UNITED STATES
                        SECURITIES EXCHANGE COMMISSION
                            Washington, D.C. 20549

--------------------------------------------------------------------------------


                                 SCHEDULE 13G

                   Under the Securities Exchange Act of 1934
                               (Amendment No. 1)

                               THERAVANCE, INC.
                               ----------------
                               (Name of Issuer)


                   Common Stock, $0.01 par value per share
                   ---------------------------------------
                        (Title of Class of Securities)


                                  88338T104
                                  ---------
                                (CUSIP Number)


                              December 31, 2006
                              -----------------
            (Date of Event which Requires Filing of this Statement)


Check the appropriate box to designate the rule pursuant to which this
Schedule is filed:

                            [_]   Rule 13d-1(b)

                            [X]   Rule 13d-1(c)

                            [_]   Rule 13d-1(d)

* The  remainder  of this  cover  page  shall be  filled  out for a  reporting
person's  initial  filing on this form with  respect to the  subject  class of
securities,  and for any subsequent  amendment  containing  information  which
would alter the disclosures provided in a prior cover page.

The  information  required  in the  remainder  of this cover page shall not be
deemed to be "filed" for the purpose of Section 18 of the Securities  Exchange
Act of 1934 ("Act") or otherwise subject to the liabilities of that section of
the Act but shall be subject to all other provisions of the Act (however,  see
the Notes).


                         Continued on following pages
                               Page 1 of 7 Pages





                                 SCHEDULE 13G

CUSIP No.: 88338T104                                           Page 2 of 7 Pages




.......... ............................................................................................................
                                                                                             
1.        Names of Reporting Persons.

          CHESAPEAKE PARTNERS MANAGEMENT CO., INC.

          I.R.S. Identification Nos. of above persons (entities only):
.......... ............................................................................................................
2.        Check the Appropriate Box if a Member of a Group

          (a) [  ]

          (b) [  ]
.......... ............................................................................................................
3.        SEC Use Only
.......... ............................................................................................................
4.        Citizenship or Place of Organization                    Maryland
...................... ........ .......................................................................................
Number of             5.       Sole Voting Power                  0
Shares                ........ .......................................................................................
Beneficially          6.       Shared Voting Power                2,622,122
Owned by Each         ........ .......................................................................................
Reporting             7.       Sole Dispositive Power             0
Person With           ........ .......................................................................................
                      8.       Shared Dispositive Power           2,622,122
.......... ............................................................................................................
9.        Aggregate Amount Beneficially Owned by Each Reporting Person

          2,622,122
.......... ............................................................................................................
10.       Check if the Aggregate Amount in Row (9) Excludes Certain Shares   [   ]
.......... ............................................................................................................
11.       Percent of Class Represented by Amount in Row (9)

          5.2% based on 50,636,432 Shares outstanding as of November 1, 2006
.......... ............................................................................................................
12.       Type of Reporting Person:

          CO
.......................................................................................................................





                                 SCHEDULE 13G

CUSIP No.: 88338T104                                           Page 3 of 7 Pages

.......... ............................................................................................................
1.        Names of Reporting Persons.

          MARK D. LERNER

          I.R.S. Identification Nos. of above persons (entities only):
.......... ............................................................................................................
2.        Check the Appropriate Box if a Member of a Group

          (a) [  ]

          (b) [  ]
.......... ............................................................................................................
3.        SEC Use Only
.......... ............................................................................................................
4.        Citizenship or Place of Organization                    United States of America
...................... ........ .......................................................................................
Number of             5.       Sole Voting Power                  0
Shares                ........ .......................................................................................
Beneficially          6.       Shared Voting Power                2,622,122
Owned by Each         ........ .......................................................................................
Reporting             7.       Sole Dispositive Power             0
Person With           ........ .......................................................................................
                      8.       Shared Dispositive Power           2,622,122
.......... ............................................................................................................
9.        Aggregate Amount Beneficially Owned by Each Reporting Person

          2,622,122
.......... ............................................................................................................
10.       Check if the Aggregate Amount in Row (9) Excludes Certain Shares   [   ]
.......... ............................................................................................................
11.       Percent of Class Represented by Amount in Row (9)

          5.2% based on 50,636,432 Shares outstanding as of November 1, 2006
.......... ............................................................................................................
12.       Type of Reporting Person:

           HC; IA
.......................................................................................................................





                                 SCHEDULE 13G

CUSIP No.: 88338T104                                           Page 4 of 7 Pages

.......... ............................................................................................................
1.        Names of Reporting Persons.

          TRACI LERNER

          I.R.S. Identification Nos. of above persons (entities only):
.......... ............................................................................................................
2.        Check the Appropriate Box if a Member of a Group

          (a) [  ]

          (b) [  ]
.......... ............................................................................................................
3.        SEC Use Only
.......... ............................................................................................................
4.        Citizenship or Place of Organization                    United States of America
...................... ........ .......................................................................................
Number of             5.       Sole Voting Power                  0
Shares                ........ .......................................................................................
Beneficially          6.       Shared Voting Power                2,622,122
Owned by Each         ........ .......................................................................................
Reporting             7.       Sole Dispositive Power             0
Person With           ........ .......................................................................................
                      8.       Shared Dispositive Power           2,622,122
.......... ............................................................................................................
9.        Aggregate Amount Beneficially Owned by Each Reporting Person

          2,622,122
.......... ............................................................................................................
10.       Check if the Aggregate Amount in Row (9) Excludes Certain Shares   [   ]
.......... ............................................................................................................
11.       Percent of Class Represented by Amount in Row (9)

          5.2% based on 50,636,432 Shares outstanding as of November 1, 2006
.......... ............................................................................................................
12.       Type of Reporting Person:

          HC; IA
.......................................................................................................................






