FORM 8-K

CURRENT REPORT

Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934

Date of Report (Date of earliest event reported): December 4, 2003

VERTEX PHARMACEUTICALS INCORPORATED
(Exact name of registrant as specified in its charter)

MASSACHUSETTS	000-19319	04-3039129
(State or other jurisdiction of incorporation)	(Commission File Number)	(IRS Employer Identification No.

130 Waverly Street Cambridge, Massachusetts 02139
(Address of principal executive offices) (Zip Code)

(617) 444-6100
Registrant’s telephone number, including area code:

Item 9. Regulation FD Disclosure.

On December 4, 2003, Vertex Pharmaceuticals Incorporated issued a press release to announce the sale of certain instrumentation assets of Vertex’s subsidiary Aurora Instruments LLC to Aurora Discovery, Inc., and updating its 2003 full-year financial guidance. A copy of this press release is attached to this Current Report on Form 8-K as Exhibit 99.1.

SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the Registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

	VERTEX PHARMACEUTICALS INCORPORATED (Registrant)


Date: December 5, 2003	/s/ Ian F. Smith
	Ian F. Smith
	Senior Vice President and Chief Financial Officer

EXHIBIT INDEX

The following exhibits are filed as part of this current report on Form 8-K:

Exhibit No.		Description
99.1		Press Release of Vertex Pharmaceuticals Incorporated dated December 4, 2003 entitled “Telegraph Hill Partners Acquires Instrumentation Assets of Aurora Instruments LLC from Vertex Pharmaceuticals.”