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[ x ]

Rule 13d-1(b)

[ x ]

Rule 13d-1(c)

[ ]

Rule 13d-1(d)

SEC 1745 (01-06)

Potential persons who are to respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB control number.

CUSIP No. 82669P104

1.

Names of Reporting Persons.
I.R.S. Identification Nos. of above persons (entities only).
Gruber and McBaine Capital Management, LLC.

2.

Check the Appropriate Box if a Member of a Group (See Instructions)

(a)

X

(b)

3.

SEC Use Only ............................................................................................................................................

4.

California

Number of
Shares
Beneficially
Owned by
Each Reporting
Person With

5.

Sole Voting Power 0

6.

Shared Voting Power 3,094,750

7.

Sole Dispositive Power 0

8.

Shared Dispositive Power 3,094,750

9.

Aggregate Amount Beneficially Owned by Each Reporting Person 3,094,750

10.

Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions).................................

11.

Percent of Class Represented by Amount in Row (9) 7.91%

12.

Type of Reporting Person (See Instructions) IA & OO

CUSIP No. 82669P104

1.

Names of Reporting Persons.
I.R.S. Identification Nos. of above persons (entities only).
Jon D. Gruber

2.

Check the Appropriate Box if a Member of a Group (See Instructions)

(a)

X

(b)

3.

SEC Use Only ............................................................................................................................................

4.

United States

Number of
Shares
Beneficially
Owned by
Each Reporting
Person With

5.

Sole Voting Power 293,950

6.

Shared Voting Power 3,094,750

7.

Sole Dispositive Power 293,950

8.

Shared Dispositive Power 3,094,750

9.

Aggregate Amount Beneficially Owned by Each Reporting Person 3,388,700

10.

Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions).................................

11.

Percent of Class Represented by Amount in Row (9) 8.66%

12.

Type of Reporting Person (See Instructions) IN

CUSIP No. 82669P104

1.

Names of Reporting Persons.
I.R.S. Identification Nos. of above persons (entities only).
J. Patterson McBaine

2.

Check the Appropriate Box if a Member of a Group (See Instructions)

(a)

X

(b)

3.

SEC Use Only ............................................................................................................................................

4.

United States

Number of
Shares
Beneficially
Owned by
Each Reporting
Person With

5.

Sole Voting Power 299,050

6.

Shared Voting Power 3,094,750

7.

Sole Dispositive Power 299,050

8.

Shared Dispositive Power 3,094,750

9.

Aggregate Amount Beneficially Owned by Each Reporting Person 3,393,800

10.

Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions).................................

11.

Percent of Class Represented by Amount in Row (9) 8.67%

12.

Type of Reporting Person (See Instructions) IN

CUSIP No. 82669P104

1.

Names of Reporting Persons.
I.R.S. Identification Nos. of above persons (entities only).
Eric B. Swergold

2.

Check the Appropriate Box if a Member of a Group (See Instructions)

(a)

X

(b)

3.

SEC Use Only ............................................................................................................................................

4.

United States

Number of
Shares
Beneficially
Owned by
Each Reporting
Person With

5.

Sole Voting Power 0

6.

Shared Voting Power 3,094,750

7.

Sole Dispositive Power 0

8.

Shared Dispositive Power 3,094,750

9.

3,094,750

10.

Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions).................................

11.

Percent of Class Represented by Amount in Row (9) 7.91%

12.

Type of Reporting Person (See Instructions) IN

CUSIP No. 82669P104

1.

Names of Reporting Persons.
I.R.S. Identification Nos. of above persons (entities only).
Lagunitas Partners

2.

Check the Appropriate Box if a Member of a Group (See Instructions)

(a)

X

(b)

3.

SEC Use Only ............................................................................................................................................

4.

United States

Number of
Shares
Beneficially
Owned by
Each Reporting
Person With

5.

Sole Voting Power 0

6.

Shared Voting Power 1,993,850

7.

Sole Dispositive Power 0

8.

Shared Dispositive Power 1,993,850

9.

1,993,850

10.

Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions).................................

11.

Percent of Class Represented by Amount in Row (9) 5.10%

12.

Type of Reporting Person (See Instructions) PN

Item 1.

(a)

Name of Issuer: SIGNALIFE, INC.

(b)

Address of Issuer's Principal Executive Offices:

Greenville, South Carolina 29601

Item 2.

(a)

Name of Person Filing:

Lagunitas Partners ("Lagunitas")

(b)

Address of Principal Business Office or, if none, Residence:

50 Osgood Place, Penthouse, San Francisco, CA 94133

(c)

Citizenship: See item 4 of cover sheet.

(d)

Title of Class of Securities: Common Stock

(e)

CUSIP Number: 82669P104

Item 3.

If this statement is filed pursuant to 240.13d-1(b) or 240.13d-2(b) or (c), check whether the person filing is a:

(a)

[ ]

Broker or dealer registered under section 15 of the Act (15 U.S.C. 78o).

(b)

[ ]

Bank as defined in section 3(a)(6) of the Act (15 U.S.C. 78c).

(c)

[ ]

Insurance company as defined in section 3(a)(19) of the Act (15 U.S.C. 78c).

(d)

[ ]

Investment company registered under section 8 of the Investment Company Act of 1940 (15 U.S.C 80a-8).

(e)

[x]

An investment adviser in accordance with 240.13d-1(b)(1)(ii)(E);

(f)

[ ]

An employee benefit plan or endowment fund in accordance with 240.13d-1(b)(1)(ii)(F);

(g)

[x]

A parent holding company or control person in accordance with 240.13d-1(b)(1)(ii)(G);

(h)

[ ]

A savings associations as defined in Section 3(b) of the Federal Deposit Insurance Act (12 U.S.C. 1813);

(i)

[ ]

A church plan that is excluded from the definition of an investment company under section 3(c)(14) of the Investment Company Act of 1940 (15 U.S.C. 80a-3);

(j)

[x]

Group, in accordance with 240.13d-1(b)(1)(ii)(J).

Item 4.

Ownership.

See Items 5-9 and 11 of the cover page for each Filer.

Item 5.

Ownership of Five Percent or Less of a Class

If this statement is being filed to report the fact that as of the date hereof the reporting person has ceased to be the beneficial owner of more than five percent of the class of securities, check the following [].

Item 6.

Ownership of More than Five Percent on Behalf of Another Person.

GMCM is a registered investment advisor whose clients have the right to receive or the power to direct the receipt of dividends from, or the proceeds from the sale of the Stock. Gruber & McBaine are the Managers, controlling persons and portfolio managers of GMCM. No individual clients holdings of the Stock are more than five percent of the outstanding Stock. Lagunitas is an investment limited partnerships of which GMCM is the general partner.

Item 7.

Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on By the Parent Holding Company or Control Person.

Not Applicable

Item 8.

Identification and Classification of Members of the Group

GMCM, Gruber, McBaine and Swergold constitute a group within the meaning of Rule 13d-5(b). Lagunitas is not a member of any group and disclaims beneficial ownership of the securities with respect to its ownership is reposited.

Item 9.

Notice of Dissolution of Group

Not Applicable

Item 10.

Certification

(a)

The following certification shall be included with respect to GMCM:

By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were acquired and are held in the ordinary course of business and were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect.

(b)

The following certification shall be included with respect to Lagunitas, Gruber, McBaine and Swergold:

By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect.

Dated: September 22, 2006

Gruber & McBaine Capital Management, LLC

By: /s/ J. Patterson McBaine

Title: Manager

Attention:

Intentional misstatements or omissions of fact constitute Federal criminal violations
(See 18 U.S.C. 1001)