About Cabling Installation & Maintenance

Our mission: Bringing practical business and technical intelligence to today's structured cabling professionals

For more than 30 years, Cabling Installation & Maintenance has provided useful, practical information to professionals responsible for the specification, design, installation and management of structured cabling systems serving enterprise, data center and other environments. These professionals are challenged to stay informed of constantly evolving standards, system-design and installation approaches, product and system capabilities, technologies, as well as applications that rely on high-performance structured cabling systems. Our editors synthesize these complex issues into multiple information products. This portfolio of information products provides concrete detail that improves the efficiency of day-to-day operations, and equips cabling professionals with the perspective that enables strategic planning for networks’ optimum long-term performance.

Throughout our annual magazine, weekly email newsletters and 24/7/365 website, Cabling Installation & Maintenance digs into the essential topics our audience focuses on.

  • Design, Installation and Testing: We explain the bottom-up design of cabling systems, from case histories of actual projects to solutions for specific problems or aspects of the design process. We also look at specific installations using a case-history approach to highlight challenging problems, solutions and unique features. Additionally, we examine evolving test-and-measurement technologies and techniques designed to address the standards-governed and practical-use performance requirements of cabling systems.
  • Technology: We evaluate product innovations and technology trends as they impact a particular product class through interviews with manufacturers, installers and users, as well as contributed articles from subject-matter experts.
  • Data Center: Cabling Installation & Maintenance takes an in-depth look at design and installation workmanship issues as well as the unique technology being deployed specifically for data centers.
  • Physical Security: Focusing on the areas in which security and IT—and the infrastructure for both—interlock and overlap, we pay specific attention to Internet Protocol’s influence over the development of security applications.
  • Standards: Tracking the activities of North American and international standards-making organizations, we provide updates on specifications that are in-progress, looking forward to how they will affect cabling-system design and installation. We also produce articles explaining the practical aspects of designing and installing cabling systems in accordance with the specifications of established standards.

Cabling Installation & Maintenance is published by Endeavor Business Media, a division of EndeavorB2B.

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Charles River Laboratories Provides Access to Relevant, Well-Characterized Pediatric PDX Collection for Oncology Research

Recently established regulatory guidelines make testing for pediatric indications a necessary step in oncology research and development

Charles River Laboratories International, Inc. (NYSE: CRL) today announced the ability to conduct preclinical cancer research using ITCC-P4’s well-characterized collection of 400 annotated pediatric cancer models. As a global partner, Charles River is offering clients access to this collection. These are critical models for research, as the U.S. Food and Drug Administration’s (FDA) Research to Accelerate Cures and Equity (RACE) for Children Act, requires all oncology drugs to be tested for pediatric indications ahead of approval. Additionally, the EU regulation of the European Medicines Agency (EMA) is being adapted to mirror the FDA’s regulations.

“Globally, 400,000 children and adolescents develop cancer each year, and approximately one in four cannot be cured with currently available therapies,” said Aidan Synnott, Corporate Vice President, Global Discovery Services at Charles River. “The ITCC-P4 collection is comprehensive, relevant, and well-characterized, meaning we can better assess the safety and efficacy of new oncology treatments specifically for children. This will ultimately lead to new treatment options for a critically important patient population.”

The ITCC-P4 repertoire offers access to models that are relevant to pediatric cancer, allowing researchers to appropriately investigate targets of interest, and ultimately increasing translation to preclinical trials. Pediatric tumors have different genomic drivers and phenotypes than adult tumors, requiring unique preclinical models. The ITCC-P4 collection is supported by an accompanying dataset consisting of molecular phenotyping and pharmacological characterization backed-up by expertise from internationally recognized pediatricians. By offering this collection, Charles River is combining decades of oncology research experience with a powerful tool that will better guide critical investigative decisions.

“Charles River worked on 84 percent of the FDA-approved cancer therapies over the last five years, and has delivered 16 oncology candidates to our partners,” added Julia Schüler, DVM, PhD, Research Director and Therapeutic Area Lead, Oncology at Charles River. “We are uniquely positioned to help researchers navigate through these new guidelines and progress their studies.”

Charles River offers a comprehensive portfolio of oncology drug discovery and development services, from model selection to safety assessment and support for biologic therapies. With a global infrastructure and deep scientific bench, Charles River is positioned to support programs from basic science to IND submission.

About Charles River

Charles River provides essential products and services to help pharmaceutical and biotechnology companies, government agencies and leading academic institutions around the globe accelerate their research and drug development efforts. Our dedicated employees are focused on providing clients with exactly what they need to improve and expedite the discovery, early-stage development and safe manufacture of new therapies for the patients who need them. To learn more about our unique portfolio and breadth of services, visit www.criver.com.

Contacts

Charles River Investor Contact:

Todd Spencer

Corporate Vice President, Investor Relations

+1- 781-222-6455

todd.spencer@crl.com



Charles River Media Contact:

Amy Cianciaruso

Corporate Vice President & Chief Communications Officer

+1-781-222-6168

amy.cianciaruso@crl.com

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