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As filed with the Securities and Exchange Commission on November 8, 2010
Registration No. 333-168770
 
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
 
 
Pre-Effective Amendment No. 3
to
Form S-1
REGISTRATION STATEMENT
UNDER
THE SECURITIES ACT OF 1933
 
 
Aradigm Corporation
(Exact name of registrant as specified in its charter)
 
 
 
 
         
California   2834   94-3133088
(State or other jurisdiction of
incorporation or organization)
  (Primary Standard Industrial
Classification Code Number)
  (I.R.S. Employer
Identification Number)
 
 
3929 Point Eden Way
Hayward, California 94545
(510) 265-9000
(Address, including zip code, and telephone number, including area code, of registrant’s principal executive offices)
 
 
Igor Gonda
President and Chief Executive Officer
Aradigm Corporation
3929 Point Eden Way
Hayward, California 94545
(510) 265-9000
(Name, address, including zip code, and telephone number, including area code, of agent for service)
 
 
With a copy to:
John W. Campbell, Esq.
Raymond T. Hum, Esq.
Morrison & Foerster LLP
425 Market Street
San Francisco, CA 94105
Tel: (415) 268-7000
Fax: (415) 268-7522
 
Approximate date of commencement of proposed sale to the public:  From time to time after the effective date of this Registration Statement.
 
If any of the securities being registered on this Form are to be offered on a delayed or continuous basis pursuant to Rule 415 under the Securities Act of 1933 check the following box:  þ
 
If this Form is filed to register additional securities for an offering pursuant to Rule 462(b) under the Securities Act, please check the following box and list the Securities Act registration statement number of the earlier effective registration statement for the same offering.  o
 
If this Form is a post-effective amendment filed pursuant to Rule 462(c) under the Securities Act, check the following box and list the Securities Act registration statement number of the earlier effective registration statement for the same offering.  o
 
If this Form is a post-effective amendment filed pursuant to Rule 462(d) under the Securities Act, check the following box and list the Securities Act registration statement number of the earlier effective registration statement for the same offering.  o
 
Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, or a smaller reporting company. See the definitions of “large accelerated filer,” “accelerated filer” and “smaller reporting company” in Rule 12b-2 of the Exchange Act. (Check one):
 
Large accelerated filer o Accelerated filer o Non-accelerated filer o Smaller reporting company þ
(Do not check if a smaller reporting company)
 
 
CALCULATION OF REGISTRATION FEE
 
 
                                         
      Amount of
    Proposed Maximum
    Proposed Maximum
    Amount of
Title of Each Class of
    Shares to be
    Offering
    Aggregate
    Registration 
Securities to be Registered     Registered     Price per Share     Offering Price     Fee
Common Stock, no par value per share(1)
      68,229,726 (2)     $ 0.135 (3)     $ 9,211,013.01       $ 656.75  
Total
      68,229,726                 $ 9,211,013.01       $ 656.75 (4)
                                         
 
(1) Includes associated rights (the “Preferred Share Purchase Rights”) to purchase shares of Series A Junior Participating Preferred Stock, no par value per share, of Aradigm Corporation (the “Registrant”). The Preferred Share Purchase Rights are attached to shares of common stock, no par value per share (the “Common Stock”), of the Registrant in accordance with the Amended and Restated Rights Agreement, dated as of September 5, 2008 (the “Rights Agreement”), as amended from time to time, by and between the Registrant and Computershare Trust Company, N.A., as Rights Agent. The Preferred Share Purchase Rights are not exercisable until the occurrence of certain events specified in the Rights Agreement, are evidenced by the stock certificates representing the Common Stock and are transferable solely with the Common Stock. The value attributable to the Preferred Share Purchase Rights, if any, is reflected in the value of the Common Stock.
 
