About Cabling Installation & Maintenance

Our mission: Bringing practical business and technical intelligence to today's structured cabling professionals

For more than 30 years, Cabling Installation & Maintenance has provided useful, practical information to professionals responsible for the specification, design, installation and management of structured cabling systems serving enterprise, data center and other environments. These professionals are challenged to stay informed of constantly evolving standards, system-design and installation approaches, product and system capabilities, technologies, as well as applications that rely on high-performance structured cabling systems. Our editors synthesize these complex issues into multiple information products. This portfolio of information products provides concrete detail that improves the efficiency of day-to-day operations, and equips cabling professionals with the perspective that enables strategic planning for networks’ optimum long-term performance.

Throughout our annual magazine, weekly email newsletters and 24/7/365 website, Cabling Installation & Maintenance digs into the essential topics our audience focuses on.

  • Design, Installation and Testing: We explain the bottom-up design of cabling systems, from case histories of actual projects to solutions for specific problems or aspects of the design process. We also look at specific installations using a case-history approach to highlight challenging problems, solutions and unique features. Additionally, we examine evolving test-and-measurement technologies and techniques designed to address the standards-governed and practical-use performance requirements of cabling systems.
  • Technology: We evaluate product innovations and technology trends as they impact a particular product class through interviews with manufacturers, installers and users, as well as contributed articles from subject-matter experts.
  • Data Center: Cabling Installation & Maintenance takes an in-depth look at design and installation workmanship issues as well as the unique technology being deployed specifically for data centers.
  • Physical Security: Focusing on the areas in which security and IT—and the infrastructure for both—interlock and overlap, we pay specific attention to Internet Protocol’s influence over the development of security applications.
  • Standards: Tracking the activities of North American and international standards-making organizations, we provide updates on specifications that are in-progress, looking forward to how they will affect cabling-system design and installation. We also produce articles explaining the practical aspects of designing and installing cabling systems in accordance with the specifications of established standards.

Cabling Installation & Maintenance is published by Endeavor Business Media, a division of EndeavorB2B.

Contact Cabling Installation & Maintenance

Editorial

Patrick McLaughlin

Serena Aburahma

Advertising and Sponsorship Sales

Peter Fretty - Vice President, Market Leader

Tim Carli - Business Development Manager

Brayden Hudspeth - Sales Development Representative

Subscriptions and Memberships

Subscribe to our newsletters and manage your subscriptions

Feedback/Problems

Send a message to our general in-box

 

Bruker Announces EpicIFTM, Revolutionary Fluorescence Signal Removal Technology, Transforming CellScape Spatial Proteomics Platform

New Technology Expands Antibody Compatibility and Doubles Throughput while maintaining Tissue Integrity and Lack of Cross-Reactivity

Bruker Corporation (Nasdaq: BRKR) today announced a major technological breakthrough in the CellScape™ Precise Spatial Proteomics platform for highly multiplexed immunofluorescence (IF). Launched in 2022, the CellScape platform has advanced the field of spatial proteomics with differentiated quantitative performance enabled by a unique combination of best-in-class resolution and high dynamic range (HDR) imaging. CellScape captures the entire continuum of protein expression in a biological sample—from least to most abundant—while capturing fine morphological details. CellScape utilizes directly-labeled primary antibodies, enabling a robust and modular chemistry that allows researchers to build assays by combining panels and/or individual markers, even after the conclusion of an experimental run. With this new technology, Bruker has further advanced the CellScape chemistry with EpicIF (Enhanced photobleaching in cyclic immunofluorescence), which expands the range of compatible commercially available fluorophore conjugated antibodies by nearly 10-fold, simplifies assay development, and increases throughput by up to 2-fold. EpicIF enhances photobleaching efficacy combining a proprietary reagent with visible light to gently erase fluorescence signal from nearly any fluorophore and, like the prior version, the epitopes are preserved while maintaining tissue integrity.

This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20241108899571/en/

Human FFPE tonsil, 48-plex proteomics assay captured on the CellScape Spatial Proteomics Instrument (inset) using EpicIF technology (Photo: Business Wire)

Human FFPE tonsil, 48-plex proteomics assay captured on the CellScape Spatial Proteomics Instrument (inset) using EpicIF technology (Photo: Business Wire)

EpicIF is supported by the concurrent release of a new version of the software. The new software, CellScape™ Navigator, also introduces a more intuitive user interface and easy experiment setup. Both EpicIF and CellScape Navigator will be available as upgrades to current CellScape instruments. “This breakthrough gives scientists an unmatched level of flexibility in their highly multiplexed IF experiments,” said Ranga Partha, PhD, Senior Vice President of Product Management and Marketing at Bruker Spatial Biology. “This new advancement builds on the best-in-class performance of the CellScape, which already offers differentiated quantitative performance, reliability, and modularity at any time. Now, by enabling the erasure of previously photostable fluorophore signals, researchers can choose a wider selection of antibody conjugates than ever before. In addition, EpicIF enables compatibility of the CellScape platform with additional fluorescent readouts, such as RNA-ISH. It’s a leap forward in versatility for high-throughput spatial proteomics and we’re thrilled to offer this transformative technology to our customers.”

Oliver Braubach, PhD, Director of R&D Assays at Bruker Spatial Biology, added, “We have developed a solution that overcomes the limitations of traditional multiplexing. The ability to erase signal from a wide range of organic fluorescent dyes without damaging tissues not only simplifies workflows, but also allows scientists to use antibodies validated in other workflows, providing cost and time savings on assay optimization. The use of directly-labeled primary antibodies also eliminates the cross-reactivity observed in other spatial proteomic techniques that rely on secondary antibodies." Bruker Spatial Biology will be sharing more about this new advancement at the Society for Immunotherapy of Cancer (SITC) 2024 Annual Meeting from Nov 8-10 in Houston, Texas at booth #419. For additional information, visit www.brukerspatialbiology.com/EpicIF.

About Bruker Spatial Biology

Bruker Spatial Biology, a division of Bruker Corporation, provides advanced spatial solutions, including instruments, assays, software, and services to support life sciences research from discovery to translation. Best-in-class technologies include the CosMx® SMI with data analysis by the AtoMx™ SIP, GeoMx® DSP, CellScape™ platform, and nCounter® system. Canopy Multiomic Services provides access to these technologies for biopharmaceutical research, custom assay development, and clinical sample testing. Learn more at www.brukerspatialbiology.com.

About Bruker Corporation – Leader of the Post-Genomic Era (Nasdaq: BRKR)

Bruker is enabling scientists and engineers to make breakthrough post-genomic discoveries and develop new applications that improve the quality of human life. Bruker’s high performance scientific instruments and high value analytical and diagnostic solutions enable scientists to explore life and materials at molecular, cellular, and microscopic levels. In close cooperation with our customers, Bruker is enabling innovation, improved productivity, and customer success in post-genomic life science molecular and cell biology research, in applied and biopharma applications, in microscopy and nanoanalysis, as well as in industrial and cleantech research, and next-gen semiconductor metrology in support of AI. Bruker offers differentiated, high value life science and diagnostics systems and solutions in preclinical imaging, clinical phenomics research, proteomics and multiomics, spatial and single-cell biology, functional structural and condensate biology, as well as in clinical microbiology and molecular diagnostics. For more information, please visit www.bruker.com.

Contacts

Stock Quote API & Stock News API supplied by www.cloudquote.io
Quotes delayed at least 20 minutes.
By accessing this page, you agree to the following
Privacy Policy and Terms Of Service.