EXTON, PA, July 17, 2025 (GLOBE NEWSWIRE) -- In the latest Special Topix™: Co-Management Approaches in aHUS (US), Spherix Global Insights explores the nuanced dynamics between hematologists and nephrologists in the management of atypical hemolytic uremic syndrome (aHUS). Based on a quantitative survey of 103 specialists conducted between May and June 2025, the research reveals both shared operational challenges and distinct clinical priorities that shape the current and future treatment landscape.
While both specialties routinely co-manage patients with aHUS, hematologists are more likely to drive treatment decisions, particularly those involving complement inhibition, whereas nephrologists often serve as the initial point of contact due to renal-related symptoms. Across both groups, collaboration is regarded as critical throughout the patient journey, especially given the complexity of diagnosis and treatment coordination,
Diagnostic uncertainty remains a central obstacle, with both specialties relying on a wide range of laboratory assessments. However, their diagnostic focus diverges: hematologists tend to prioritize hematologic markers such as LDH and platelet counts, while nephrologists place greater emphasis on renal function indicators and secondary triggers like infections or autoimmune conditions.
Complement inhibitors continue to serve as the cornerstone of aHUS management, with high satisfaction reported for Alexion’s Soliris and Ultomiris. Hematologists report broader prescribing experience, including the use and familiarity with biosimilars and Apellis’ Empaveli. In contrast, nephrologists adopt a more holistic approach that frequently incorporates supportive measures such as blood pressure control and dialysis when needed.
Despite current satisfaction levels, both specialties anticipate evolving their treatment approach, with a shift away from Soliris in favor of newer agents expected over the next six months. Hematologists and nephrologists alike express strong interest in Novartis’ oral complement inhibitor Fabhalta (iptacopan), citing convenience of administration and familiarity from its use in other complement-mediated disorders. Nearly half of all respondents report they would consider prescribing Fabhalta within three months of approval.
Looking ahead, treatment goals diverge across specialties: hematologists are more likely to emphasize durable efficacy and extended survival, whereas nephrologists focus more heavily on preserving long-term kidney function. Hematologists also demonstrate higher receptivity to novel mechanisms of action, including NovelMed’s investigational agent ruxoprubart. Nephrologists, while less experienced with biosimilars and emerging therapeutic classes, indicate a growing openness to expanding their understanding of innovative treatment strategies.
Spherix will continue to monitor how these evolving priorities and specialty-specific expectations influence treatment adoption and commercial trajectories as new therapies enter the aHUS market.
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Sarah Hendry, Hematology Franchise Head Spherix Global Insights 4848794284 sarah.hendry@spherixglobalinsights.com