(2) Consists of shares to be offered by selling shareholders. Consists of (a) 34,702,512 outstanding shares of common stock issued in a private placement that closed on June 21, 2010 (the “June 2010 private placement”), (b) 7,527,214 outstanding shares of common stock that were issued upon exercise of warrants issued in the June 2010 private placement and (c) 26,000,000 outstanding shares of common stock that were issued under a stock purchase agreement, dated as of July 30, 2010, by and among the Registrant and Novo Nordisk A/S. Pursuant to Rule 416 under the Securities Act of 1933, as amended (the “Securities Act”), there is also being registered hereby such indeterminate number of additional shares of common stock as may be issued or issuable because of stock splits, stock dividends, stock distributions, and similar transactions.
 
(3) Estimated solely for the purpose of calculating the registration fee in accordance with Rule 457(c) under the Securities Act based on the average of the high and low prices of the Registrant’s common stock reported on the OTC Bulletin Board on August 9, 2010.
 
(4) Previously paid.
 
The Registrant hereby amends this Registration Statement on such date or dates as may be necessary to delay its effective date until the Registrant shall file a further amendment which specifically states that this Registration Statement shall thereafter become effective in accordance with Section 8(a) of the Securities Act of 1933 or until the Registration Statement shall become effective on such date as the Commission acting pursuant to said Section 8(a), may determine.
 


 

EXPLANATORY NOTE
     This Pre-Effective Amendment No. 3 to Registration Statement on Form S-l is being filed solely to file Exhibit 5.1 and to update the Exhibit List accordingly.


 

 
PART II
 
INFORMATION NOT REQUIRED IN PROSPECTUS
 
Item 13.   Other Expenses of Issuance and Distribution.
 
The estimated expenses (except for the SEC registration fee, which is an actual expense) payable by the Registrant in connection with the issuance and distribution of the securities being registered are as follows:
 
         
SEC registration fee
  $ 656.75  
Legal fees
    85,000.00  
Accounting fees
    3,500.00  
Miscellaneous fees
    23,180.00  
Total
  $ 112,336.75  
 
Item 14.   Indemnification of Directors and Officers.
 
Our articles of incorporation and bylaws include provisions to (i) eliminate the personal liability of our directors for monetary damages resulting from breaches of their fiduciary duty, to the extent permitted by California law and (ii) permit us to indemnify our directors and officers, employees and other agents to the fullest extent permitted by the California Corporations Code. Pursuant to Section 317 of the California Corporations Code, a corporation generally has the power to indemnify its present and former directors, officers, employees and agents against any expenses incurred by them in connection with any suit to which they are, or are threatened to be made, a party by reason of their serving in such positions so long as they acted in good faith and in a manner they reasonably believed to be in, or not opposed to, the best interests of a corporation and, with respect to any criminal action, they had no reasonable cause to believe their conduct was unlawful. We believe that these provisions are necessary to attract and retain qualified persons as directors and officers. These provisions do not eliminate liability for breach of the directors’ duty of loyalty to us or our shareholders, for acts or omissions not in good faith or involving intentional misconduct or knowing violations of law, for any transaction from which the director derived an improper personal benefit or for any willful or negligent payment of any unlawful dividend.
 
We entered into indemnification agreements with certain officers, including each of our named executive officers, and each of our directors that provide, among other things, that we will indemnify such officer or director, under the circumstances and to the extent provided for therein, for expenses, damages, judgments, fines and settlements such officer or director may be required to pay in actions or proceedings to which such officer or director is or may be made a party by reason of such officer’s or director’s position as an officer, director or other agent of us, and otherwise to the full extent permitted under California law and our bylaws.
 
Item 15.   Recent Sales of Unregistered Securities.
 
On June 21, 2010, we closed a private placement, which we refer to in this prospectus as the June 2010 private placement, in which we sold 34,702,512 shares of our common stock and warrants to purchase an aggregate of 7,527,214 shares of our common stock to accredited investors (which included a few then-existing significant shareholders) under the terms of a securities purchase agreement that we entered into with the selling shareholders on June 18, 2010. At the closing of the June 2010 private placement, we received approximately $4.1 million in aggregate gross proceeds from the sale of the common stock and the warrants. After deducting for fees and expenses, the aggregate net proceeds from the sale of the common stock and the warrants were approximately $3.7 million. After we held our special meeting of shareholders on September 14, 2010 and obtained the requisite shareholder approval on a proposal to amend our amended and restated articles of incorporation to increase the total number of authorized shares of our common stock to cover the shares issuable upon exercise of the warrants, the warrants were exercised and we received approximately $891,000 in additional aggregate net proceeds from the exercise of the warrants. The common stock and the warrants were offered and sold to the selling shareholders without registration under the Securities Act of 1933, as amended (the “Securities Act”), or any state securities laws in reliance on the exemption from the registration requirements of the Securities Act pursuant to Section 4(2) thereof and Rule 506 of Regulation D promulgated thereunder.
 