                                                               Page 5 of 7 Pages

Item 1(a).      Name of Issuer:

                Theravance, Inc.  (the "Issuer")

Item 1(b).      Address of Issuer's Principal Executive Offices:

                901 Gateway Boulevard, San Francisco, CA 94080

Item 2(a).      Name of Person Filing

                This Statement is filed on behalf of each of the following
persons (collectively, the "Reporting Persons"):

                i)    Chesapeake Partners Management Co., Inc. ("CPMC");

                ii)   Mark D. Lerner ("Mr. Lerner"); and

                iii)  Traci Lerner ("Ms. Lerner").

                This Statement  relates to Shares (as defined herein) held for
the accounts of each of Chesapeake  Partners Limited  Partnership,  a Maryland
limited partnership  ("CPLP");  and Chesapeake Partners  International Ltd., a
Cayman Islands exempted company ("CPINTL").  CPMC serves as investment manager
to each of CPLP and CPINTL.  CPMC also serves as the General  Partner of CPLP.
Mr. Lerner and Ms. Lerner are officers of CPMC.  In such  capacities,  each of
CPMC,  Mr. Lerner and Ms. Lerner may be deemed to have voting and  dispositive
power over the Shares held for each of CPLP and CPINTL.

Item 2(b).      Address of Principal Business Office or, if None, Residence

                The address of the principal  business office of each of CPMC,
Mr. Lerner and Ms. Lerner is 1829  Reisterstown  Road,  Suite 420,  Baltimore,
Maryland 21208.

Item 2(c).      Citizenship:

                i)   CPMC is a Maryland corporation;

                ii)  Mr. Lerner is a citizen of the United States of America;
                     and

                iii) Ms. Lerner is a citizen of the United States of America.

Item 2(d).      Title of Class of Securities:

                Common Stock, $0.01 par value per share (the "Shares").

Item 2(e).      CUSIP Number:

                88338T104

Item 3.         If This  Statement is Filed Pursuan to  ss.ss.240.13d-1(b)  or
                240.13d-2(b) or (c), Check Whether the Person Filing is a:

                This Item 3 is not applicable.





                                                               Page 6 of 7 Pages

Item 4.         Ownership:

Item 4(a).      Amount Beneficially Owned:

                As of  February  7,  2007,  the Reporting Persons may be deemed
to be the  beneficial owner of  2,622,122  Shares.  This amount consists of (A)
1,318,263  Shares  held  for the account of CPLP, and (B) 1,303,859 Shares held
for the account of CPINTL.

Item 4(b).      Percent of Class:

                The  number of Shares of which the  Reporting  Persons  may be
deemed to be the beneficial owner constitutes  approximately 5.2% of the total
number of Shares outstanding (based upon information provided by the Issuer in
its  most  recently  filed   quarterly   report  on  Form  10-Q,   there  were
approximately 50,636,432 shares outstanding as of November 1, 2006).

Item 4(c).      Number of Shares of which such person has:

CPMC, Mr. Lerner and Ms. Lerner:
--------------------------------

(i) Sole power to vote or direct the vote:                                  0

(ii) Shared power to vote or direct the vote:                       2,622,122

(iii) Sole power to dispose or direct the disposition of:                   0

(iv) Shared power to dispose or direct the disposition of:          2,622,122

Item 5.         Ownership of Five Percent or Less of a Class:

                This Item 5 is not applicable.

Item 6.         Ownership of More than Five Percent on Behalf of Another Person:

                This Item 6 is not applicable.

Item 7.         Identification and Classification of the Subsidiary Which
                Acquired the Security Being Reported on By the Parent Holding
                Company:

                See disclosure in Item 2 hereof.

Item 8.         Identification and Classification of Members of the Group:

                This Item 8 is not applicable.

Item 9.         Notice of Dissolution of Group:

                This Item 9 is not applicable.

Item 10.        Certification:

                By signing below each of the Reporting Persons certifies that,
to the best of their  knowledge and belief,  the securities  referred to above
were not  acquired  and are not held for the  purpose of or with the effect of
changing or  influencing  the control of the issuer of the securities and were
not acquired and are not held in connection  with or as a  participant  in any
transaction having that purpose or effect.





                                                               Page 7 of 7 Pages

                                   SIGNATURE

      After  reasonable  inquiry and to the best of my knowledge and belief, I
certify that the information set forth in this statement is true, complete and
correct.

Date: February 14, 2007                CHESAPEAKE PARTNERS MANAGEMENT CO., INC.


                                       By: /s/ Mark D. Lerner
                                           ----------------------------
                                       Name:  Mark D. Lerner
                                       Title: Vice President

Date: February 14, 2007                MARK D. LERNER


                                       /s/ Mark D. Lerner
                                       ----------------------------

Date: February 14, 2007                TRACI LERNER


                                       /s/ Traci Lerner
                                       ----------------------------