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                                 UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                              WASHINGTON, DC 20549

                                  SCHEDULE 13D

                    UNDER THE SECURITIES EXCHANGE ACT OF 1934
                               (AMENDMENT NO. 5)*

                               Aradigm Corporation
--------------------------------------------------------------------------------
                                (Name of Issuer)

                           Common Stock, no par value
--------------------------------------------------------------------------------
                         (Title of Class of Securities)

                                    38505103
--------------------------------------------------------------------------------
                                 (CUSIP Number)

                              Louis S. Citron, Esq.
                           New Enterprise Associates
                   1119 St. Paul Street, Baltimore, MD 21202
                                 (410) 246-2927
--------------------------------------------------------------------------------
                  (Name, Address and Telephone Number of Person
                Authorized to Receive Notices and Communications)

                                January 30, 2007
--------------------------------------------------------------------------------
             (Date of Event Which Requires Filing of This Statement)

If the filing person has previously  filed a statement on Schedule 13G to report
the  acquisition  that is the subject of this  Schedule  13D, and is filing this
schedule because of Sections 240.13d-1(e), 240.13d-1(f) or 240.13d-1(g), check
the following box |_|.

NOTE:  Schedules  filed in paper format shall include a signed original and five
copies of the schedule, including all exhibits. See Rule 13d-7 for other parties
to whom copies are to be sent.

*The  remainder of this cover page shall be filled out for a reporting  person's
initial filing on this form with respect to the subject class of securities, and
for  any  subsequent   amendment   containing   information  which  would  alter
disclosures provided in a prior cover page.

The information required on the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the  Securities  Exchange  Act of
1934 ("Act") or  otherwise  subject to the  liabilities  of that  section of the
Act but shall be subject to all other provisions of the Act (however, see the
Notes).


PERSONS WHO RESPOND TO THE COLLECTION OF INFORMATION CONTAINED IN THIS FORM ARE
NOT REQUIRED TO RESPOND UNLESS THE FORM DISPLAYS A CURRENTLY VALID OMB CONTROL
NUMBER.



                                 Schedule 13D


ITEM 1.  SECURITY AND ISSUER.

      This statement relates to the common stock, no par value (the "Common
Stock"), of Aradigm Corporation (the "Issuer") having its principal executive
office at 3929 Point Eden Way, Hayward, CA 94545.

ITEM 2.  IDENTITY AND BACKGROUND.

     This  statement is being filed by New  Enterprise  Associates  10,  Limited
Partnership  ("NEA 10"),  NEA Partners 10,  Limited  Partnership  ("NEA Partners
10"),  which is the sole general partner of NEA 10, and Stewart Alsop ("Alsop"),
Michael  James  Barrett  ("Barrett"),  Peter J.  Barris  ("Barris"),  Robert  T.
Coneybeer ("Coneybeer"), Nancy L. Dorman ("Dorman"), Ronald H. Kase ("Kase"), C.
Richard  Kramlich  ("Kramlich"),  Thomas C.  McConnell  ("McConnell"),  Peter T.
Morris ("Morris"),  Charles W. Newhall III ("Newhall"), Mark W. Perry ("Perry"),
Scott  D.   Sandell   ("Sandell")   and  Eugene  A.   Trainor  III   ("Trainor")
(collectively,  the "General Partners"). The General Partners are the individual
general  partners of NEA  Partners  10. NEA 10, NEA  Partners 10 and the General
Partners  are  sometimes  referred  to  collectively  herein  as the  "Reporting
Persons."

     The address of the  principal  business  office of NEA 10, NEA Partners 10,
Barrett, Dorman, Newhall and Trainor is New Enterprise Associates, 1119 St. Paul
Street,  Baltimore,  MD 21202.  The address of the principal  business office of
Alsop, Coneybeer,  Kase, Kramlich,  McConnell,  Morris, Perry and Sandell is New
Enterprise  Associates,  2490 Sand Hill Road, Menlo Park,  California 94025. The
address of the principal business office of Barris is New Enterprise Associates,
11951 Freedom Drive, Suite 1240, Reston, Virginia 20190.

     The principal business of NEA 10 is to invest in and assist growth-oriented
businesses  located  principally in the United States. The principal business of
NEA Partners 10 is to act as the sole general  partner of NEA 10. The  principal
business of each of the General  Partners is to act as a general  partner of NEA
Partners 10 and a number of affiliated partnerships with similar businesses.

     During  the five  years  prior to the date  hereof,  none of the  Reporting
Persons has been  convicted  in a criminal  proceeding  or has been a party to a
civil  proceeding  ending in a judgment,  decree or final order enjoining future
violations  of, or prohibiting  or mandating  activities  subject to, federal or
state securities laws or finding any violation with respect to such laws.