On September 15, 2010, we closed the issuance to Novo Nordisk A/S of 26,000,000 shares of our common stock under a stock purchase agreement, dated as of July 30, 2010, by and among us and Novo Nordisk A/S, which


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we refer to in this prospectus as the Novo Nordisk stock purchase agreement, in consideration for the termination of all of our obligations under a promissory note and security agreement dated July 3, 2006 in favor of Novo Nordisk A/S. The closing occurred after we held our special meeting of shareholders on September 14, 2010 and obtained the requisite shareholder approval on a proposal to amend our amended and restated articles of incorporation to increase the total number of authorized shares of our common stock to cover the 26,000,000 shares issuable under the Novo Nordisk stock purchase agreement. An amended and restated stock purchase agreement, dated as of January 26, 2005, previously entered into by us, Novo Nordisk A/S and Novo Nordisk Pharmaceuticals, Inc. in connection with our January 2005 restructuring transaction with Novo Nordisk was also terminated at the closing. The July 3, 2006 promissory note and security agreement had evidenced, among other things, a loan that had been previously made by Novo Nordisk A/S to us in the principal amount of $7.5 million, which had bore interest accruing at 5% per annum and the principal, along with the accrued interest, had been payable in three equal payments of approximately $3.5 million on July 2, 2012, July 1, 2013 and June 30, 2014. The shares were offered and issued to Novo Nordisk without registration under the Securities Act, or any state securities laws in reliance on the exemption from the registration requirements of the Securities Act afforded by Section 4(2) thereof.
 
Item 16.   Exhibits and Financial Statement Schedules.
 
(a) See the exhibit index immediately following the signature page.
 
(b) No financial statement schedules are required.
 
Item 17.   Undertakings.
 
 
The undersigned registrant hereby undertakes:
 
(1) To file, during any period in which offers or sales are being made, a post-effective amendment to this registration statement:
 
(i) To include any prospectus required by section 10(a)(3) of the Securities Act of 1933;
 
(ii) To reflect in the prospectus any facts or events arising after the effective date of the registration statement (or the most recent post-effective amendment thereof) which, individually or in the aggregate, represent a fundamental change in the information set forth in the registration statement. Notwithstanding the foregoing, any increase or decrease in volume of securities offered (if the total dollar value of securities offered would not exceed that which was registered) and any deviation from the low or high end of the estimated maximum offering range may be reflected in the form of prospectus filed with the Commission pursuant to Rule 424(b) if, in the aggregate, the changes in volume and price represent no more than 20% change in the maximum aggregate offering price set forth in the “Calculation of Registration Fee” table in the effective registration statement; and
 
(iii) To include any material information with respect to the plan of distribution not previously disclosed in the registration statement or any material change to such information in the registration statement.
 
(2) That, for the purpose of determining any liability under the Securities Act of 1933, each such post-effective amendment shall be deemed to be a new registration statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof.
 
(3) To remove from registration by means of a post-effective amendment any of the securities being registered which remain unsold at the termination of the offering; and
 
(4) That, for the purpose of determining liability under the Securities Act of 1933 to any purchaser, each prospectus filed pursuant to Rule 424(b) as part of a registration statement relating to an offering, other than registration statements relying on Rule 430B or other than prospectuses filed in reliance on Rule 430A, shall be deemed to be part of and included in the registration statement as of the date it is first used after effectiveness. Provided, however, that no statement made in a registration statement or prospectus that is part of the registration statement or made in a document incorporated or deemed incorporated by reference into the registration statement or prospectus that is part of the registration statement will, as to a purchaser with a time of contract of sale prior to such first use, supersede or modify any statement that was made in the registration


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statement or prospectus that was part of the registration statement or made in any such document immediately prior to such date of first use.
 
