Edgar Filing: Regulus Therapeutics Inc.

You are receiving this communication because you hold shares in the company named above.

This is not a ballot. You cannot use this notice to vote these shares. This communication presents only an overview of the more complete proxy materials that are available to you on the Internet. You may view the proxy materials online at www.proxyvote.com or easily request a paper copy (see reverse side).

We encourage you to access and review all of the important information contained in the proxy materials before voting.

See the reverse side of this notice to obtain proxy materials and voting instructions.

DEFA14A

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

SCHEDULE 14A INFORMATION

Proxy Statement Pursuant to Section 14(a) of the

Securities Exchange Act of 1934

(Amendment No. )

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Regulus Therapeutics Inc.

(Name of Registrant as Specified In Its Charter)

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*** Exercise Your Right to Vote ***

Important Notice Regarding the Availability of Proxy Materials for the

Stockholder Meeting to Be Held on June 2, 2016.

REGULUS THERAPEUTICS INC.

Meeting Information

Meeting Type:

Annual Meeting

For holders as of:

April 8, 2016

Date: June 2, 2016

Time: 9:00 AM PDT

Location: The Company’s Offices

10614 Science Center Dr.

REGULUS THERAPEUTICS INC.

10614 SCIENCE CENTER DRIVE

SAN DIEGO, CA 92121

San Diego, CA 92121

How to Access the Proxy Materials


						Proxy Materials Available to VIEW or RECEIVE:
						PROXY STATEMENT 2015 ANNUAL REPORT TO STOCKHOLDERS FORM 10-K How to View Online: Have the information that is printed in the box marked by the arrow (located on the following page) and visit: www.proxyvote.com. How to Request and Receive a PAPER or E-MAIL Copy: If you want to receive a paper or e-mail copy of these documents, you must request one. There is NO charge for requesting a copy. Please choose one of the following methods to make your request: 1) BY INTERNET: www.proxyvote.com 2) BY TELEPHONE: 1-800-579-1639 3) BY E-MAIL: sendmaterial@proxyvote.com If requesting materials by e-mail, please send a blank e-mail with the information that is printed in the box marked by the arrow (located on the following page) in the subject line. Requests, instructions and other inquiries sent to this e-mail address will NOT be forwarded to your investment advisor. Please make the request as instructed above on or before May 19, 2016 to facilitate timely delivery.

Please Choose One of the Following Voting Methods



						Vote In Person: Many stockholder meetings have attendance requirements including, but not limited to, the possession of an attendance ticket issued by the entity holding the meeting. Please check the meeting materials for any special requirements for meeting attendance. At the meeting, you will need to request a ballot to vote these shares. Vote By Internet: To vote now by Internet, go to www.proxyvote.com. Have the information that is printed in the box marked by the arrow (located on the following page) available and follow the instructions. Vote By Mail: You can vote by mail by requesting a paper copy of the materials, which will include a proxy card.


		Voting Items
		The Board of Directors recommends you vote FOR the following:

		1. Election of Directors
		Nominees:
		01) David Baltimore, Ph.D. 02) Mark Foletta 03) Paul Grint, M.D. 04) Stelios Papadopoulos, Ph.D.				05) William Rastetter, Ph.D. 06) Hugh Rosen, M.D., Ph.D. 07) Douglas Williams, Ph.D.

		The Board of Directors recommends you vote FOR proposals 2 and 3.

		2. Approval of Amendment to the Company’s Amended and Restated Certificate of Incorporation to permit removal of a member of the Board of Directors with or without cause by majority vote of stockholders.

		3. Ratification of the selection of Ernst & Young LLP as the independent registered public accounting firm of the company for the year ending December 31, 2016.

		NOTE: Such other business as may properly come before the meeting or any adjournment thereof.

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