'Constantly stressed out': A woman's battle with excess cortisol

October 18, 2024 at 12:01 PM EDT

(BPT) - For Janice, health and fitness were always priorities. Growing up in Jamaica, she'd been a sprinter for her high school track team. After moving to the U.S. in her mid-20s, she built a successful career in sales while raising two young children. Although she was busy, she maintained a healthy and active lifestyle. In fact, other than having slightly elevated blood pressure, she was the picture of good health.

Yet things changed dramatically for Janice when she reached her mid-40s. Her blood pressure escalated significantly and no longer responded to medication. Her menstrual cycles became unpredictable. Most unsettling of all were the alarming changes in her appearance. Her face swelled and she gained a significant amount of weight around the center of her body. 'People asked me if I was on steroids,' Janice recalls. Her legs became emaciated and weak. She developed a fatty hump between the shoulders (buffalo hump) and grew so much facial hair she had to start shaving it. She fought constant lethargy during the day, but then would be unable to sleep during the night.

Looking back, she remembers, 'I was constantly stressed out. I didn't look well, and I didn't feel well.'

'My blood sugar would just skyrocket.'

Things came to a head one afternoon. Feeling unwell, Janice experienced a dizzy spell and fell while getting out of the shower. Unable to move or see clearly, she was rushed to the emergency room, where her blood sugar was measured at 1,000 mg/dL - a level so high it could trigger a diabetic coma. She was diagnosed with type 2 diabetes and discharged with a new regimen of medications and lifestyle modifications.

Despite following her doctor's instructions, Janice's problems persisted. 'Even when eating healthy and taking all my meds, my blood sugar would just skyrocket after meals.' She soon learned her kidneys and heart were also being impacted.

'Nobody had bothered to put it all together.'

Janice was on up to 25 different medications, but her symptoms continued, and her frustration grew. 'I saw so many doctors - nearly every kind of -ologist you can think of,' she recounts.

One day, a chance conversation with someone else's healthcare provider led to a breakthrough. After mentioning her health struggles in passing, the doctor suggested she might have Cushing's syndrome. Janice began to research Cushing's syndrome (also known as hypercortisolism) and was struck by how similar the symptoms seemed to her own. She found a local endocrinologist, shared her suspicions about Cushing's syndrome, and a combination of blood tests confirmed her theory: Her cortisol levels were highly elevated. Further testing revealed a growth on her pituitary gland was causing the excess cortisol.

'For so long,' she recalls, 'nobody had bothered to put it all together.'

'Finally, I look and feel normal again.'

With her Cushing's syndrome properly diagnosed, Janice underwent surgery to remove her pituitary growth. Her recovery was difficult, but since receiving treatment she has grown stronger, and her Cushing's symptoms are better. She remembers feeling that 'at last, there was light at the end of the tunnel.'

While Janice's journey has not been easy, today she is much healthier. She has lost 50 pounds, her hypertension is under control, her blood sugar has returned to normal levels, her kidney function is stable, and she has resumed her active lifestyle.

When speaking with other patients who face similar symptoms, she urges them to be proactive in their care. 'A lot of people are walking around with Cushing's and don't know it. It's everyone's responsibility to educate doctors so they can help new patients.' She cites her own experience as living proof, adding: 'Finally, I look and feel normal again. And I'm so grateful.'

If you suspect you may have hypercortisolism or Cushing's syndrome, talk to your doctor.

You can visit corcept.com to learn more about how Corcept Therapeutics is unlocking the potential of cortisol modulation to revolutionize the treatment of serious diseases.

This article is the experience of one person and is not medical advice. Consult a medical professional for medical advice, diagnoses or treatment.

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'Constantly stressed out': A woman's battle with excess cortisol

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