Registration No. __________

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                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

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             REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933

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                             Sharps Compliance Corp.
             (Exact name of Registrant as specified in its charter)

                   Delaware                                      74-2657168
(State or other jurisdiction of incorporation or              (I.R.S. Employer
                 organization)                               Identification No.)

                9350 Kirby Drive, Suite 300, Houston, Texas 77054
                     (Address of principal executive office)

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                             Sharps Compliance Corp.
                                 1993 STOCK PLAN
                            (Full title of the Plan)

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                               RL&F Service Corp.
                          One Rodney Square, 10th Floor
                           Wilmington, Delaware 19801
                                 (302) 651.7700

                (Name, address, including zip code, and telephone
               number, including area code, of agent for service)

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                         CALCULATION OF REGISTRATION FEE
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                                                     Proposed Maximum   Proposed Maximum        Amount of
  Title of Securities to be        Amount to be        Offering Price       Aggregate       Registration Fee
       Registered                   Registered          Per Share(2)    Offering Price(2)
============================================================================================================
                                                                                      
Common Stock, Par Value $0.01    500,000 shares(1)         $0.84           $420,000.00            $44.94





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(1)
         Pursuant to Rule 416 under the  Securities  Act of 1933 as amended (the
         "Securities Act"), additional shares of the common stock of the Company
         issued or which become issuable in order to prevent dilution  resulting
         from any future stock split, stock dividend or similar transaction that
         are being registered hereunder.

(2)
         Estimated  pursuant to Rules 457(c) and 457(h) under the Securities Act
         solely for the purpose of calculating the  registration  fee based upon
         the  average  of the bid and asked  prices of the  Registrant's  Common
         Stock on the OTC Electronic Bulletin Board on February 1, 2006.

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                                EXPLANATORY NOTE

         This  Registration  Statement is being filed for purpose of registering
additional   securities  of  the  same  class  as  other  securities  for  which
registration  statements  on Form S-8 were filed  relating to the same  employee
benefit plan and are effective.  Pursuant to General  Instruction E of Form S-8,
the Company's Registration Statements on Form S-8, filed with the Securities and
Exchange  Commission  on September 25, 2002 (File No.  333-100093),  January 21,
2003 (File No.  333-102626),  and February 12, 2003 (File No.  333-103158),  are
hereby incorporated by reference.

                                     PART II
               INFORMATION REQUIRED IN THE REGISTRATION STATEMENT


Item 3.  Incorporation of Documents by Reference

         The following  documents and reports filed by the  Registrant  with the
Securities and Exchange Commission (the "Commission") are incorporated herein by
reference:

         (a) Annual  Report of the  Registrant on Form 10-KSB for the year ended
         June 30, 2005.
         (b) Quarterly  Reports of the Registrant on Form 10-QSB for the quarter
         ended  September 30, 2005 and December 31, 2005 and Current  Reports of
         the  Registrant  on Form 8-K filed  with the  Commission  on August 12,
         2005,  August 24, 2005,  October 3, 2005,  October 25, 2005 and January
         24, 2006.
         (c) The description of the Registrant's  common stock, par value $0.01,
         set forth on Form 8-K, dated February 27, 1998, including any amendment
         or report filed for the purpose of updating such description.

         All documents filed by the Registrant  with the Commission  pursuant to
Sections 13(a),  13(c),  14 or 15(d) of the Securities  Exchange Act of 1934, as
amended  (the  "Exchange  Act"),  subsequent  to the  date of this  registration
statement and prior to filing of a post-effective amendment to this registration
statement  which  indicates that all securities  offered have been sold or which
deregisters  all  securities  then  remaining  unsold  shall  be  deemed  to  be
incorporated  by reference  into this  registration  statement  and to be a part
hereof from the date of filing of such documents.

Item 4.  Description of Securities.

         Not applicable.

Item 5.  Interests of Named Experts and Counsel.

         Not applicable.





Item 6.  Indemnification of Directors and Officers

         Delaware law generally  sets forth our power to indemnify our officers,
directors,  employees  and agents.  We have  authority  under Section 145 of the
Delaware General Corporation Law to indemnify our directors, officers, employees
and  agents  to the  extent  provided  for in  that  statute.  Our  Articles  of
Incorporation provide as follows:

         The  corporation  shall  indemnify and advance  expenses to any and all
persons who may serve or who have served at any time as  directors  or officers,
or who at the request of the Board of Directors of the  corporation may serve or
at any time have served as directors or officers of another corporation in which
the corporation at such time owned or may own shares of stock or of which it was
or may be a creditor, and their respective heirs, administrators, successors and
assigns,  against any and all expenses,  including  amounts paid upon judgments,
counsel fees and amounts paid in settlement (before or after suit is commenced),
actually and necessarily incurred by such persons in connection with the defense
or settlement of any claim,  action, suit or proceeding in which they, or any of
them, are made parties, or a party, or which may be asserted against them or any
of them,  by reason of being or having been  directors or officers or a director
or officer of the corporation, or of such other corporation,  except in relation
to  matters as to which any such  director  or  officer  or former  director  or
officer or person  shall be  adjudged in any action,  suit or  proceeding  to be
liable for his own negligence or misconduct in the performance of his duty. Such
indemnification  shall  be in  addition  to any  other  rights  to  which  those
indemnified  may  be  entitled  under  any  law,  by-law,   amendment,  vote  of
stockholders or otherwise.

         Except to the  extent  herein  above  set  forth,  there is no  charter
provision, bylaw, contract,  arrangement or statute pursuant to which any of our
directors or officers are  indemnified in any manner against any liability which
he may incur in his  capacity  as a  director  or  officer.  We also  maintain a
standard  director and officer liability policy to fund our obligation as stated
herein above.

         Insofar as indemnification for liabilities arising under the Securities
Act may be  permitted to  directors,  officers  and  controlling  persons of the
Company pursuant to the foregoing provisions, or otherwise, the Company has been
advised  that in the opinion of the  Securities  and  Exchange  Commission  such
indemnification  is against public policy as expressed in the Securities Act and
is,  therefore,  unenforceable.  In the event  that a claim for  indemnification
against  such  liabilities  (other  than the  payment by the Company of expenses
incurred or paid by a director,  officer or controlling person of the Company in
the  successful  defense of any action,  suit or proceeding) is asserted by such
director,  officer or controlling person in connection with the securities being
registered,  the Company  will,  unless in the opinion of its counsel the matter
has been  settled by  controlling  precedent,  submit to a court of  appropriate
jurisdiction the question whether such  indemnification  by it is against public
policy as  expressed  in the  Securities  Act and will be  governed by the final
adjudication of such issue.


Item 7.  Exemption from Registration Claims.

        Not applicable.


Item 8.  Exhibits.

         Except as noted below,  the following  Exhibits are filed  herewith and
made a part hereof.

Exhibit   Description of Document
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4.1      Sharps Compliance Corp. Employee Stock Purchase Plan

5.1*     Opinion of Looper Reed & McGraw, a professional corporation and Consent

23.1*    Consent of Independent Accountants

24.1*    Power of Attorney






99.1*    Certification by Chief Executive Officer

99.2*    Certification by Chief Financial Officer
-----------------------
*Filed herewith.

Item 9.  Undertakings

         (a) The undersigned Registrant hereby undertakes:

                  (1) To file,  during any  period in which  offers or sales are
         being made, a post-effective amendment to the Registration Statement:

                           (i) To include  any  prospectus  required  by Section
                  10(a)(3) of the Securities Act of 1933;

                           (ii) To reflect in the prospectus any facts or events
                  arising after the effective date of the Registration Statement
                  (or the most recent  post-effective  amendment thereof) which,
                  individually  or in the  aggregate,  represent  a  fundamental
                  change  in the  information  set  forth  in  the  registration
                  statement.  Notwithstanding  the  foregoing,  any  increase or
                  decrease in volume of securities  offered (if the total dollar
                  value of  securities  offered  would not exceed that which was
                  registered)  and any deviation from the low or high end of the
                  estimated  maximum offering range may be reflected in the form
                  of  prospectus  filed  with the  Commission  pursuant  to Rule
                  424(b) if, in the  aggregate,  the changes in volume and price
                  represent  no  more  than 20  percent  change  in the  maximum
                  aggregate  offering  price  set forth in the  "Calculation  of
                  Registration   Fee"  table  in  the   effective   registration
                  statement;

                          (iii) To include any material information with respect
                  to the plan of distribution not previously disclosed in the
                  registration statement or any material change to such
                  information in the Registration Statement; provided, however,
                  that paragraphs (a)(1)(i) and (a)(1)(ii) do not apply if the
                  Registration Statement is on Form S-3, Form S-8 or Form F-3,
                  and the information required to be included in a
                  post-effective amendment by those paragraphs is contained in
                  periodic reports filed with or furnished to the Commission by
                  the registrant pursuant to Section 13 or 15(d) of the
                  Securities Exchange Act of 1934 that are incorporated by
                  reference in the Registration Statement.

                  (2) That, for the purpose of determining  any liability  under
         the Securities Act of 1933, each such post-effective amendment shall be
         deemed to be a new  registration  statement  relating to the securities
         offered therein, and the offering of such securities at that time shall
         be deemed to be the initial bona fide offering thereof.