     Each of NEA 10 and NEA Partners 10 is a limited partnership organized under
the laws of the State of  Delaware.  Each of the  General  Partners  is a United
States citizen.

ITEM 3.  SOURCE AND AMOUNT OF FUNDS OR OTHER CONSIDERATION.

     Not applicable.


ITEM 4.  PURPOSE OF TRANSACTION.

     Not applicable.

ITEM 5.  INTEREST IN SECURITIES OF THE ISSUER.



    Each Reporting Person has ceased to own beneficially five percent (5%)
or more of the Issuer's outstanding Common Stock.

ITEM 6. CONTRACTS, ARRANGEMENTS, UNDERSTANDINGS OR RELATIONSHIPS WITH
RESPECT TO SECURITIES OF THE ISSUER.

     Not applicable.

ITEM 7. MATERIAL TO BE FILED AS EXHIBITS.

     Exhibit 1 - Agreement regarding filing of joint Schedule 13D





                                   SIGNATURE

      After reasonable inquiry and to the best of my knowledge and belief, I
certify that the information set forth in this statement is true, complete and
correct.

Dated: March 2, 2007

NEW ENTERPRISE ASSOCIATES 10,
  LIMITED PARTNERSHIP


By:     NEA PARTNERS 10, LIMITED PARTNERSHIP
        General Partner

        By:          *
           --------------------------
           Charles W. Newhall III
           General Partner


NEA PARTNERS 10, LIMITED PARTNERSHIP


By:           *
   --------------------------
   Charles W. Newhall III
   General Partner

           *
--------------------------
Stewart Alsop


           *
--------------------------
Michael James Barrett


           *
--------------------------
Peter J. Barris


           *
--------------------------
Robert T. Coneybeer


           *
--------------------------
Nancy L. Dorman



           *
--------------------------
Ronald H. Kase


           *
--------------------------
C. Richard Kramlich


           *
--------------------------
Thomas C. McConnell


           *
--------------------------
Peter T. Morris


           *
--------------------------
Charles W. Newhall III


           *
--------------------------
Mark W. Perry


           *
--------------------------
Scott D. Sandell


           *
--------------------------
Eugene A. Trainor III





                                *By:  /s/ Louis S. Citron
                                      ---------------------------
                                      Louis S. Citron
                                      As attorney-in-fact





*This Amendment No. 5 to Schedule 13D was executed by Louis S. Citron pursuant
to Powers of Attorney which have been filed with the Securities and Exchange
Commission on June 25, 2003 in connection with Amendment No. 4 to Schedule 13D
filing for Aradigm Corporation, which Powers of Attorney are incorporated herein
by reference.



EXHIBIT 1

                                   AGREEMENT

        Pursuant to Rule 13d-1(k)(1) under the Securities Exchange Act of 1934,
the undersigned hereby agree that only one statement containing the information
required by Schedule 13D need be filed with respect to the ownership by each of
the undersigned of shares of stock of Aradigm Corporation.

         EXECUTED this 2nd day of March, 2007.

NEW ENTERPRISE ASSOCIATES 10,
  LIMITED PARTNERSHIP


By:     NEA PARTNERS 10, LIMITED PARTNERSHIP
        General Partner

        By:          *
           --------------------------
           Charles W. Newhall III
           General Partner


NEA PARTNERS 10, LIMITED PARTNERSHIP


By:           *
   --------------------------
   Charles W. Newhall III
   General Partner

           *
--------------------------
Stewart Alsop


           *
--------------------------
Michael James Barrett


           *
--------------------------
Peter J. Barris


           *
--------------------------
Robert T. Coneybeer


           *
--------------------------
Nancy L. Dorman



           *
--------------------------
Ronald H. Kase


           *
--------------------------
C. Richard Kramlich


           *
--------------------------
Thomas C. McConnell


           *
--------------------------
Peter T. Morris


           *
--------------------------
Charles W. Newhall III


           *
--------------------------
Mark W. Perry


           *
--------------------------
Scott D. Sandell


           *
--------------------------
Eugene A. Trainor III





                                *By:  /s/ Louis S. Citron
                                      ---------------------------
                                      Louis S. Citron
                                      As attorney-in-fact




*This Agreement with respect to Amendment No. 5 to Schedule 13D was executed by
Louis S. Citron pursuant to Powers of Attorney which have been filed with the
Securities and Exchange Commission on June 25, 2003 in connection with Amendment
No. 4 to Schedule 13D filing for Aradigm Corporation, which Powers of Attorney
are incorporated herein by reference.