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For more than 30 years, Cabling Installation & Maintenance has provided useful, practical information to professionals responsible for the specification, design, installation and management of structured cabling systems serving enterprise, data center and other environments. These professionals are challenged to stay informed of constantly evolving standards, system-design and installation approaches, product and system capabilities, technologies, as well as applications that rely on high-performance structured cabling systems. Our editors synthesize these complex issues into multiple information products. This portfolio of information products provides concrete detail that improves the efficiency of day-to-day operations, and equips cabling professionals with the perspective that enables strategic planning for networks’ optimum long-term performance.

Throughout our annual magazine, weekly email newsletters and 24/7/365 website, Cabling Installation & Maintenance digs into the essential topics our audience focuses on.

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Cabling Installation & Maintenance is published by Endeavor Business Media, a division of EndeavorB2B.

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Latest Clinical Evidence Points to Paragonix SherpaPak® as a Tool to Reduce Unpredictable, Severe Complications following Heart Transplantation

By: via Business Wire

GUARDIAN Registry data presented at ACC 2023 has shown use of the Paragonix SherpaPak® Cardiac Transport System was associated with improved outcomes as compared to the use of traditional cold storage in LVAD patients undergoing Heart Transplantation.1

Paragonix Technologies, Inc., a leading organ transplant company, announces new research from a multi-center study on transplant patient outcomes following heart transplant surgery. The study compared the use of the Paragonix SherpaPak® Cardiac Transport System, an FDA-cleared and CE-marked donor heart transport and preservation device, to the use of conventional ice storage for LVAD patients undergoing heart transplantation. Presented at the 2023 American Association of Cardiology Annual Meeting (ACC23) on March 6, the study focused on short term post-transplant outcomes, and utilized data collected by the GUARDIAN-Heart Registry, the world’s largest clinical database specifically dedicated to heart preservation.

The US Multi-Center Early Post-Transplant Outcomes In LVAD Patients Analysis of the GUARDIAN Registry included 327 adult patients. The study compared outcomes of patients transplanted with hearts preserved in the Paragonix SherpaPak® and with conventional ice storage. The researchers also analyzed several known risk variables for severe Primary Graft Function (PGD), which have been the subject of decades of clinical research. The multivariable logistic regression analysis showed that the use of the Paragonix SherpaPak® CTS was associated with a significantly reduced risk of PGD (44% reduction, P=0.045), and severe PGD (69% reduction, P=0.009). 1 In addition, Paragonix SherpaPak® had the strongest effect out of all of the variables analyzed in the study, including recipient age and total ischemic time.

“The data suggests that this FDA-cleared device is an important tool for clinicians to reduce risk in heart transplantation. In clinical practice, we as clinicians are considering a multitude of recipient, donor and organ factors to ensure success of the transplant. It’s highly encouraging that this technology was found to have a strong positive effect on unpredictable, severe complications in heart transplantation for patients who are bridged to transplant with an LVAD,” said Dr. Joseph Lerman, Clinical Research Fellow at Duke Clinical Research Institute.

“This groundbreaking research has demonstrated that the SherpaPak® can be a tool for heart transplant surgeons to control the complications associated with high-risk heart transplant recipients. With each subsequent analysis of the GUARDIAN Heart Registry, now with over 1500 enrolled patients who have undergone heart transplantation, the data generated by the researchers continues to show improved clinical outcomes when utilizing Advanced Organ Preservation with the SherpaPak in a direct comparison to traditional ice storage,” said Dr. Lisa Anderson, CEO and President of Paragonix. “We are witnessing a paradigm shift in the standard of care for donor organ preservation, and we are thrilled to be at the forefront of that movement, providing every possible advantage for transplant patients.”

For more information about Paragonix, visit www.paragonixtechnologies.com

About Paragonix Technologies

Paragonix Technologies (“Paragonix”) is a leading provider of Advanced Organ Preservation (“AOP”) devices that safeguard donor organs during the journey between donor and recipient patients. Our FDA-cleared and CE-marked devices incorporate clinically proven and medically trusted cold preservation techniques that allow unprecedented physical and thermal protection to the organ in transit. Every Paragonix AOP device natively integrates with our novel digital app, delivering real-time organ tracking data and monitoring logistics for transplant teams seeking a secure and centralized solution.

Follow us on Twitter: @ParagonixSherpa

Connect with us on LinkedIn: Paragonix Technologies

Like Us on Facebook: Paragonix SherpaPak

References

  1. Lerman, Joseph, et al. Early Post Transplant Outcomes In LVAD Patients Undergoing Heart Transplant Via Use of the SherpaPak Cardiac Transport System as Compared with Traditional Cold Storage: Insights From the GUARDIAN Registry. Moderated Poster Presentation at ACC 2023.

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