The markets closed mixed with the Dow gaining 46 points to 21,374 while Nasdaq fell 25 points to 6,194 after the Federal Reserve raised interest rates by a quarter percentage point.
On the upside
Epizyme (Nasdaq: EPZM) reported upbeat interim data from a Phase 2 clinical trial of tazemetostat
Shares of Athenex (Nasdaq: ATNX) climbed in its market debut.
Shares of Omeros (Nasdaq: OMER) extended its gains.
On the downside
Retreating crude oil prices weighed down shares of Halcon Resources (NYSE: HK), Oasis Petroleum (NYSE: OAS), SM Energy (NYSE: SM).
Shares of oilfield services firm Weatherford International (NYSE: WFT) fell alongside oil companies.
Synchronoss Technologies (Nasdaq: SNCR) must restate financial reports from 2015 and 2016.
In the broad market, declining issues edged out advancers by a margin of 9 to 8 on the NYSE and by nearly 3 to 2 on Nasdaq. The broader S&P 500 slipped 2 points to 2,437. Bitcoin plummeted $159 to $2528.