UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                  SCHEDULE 13G
                    Under the Securities Exchange Act of 1934

                                 Amendment No. 2
                            Atrix Laboratories, Inc.
                                (Name of Issuer)

                                  Common Stock
                         (Title of Class of Securities)

                                    04962L101
                                 (CUSIP Number)

                                  June 14, 2004

             (Date of Event Which Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule
is filed:

[x] Rule 13d-1(b)

[ ] Rule 13d-1(c)

[ ] Rule 13d-1(d)

*The remainder of this cover page shall be filled out for a reporting person's
initial filing on this form with respect to the subject class of securities, and
for any subsequent amendment containing information which would alter the
disclosures provided in a prior cover page.


The information required in the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the Securities Exchange Act of
1934 ("Act") or otherwise subject to the liabilities of that section of the Act
but shall be subject to all other provisions of the Act (however, see the
Notes).





                               CUSIP No. 04962L101


        1.  Names of Reporting Persons.
            I.R.S. Identification Nos. of above persons (entities only).

            OrbiMed Advisors LLC

        2.  Check the Appropriate Box if a Member of a Group (See Instructions)

            [ ] (a)
            [ ] (b)

        3.  SEC Use Only

        4.  Citizenship or Place of Organization

             Delaware

       5.  Sole Voting Power: 0
Number of
Shares           6.  Shared Voting Power: 0
Beneficially
Owned by         7.  Sole Dispositive Power:  0
Each Reporting
Person With      8.  Shared Dispositive Power: 0

        9.  Aggregate Amount Beneficially Owned by Each Reporting Person:  0

        10. Check if the Aggregate Amount in Row (9) Excludes Certain Shares
            (See Instructions)

        11. Percent of Class Represented by Amount in Row (9):    0%

        12. Type of Reporting Person (See Instructions):   IA








                               CUSIP No. 04962L101


        1.  Names of Reporting Persons.
            I.R.S. Identification Nos. of above persons (entities only).

            OrbiMed Capital LLC

        2.  Check the Appropriate Box if a Member of a Group (See Instructions)

             [ ] (a)
             [ ] (b)

        3.  SEC Use Only

        4.  Citizenship or Place of Organization

            Delaware

               5.  Sole Voting Power:  0
Number of
Shares         6.  Shared Voting Power:  0
Beneficially
Owned by       7.  Sole Dispositive Power:  0
Each Reporting
Person With    8.  Shared Dispositive Power:  0

        9.  Aggregate Amount Beneficially Owned by Each Reporting Person 0

        10. Check if the Aggregate Amount in Row (9) Excludes Certain Shares
            (See Instructions)

        11. Percent of Class Represented by Amount in Row (9) 0%

        12. Type of Reporting Person (See Instructions) IA







                               CUSIP No. 04962L101


        1.  Names of Reporting Persons.
            I.R.S. Identification Nos. of above persons (entities only).

            Samuel D. Isaly

        2.  Check the Appropriate Box if a Member of a Group (See Instructions)

             [ ] (a)
             [ ] (b)

        3.  SEC Use Only

        4.  Citizenship or Place of Organization

            United States

               5.  Sole Voting Power:  0
Number of
Shares         6.  Shared Voting Power:  0
Beneficially
Owned by       7.  Sole Dispositive Power:  0
Each Reporting
Person With    8.  Shared Dispositive Power:  0

        9.  Aggregate Amount Beneficially Owned by Each Reporting Person: 0

        10. Check if the Aggregate Amount in Row (9) Excludes Certain Shares
            (See Instructions)

        11. Percent of Class Represented by Amount in Row (9) 0%

        12. Type of Reporting Person (See Instructions) HC







Item 1. (a)  Issuer: Atrix Laboratories, Inc.

        1.  Address:
            2579 Midpoint Drive
            Fort Collins, Colorado 80525

Item 2. (a)  Name of Person Filing:
             OrbiMed Advisors LLC
             OrbiMed Capital LLC
             Samuel D. Isaly

        (b)  Address of Principal Business Offices:
             767 Third Avenue, 30th Floor
             New York, New York 10017

        (c)  Citizenship:
             Please refer to Item 4 on each cover sheet for each filing person

        (d)  Title of Class of Securities
             Common stock

                       (e) CUSIP Number: 04962L101

Item 3. OrbiMed Advisors LLC and OrbiMed Capital LLC are investment advisors in
accordance with ss.240.13d-1(b)(1)(ii)(E). Samuel D. Isaly is a control person
in accordance with ss.240.13d-1(b)(1)(ii)(G).

Item 4.  Ownership

         Please see Items 5 - 9 and 11 for each cover sheet for each filing
separately

Item 5.  Ownership of Five Percent or Less of a Class

         Reporting persons no longer hold any of the securities. Previously, the
Reporting Persons held securities on behalf of other persons who have the right
to receive or the power to direct the receipt of dividends from, or proceeds
from sale of, such securities.

Item 6.  Ownership of More than Five Percent on Behalf of Another Person.

         Not Applicable



Item 7.  Identification and Classification of the Subsidiary Which Acquired the
Security Being Reported on by the Parent Holding Company

         Not Applicable

Item 8.  Identification and Classification of Members of the Group

         Not Applicable


Item 9.  Notice of Dissolution of Group

         Not Applicable

Item 10. Certification

         By signing below I certify that, to the best of my knowledge and
belief, the securities referred to above were acquired and held in the ordinary
course of business and were not acquired and are not held for the purpose of or
with the effect of changing or influencing the control of the issuer of the
securities and were not acquired and are not held in connection with or as a
participant in any transaction having that purpose or effect.





                                    SIGNATURE

After reasonable inquiry and to the best of my knowledge and belief, I certify
that the information set forth in this statement is true, complete and correct.

Date: June 29, 2004
                                       OrbiMed Advisors LLC

                                       By:  /s/ Samuel D. Isaly
                                       --------------------------
                                       Name:  Samuel D. Isaly
                                       Title: President

                                       OrbiMed Capital LLC

                                       By: /s/ Samuel D. Isaly
                                       --------------------------
                                       Name:  Samuel D. Isaly
                                       Title: Managing Member


                                       By: /s/ Samuel D. Isaly
                                       --------------------------
                                       Name:  Samuel D. Isaly