stock 02/29/2008   S   900 D $ 37.67 17,067 D  
Common Stock 02/29/2008   S   1,900 D $ 37.68 15,167 D  
Common Stock 02/29/2008   S   1,017 D $ 37.69 14,150 D  
Common Stock 02/29/2008   S   883 D $ 37.7 13,267 D  
Common Stock 02/29/2008   S   557 D $ 37.72 12,710 D  
Common Stock 02/29/2008   S   100 D $ 37.73 12,610 D  
Common Stock 02/29/2008   S   100 D $ 37.74 12,510 D  
Common Stock 02/29/2008   S   1,400 D $ 37.75 11,110 D  
Common Stock 02/29/2008   S   1,100 D $ 37.76 10,010 D  
Common Stock 02/29/2008   S   2,300 D $ 37.77 7,710 D  
Common Stock 02/29/2008   S   500 D $ 37.78 7,210 D  
Common Stock 02/29/2008   S   300 D $ 37.79 6,910 D  

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
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Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 3)		 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year) 3A. Deemed Execution Date, if any (Month/Day/Year) 4. Transaction Code
(Instr. 8)		 5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4, and 5)		 6. Date Exercisable and Expiration Date
(Month/Day/Year)		 7. Title and Amount of Underlying Securities
(Instr. 3 and 4)		 8. Price of Derivative Security
(Instr. 5)		 9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 4)		 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 4)		 11. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares
Stock Option (right to buy) $ 8.1 02/29/2008   M     2,084 04/06/2004(1) 10/05/2013 Common Stock 2,084 $ 0 217,500 D  
Stock Option (right to buy) $ 7.76 02/29/2008   M     1,042 06/30/2004(2) 12/30/2013 Common Stock 1,042 $ 0 216,458 D  
Stock Option (right to buy) $ 5.15 02/29/2008   M     1,250 02/19/2005(3) 08/18/2014 Common Stock 1,250 $ 0 215,208 D  
Stock Option (right to buy) $ 6.13 02/29/2008   M     19,999 07/07/2005(4) 01/07/2015 Common Stock 19,999 $ 0 195,209 D  
Stock Option (right to buy) $ 11.74 02/29/2008   M     31,250 07/13/2006(5) 01/13/2016 Common Stock 31,250 $ 0 163,959 D  

Reporting Owners

Reporting Owner Name / Address Relationships
 Director  10% Owner  Officer  Other
Cooper Jeffrey H
C/O BIOMARIN PHARMACEUTICAL INC.
105 DIGITAL DRIVE
NOVATO, CA 94949		       SVP, Chief Financial Officer  

Signatures

 /s/ G. Eric Davis, Attorney-in-Fact   03/04/2008
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) Original option grant vested 6/48ths on April 6, 2004 and 1/48th on the 6th of every month thereafter.
(2) Original option grant vested 6/48ths on June 30, 2004 and 1/48th on the 30th of every month thereafter.
(3) Original option grant vested 6/48ths on February 19, 2005 and 1/48th on the 19th of every month thereafter.
(4) Original option grant vested 6/48ths on July 7, 2005 and 1/48th on the 7th of every month thereafter.
(5) Original option grant vested 6/48ths on July 13, 2006 and 1/48th on the 13th of every month thereafter.

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