Insofar as indemnification for liabilities arising under the Securities Act of 1933 may be permitted to directors, officers and controlling persons of the registrant pursuant to the foregoing provisions, or otherwise, the registrant has been advised that in the opinion of the Securities and Exchange Commission such indemnification is against public policy as expressed in the Act and is, therefore, unenforceable. In the event that a claim for indemnification against such liabilities (other than the payment by the registrant of expenses incurred or paid by a director, officer or controlling person of the registrant in the successful defense of any action, suit or proceeding) is asserted by such director, officer or controlling person in connection with the securities being registered, the registrant will, unless in the opinion of its counsel the matter has been settled by controlling precedent, submit to a court of appropriate jurisdiction the question whether such indemnification by it is against public policy as expressed in the Act and will be governed by the final adjudication of such issue.


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SIGNATURES
 
Pursuant to the requirements of the Securities Act of 1933, the registrant has duly caused this Pre-Effective Amendment No. 3 to Registration Statement on Form S-1 to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Hayward, State of California, on the 8th day of November, 2010.
 
ARADIGM CORPORATION
 
  By: 
/s/  Igor Gonda
Igor Gonda
President and Chief Executive Officer
 
Pursuant to the requirements of the Securities Act of 1933, this Pre-Effective Amendment No. 3 to Registration Statement has been signed by the following persons in the capacities and on the dates indicated.
 
             
Signature
 
Title
 
Date
 
         
/s/  Igor Gonda

Igor Gonda
  President, Chief Executive
Officer and Director
(Principal Executive Officer)
  November 8, 2010
         
/s/  Nancy E. Pecota

Nancy E. Pecota
  Vice President, Finance and Chief Financial Officer (Principal Financial and Accounting Officer)   November 8, 2010
         
*

Virgil D. Thompson
  Chairman of the Board and Director   November 8, 2010
         
*

Frank H. Barker
  Director   November 8, 2010
         
*

John M. Siebert
  Director   November 8, 2010
         
    

