About Cabling Installation & Maintenance

Our mission: Bringing practical business and technical intelligence to today's structured cabling professionals

For more than 30 years, Cabling Installation & Maintenance has provided useful, practical information to professionals responsible for the specification, design, installation and management of structured cabling systems serving enterprise, data center and other environments. These professionals are challenged to stay informed of constantly evolving standards, system-design and installation approaches, product and system capabilities, technologies, as well as applications that rely on high-performance structured cabling systems. Our editors synthesize these complex issues into multiple information products. This portfolio of information products provides concrete detail that improves the efficiency of day-to-day operations, and equips cabling professionals with the perspective that enables strategic planning for networks’ optimum long-term performance.

Throughout our annual magazine, weekly email newsletters and 24/7/365 website, Cabling Installation & Maintenance digs into the essential topics our audience focuses on.

  • Design, Installation and Testing: We explain the bottom-up design of cabling systems, from case histories of actual projects to solutions for specific problems or aspects of the design process. We also look at specific installations using a case-history approach to highlight challenging problems, solutions and unique features. Additionally, we examine evolving test-and-measurement technologies and techniques designed to address the standards-governed and practical-use performance requirements of cabling systems.
  • Technology: We evaluate product innovations and technology trends as they impact a particular product class through interviews with manufacturers, installers and users, as well as contributed articles from subject-matter experts.
  • Data Center: Cabling Installation & Maintenance takes an in-depth look at design and installation workmanship issues as well as the unique technology being deployed specifically for data centers.
  • Physical Security: Focusing on the areas in which security and IT—and the infrastructure for both—interlock and overlap, we pay specific attention to Internet Protocol’s influence over the development of security applications.
  • Standards: Tracking the activities of North American and international standards-making organizations, we provide updates on specifications that are in-progress, looking forward to how they will affect cabling-system design and installation. We also produce articles explaining the practical aspects of designing and installing cabling systems in accordance with the specifications of established standards.

Cabling Installation & Maintenance is published by Endeavor Business Media, a division of EndeavorB2B.

Contact Cabling Installation & Maintenance

Editorial

Patrick McLaughlin

Serena Aburahma

Advertising and Sponsorship Sales

Peter Fretty - Vice President, Market Leader

Tim Carli - Business Development Manager

Brayden Hudspeth - Sales Development Representative

Subscriptions and Memberships

Subscribe to our newsletters and manage your subscriptions

Feedback/Problems

Send a message to our general in-box

 

Icosavax Initiates Phase 1/2 Trial of COVID-19 VLP Vaccine Candidate

  • First participants dosed in a Phase 1 clinical trial to assess safety and efficacy of IVX-411 with or without Seqirus Inc.’s proprietary adjuvant MF59® in subjects naïve to COVID-19
  • Phase 2 will evaluate safety and efficacy of adjuvanted or unadjuvanted IVX-411 as a booster in adults who have been previously vaccinated with an approved vaccine against COVID-19

Icosavax, Inc. today announced the first subjects have been dosed with IVX-411, a virus-like particle (VLP) displaying the SARS-CoV-2 receptor-binding domain (RBD), in a Phase 1/2 clinical trial. As previously announced, the Phase 1/2 trial is being funded by the Bill & Melinda Gates Foundation. Amgen is manufacturing a key intermediate, and Seqirus is providing its proprietary MF59® adjuvant for this trial.

“We believe a variety of vaccine approaches, including boosters, will be needed to continue the fight against COVID-19,” said Adam Simpson, Chief Executive Officer of Icosavax. “We are pleased to be working with Seqirus to evaluate MF59 in combination with IVX-411, our COVID-19 VLP vaccine candidate. Subject to successful clinical development, we believe that IVX-411 could become a leading next generation vaccine against SARS-CoV-2, particularly for older adults who have a diminished immune response.”

The Phase 1/2 clinical trial is a randomized, observer-blinded, placebo-controlled trial designed to evaluate the safety and immunogenicity of adjuvanted and unadjuvanted IVX-411. The trial is enrolling up to 168 healthy volunteers (18 to 69 years of age) in Australia. The Phase 1 part of the trial will enroll SARS-CoV-2 seronegative adults who have not had COVID-19 and have not been vaccinated with a licensed COVID-19 vaccine. The Phase 2 part of the trial will enroll SARS-CoV-2 seropositive adults who have completed a vaccine regimen using a licensed COVID-19 vaccine.

The trial will evaluate different dose levels of adjuvanted and unadjuvanted IVX-411 to help determine if an adjuvant may boost the immune response and potentially reduce the amount of antigen required for protection against SARS-CoV-2.

“We are delighted that Seqirus’ proprietary adjuvant MF59 will be evaluated in combination with Icosavax’s virus-like particles,” said Russell Basser, M.D., Senior Vice President of Research and Development at Seqirus. “As a company dedicated to protecting millions of people around the world each year from influenza, Seqirus is happy to partner with Icosavax to advance a next generation vaccine solution in the global fight against COVID-19.”

About Virus-Like Particles (VLP) Vaccines

VLPs enable high-density, multivalent display of antigens in a manner that closely resembles viruses, with an important difference: VLPs contain no genetic material, so they are non-infectious and can provide a safer alternative to live-attenuated or inactivated vaccines. Because VLP vaccines have the potential to induce high-neutralizing antibody titers, they could be especially important for older adults where the gradual deterioration of the immune system as adults age can make vaccines less effective. The high yield and stability of the protein components and assembled nanoparticles suggest that manufacture of the nanoparticle vaccines will be highly scalable.

About IVX-411, COVID-19 VLP Vaccine Candidate

Developed by scientists at the University of Washington School of Medicine using structure-based vaccine design techniques invented at the Institute for Protein Design (IPD) at the UW Medicine, IVX-411, the lead Icosavax vaccine candidate for COVID-19, is a self-assembling protein nanoparticle that displays 60 copies of the SARS-CoV-2 spike (S) glycoprotein receptor-binding domain (RBD) in a highly immunogenic array. Preclinical data on IVX-411 and precursor candidates in mice and non-human primates show induction of robust neutralizing antibody titers and protection from viral challenge (Cell 2020, Nature 2021). The data also showed a strong B-cell response after immunization, critical for immune memory and a durable vaccine effect.

About Icosavax

Icosavax is focused on developing safe and effective vaccines against infectious diseases that cause severe, life-threatening respiratory illnesses. Icosavax is advancing VLP vaccine candidates against respiratory syncytial virus (RSV), human metapneumovirus (hMPV), and SARS-CoV-2 (COVID-19). These vaccine candidates have shown induction of high and durable neutralizing antibody titers in preclinical studies and could protect the most vulnerable populations, including older adults. Icosavax was founded on breakthrough computationally designed VLP technology developed at the Institute for Protein Design. Icosavax exclusively licensed the technology for use in several vaccine fields from the University of Washington. For SARS-CoV-2, Icosavax has a worldwide license with an exclusive option for IVX-411 in North America and Europe from the University of Washington. Icosavax is located in Seattle. For more info, visit www.icosavax.com.

Contacts

Stock Quote API & Stock News API supplied by www.cloudquote.io
Quotes delayed at least 20 minutes.
By accessing this page, you agree to the following
Privacy Policy and Terms Of Service.