What you need to know about this season's COVID-19 vaccine

October 08, 2025 at 17:17 PM EDT

(BPT) - As we head into fall and colder months approach, it's important to stay vigilant of the increased risk of respiratory viruses, especially COVID-19. Over the past four years, data has shown that COVID-19 cases, hospitalizations and deaths consistently rise during the fall and winter seasons.¹

This seasonal trend is reflected in recent data, underscoring the ongoing impact of COVID-19 across the country. Recent estimates from the Centers for Disease Control and Prevention (CDC) show that between October 1, 2024, and August 9, 2025, COVID-19 led to approximately 320,000 to 480,000 hospitalizations and 37,000 to 56,000 deaths in the United States.² Older adults remain especially vulnerable. Those aged 65 and older accounted for two-thirds of COVID-19-related hospitalizations between March 2020 and September 2024.³

In August, the U.S. Food and Drug Administration approved updated COVID-19 vaccines for the 2025-2026 season targeting the LP.8.1 variant of SARS-CoV-2. The CDC's Advisory Committee on Immunization Practices (ACIP) recommends that individuals consult with their health care providers to determine if the COVID-19 vaccine is right for you, especially for those under the age of 65 who have health conditions that put them at higher risk for severe illness.⁴

"Many people view COVID-19 as a thing of the past, but the reality is, it's still making people sick," said Dr. Donald Middleton, Professor of Family Medicine at the University of Pittsburgh School of Medicine and Vice President of Family Practice Education at UPMC St. Margaret. "While many have stopped testing when they feel ill, they could still have COVID-19 and unknowingly spread it. That's why it's so important to reduce your risk of serious illness by getting vaccinated. COVID-19 frequently changes, so an updated vaccine can help keep you protected, even if you have been vaccinated previously."

Here are three reasons to get the updated COVID-19 vaccine this fall:

1. Your immunity to COVID-19 wanes over time

The SARS-CoV-2 virus is constantly changing, and immunity from previous vaccinations or infections decreases over time.^5,⁶ The updated vaccines are designed to provide better protection as the virus mutates, prevent serious COVID-19 outcomes, and even help prevent Long COVID.^5,⁷

Per the CDC, if you have recently recovered from a COVID-19 infection, you may consider delaying your vaccine dose by three months.⁸ For example, if you had COVID-19 in July, you could wait until October to get your vaccine. Speaking to your healthcare provider remains one of the best ways to learn more about staying up to date with your vaccinations.

2. Many people have a high risk for complications

Approximately three in four adults in the U.S. have at least one underlying health condition that can increase their risk for developing severe illness from a COVID-19 infection.⁹ These underlying conditions include but are not limited to diabetes, obesity, heart conditions, lung disease and possibly high blood pressure (hypertension).¹⁰

In addition to underlying medical conditions, additional factors that can elevate a person's risk of developing severe COVID-19, include:¹⁰

Older adults are at highest risk of getting very sick from COVID-19.
Your risk of severe illness from COVID-19 increases as the number of your underlying medical conditions increases.
Some people are at increased risk of getting very sick or dying from COVID-19 because of where they live or work, or because they can't get health care.

The risk of severe illness increases with the number of underlying conditions a person has.¹⁰ Older adults, especially those aged 65 and older, are particularly vulnerable due to age-related weakening of the immune system.¹¹ This group, made up of roughly one in six Americans, accounts for the majority of COVID-19-related hospitalizations and deaths.³^,12

Given these risks, it's important for all adults, especially those with underlying conditions or who are older, to take appropriate precautions to protect themselves and others.

3. Long COVID still poses a threat

Healthcare professionals estimate that nearly one in three Americans who have had COVID-19 experience Long COVID, regardless of age or prior health status.¹³ This means that anyone who contracts COVID-19 is potentially at risk.

Long COVID is a chronic condition that persists for at least three months after initial infection with SARS-CoV-2.⁷ It can involve a wide range of symptoms, including difficulty concentrating, fatigue and chest pain. These symptoms may improve, worsen or persist over time, lasting for several months or even years.⁷^,14 In addition to these symptoms, individuals who experienced severe acute COVID-19 are at an increased risk for long-term complications such as cardiovascular disease, diabetes, kidney issues and gastrointestinal disorders.¹⁵

Certain groups are more likely to develop Long COVID, including those who are unvaccinated, aged 65 and older, or have underlying health conditions. For these individuals, the risk of both severe illness and long-term effects is significantly higher.⁷

Protect yourself and your loved ones this fall

Vaccination remains one of the most effective tools in defending yourself against COVID-19.¹⁶ If you're unsure about when to get vaccinated, what your personal risk factors are, or how best to protect yourself during respiratory illness season, talk to your healthcare provider to make informed decisions.

To learn more about the COVID-19 vaccine, visit the CDC website. To find a vaccine near you, visit your local pharmacy's website.

Content sponsored by Moderna.

1 CDC, 2025. Accessed August 15, 2025. https://www.cdc.gov/resp-net/dashboard/index.html

2 CDC, 2024. Accessed August 15, 2025. https://www.cdc.gov/covid/php/surveillance/burden-estimates.html

3 Taylor CA, et al. Trends in COVID-19-Attributable Hospitalizations Among Adults With Laboratory-Confirmed SARS-CoV-2-COVID-NET, June 2020 to September 2023. Influenza Other Respir Viruses. 2024 Nov;18(11):e70021

4 HHS, 2025. ACIP Recommends COVID-19 Immunization Based on Individual Decision-making. https://www.hhs.gov/press-room/acip-recommends-covid19-vaccination-individual-decision-making.html

5 CDC, 2023. Accessed August 15, 2025. https://www.cdc.gov/ncird/whats-new/variants-happen.html

6 CDC, 2025. Accessed August 15, 2025. https://www.cdc.gov/covid/vaccines/stay-up-to-date.html

7 CDC, 2025. Accessed August 15, 2025. https://www.cdc.gov/covid/long-term-effects/index.html

8 CDC, 2025. Accessed August 29, 2025. https://www.cdc.gov/covid/vaccines/getting-your-covid-19-vaccine.html

9 Ajufo E, et al. U.S. population at increased risk of severe illness from COVID-19. Am J Prev Cardiol. 2021;6(100156):100156

10 CDC, 2025. Accessed August 15, 2025. https://www.cdc.gov/covid/risk-factors/index.html

11 Haynes L. Aging of the Immune System: Research Challenges to Enhance the Health Span of Older Adults. Frontiers in aging. 2020, 1, 602108. https://doi.org/10.3389/fragi.2020.602108

12 Caplan, Z. 2020 Census: 1 in 6 people in the United States were 65 and over. U.S. Census Bureau. 2023, May 25. https://www.census.gov/library/stories/2023/05/2020-census-united-states-older-population-grew.html

13 Hou, Y, et al. Global Prevalence of Long COVID, its Subtypes and Risk factors: An Updated Systematic Review and Meta-Analysis. medRxiv [Preprint]. 2025 Jan 6:2025.01.01.24319384. doi: 10.1101/2025.01.01.24319384

14 CDC, 2025. Accessed August 15, 2025. https://www.cdc.gov/covid/long-term-effects/long-covid-signs-symptoms.html

15 Bowe, B., et al. Postacute sequelae of COVID-19 at 2 years. Nat Med 29, 2347-2357 (2023). https://doi.org/10.1038/s41591-023-02521-2

16 CDC, 2024. Accessed August 15, 2025. https://www.cdc.gov/covid/vaccines/how-they-work.html

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What you need to know about this season's COVID-19 vaccine

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