Ownership Submission
FORM 3
 UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940
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(Print or Type Responses)
1. Name and Address of Reporting Person *
  Miller Michele Marie
 2. Date of Event Requiring Statement (Month/Day/Year)
10/29/2018		 3. Issuer Name and Ticker or Trading Symbol
ORASURE TECHNOLOGIES INC [OSUR]
(Last)
(First)
(Middle)
220 EAST FIRST STREET		 4. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
_____ Director _____ 10% Owner
__X__ Officer (give title below) _____ Other (specify below)
VP, Finance and Controller
 5. If Amendment, Date Original Filed(Month/Day/Year)
(Street)

BETHLEHEM, PA 18015		 6. Individual or Joint/Group Filing(Check Applicable Line)
_X_ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Beneficially Owned
1.Title of Security
(Instr. 4)		 2. Amount of Securities Beneficially Owned
(Instr. 4)		 3. Ownership Form: Direct (D) or Indirect (I)
(Instr. 5)		 4. Nature of Indirect Beneficial Ownership
(Instr. 5)
Common Stock 1,573
D
 
Common Stock 1,130 (1)
D
 
Common Stock 1,288 (2)
D
 
Common Stock 974 (3)
D
 

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly. SEC 1473 (7-02)
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Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 4)		 2. Date Exercisable and Expiration Date
(Month/Day/Year)		 3. Title and Amount of Securities Underlying Derivative Security
(Instr. 4)		 4. Conversion or Exercise Price of Derivative Security 5. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 5)		 6. Nature of Indirect Beneficial Ownership
(Instr. 5)
Date Exercisable Expiration Date Title Amount or Number of Shares
Non-Qualified Stock Options   (4) 02/03/2024 Common Stock 1,758 $ 5.71 D  
Non-Qualified Stock Options   (5) 02/03/2025 Common Stock 2,362 $ 9.31 D  
Non-Qualified Stock Options   (6) 02/01/2026 Common Stock 7,140 $ 5.37 D  
Non-Qualified Stock Options   (7) 02/01/2027 Common Stock 6,091 $ 8.87 D  
Non-Qualified Stock Options   (8) 02/01/2028 Common Stock 3,254 $ 21.65 D  

Reporting Owners

Reporting Owner Name / Address Relationships
Director 10% Owner Officer Other
Miller Michele Marie
220 EAST FIRST STREET
BETHLEHEM, PA 18015		       VP, Finance and Controller  

Signatures

/s/ Jack E. Jerrett As Attorney-In-Fact For Michele Marie Miller 11/02/2018
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 5(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) Grant of restricted shares under OraSure Technologies, Inc. Stock Award Plan, all of which vest February 1, 2019. Vesting shall cease upon voluntary termination of employment.
(2) Grant of restricted shares under OraSure Technologies, Inc. Stock Award Plan, one-half of which vest on February 1, 2019 and the other half on February 1, 2020. Vesting shall cease upon voluntary termination of employment.
(3) Grant of restricted shares under OraSure Technologies, Inc. Stock Award Plan, one third of which vest on February 1, 2019, the second third on February 1, 2020 and the final third on February 1, 2021. Vesting shall cease upon voluntary termination of employment.
(4) Non-qualified stock options granted on February 3, 2014, vesting 25% at the end of 12 months after the grant date and 75% ratably on a monthly basis over the next 36 months. Vesting shall cease upon voluntary termination of employment.
(5) Non-qualified stock options granted on February 3, 2015, vesting 25% at the end of 12 months after the grant date and 75% ratably on a monthly basis over the next 36 months. Vesting shall cease upon voluntary termination of employment.
(6) Non-qualified stock options granted on February 1, 2016, vesting 25% at the end of 12 months after the grant date and 75% ratably on a monthly basis over the next 36 months. Vesting shall cease upon voluntary termination of employment.
(7) Non-qualified stock options granted on February 1, 2017, vesting 25% at the end of 12 months after the grant date and 75% ratably on a monthly basis over the next 36 months. Vesting shall cease upon voluntary termination of employment.
(8) Non-qualified stock options granted on February 1, 2018, vesting 25% at the end of 12 months after the grant date and 75% ratably on a monthly basis over the next 36 months. Vesting shall cease upon voluntary termination of employment.

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