Shire officially in play after $46B AbbVie offer By: CNBC.com News June 20, 2014 at 02:32 AM EDT Shire, the FTSE 100 pharmaceutical company which has often been the subject of bid speculation, has rejected a takeover bid from U.S. company AbbVie. Read More >> Related Stocks: AbbVie Astrazeneca Plc ADR Citigroup JPMorgan Chase & Co Pfizer