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Acousia Therapeutics Reaches 50% Patient Enrollment Milestone in Phase 2 PROHEAR Study

By: PR Leap
(PRLeap.com) Tübingen, Germany, April 29, 2025 - Acousia Therapeutics GmbH announced that it has successfully enrolled 50% of patients in its ongoing Phase 2 clinical trial, the PROHEAR Study, evaluating ACOU085 (INN: bimokalner) for the prevention of cisplatin-induced hearing loss in patients with testicular cancer undergoing chemotherapy.

Cisplatin is a cornerstone in modern oncology and is used annually in more than 500,000 cancer patients worldwide. Its introduction in the late 1970s revolutionized testicular cancer treatment, improving the 5-year survival rate (from just 5% to 98%). However, its life-saving efficacy is often overshadowed by severe side effects, with permanent, bilateral hearing loss among the most debilitating. Studies indicate that up to 80% of patients treated with cisplatin may experience clinically-relevant hearing loss.

The PROHEAR Study is a placebo-controlled, randomized, double-blind, split-body trial in which participants receive ACOU085, a Kv7.4 channel activator, in one ear and a placebo in the contralateral ear. The study is currently being conducted at 13 leading German ENT university clinics and is still actively recruiting.

"This marks a significant milestone on Acousia's journey to offer a treatment for the prevention of permanent hearing loss caused by cisplatin," said Professor Hubert Löwenheim, Chair of the Department of Otolaryngology - Head & Neck Surgery at Tuebingen University and Scientific Supervisor of the study. "Preventing this often overlooked side effect is critical for cancer patients. Notably, all PROHEAR participants who have received ≥300 mg/m² of cisplatin to date have developed ototoxicity. This is higher than reported in most, if not all, previous studies."

The PROHEAR Study is on track to complete enrollment by the end of the second half of 2025. For more information, visit clinicaltrials.gov.

ACOU085 (INN: bimokalner) is a first-in-class, small-molecule, etiology-agnostic otoprotective drug-candidate delivered using standard transtympanic administration of a proprietary, slow-release gel formulation. Ototoxic hearing loss is a typical, severe, and permanent side effect of cisplatin treatment and is a consequence of irreversible damage to the sensory cells in the inner ear, the so-called outer hair cells (OHCs). ACOU085 modulates a biologically validated target, the KCNQ4-encoded Kv7.4 potassium channel of the OHCs, and has demonstrated significant potential to reduce cisplatin-induced hearing loss and preserve outer hair cells from ototoxicity in preclinical models.

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Tim Boelke, M.D.
Acousia Therapeutics GmbH
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http://www.acousia.com

You can see the original version and more on PRLeap here: http://www.prleap.com/pr/304781/acousia-therapeutics-reaches-50-patient-enrollment-milestone-in-phase-2-prohear-study-

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