GenoFAB Launches Hybrid Plasmid Sequencing Service To Set a New Standard for Reproducibility in Biotechnology

February 24, 2025 at 10:16 AM EST

New service enhances plasmid quality control for research and manufacturing.

GenoFAB is introducing a whole plasmid sequencing service, a groundbreaking solution designed to enhance reproducibility and quality control in biotechnology research and biomanufacturing. By leveraging both long-read and short-read sequencing technologies, GenoFAB ensures unprecedented base-level accuracy, addressing a critical challenge in the field.

Plasmids are the foundation of many biopharmaceutical, synthetic biology, and gene therapy applications, yet plasmid quality control remains a persistent bottleneck. Errors in plasmid sequences can lead to failed experiments, regulatory setbacks, and compromised product performance. GenoFAB’s new service provides researchers and biotech companies with a reliable way to validate and manage plasmid integrity throughout the entire product lifecycle—from early-stage R&D to commercial manufacturing.

Meeting the Growing Need for Plasmid Quality Control

As biomanufacturing scales up and regulatory standards tighten, ensuring the integrity of plasmids has become more critical than ever. Unlike traditional sequencing approaches that can be challenged by complex sequences, GenoFAB’s hybrid sequencing method combines the advantages of long-read sequencing for Oxford Nanopore to capture structural variants and short-read sequencing from Illumina to ensure base-level accuracy.

This service builds on recent research results published in ACS Synthetic Biology and Bioinformatics, where GenoFAB’s team introduced a new bioinformatics pipeline designed to increase the reproducibility and reliability of sequencing workflows. The service is an integral part of GenoFAB’s plasmid management platform that includes plasmid design, plasmid construction and purification, and the management of private plasmid repositories. These integrated services ensure that plasmids meet the highest standards at every stage of development and manufacturing.

Designed for a Wide Range of Users

GenoFAB’s plasmid sequencing service can be tailored to meet the needs of a variety of stakeholders in the life sciences, including:

- Academic scientists who need to control plasmids the integrity of the plasmids they use to test novel scientific hypotheses or groundbreaking applications of machine learning and artificial intelligence.

- Biotech companies who rely on plasmids to develop gene therapies, cell therapies, and engineer cell lines to produce biologic drugs and regenerative medicines.

- Operators of biomanufacturing facilities needing to control the quality of plasmids used to produce recombinant proteins and mRNAs

“We’re excited to bring our plasmid sequencing capabilities to the scientific community,” said Jean Peccoud, Founder of GenoFAB and Professor at Colorado State University. “For years, the industry has struggled with reproducibility issues. By ensuring plasmid quality at every stage of the research and development process, we can help scientists improve the performance of their products while meeting the most stringent regulatory standards.”

A Step Toward Smarter Plasmid Management

GenoFAB’s all-inclusive sequencing service eliminates the need for users to prepare sequencing-grade plasmid solutions, reducing the risk of contamination and user error. By combining automated workflows with cutting-edge bioinformatics, the service offers a scalable solution that enables life scientists to focus on discovery rather than troubleshooting plasmid errors.

Looking ahead, GenoFAB is expanding its suite of plasmid management tools with the goal of securing the exchange of critical biological materials in the bioeconomy supply chain.

Learn more about GenoFAB’s whole plasmid sequencing services.

About GenoFAB

GenoFAB helps life scientists and biotechnology companies accelerate research and product development by delivering the plasmids they need when they need them. The company eliminates the risks of poor plasmid management—unexpected delays, cost overruns, quality control issues, and commercialization roadblocks—so scientists can focus on discovery and companies can focus on their core business. GenoFAB’s comprehensive plasmid management services span the entire plasmid lifecycle, from design to distribution and commercialization.

Media Contact
Company Name: GenoFAB, Inc.
Contact Person: Jean Peccoud
Email: Send Email
Country: United States
Website: https://www.genofab.com

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GenoFAB Launches Hybrid Plasmid Sequencing Service To Set a New Standard for Reproducibility in Biotechnology

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