                  (3) To remove from  registration by means of a  post-effective
         amendment any of the securities being registered which remain unsold at
         the termination of the offering.

         (b) For the purpose of determining  any liability  under the Securities
Act of 1933, each filing of the  Registrant's  annual report pursuant to section
13(a) or  section  15(d) of the  Securities  Exchange  Act of 1934  (and,  where
applicable,  each filing of an employee benefit plan's annual report pursuant to
section 15(d) of the Securities  Exchange Act of 1934) that is  incorporated  by
reference in the Registration Statement shall be deemed to be a new registration
statement relating to the securities  offered therein,  and the offering of such
securities  at that time shall be deemed to be the  initial  bona fide  offering
thereof.

         (c)  Insofar  as  indemnification  for  liabilities  arising  under the
Securities Act of 1933 may be permitted to directors,  officers and  controlling
persons of the Registrant  pursuant to the foregoing  provisions,  or otherwise,
the  Registrant  has been  advised  that in the  opinion of the  Securities  and
Exchange  Commission such  indemnification is against public policy as expressed
in the Act and is,  therefore,  unenforceable.  In the  event  that a claim  for





indemnification  against  such  liabilities  (other  than  the  payment  by  the
Registrant of expenses  incurred or paid by a director,  officer or  controlling
person of the  Registrant  in the  successful  defense  of any  action,  suit or
proceeding)  is  asserted by such  director,  officer or  controlling  person in
connection with the securities being registered,  the Registrant will, unless in
the opinion of its counsel the matter has been settled by controlling precedent,
submit  to a  court  of  appropriate  jurisdiction  the  question  whether  such
indemnification  by it is against public policy as expressed in the Act and will
be governed by the final adjudication of such issue.


                                   SIGNATURES

         Pursuant to the  requirements  of the  Securities  Act, the  Registrant
certifies  that it has  reasonable  grounds  to  believe  that it meets  all the
requirements  for  filing  on Form S-8 and has  duly  caused  this  Registration
Statement  to be  signed  on its  behalf  by  the  undersigned,  thereunto  duly
authorized, in the City of Houston, State of Texas, on January 30, 2006.

                                        Sharps Compliance Corp.

                                        By: /s/  DR. BURTON J. KUNIK
                                           -------------------------------------
                                           Dr. Burton J. Kunik,
                                           Chief Executive Officer and President

         Pursuant  to the  requirements  of the  Securities  Act of  1933,  this
Registration  Statement  has been signed below by the  following  persons in the
capacities indicated as of the dates indicated.

       Signatures                      Titles                         Date
--------------------------    ----------------------------      ----------------

 /s/  DR. BURTON J. KUNIK     Chairman of the Board, Chief      January 30, 2006
--------------------------    Executive Officer, President,
Dr. Burton J. Kunik           and Director

 /s/ RAMSEY GILLMAN*          Director                          January 30, 2006
--------------------------
Ramsey Gillman*


 /s/ F. GARDNER PARKER.*      Director                          January 30, 2006
--------------------------
F. Gardner Parker*


 /s/ JOHN R. (RANDY) GROW*    Director                          January 30, 2006
--------------------------
John R. (Randy) Grow*

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         Dr. Burton J. Kunik, the undersigned  attorney-in-fact,  by signing his
name  below,  does  hereby  sign this  Registration  Statement  on behalf of the
directors and officers of Sharps  Compliance  Corp.  indicated above by asterisk
(constituting  a majority  of the  directors)  pursuant  to a power of  attorney
executed by such persons and filed with the Securities  and Exchange  Commission
contemporaneously herewith.

By: /s/ Dr. Burton J. Kunik, as attorney-in-fact





         Pursuant  to the  requirements  of the  Securities  Act  of  1933,  the
administrators  of the Plan have duly caused this  Registration  Statement to be
signed on its behalf by the undersigned,  thereunto duly authorized, in the City
of Houston, State of Texas, on January 30, 2006.

                               Sharps Compliance Corp

                               By:              /s/  David P. Tusa
                                  ----------------------------------------------
                                                   David P. Tusa
                                  Senior Vice President, Chief Financial Officer
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                                  EXHIBIT INDEX


Exhibit Number    Exhibit
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4.1               Sharps Compliance Corp. Employee Stock Purchase Plan

5.1*              Opinion  of  Looper  Reed  &  McGraw,   P.C.,  a  professional
                  corporation and Consent

23.1*             Consent of Independent Accountants

24.1*             Power of Attorney

99.1*             Certification by Chief Executive Officer

99.2*             Certification by Chief Financial Officer
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 *Filed herewith.