Tamar D. Howson
  Director    
             
*By:  
/s/  Igor Gonda

Name: Igor Gonda
Title: Attorney-in-fact
       


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EXHIBIT INDEX
 
         
Exhibit
   
No.  
Description
 
  3 .1(1)   Amended and Restated Articles of Incorporation of the Company, as amended.
  3 .2(2)   Amended and Restated Bylaws of the Company, as amended.
  3 .3(3)   Certificate of Determination of Series A Junior Participating Preferred Stock.
  3 .4(4)   Amended and Restated Certificate of Determination of Preferences of Series A Convertible Preferred Stock.
  3 .5(3)   Certificate of Amendment of Amended and Restated Articles of Incorporation of the Company.
  3 .6(3)   Certificate of Amendment of Certificate of Determination of Series A Junior Participating Preferred Stock.
  3 .7(5)   Certificate of Amendment of Amended and Restated Articles of Incorporation of the Company.
  3 .8(5)   Certificate of Amendment of Certificate of Determination of Series A Junior Participating Preferred Stock.
  3 .9(6)   Certificate of Amendment of Amended and Restated Articles of Incorporation of the Company.
  3 .10(17)   Certificate of Amendment of Amended and Restated Articles of Incorporation of the Company.
  3 .11(24)   Certificate of Amendment of Amended and Restated Articles of Incorporation of the Company.
  4 .1   Reference is made to Exhibits 3.1, 3.2, 3.3, 3.4, 3.5, 3.6, 3.7, 3.8, 3.9 and 3.10.
  4 .2(1)   Specimen common stock certificate.
  5 .1   Opinion of Morrison & Foerster LLP
  10 .1(1)+   Form of Indemnity Agreement between the Registrant and each of its directors and officers.
  10 .2(1)+   Form of the Company’s Incentive Stock Option Agreement under the 2005 Equity Incentive Plan.
  10 .3(1)+   Form of the Company’s Non-statutory Stock Option Agreement under the 2005 Equity Incentive Plan.
  10 .4(1)+   1996 Non-Employee Directors’ Stock Option Plan.
  10 .5(1)+   Form of the Company’s Non-statutory Stock Option Agreement under the 1996 Non-Employee Directors’ Stock Option Plan.
  10 .6(1)+   Form of the Company’s Employee Stock Purchase Plan Offering Document.
  10 .7(6)+   Form of the Company’s Restricted Stock Bonus Agreement under the 2005 Equity Incentive Plan.
  10 .8(7)   Promissory Note and Security Agreement, dated July 3, 2006, by and between the Company and Novo Nordisk AS
  10 .9(7)   Amended and Restated Stock Purchase Agreement, dated as of January 26, 2005, by and among the Company, Novo Nordisk A/S and Novo Nordisk Pharmaceuticals, Inc.
  10 .10(7)#   Asset Purchase Agreement, dated as of August 25, 2006, by and between the Company and Zogenix, Inc.
  10 .11(7)+   Employment Agreement, dated as of August 10, 2006, with Dr. Igor Gonda.
  10 .12(8)   Lease Agreement for the property located in Phase V of the Britannia Point Eden Business Park in Hayward, California, dated January 28, 1998, between the Company and Britannia Point Eden, LLC.
  10 .13(9)#   Restructuring Agreement, dated as of September 28, 2004, by and among the Company, Novo Nordisk A/S and Novo Nordisk Delivery Technologies, Inc.
  10 .14(10)   Securities Purchase Agreement, dated as of December 17, 2004, by and among the Company and the purchasers named therein.
  10 .15(11)#   Second Amended and Restated License Agreement, dated as of July 3, 2006, by and between the Company and Novo Nordisk A/S.
  10 .16(12)   Consulting Agreement effective as of July 2, 2007 by and between the Company and Norman Halleen.


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Exhibit
   
No.  
Description
 
  10 .17(13)   Sublease between the Company and Mendel Biotechnology, Inc., dated July 11, 2007, under the Lease Agreement by and between the Company and Hayward Point Eden I Limited Partnership, a Delaware limited partnership, as successor-in-interest to Britannia Point Eden, LLC, as amended, for 3929 Point Eden Way, Hayward, California.
  10 .18(14)   Manufacturing Agreement between the Company and Enzon Pharmaceuticals, Inc. dated August 8, 2007.
  10 .19(15)#   Exclusive License, Development and Commercialization Agreement, dated as of August 30, 2007, by and between the Company and Lung Rx, Inc.
  10 .20(15)#   Collaboration Agreement, dated as of August 31, 2007, by and between the Company and CyDex, Inc.
  10 .21 (16)+   2005 Equity Incentive Plan, as amended
  10 .22(17)+   Employee Stock Purchase Plan, as amended.
  10 .23(18)   Amended and Restated Rights Agreement, dated as of September 5, 2008 by and between the Company and ComputerShare Trust Company, N.A.
  10 .24(19)   Separation Agreement between the Company and Dr. Babatunde Otulana, dated as of December 12, 2008.
  10 .25(19)   Consulting Agreement for Independent Contractors between the Company and Dr. Babatunde Otulana, effective as of January 1, 2009.
  10 .26(19)   International Scientific Advisory Agreement between the Company and Dr. Babatunde Otulana, effective as of January 1, 2009.
  10 .27(20)+   Amended and Restated form of Change of Control Agreement entered into between the Company and certain of the Company’s senior officers.
  10 .28(20)+   Amended and Restated Executive Officer Severance Benefit Plan.
  10 .29(21)+   Amended and Restated Change of Control Agreement, dated as of July 30, 2009 by and between Aradigm Corporation and Igor Gonda.
  10 .30(21)+   Amended and Restated Change of Control Agreement, dated as of July 30, 2009 by and between Aradigm Corporation and Nancy Pecota.
  10 .31(21)+   Amended and Restated Change of Control Agreement, dated as of July 30, 2009 by and between Aradigm Corporation and Jeffery Grimes.
  10 .32(21)   Security Agreement, dated as of July 30, 2009 by and among Aradigm Corporation, Igor Gonda, Jeffery Grimes and Nancy Pecota.
  10 .33(22)   Securities Purchase Agreement, dated June 18, 2010, by and among Aradigm Corporation and the investors listed on the Schedule of Buyers attached thereto.*
  10 .34(22)   Form of Registration Rights Agreement used in connection with the June 2010 private placement.
  10 .35(22)   Form of Warrant used in connection with the June 2010 private placement.
  10 .36(23)   Stock Purchase Agreement, dated as of July 30, 2010, by and among Aradigm Corporation and Novo Nordisk A/S.*
  10 .37(23)   Registration Rights Agreement, dated as of July 30, 2010, by and among Aradigm Corporation and Novo Nordisk A/S.
  10 .38(23)   First Amendment to Securities Purchase Agreement and Registration Rights Agreement, dated as of July 20, 2010, by and among Aradigm Corporation and the investors party thereto.
  23 .1†   Consent of Odenberg Ullakko Muranishi & Co LLP, Independent Registered Public Accounting Firm.
  23 .2   Consent of Morrison & Foerster LLP (included in Exhibit 5.1)
  24 .1   Power of Attorney. Reference is made to the signature page included with the initial filing of the Registration Statement on August 11, 2010.
 
