FORM 4 Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940

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1. Name and Address of Reporting Person * Demopulos Gregory A MD   2. Issuer Name and Ticker or Trading Symbol OMEROS CORP [OMER] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable) __X__ Director _____ 10% Owner __X__ Officer (give title below) _____ Other (specify below) Chairman, CEO & President (Last) (First) (Middle) 201 ELLIOTT AVENUE WEST 3. Date of Earliest Transaction (Month/Day/Year) 12/28/2017 (Street) SEATTLE, WA 98119 4. If Amendment, Date Original Filed(Month/Day/Year) 6. Individual or Joint/Group Filing(Check Applicable Line) _X_ Form filed by One Reporting Person ___ Form filed by More than One Reporting Person (City) (State) (Zip) Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned

1.Title of Security (Instr. 3) 2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4) Code V Amount (A) or (D) Price Common Stock 12/28/2017   M   102,040 A $ 2.45 1,987,025 D   Common Stock 12/28/2017   M   39,961 A $ 4.1 2,026,986 D

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Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)

1. Title of Derivative Security (Instr. 3)

2. Conversion or Exercise Price of Derivative Security

3. Transaction Date (Month/Day/Year)

3A. Deemed Execution Date, if any (Month/Day/Year)

4. Transaction Code (Instr. 8)

5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4, and 5)

6. Date Exercisable and Expiration Date (Month/Day/Year)

7. Title and Amount of Underlying Securities (Instr. 3 and 4)

8. Price of Derivative Security (Instr. 5)

9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)

10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4)

11. Nature of Indirect Beneficial Ownership (Instr. 4)

Code

V

(A)

(D)

Date Exercisable

Expiration Date

Title

Amount or Number of Shares

Stock Option (Right to Buy)

$ 2.45

12/28/2017

M

102,040

(1)

12/29/2017

Common Stock

102,040

$ 0

0

D

Stock Option (Right to Buy)

$ 4.1

12/28/2017

M

39,961

(2)

01/08/2022

Common Stock

39,961

$ 0

220,039

D

Reporting Owners

Reporting Owner Name / Address	Relationships
	Director	10% Owner	Officer	Other
Demopulos Gregory A MD 201 ELLIOTT AVENUE WEST SEATTLE, WA 98119	X		Chairman, CEO & President

Signatures

/s/ Marcia S. Kelbon, attorney in-fact on behalf of Gegory A. Demopulos		12/28/2017
**Signature of Reporting Person		Date

Explanation of Responses:

*	If the form is filed by more than one reporting person, see Instruction 4(b)(v).
**	Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1)	On December 28, 2017, the reporting person paid the exercise price and exercised expiring non-qualified stock options to purchase 102,040 shares of the company's common stock. These shares have not been sold and are held for the account of the reporting person. One-fourth of the shares subject to this option vested on December 30, 2008, which was the first anniversary of the grant date, and the remainder became exercisable in equal monthly installments over the following 48 months. In addition to paying the exercise price of the expiring non-qualified stock options, the reporting person is concurrently paying ordinary income taxes incurred as a result of the exercise of these options.
(2)	On December 28, 2017, the reporting person paid the exercise price and exercised incentive stock options to purchase 39,961 shares of the company's common stock. These shares have not been sold and are held for the account of the reporting person. This option vested and became exercisable in 48 equal monthly installments. The first installment became exercisable on April 1, 2011 and subsequent installments became exercisable on each monthly anniversary thereafter.

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