 
†  Previously filed.

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Represents a management contract or compensatory plan or arrangement.
 
The Commission has granted the Company’s request for confidential treatment with respect to portions of this exhibit.
 
Certain schedules have been omitted. The registrant agrees to furnish supplementally a copy of any omitted schedule or exhibit to the Commission upon request.
 
(1) Incorporated by reference to the Company’s Form S-1 (No. 333-4236) filed on April 30, 1996, as amended.
 
(2) Incorporated by reference to the Company’s Form 10-Q filed on August 14, 1998.
 
(3) Incorporated by reference to the Company’s Form 10-K filed on March 29, 2002.
 
(4) Incorporated by reference to the Company’s Form S-3 (No. 333-76584) filed on January 11, 2002, as amended.
 
(5) Incorporated by reference to the Company’s Form 10-Q filed on August 13, 2004.
 
(6) Incorporated by reference to the Company’s Form 10-K filed on March 31, 2006.
 
(7) Incorporated by reference to the Company’s Form S-1 (No. 333-138169) filed on October 24, 2006, as amended.
 
(8) Incorporated by reference to the Company’s Form 10-K filed on March 24, 1998, as amended.
 
(9) Incorporated by reference to the Company’s Form 8-K filed on December 23, 2004.
 
(10) Incorporated by reference to the Company’s Form 10-Q filed on August 14, 2006.
 
(11) Incorporated by reference to the Company’s Form 8-K filed on October 13, 2005.
 
(12) Incorporated by reference to the Company’s Form 8-K filed on July 11, 2007.
 
(13) Incorporated by reference to the Company’s Form 8-K filed on July 24, 2007.
 
(14) Incorporated by reference to the Company’s Form 8-K filed on August 14, 2007.
 
(15) Incorporated by reference to the Company’s Form 10-Q filed on November 14, 2007.
 
(16) Incorporated by reference to the Company’s definitive proxy statement filed on April 7, 2008.
 
(17) Incorporated by reference to the Company’s Form 8-K filed on May 21, 2009.
 
(18) Incorporated by reference to the Company’s Form 10-Q filed on November 12, 2008.
 
(19) Incorporated by reference to the Company’s Form 8-K filed on December 19, 2008.
 
(20) Incorporated by reference to the Company’s Form 8-K filed on January 8, 2009.
 
(21) Incorporated by reference to the Company’s Form 10-Q filed on November 6, 2009.
 
(22) Incorporated by reference to the Company’s Form 8-K filed on June 21, 2010.
 
(23) Incorporated by reference to the Company’s Form 8-K filed on August 2, 2010.
 
(24) Incorporated by reference to the Company’s Form 8-K filed on September 20, 2010.


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